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公开(公告)号：US20230305649A1
公开(公告)日：2023-09-28
申请号：US18203808
申请日：2023-05-31
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Yunlu ZOU
IPC: G06F3/0362 , G06F3/04845 , G06F3/02 , G06F3/0354
CPC classification number: G06F3/0362 , G06F3/04845 , G06F3/0213 , G06F3/03547
Abstract: An input device allows a user to manipulate an image displayed by a user interface (UI) of a computer. The input device includes a housing, a first rotatable control knob supported by the housing, and a second rotatable control knob supported by the housing. The first and second rotatable control knobs allow the user to perform at least zooming and panning manipulations of the image on the UI. The input device can further include a third rotatable control knob and a touch pad. The input device can be configured as a keyboard.
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公开(公告)号：US20210080707A1
公开(公告)日：2021-03-18
申请号：US17105232
申请日：2020-11-25
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Yunlu ZOU , Gregory CRANDALL , Allen OLSON
Abstract: Systems and methods for capturing a digital image of a slide using an imaging line sensor and a focusing line sensor. In an embodiment, a beam-splitter is optically coupled to an objective lens and configured to receive one or more images of a portion of a sample through the objective lens. The beam-splitter simultaneously provides a first portion of the one or more images to the focusing sensor and a second portion of the one or more images to the imaging sensor. A processor controls the stage and/or objective lens such that each portion of the one or more images is received by the focusing sensor prior to it being received by the imaging sensor. In this manner, a focus of the objective lens can be controlled using data received from the focusing sensor prior to capturing an image of a portion of the sample using the imaging sensor.
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公开(公告)号：US20200209600A1
公开(公告)日：2020-07-02
申请号：US16812010
申请日：2020-03-06
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Leng-Chun CHEN , Yunlu ZOU , Allen OLSON , Peyman NAJMABADI , Greg CRANDALL , Nicholas NEWBERG , Aaron STEARRETT
Abstract: Two-pass capture of a macro image. In an embodiment, a scanning apparatus comprises a stage, a high-resolution camera, and a lens that provides a field of view, substantially equal in width to a slide width, to the high-resolution camera. The apparatus also comprises a first illumination system for transmission-mode illumination, and a second illumination system for reflection-mode illumination. Processor(s) move the stage in a first direction to capture a first macro image of a specimen during a single pass while the field of view is illuminated by the first illumination system, and move the stage in a second direction to capture a second macro image of the specimen during a single pass while the field of view is illuminated by the second illumination system. The processor(s) identify artifacts in the second macro image, and, based on those artifacts, correct the first macro image to generate a modified first macro image.
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公开(公告)号：US20240064400A1
公开(公告)日：2024-02-22
申请号：US18500231
申请日：2023-11-02
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Allen H. OLSON , Yunlu ZOU , Bharat ANNALDAS , Leng-Chun CHEN
CPC classification number: H04N23/67 , G02B21/002 , G02B21/244 , G02B21/367 , H04N3/06 , H04N23/90 , H04N23/56
Abstract: Real-time focusing in a slide-scanning system. In an embodiment, focus points are added to 500 an initialized focus map while acquiring a plurality of image stripes of a sample on a glass slide. For each image stripe, a plurality of frames, collectively representing the image stripe, may be acquired using both an imaging line-scan camera and a tilted focusing line-scan camera. Focus points, representing positions of best focus for trusted frames, are added to the focus map. Outlying focus points are removed from the focus map. In some cases, one or more image stripes may be reacquired. Finally, the image stripes are assembled into a composite image of the sample.
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公开(公告)号：US20210048659A1
公开(公告)日：2021-02-18
申请号：US17072785
申请日：2020-10-16
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Yunlu ZOU , Nicholas NEWBERG , Gregory CRANDALL
Abstract: A digital pathology imaging apparatus includes a single line scan camera sensor optically coupled with first and second optical paths. In a first embodiment, transmission mode illumination and oblique mode illumination are simultaneously used during a single stage movement that captures a low resolution macro image of the entire sample area and the entire label area of the slide via the first optical path. In a second embodiment, transmission mode illumination is used during a first stage movement that captures a low resolution macro image of at least the entire sample area via the first optical path and oblique mode illumination is used during a second stage movement that captures a low resolution macro image of at least the entire label area via the first optical path.
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Patent Agency Ranking
公开(公告)号：US20190101739A1
公开(公告)日：2019-04-04
申请号：US16147465
申请日：2018-09-28
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
CPC classification number: G02B21/244 , G02B21/006 , G02B21/0076 , G02B21/008 , G06T7/50 , G06T2207/10061 , G06T2207/10064 , H04N5/37206
Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
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公开(公告)号：US20190101737A1
公开(公告)日：2019-04-04
申请号：US16147476
申请日：2018-09-28
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Yunlu ZOU , Peyman NAJMABADI
Abstract: Apparatus and methods for scanning a 2D or 3D image of a specimen without relative Z-axis motion between the specimen and the objective lens. In an embodiment, the apparatus includes a tilted camera having individual lines of pixels. Each line of pixels can be separately processed and is at a different image plane with respect to the stage. The depth of field of each line of pixels abuts, slightly overlaps, or is slightly spaced apart from the adjacent lines of pixels in the tilted camera. The angle of the tilt determines the relationship (abut, overlapping, or spaced) of the adjacent lines of pixels. The individual image lines produced by each line of pixels can be combined into a 3D volume image of a sample. Also, the highest-contrast line at each X-Y location can be combined into an in-focus 2D image of the sample.
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公开(公告)号：US20210048606A1
公开(公告)日：2021-02-18
申请号：US17085962
申请日：2020-10-30
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Allen OLSON , Kiran SALIGRAMA , Yunlu ZOU , Peyman NAJMABADI
Abstract: A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.
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公开(公告)号：US20190121108A1
公开(公告)日：2019-04-25
申请号：US16224397
申请日：2018-12-18
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Yunlu ZOU , Gregory CRANDALL , Allen OLSON
Abstract: Systems and methods for capturing a digital image of a slide using an imaging line sensor and a focusing line sensor. In an embodiment, a beam-splitter is optically coupled to an objective lens and configured to receive one or more images of a portion of a sample through the objective lens. The beam-splitter simultaneously provides a first portion of the one or more images to the focusing sensor and a second portion of the one or more images to the imaging sensor. A processor controls the stage and/or objective lens such that each portion of the one or more images is received by the focusing sensor prior to it being received by the imaging sensor. In this manner, a focus of the objective lens can be controlled using data received from the focusing sensor prior to capturing an image of a portion of the sample using the imaging sensor.
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公开(公告)号：US20190101736A1
公开(公告)日：2019-04-04
申请号：US16146991
申请日：2018-09-28
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Leng-Chun CHEN , Yunlu ZOU , Allen OLSON , Peyman NAJMABADI , Greg CRANDALL , Nicholas NEWBERG , Aaron STEARRETT
Abstract: Two-pass capture of a macro image. In an embodiment, a scanning apparatus comprises a stage, a high-resolution camera, and a lens that provides a field of view, substantially equal in width to a slide width, to the high-resolution camera. The apparatus also comprises a first illumination system for transmission-mode illumination, and a second illumination system for reflection-mode illumination. Processor(s) move the stage in a first direction to capture a first macro image of a specimen during a single pass while the field of view is illuminated by the first illumination system, and move the stage in a second direction to capture a second macro image of the specimen during a single pass while the field of view is illuminated by the second illumination system. The processor(s) identify artifacts in the second macro image, and, based on those artifacts, correct the first macro image to generate a modified first macro image.
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