公开(公告)号：US11262308B2

公开(公告)日：2022-03-01

申请号：US17078936

申请日：2020-10-23

Applicant: Labrador Diagnostics LLC

Inventor： Chinmay Pangarkar ,  Karan Mohan

IPC: G01N21/64 ,  G01N21/47 ,  G01N15/14

Abstract: Methods and devices for cytometric analysis are provided. A cytometry apparatus is provided which may be used with a stationary sample cuvette for analysis of a stationary sample or with a flow sample cuvette for analysis of a flowing sample. The methods and devices provided herein may be used to perform cytometric analysis of samples under a wide range of experimental and environmental conditions.

公开(公告)号：US11112418B1

公开(公告)日：2021-09-07

申请号：US15664138

申请日：2017-07-31

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Daniel Young ,  Samartha Anekal ,  Chinmay Pangarkar

IPC: G01N35/00 ,  G01N15/14 ,  G01N21/01 ,  B01L3/00 ,  G01N15/00

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20210140890A1

公开(公告)日：2021-05-13

申请号：US17078936

申请日：2020-10-23

Applicant: Labrador Diagnostics LLC

Inventor： Chinmay Pangarkar ,  Karan Mohan

IPC: G01N21/64 ,  G01N21/47 ,  G01N15/14

Abstract: Methods and devices for cytometric analysis are provided. A cytometry apparatus is provided which may be used with a stationary sample cuvette for analysis of a stationary sample or with a flow sample cuvette for analysis of a flowing sample. The methods and devices provided herein may be used to perform cytometric analysis of samples under a wide range of experimental and environmental conditions.

公开(公告)号：US12209290B2

公开(公告)日：2025-01-28

申请号：US17319906

申请日：2021-05-13

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Timothy Smith ,  Samartha Anekal ,  James R. Wasson ,  Daniel L. Young ,  Chinmay Pangarkar

IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/70 ,  G01N33/569

Abstract: In one embodiment, a method is provided comprising analyte testing on one or more types of samples.

公开(公告)号：US11524299B2

公开(公告)日：2022-12-13

申请号：US16712664

申请日：2019-12-12

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Joy Roy ,  John Kent Frankovich ,  Daniel L. Young ,  Timothy Smith ,  Chinmay Pangarkar ,  Samartha Anekal

IPC: G01N35/00 ,  B01L3/00 ,  G01N35/10 ,  B01L3/02 ,  B01L7/00 ,  B01L9/06

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20210318348A1

公开(公告)日：2021-10-14

申请号：US17236835

申请日：2021-04-21

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Daniel Young ,  Samartha Anekal ,  Timothy Smith ,  James R. Wasson ,  Chinmay Pangarkar

IPC: G01N35/04 ,  G01J3/28 ,  G01N15/14

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20210025866A1

公开(公告)日：2021-01-28

申请号：US16990232

申请日：2020-08-11

Applicant: Labrador Diagnostics LLC

Inventor： Chinmay Pangarkar ,  Elizabeth A. Holmes

IPC: G01N33/483

Abstract: Devices, systems and methods for optical analysis of cells in microgravity are disclosed.
Effective cellular microscopic and image analysis requires placement of cells into a proper focal plane, region, or volume. Such placement often requires immobilization of the cells. Cell settling onto a substrate is often sufficient for cell immobilization; however, no significant settling occurs in microgravity. Cell immobilization in microgravity may be accomplished by treatment of a substrate, the cells, or both effective that the substrate captures and immobilizes the cells for inspection. Cells may be immobilized in microgravity by adhering magnetic particles to the cells and applying a magnetic field. Cells may be placed in a proper location for viewing in microgravity by placing the cells into a small chamber or narrow channel. Centrifugal force may effect cell settling and aid cell immobilization. Proper placement or immobilization of cells aids cellular microscopic and image analysis in microgravity.

公开(公告)号：US10768105B1

公开(公告)日：2020-09-08

申请号：US15664580

申请日：2017-07-31

Applicant: Labrador Diagnostics LLC

Inventor： Karan Mohan ,  Chinmay Pangarkar

IPC: G01N21/47 ,  G01N15/14 ,  G01N21/64 ,  G02B26/00 ,  B01L3/00

Abstract: Methods, devices, apparatus, and systems are provided for image analysis. Methods of image analysis may include observation, measurement, and analysis of images of biological and other samples; devices, apparatus, and systems provided herein are useful for observation, measurement, and analysis of images of such samples. The methods, devices, apparatus, and systems disclosed herein provide advantages over other methods, devices, apparatus, and systems.

公开(公告)号：US20210148908A1

公开(公告)日：2021-05-20

申请号：US17082979

申请日：2020-10-28

Applicant: Labrador Diagnostics LLC

Inventor： Chinmay Pangarkar ,  Karan Mohan ,  James R. Wasson

IPC: G01N33/569 ,  B01L3/00 ,  G01N15/10 ,  G02B21/00 ,  G02B21/12 ,  G01N21/05 ,  G02B21/08 ,  G01N33/50 ,  G01N1/30 ,  G01N33/53 ,  G01N33/58 ,  G01N21/64 ,  G02B7/09 ,  G01N21/03 ,  G01N21/17 ,  G02B21/24 ,  G01N33/487 ,  G01N33/49 ,  G01N21/27 ,  G02B21/16 ,  G02B21/36

Abstract: Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples.

公开(公告)号：US10823731B2

公开(公告)日：2020-11-03

申请号：US14600630

申请日：2015-01-20

Applicant: Labrador Diagnostics LLC

Inventor： Chinmay Pangarkar ,  Karan Mohan ,  James R. Wasson

IPC: G01N33/49 ,  G02B7/09 ,  G02B21/16 ,  G01N21/17 ,  G01N33/569 ,  B01L3/00 ,  G01N15/10 ,  G02B21/00 ,  G02B21/12 ,  G01N21/05 ,  G02B21/08 ,  G01N33/50 ,  G01N1/30 ,  G01N21/64 ,  G01N21/03 ,  G02B21/24 ,  G01N33/487 ,  G01N21/27 ,  G02B21/36

Abstract: Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples. Specifically, methods are provided for detecting and measuring, in a sample, cell morphology; measurement of cell numbers; detection of particles; measurement of particle numbers; and other properties and quantities of or in a sample. Some embodiments may use a sample holder comprising a sample chamber configured to hold said sample, at least a portion of said sample holder comprising an optically transmissive material, said optically transmissive material comprising an optically transmissive surface and a reflective surface.