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公开(公告)号：US20200209600A1
公开(公告)日：2020-07-02
申请号：US16812010
申请日：2020-03-06
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Leng-Chun CHEN , Yunlu ZOU , Allen OLSON , Peyman NAJMABADI , Greg CRANDALL , Nicholas NEWBERG , Aaron STEARRETT
Abstract: Two-pass capture of a macro image. In an embodiment, a scanning apparatus comprises a stage, a high-resolution camera, and a lens that provides a field of view, substantially equal in width to a slide width, to the high-resolution camera. The apparatus also comprises a first illumination system for transmission-mode illumination, and a second illumination system for reflection-mode illumination. Processor(s) move the stage in a first direction to capture a first macro image of a specimen during a single pass while the field of view is illuminated by the first illumination system, and move the stage in a second direction to capture a second macro image of the specimen during a single pass while the field of view is illuminated by the second illumination system. The processor(s) identify artifacts in the second macro image, and, based on those artifacts, correct the first macro image to generate a modified first macro image.
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公开(公告)号：US20190101739A1
公开(公告)日：2019-04-04
申请号：US16147465
申请日：2018-09-28
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
CPC classification number: G02B21/244 , G02B21/006 , G02B21/0076 , G02B21/008 , G06T7/50 , G06T2207/10061 , G06T2207/10064 , H04N5/37206
Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
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公开(公告)号：US20210103134A1
公开(公告)日：2021-04-08
申请号：US17105251
申请日：2020-11-25
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
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Patent Agency Ranking
公开(公告)号：US20190101736A1
公开(公告)日：2019-04-04
申请号：US16146991
申请日：2018-09-28
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Leng-Chun CHEN , Yunlu ZOU , Allen OLSON , Peyman NAJMABADI , Greg CRANDALL , Nicholas NEWBERG , Aaron STEARRETT
Abstract: Two-pass capture of a macro image. In an embodiment, a scanning apparatus comprises a stage, a high-resolution camera, and a lens that provides a field of view, substantially equal in width to a slide width, to the high-resolution camera. The apparatus also comprises a first illumination system for transmission-mode illumination, and a second illumination system for reflection-mode illumination. Processor(s) move the stage in a first direction to capture a first macro image of a specimen during a single pass while the field of view is illuminated by the first illumination system, and move the stage in a second direction to capture a second macro image of the specimen during a single pass while the field of view is illuminated by the second illumination system. The processor(s) identify artifacts in the second macro image, and, based on those artifacts, correct the first macro image to generate a modified first macro image.
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公开(公告)号：US20180275388A1
公开(公告)日：2018-09-27
申请号：US15763061
申请日：2016-09-23
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Yunlu ZOU , Allen OLSON , Kiran SALIGRAMA , Ruby CHEN , Peyman NAJMABADI , Greg CRANDALL
CPC classification number: G02B21/244 , G02B7/38 , G02B21/02 , G02B21/18 , G02B21/245 , G02B21/26 , G02B21/34 , G02B21/361 , G03B13/36 , H04N5/23212
Abstract: System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. The system further comprises at least one beam splitter optically coupled to the objective lens and configured to receive a field of view corresponding to the optical axis of the objective lens, and simultaneously provide at least a first portion of the field of view to the imaging sensor and at least a second portion of the field of view to the focusing sensor. The focusing sensor may simultaneously acquire image(s) at a plurality of different focal distances and/or simultaneously acquire a pair of mirrored images, each comprising pixels acquired at a plurality of different focal distances.
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公开(公告)号：US20220357565A1
公开(公告)日：2022-11-10
申请号：US17814180
申请日：2022-07-21
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
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公开(公告)号：US20200218053A1
公开(公告)日：2020-07-09
申请号：US16818916
申请日：2020-03-13
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Yunlu ZOU , Allen OLSON , Kiran SALIGRAMA , Ruby CHEN , Peyman NAJMABADI , Greg CRANDALL
IPC: G02B21/24 , G03B13/36 , G02B7/38 , H04N5/232 , G02B21/36 , G02B21/34 , G02B21/26 , G02B21/18 , G02B21/02
Abstract: System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. The system further comprises at least one beam splitter optically coupled to the objective lens and configured to receive a field of view corresponding to the optical axis of the objective lens, and simultaneously provide at least a first portion of the field of view to the imaging sensor and at least a second portion of the field of view to the focusing sensor. The focusing sensor may simultaneously acquire image(s) at a plurality of different focal distances and/or simultaneously acquire a pair of mirrored images, each comprising pixels acquired at a plurality of different focal distances.
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公开(公告)号：US20200064612A1
公开(公告)日：2020-02-27
申请号：US16674742
申请日：2019-11-05
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
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