公开(公告)号：US20170158611A1

公开(公告)日：2017-06-08

申请号：US15352132

申请日：2016-11-15

Applicant: Novartis AG

Inventor： Frank Chang ,  Ryan DeSousa ,  Troy Vernon Holland ,  Walter R. Laredo

IPC: C07C225/22 ,  C07C225/10 ,  G02C7/04 ,  G02B1/04 ,  G02C7/10 ,  C07D249/20 ,  C08F116/06

CPC classification number: C07C225/22 ,  B29D11/00038 ,  C07C225/10 ,  C07D249/20 ,  C08F116/06 ,  G02B1/043 ,  G02C7/049 ,  G02C7/108 ,  C08L2666/70

Abstract: Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.

公开(公告)号：US20190225726A1

公开(公告)日：2019-07-25

申请号：US16250003

申请日：2019-01-17

Applicant: Novartis AG

Inventor： Ryan DeSousa ,  Troy Vernon Holland ,  Frank Chang

IPC: C08F216/06 ,  B29D11/00 ,  B29C35/08 ,  C08K5/17 ,  C08K5/3435 ,  C08J3/24 ,  C08L29/06 ,  C08L83/04

Abstract: Described herein is a cast-molding process for producing contact lenses in a relatively-short curing time from a lens-forming composition, which comprises (a) at least one thiol-containing compound or component, (b) at least one metal scavenger, and (c) at least one free radical scavenger and which has a pH of from about 2.5 to about 5. The addition of a chain-transfer agent into a lens-forming composition can reduce not only the curing time of the lens-forming composition but also reduce the elastic modulus of resultant crosslinked materials (e.g., contact lenses) from the lens-forming composition. The lower pH and the addition of metal scavenger and the free radical scavenger into the lens-forming composition can ensure that the lens-forming composition to have a shelf life of at least three days.

公开(公告)号：US20190179170A1

公开(公告)日：2019-06-13

申请号：US16280084

申请日：2019-02-20

Applicant: Novartis AG

Inventor： Frank Chang ,  Ryan DeSousa ,  Troy Vernon Holland ,  John Dallas Pruitt ,  Jared Nelson

IPC: G02C7/10 ,  C07C233/38 ,  G02B5/22 ,  G02B5/20 ,  C08F20/36 ,  B29D11/00 ,  C07D249/20 ,  G02C7/04 ,  G02B1/04 ,  C08F230/08 ,  C08F220/70

Abstract: Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.

公开(公告)号：US20190153141A1

公开(公告)日：2019-05-23

申请号：US16255043

申请日：2019-01-23

Applicant: Novartis AG

Inventor： Frank Chang ,  Ryan DeSousa ,  Jinyu Huang

IPC: C08F290/06 ,  C08G77/38 ,  C08G77/14 ,  G02B1/04 ,  C08G77/20

CPC classification number: C08F290/068 ,  C08G77/12 ,  C08G77/14 ,  C08G77/20 ,  C08G77/38 ,  C08G2210/00 ,  G02B1/043 ,  C08L101/14 ,  C08L83/04

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C10-C50 organic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

公开(公告)号：US20180105620A1

公开(公告)日：2018-04-19

申请号：US15730785

申请日：2017-10-12

Applicant: Novartis AG

Inventor： Frank Chang ,  Troy Vernon Holland ,  Feng Jing ,  Ryan DeSousa

IPC: C08F28/02 ,  C08F24/00 ,  C08F26/06 ,  C08B37/00

CPC classification number: C08F28/02 ,  C08B37/0063 ,  C08F8/30 ,  C08F8/34 ,  C08F8/48 ,  C08F20/56 ,  C08F24/00 ,  C08F26/06 ,  C08F2810/20 ,  G02B1/04 ,  G02B1/043 ,  G02C7/04 ,  C08F216/06 ,  C08F220/36 ,  C08F216/38 ,  C08L1/00 ,  C08L29/04 ,  C08L37/00

Abstract: The invention is related to a class of hydrophilic copolymers comprising loosely dangling thiol-containing pendant groups. The hydrophilic copolymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.

公开(公告)号：US20170242274A1

公开(公告)日：2017-08-24

申请号：US15434098

申请日：2017-02-16

Applicant: Novartis AG

Inventor： Troy Vernon Holland ,  Frank Chang ,  Walter R. Laredo ,  Xuwei Jiang ,  Ryan DeSousa

IPC: G02C7/10 ,  G02C7/04 ,  G02B1/04 ,  C07C233/33 ,  C08F283/12

CPC classification number: G02C7/108 ,  C07C225/22 ,  C07C233/33 ,  C07C237/32 ,  C07C237/34 ,  C08F283/124 ,  G02B1/043 ,  G02C7/049

Abstract: Described herein are UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation.

公开(公告)号：US10324311B2

公开(公告)日：2019-06-18

申请号：US15168697

申请日：2016-05-31

Applicant: Novartis AG

Inventor： Troy Vernon Holland ,  Frank Chang ,  Ryan DeSousa

IPC: G02C7/10 ,  B29D11/00 ,  C08F2/48 ,  C08F2/50 ,  G02B1/04 ,  C07F7/30 ,  C07F9/09 ,  C08F26/06 ,  G02C7/04 ,  C08F220/54 ,  B29K83/00 ,  B29K105/00

Abstract: Described herein are acyl germanium photoinitiator for cost-effective and time-efficient method for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a method for making UV-absorbing contact lenses made by using an acyl germanium photoinitiator of the invention.

公开(公告)号：US10227435B2

公开(公告)日：2019-03-12

申请号：US15376702

申请日：2016-12-13

Applicant: Novartis AG

Inventor： Frank Chang ,  Ryan DeSousa ,  Jinyu Huang

IPC: C08L101/14 ,  C08L83/04 ,  C08F290/06 ,  G02B1/04 ,  C08G77/20 ,  C08G77/14 ,  C08G77/38 ,  C08G77/12

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C10-C50 organic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

公开(公告)号：US20190061293A1

公开(公告)日：2019-02-28

申请号：US16114528

申请日：2018-08-28

Applicant: Novartis AG

Inventor： Troy Vernon Holland ,  Frank Chang ,  Ryan DeSousa

IPC: B29D11/00 ,  C08F16/06

Abstract: Described herein is a cast-molding process for producing contact lenses in a relatively short curing time. The short curing time has been achieved by adding a chain transfer agent into a lens-forming composition.

公开(公告)号：US20170242275A1

公开(公告)日：2017-08-24

申请号：US15434105

申请日：2017-02-16

Applicant: Novartis AG

Inventor： Frank Chang ,  Ryan DeSousa ,  Troy Vernon Holland ,  John Dallas Pruitt ,  Jared Nelson

IPC: G02C7/10 ,  C07D249/20 ,  B29D11/00 ,  C08F230/08 ,  G02B1/04 ,  G02C7/04 ,  C07C237/20 ,  C08F220/70

CPC classification number: G02C7/108 ,  B29D11/00134 ,  B29K2105/0002 ,  C07C233/38 ,  C07D249/20 ,  C08F20/36 ,  C08F220/70 ,  C08F230/08 ,  G02B1/043 ,  G02B5/208 ,  G02B5/223 ,  G02C7/049

Abstract: Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.