公开(公告)号：US20180275388A1

公开(公告)日：2018-09-27

申请号：US15763061

申请日：2016-09-23

Applicant: LEICA BIOSYSTEMS IMAGING, INC.

Inventor： Yunlu ZOU ,  Allen OLSON ,  Kiran SALIGRAMA ,  Ruby CHEN ,  Peyman NAJMABADI ,  Greg CRANDALL

IPC: G02B21/24 ,  G02B21/36 ,  G02B21/02 ,  G02B21/18 ,  G02B21/26 ,  G02B21/34 ,  H04N5/232

CPC classification number: G02B21/244 ,  G02B7/38 ,  G02B21/02 ,  G02B21/18 ,  G02B21/245 ,  G02B21/26 ,  G02B21/34 ,  G02B21/361 ,  G03B13/36 ,  H04N5/23212

Abstract: System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. The system further comprises at least one beam splitter optically coupled to the objective lens and configured to receive a field of view corresponding to the optical axis of the objective lens, and simultaneously provide at least a first portion of the field of view to the imaging sensor and at least a second portion of the field of view to the focusing sensor. The focusing sensor may simultaneously acquire image(s) at a plurality of different focal distances and/or simultaneously acquire a pair of mirrored images, each comprising pixels acquired at a plurality of different focal distances.

公开(公告)号：US20200218053A1

公开(公告)日：2020-07-09

申请号：US16818916

申请日：2020-03-13

Applicant: LEICA BIOSYSTEMS IMAGING, INC.

Inventor： Yunlu ZOU ,  Allen OLSON ,  Kiran SALIGRAMA ,  Ruby CHEN ,  Peyman NAJMABADI ,  Greg CRANDALL

IPC: G02B21/24 ,  G03B13/36 ,  G02B7/38 ,  H04N5/232 ,  G02B21/36 ,  G02B21/34 ,  G02B21/26 ,  G02B21/18 ,  G02B21/02

Abstract: System for acquiring a digital image of a sample on a microscope slide. In an embodiment, the system comprises a stage configured to support a sample, an objective lens having a single optical axis that is orthogonal to the stage, an imaging sensor, and a focusing sensor. The system further comprises at least one beam splitter optically coupled to the objective lens and configured to receive a field of view corresponding to the optical axis of the objective lens, and simultaneously provide at least a first portion of the field of view to the imaging sensor and at least a second portion of the field of view to the focusing sensor. The focusing sensor may simultaneously acquire image(s) at a plurality of different focal distances and/or simultaneously acquire a pair of mirrored images, each comprising pixels acquired at a plurality of different focal distances.