公开(公告)号：US20220196657A1

公开(公告)日：2022-06-23

申请号：US17516462

申请日：2021-11-01

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Ian Gibbons

IPC: G01N33/569 ,  B01L3/00 ,  C12Q1/70 ,  G01N33/543

Abstract: The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection in a sample of bodily fluid.

公开(公告)号：US11158429B2

公开(公告)日：2021-10-26

申请号：US15952957

申请日：2018-04-13

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Ian Gibbons ,  Daniel Young ,  Seth G. Michelson

IPC: G16H50/50 ,  G16H50/70 ,  G16H50/80 ,  G16H50/20 ,  G06F19/00

Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.

公开(公告)号：US11143647B2

公开(公告)日：2021-10-12

申请号：US15160491

申请日：2016-05-20

Applicant: Labrador Diagnostics LLC

Inventor： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC: G01N33/53 ,  G01N33/543 ,  B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  G01N35/02 ,  B01L9/00 ,  G16H10/40 ,  G01N1/38 ,  G01N33/569 ,  A61B5/15 ,  A61B5/151 ,  G01N35/10 ,  B01L7/00 ,  G01N33/68 ,  G01N33/94 ,  G01N35/00 ,  G01N33/574 ,  A61B10/00 ,  A61B10/02

Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US11139084B2

公开(公告)日：2021-10-05

申请号：US15246401

申请日：2016-08-24

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Ian Gibbons ,  Daniel Young ,  Seth G. Michelson

IPC: G16H50/50 ,  G16H50/80 ,  G16H50/70 ,  G16H50/20 ,  G06F19/00

Abstract: The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.

公开(公告)号：US10908093B2

公开(公告)日：2021-02-02

申请号：US14867271

申请日：2015-09-28

Applicant: Labrador Diagnostics LLC

Inventor： Ian Gibbons ,  Chengwang Wang ,  Shaunak Roy ,  Elizabeth A. Holmes

IPC: G01N21/76 ,  G01N33/53 ,  B01L3/00 ,  A61B5/151 ,  A61B5/157 ,  A61B5/145 ,  A61B5/00 ,  G16H40/63 ,  A61B5/15 ,  G01N33/50 ,  A61B5/155 ,  G01N33/543 ,  A61B5/1495

Abstract: The present invention provides methods of calibrating a fluidic device useful for detecting an analyte of interest in a bodily fluid. The invention also provides methods for assessing the reliability of an assay for an analyte in a bodily fluid with the use of a fluidic device. Another aspect of the invention is a method for performing a trend analysis on the concentration of an analyte in a subject using a fluidic device.

公开(公告)号：US10761030B2

公开(公告)日：2020-09-01

申请号：US14481264

申请日：2014-09-09

Applicant: Labrador Diagnostics LLC

Inventor： Elizabeth A. Holmes ,  Ian Gibbons ,  Timothy M. Kemp ,  John Howard ,  Shaunak Roy

IPC: G01N21/76 ,  B01L3/00 ,  G01N33/53 ,  A61B5/151 ,  A61B5/157 ,  A61B5/145 ,  A61B5/00 ,  G16H40/63 ,  A61B5/15 ,  G01N33/50 ,  A61B5/155 ,  G01N33/543 ,  A61B5/1495

Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

公开(公告)号：US11899010B2

公开(公告)日：2024-02-13

申请号：US17664790

申请日：2022-05-24

Applicant: Labrador Diagnostics LLC

Inventor： Tammy Burd ,  Ian Gibbons ,  Elizabeth A. Holmes ,  Gary Frenzel ,  Anthony Joseph Nugent

IPC: G01N33/53 ,  G01N33/543 ,  B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  G01N35/02 ,  B01L9/00 ,  G16H10/40 ,  G01N1/38 ,  G01N33/569 ,  A61B5/15 ,  A61B5/151 ,  G01N35/10 ,  B01L7/00 ,  G01N33/68 ,  G01N33/94 ,  G01N35/00 ,  G01N33/574 ,  A61B10/00 ,  A61B10/02

CPC classification number: G01N33/5304 ,  A61B5/15 ,  A61B5/151 ,  A61B5/150755 ,  B01J19/0046 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L9/543 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G16H10/40 ,  A61B10/007 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J2219/005 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L7/5255 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N2035/0097 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/475 ,  G01N2333/4737 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/9129 ,  G01N2333/91205 ,  G01N2800/26 ,  G01N2800/60 ,  Y10T29/49826 ,  Y10T436/25375

Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US11802882B2

公开(公告)日：2023-10-31

申请号：US16222845

申请日：2018-12-17

Applicant: Labrador Diagnostics LLC

Inventor： Ian Gibbons ,  Shaunak Roy ,  Edmond Ku

IPC: G01N33/92 ,  B01L3/00 ,  G01N21/31 ,  G01N33/53 ,  C12Q1/60 ,  G01N21/27 ,  G01N33/52

CPC classification number: G01N33/92 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502753 ,  C12Q1/60 ,  G01N21/27 ,  G01N21/31 ,  G01N33/525 ,  G01N33/5302 ,  B01L2200/0605 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/087 ,  B01L2300/0819 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/168 ,  G01N2201/061 ,  G01N2201/062 ,  Y10T436/20

Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

公开(公告)号：US11754554B2

公开(公告)日：2023-09-12

申请号：US15403553

申请日：2017-01-11

Applicant: Labrador Diagnostics LLC

Inventor： Shaunak Roy ,  Melissa Takahashi ,  Ian Gibbons ,  Edmond Ku ,  Thanh Dang ,  Tammy Burd ,  Adam Vollmer ,  Elizabeth A. Holmes

IPC: G01N33/53 ,  G01N35/10 ,  G01N33/49 ,  G01N27/07 ,  G01N33/86 ,  G01N27/06

CPC classification number: G01N33/5304 ,  G01N27/07 ,  G01N33/49 ,  G01N33/5302 ,  G01N33/86 ,  G01N35/1002 ,  G01N27/06 ,  G01N2201/12746 ,  G01N2800/52 ,  Y10S435/973 ,  Y10S436/809 ,  Y10T436/106664

Abstract: The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

公开(公告)号：US11630069B2

公开(公告)日：2023-04-18

申请号：US15689905

申请日：2017-08-29

Applicant: Labrador Diagnostics LLC

Inventor： Timothy Michael Kemp ,  Chris Todd ,  Ron Oral ,  Shulin Zeng ,  John Howard ,  Jeff Fenton ,  Elizabeth A. Holmes ,  Ian Gibbons ,  Shaunak Roy

IPC: G01N33/543 ,  G01N21/76 ,  A61B5/155 ,  A61B5/145 ,  A61B5/157 ,  A61B5/151 ,  A61B5/00 ,  B01L3/00 ,  G01N33/50 ,  G01N33/53 ,  G16H40/63 ,  A61B5/15 ,  A61B5/1495

Abstract: This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.