公开(公告)号：US20220193988A1

公开(公告)日：2022-06-23

申请号：US17436754

申请日：2020-03-09

Applicant: NORTHWESTERN UNIVERSITY

Inventor： David A. Walker ,  James L. Hedrick, III ,  Chad A. Mirkin

IPC: B29C64/129 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/00 ,  B29C64/357 ,  B29C64/364 ,  B29C64/307

Abstract: Methods and apparatus comprising a dewetting material and a polymerization liquid that are immiscible and dewetting, and can be used for the formation of three-dimensional objects, wherein the method does not require a dead zone. Additionally, methods and apparatus that employ the use of a flowing dewetting material to provide a shearing interface to reduce interfacial adhesive forces.

公开(公告)号：US11285106B2

公开(公告)日：2022-03-29

申请号：US16384749

申请日：2019-04-15

Applicant: Northwestern University

Inventor： C. Shad Thaxton ,  Chad A. Mirkin ,  Kaylin M. McMahon ,  Sushant Tripathy ,  Raja Kannan Mutharasan ,  David M. Leander ,  Andrea Luthi

IPC: A61K9/127 ,  A61K31/7088 ,  B82Y5/00 ,  C12N15/87 ,  A61K47/54 ,  A61K47/69 ,  A61K9/51 ,  C12N15/11

Abstract: Articles, compositions, kits, and methods relating to nanostructures, including synthetic nanostructures, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanostructure core may surrounded by a shell including a material, such as a lipid bilayer, and may include other components such as oligonucleotides. In some embodiments, the structures, when introduced into a subject, can be used to deliver nucleic acids and/or can regulate gene expression. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions. In some cases, the structures are both a therapeutic agent and a diagnostic agent.

公开(公告)号：US20210332495A1

公开(公告)日：2021-10-28

申请号：US17311108

申请日：2019-12-06

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Janet R. McMillan ,  Oliver G. Hayes ,  Peter H. Winegar

IPC: C30B7/14 ,  C07K1/30 ,  C12P19/02 ,  B01D9/00 ,  C30B29/58

Abstract: The present disclosure provides compositions comprising protein crystals and methods for programmable biomaterial synthesis. The methods of the disclosure provide the ability to organize proteins within protein crystals with control over protein orientation.

公开(公告)号：US20210236651A1

公开(公告)日：2021-08-05

申请号：US16629686

申请日：2018-07-13

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Shunzhi Wang

IPC: A61K47/69 ,  C12N15/113 ,  A61K47/54 ,  A61K38/28

Abstract: The present disclosure generally relates to metal-organic framework nanoparticles containing terminal phosphate-modified oligonucleotides, methods for making the same, and methods of using the same.

公开(公告)号：US20210220454A1

公开(公告)日：2021-07-22

申请号：US16886712

申请日：2020-05-28

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Shuya Wang ,  Kacper Skakuj ,  Xiaoyi S. Hu

IPC: A61K39/00 ,  A61K39/39 ,  A61P35/00

Abstract: The disclosure is generally directed to immunostimulatory protein-core spherical nucleic acids (SNAs) comprising a protein core and a ratio of immunostimulatory and non-immunostimulatory strands, methods of making the immunostimulatory protein-core SNAs as well as their use.

公开(公告)号：US20210189397A1

公开(公告)日：2021-06-24

申请号：US17054441

申请日：2019-05-10

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Anthony J. Sprangers ,  Shengshuang Zhu ,  Adam J. Ponedal ,  Timothy J. Merkel ,  Suguna P. Narayan

IPC: C12N15/113 ,  A61P17/02 ,  A61K9/00 ,  A61K9/127 ,  A61K47/69 ,  A61K47/54 ,  A61K47/68

Abstract: The disclosure is related to compositions and methods comprising spherical nucleic acids (SNAs) and their use in penetrating skin and inhibiting gene expression to develop a scar treatment.

公开(公告)号：US10370661B2

公开(公告)日：2019-08-06

申请号：US15654401

申请日：2017-07-19

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Nathaniel L. Rosi ,  C. Shad Thaxton ,  David A. Giljohann

IPC: C07H21/04 ,  C12N15/113 ,  A61K9/51 ,  A61K31/7088 ,  B82Y5/00 ,  C12N15/11 ,  A61K47/69

Abstract: Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.

公开(公告)号：US10370656B2

公开(公告)日：2019-08-06

申请号：US15296387

申请日：2016-10-18

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  David A. Giljohann ,  Dwight S. Seferos

IPC: C12N15/113 ,  A61K31/7088 ,  A61K9/51 ,  C12N15/11 ,  C12N15/87

Abstract: Materials and methods for modulating cellular uptake of functionalized nanoparticles are provided. Also provided are materials and methods for modulating the effectiveness of a therapeutic agent with a functionalized nanoparticle.

公开(公告)号：US09969759B2

公开(公告)日：2018-05-15

申请号：US15312221

申请日：2015-05-22

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Chad M. Shade ,  Robert D. Kennedy ,  Jessica Lynn Rouge ,  Soyoung E. Seo ,  Mary X. Wang

IPC: C07F15/00 ,  C12Q1/68 ,  C07H23/00 ,  G01N27/447 ,  G01N33/53 ,  G01N33/58

CPC classification number: C07F15/0053 ,  C07H23/00 ,  C12Q1/6816 ,  G01N27/44726 ,  G01N27/44747 ,  G01N33/5308 ,  G01N33/582 ,  G01N33/587 ,  C12Q2563/173

Abstract: Disclosed herein are organometallic complexes and methods of using the same in detecting double stranded DNA or RNA, selectively over single stranded DNA or RNA.

公开(公告)号：US09766551B2

公开(公告)日：2017-09-19

申请号：US14439252

申请日：2013-10-15

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Chad A. Mirkin ,  Xing Liao ,  Keith A. Brown ,  Guoliang Liu ,  Abrin L. Schmucker ,  Shu He ,  Wooyoung Shim ,  Daniel J. Eichelsdoerfer ,  Boris Rasin

IPC: G03B27/52 ,  G03B27/54 ,  G03F7/20 ,  G03F7/00 ,  B05D1/26 ,  B05D3/06 ,  G02B13/14 ,  B82Y40/00

CPC classification number: G03F7/7035 ,  B05D1/26 ,  B05D3/06 ,  B82Y40/00 ,  G02B13/143 ,  G03F7/0002 ,  G03F7/20 ,  G03F7/2049 ,  G03F7/70141 ,  G03F7/70325 ,  G03F7/70383 ,  G03F7/7045

Abstract: In accordance with an embodiment of the disclosure, a method of patterning can include dividing an image into a set of frame sections; determining a tip pattern for a respective portion of an image to be patterned by each tip of the tip array in each frame section of the set of frame sections; disposing the tip array in a patterning position in a first location of the substrate corresponding to a location of the substrate in which the first frame section in the set of frame sections is to be patterned; projecting a first pattern of radiation onto the tip array to selectively irradiate one or more tips of the tip array and pattern the substrate, wherein the first pattern of radiation corresponds to a tip pattern for the first frame section; disposing the tip array in a patterning position in a second location of the substrate corresponding to a location of the substrate in which the second frame section in the set of frame sections is to be patterned; projecting a second pattern of radiation onto the tip array to selectively irradiate tips of the tip array and pattern the substrate, wherein the second pattern of radiation corresponds to a tip pattern for the second frame section; and repeating the disposing and projecting for each frame section in the set of frame sections to pattern the image.