公开(公告)号：US12085583B2

公开(公告)日：2024-09-10

申请号：US17319842

申请日：2021-05-13

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Michael Chen ,  Pey-Jiun Ko

IPC: G01N33/00 ,  B01L3/00 ,  B01L3/02 ,  B01L7/00 ,  B01L9/00 ,  B01L9/06 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1433 ,  G01N21/25 ,  G01N21/27 ,  G01N33/543 ,  G01N33/569 ,  G01N33/62 ,  G01N33/68 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N15/01 ,  G01N15/10 ,  G01N15/14 ,  G01N33/50

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5027 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/543 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1433 ,  G01N21/25 ,  G01N21/27 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56972 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  B01L9/52 ,  B01L2300/1827 ,  B01L2300/1855 ,  G01N2015/012 ,  G01N2015/016 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N33/5005 ,  G01N35/00 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US11649487B2

公开(公告)日：2023-05-16

申请号：US16986557

申请日：2020-08-06

Applicant: Labrador Diagnostics LLC

Inventor： Kamila Belhocine ,  Josephine Lee ,  Pranav Patel ,  Aaron Richardson ,  Scott Tabakman

IPC: C12Q1/686 ,  C12Q1/6844 ,  C12P19/34 ,  C07H1/00

CPC classification number: C12Q1/6844 ,  C07H1/00 ,  C12P19/34 ,  C12Q1/686 ,  C12Q1/686 ,  C12Q2525/151 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q1/686 ,  C12Q2525/151 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2527/101 ,  C12Q2527/101 ,  C12Q2531/119

Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such nucleic acid polymerases and primers.

公开(公告)号：US11603558B2

公开(公告)日：2023-03-14

申请号：US16190625

申请日：2018-11-14

Applicant: Labrador Diagnostics LLC

Inventor： Kamila Belhocine ,  Josephine Lee ,  Pranav Patel ,  Aaron Richardson ,  Scott Tabakman

IPC: C12Q1/6844 ,  C12Q1/686 ,  C12P19/34 ,  C07H1/00

Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases and primers.

公开(公告)号：US20230035908A1

公开(公告)日：2023-02-02

申请号：US17706102

申请日：2022-03-28

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Shaunak Roy ,  Ian Gibbons ,  Shize Daniel Qi ,  Edmond Ku ,  Chris Todd ,  Melissa Takahashi ,  Bruce Johnson ,  Jeff Fenton ,  Keith Moravick ,  Uwe Springborn ,  Anthony Delacruz

IPC: G01N33/53 ,  A61B5/15 ,  A61B5/1486 ,  A61B5/00 ,  G01N33/536 ,  G01N33/573

Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

公开(公告)号：US11366106B2

公开(公告)日：2022-06-21

申请号：US15069843

申请日：2016-03-14

Applicant: Labrador Diagnostics LLC

Inventor： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC: G01N33/53 ,  G01N33/543 ,  B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  G01N35/02 ,  B01L9/00 ,  G16H10/40 ,  G01N1/38 ,  G01N33/569 ,  A61B5/15 ,  A61B5/151 ,  G01N35/10 ,  B01L7/00 ,  G01N33/68 ,  G01N33/94 ,  G01N35/00 ,  G01N33/574 ,  A61B10/00 ,  A61B10/02

Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US20220170951A1

公开(公告)日：2022-06-02

申请号：US17466314

申请日：2021-09-03

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Daniel Young ,  Samartha Anekal ,  Chinmay Pangarkar

IPC: G01N35/00 ,  G01N15/14 ,  G01N21/01 ,  B01L3/00

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20220137075A1

公开(公告)日：2022-05-05

申请号：US17470596

申请日：2021-09-09

Applicant: Labrador Diagnostics LLC

Inventor： Mark Dayel ,  Samartha Anekal ,  Paul Patel ,  Ian Gibbons ,  Elizabeth A. Holmes

IPC: G01N33/86 ,  C12Q1/56 ,  G01N21/84 ,  G01N33/49 ,  G01N33/58

Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 μL) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.

公开(公告)号：US11305275B2

公开(公告)日：2022-04-19

申请号：US16514920

申请日：2019-07-17

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Clarissa Lui ,  Michael Chen ,  Daniel Young

IPC: G01N1/38 ,  G01N33/49 ,  G01N1/40 ,  G01N1/00 ,  B01L3/00 ,  A61B5/15 ,  A61B5/151 ,  A61B5/154 ,  G01N35/00

Abstract: Bodily fluid sample collection systems, devices, and method are provided. The sample is collected at a first location and subjected to a first sample processing step. The sample may be shipped to a second location and subjected to a second sample processing step that does not introduce contaminants into a plasma portion of the sample formed from the first processing step. The sample may also be mixed with other material(s) in the collection device.

公开(公告)号：US20210404022A1

公开(公告)日：2021-12-30

申请号：US17319906

申请日：2021-05-13

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Timothy Smith ,  Samartha Anekal ,  James R. Wasson ,  Daniel L. Young ,  Chinmay Pangarkar

IPC: C12Q1/70 ,  G01N33/569 ,  B01L7/00 ,  B01L3/00

Abstract: In one embodiment, a method is provided comprising analyte testing on one or more types of samples.

公开(公告)号：US11162947B2

公开(公告)日：2021-11-02

申请号：US15865037

申请日：2018-01-08

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Ian Gibbons

IPC: A61K39/145 ,  G01N33/569 ,  B01L3/00 ,  C12Q1/70 ,  G01N33/543

Abstract: The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection in a sample of bodily fluid.