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公开(公告)号：US20180275388A1
公开(公告)日：2018-09-27
申请号：US15763061
申请日：2016-09-23
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Yunlu ZOU , Allen OLSON , Kiran SALIGRAMA , Ruby CHEN , Peyman NAJMABADI , Greg CRANDALL
CPC classification number: G02B21/244 , G02B7/38 , G02B21/02 , G02B21/18 , G02B21/245 , G02B21/26 , G02B21/34 , G02B21/361 , G03B13/36 , H04N5/23212
Abstract: System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. The system further comprises at least one beam splitter optically coupled to the objective lens and configured to receive a field of view corresponding to the optical axis of the objective lens, and simultaneously provide at least a first portion of the field of view to the imaging sensor and at least a second portion of the field of view to the focusing sensor. The focusing sensor may simultaneously acquire image(s) at a plurality of different focal distances and/or simultaneously acquire a pair of mirrored images, each comprising pixels acquired at a plurality of different focal distances.
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公开(公告)号：US20220357565A1
公开(公告)日：2022-11-10
申请号：US17814180
申请日：2022-07-21
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
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公开(公告)号：US20200218053A1
公开(公告)日：2020-07-09
申请号：US16818916
申请日：2020-03-13
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Yunlu ZOU , Allen OLSON , Kiran SALIGRAMA , Ruby CHEN , Peyman NAJMABADI , Greg CRANDALL
IPC: G02B21/24 , G03B13/36 , G02B7/38 , H04N5/232 , G02B21/36 , G02B21/34 , G02B21/26 , G02B21/18 , G02B21/02
Abstract: System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. The system further comprises at least one beam splitter optically coupled to the objective lens and configured to receive a field of view corresponding to the optical axis of the objective lens, and simultaneously provide at least a first portion of the field of view to the imaging sensor and at least a second portion of the field of view to the focusing sensor. The focusing sensor may simultaneously acquire image(s) at a plurality of different focal distances and/or simultaneously acquire a pair of mirrored images, each comprising pixels acquired at a plurality of different focal distances.
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公开(公告)号：US20200064612A1
公开(公告)日：2020-02-27
申请号：US16674742
申请日：2019-11-05
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
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Patent Agency Ranking
公开(公告)号：US20180188517A1
公开(公告)日：2018-07-05
申请号：US15858487
申请日：2017-12-29
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Yunlu ZOU , Nicholas NEWBERG , Gregory CRANDALL
CPC classification number: G02B21/361 , G02B21/002 , G02B21/245 , G02B21/26 , G02B21/34 , G02B21/365 , G06T2207/10056
Abstract: A digital pathology imaging apparatus includes a single line scan camera sensor optically coupled with first and second optical paths. In a first embodiment, transmission mode illumination and oblique mode illumination are simultaneously used during a single stage movement that captures a low resolution macro image of the entire sample area and the entire label area of the slide via the first optical path. In a second embodiment, transmission mode illumination is used during a first stage movement that captures a low resolution macro image of at least the entire sample area via the first optical path and oblique mode illumination is used during a second stage movement that captures a low resolution macro image of at least the entire label area via the first optical path.
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公开(公告)号：US20210103134A1
公开(公告)日：2021-04-08
申请号：US17105251
申请日：2020-11-25
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Leng-Chun CHEN , Allen OLSON , Yunlu ZOU , Peyman NAJMABADI , Greg CRANDALL
Abstract: Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
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公开(公告)号：US20200026056A1
公开(公告)日：2020-01-23
申请号：US16557623
申请日：2019-08-30
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Yunlu ZOU , Nicholas NEWBERG , Gregory CRANDALL
Abstract: A digital pathology imaging apparatus includes a single line scan camera sensor optically coupled with first and second optical paths. In a first embodiment, transmission mode illumination and oblique mode illumination are simultaneously used during a single stage movement that captures a low resolution macro image of the entire sample area and the entire label area of the slide via the first optical path. In a second embodiment, transmission mode illumination is used during a first stage movement that captures a low resolution macro image of at least the entire sample area via the first optical path and oblique mode illumination is used during a second stage movement that captures a low resolution macro image of at least the entire label area via the first optical path.
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公开(公告)号：US20190101723A1
公开(公告)日：2019-04-04
申请号：US16147448
申请日：2018-09-28
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Allen OLSON , Kiran SALIGRAMA , Yunlu ZOU , Peyman NAJMABADI
Abstract: A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.
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公开(公告)号：US20180100997A1
公开(公告)日：2018-04-12
申请号：US15838043
申请日：2017-12-11
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Yunlu ZOU , Gregory CRANDALL , Allen OLSON
CPC classification number: G02B21/006 , G02B21/245 , G02B21/361 , G02B21/365
Abstract: Systems and methods for capturing a digital image of a slide using an imaging line sensor and a focusing line sensor. In an embodiment, a beam-splitter is optically coupled to an objective lens and configured to receive one or more images of a portion of a sample through the objective lens. The beam-splitter simultaneously provides a first portion of the one or more images to the focusing sensor and a second portion of the one or more images to the imaging sensor. A processor controls the stage and/or objective lens such that each portion of the one or more images is received by the focusing sensor prior to it being received by the imaging sensor. In this manner, a focus of the objective lens can be controlled using data received from the focusing sensor prior to capturing an image of a portion of the sample using the imaging sensor.
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