公开(公告)号：US11256003B2

公开(公告)日：2022-02-22

申请号：US16204641

申请日：2018-11-29

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  C08L33/02 ,  C08L79/04 ,  C09D133/02 ,  B29D11/00 ,  G02C7/04 ,  G02B1/18 ,  C08L83/04 ,  B05D5/00 ,  B65B55/22 ,  B05D3/00 ,  B05D5/10 ,  B05D1/38 ,  B05D3/02 ,  B05D1/18 ,  B29K83/00 ,  B29K105/00

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

公开(公告)号：US10830923B2

公开(公告)日：2020-11-10

申请号：US16204729

申请日：2018-11-29

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Kasey Jon Minick ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Kelly Kayi Tallau ,  Matthew McCollum ,  Richard Govan

IPC: G02B1/04 ,  C08L83/04 ,  C08L33/02 ,  C08L79/04 ,  C09D133/02 ,  B29D11/00 ,  G02C7/04 ,  G02B1/18 ,  B65B55/22 ,  B29K83/00 ,  B29K105/00

Abstract: The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a simulated 30-days lens care regime.

公开(公告)号：US20200017713A1

公开(公告)日：2020-01-16

申请号：US16582624

申请日：2019-09-25

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Sibichen J. Thekveli ,  Robert Carey Tucker ,  Jared Nelson

IPC: C09D177/06 ,  B29D11/00 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02

Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

公开(公告)号：US20190179170A1

公开(公告)日：2019-06-13

申请号：US16280084

申请日：2019-02-20

Applicant: Novartis AG

Inventor： Frank Chang ,  Ryan DeSousa ,  Troy Vernon Holland ,  John Dallas Pruitt ,  Jared Nelson

IPC: G02C7/10 ,  C07C233/38 ,  G02B5/22 ,  G02B5/20 ,  C08F20/36 ,  B29D11/00 ,  C07D249/20 ,  G02C7/04 ,  G02B1/04 ,  C08F230/08 ,  C08F220/70

Abstract: Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.

公开(公告)号：US10308835B2

公开(公告)日：2019-06-04

申请号：US15646291

申请日：2017-07-11

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: C09D177/06 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  B29D11/00 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

公开(公告)号：US10100219B2

公开(公告)日：2018-10-16

申请号：US15216125

申请日：2016-07-21

Applicant: Novartis AG

Inventor： Troy Vernon Holland ,  Frank Chang ,  Yongxing Qiu ,  John Dallas Pruitt ,  Chung-Yuan Chiang ,  Venkat Shankar ,  Robert Scott ,  Yash Kapoor

IPC: C09D133/24 ,  C07D205/04 ,  C08F220/56 ,  B29D11/00 ,  C08F224/00 ,  C09D137/00 ,  C08F283/12 ,  C09D151/08 ,  C08F220/54 ,  C09D133/26 ,  C09D139/04 ,  C08F20/00 ,  C08F26/00

Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

公开(公告)号：US20160326395A1

公开(公告)日：2016-11-10

申请号：US15216125

申请日：2016-07-21

Applicant: Novartis AG

Inventor： Troy Vernon Holland ,  Frank Chang ,  Yongxing Qiu ,  John Dallas Pruitt ,  Chung-Yuan Chiang ,  Venkat Shankar ,  Robert Scott ,  Yash Kapoor

IPC: C09D133/24 ,  C07D205/04 ,  C08F220/56 ,  B29D11/00 ,  C08F224/00 ,  C09D137/00 ,  C08F283/12 ,  C09D151/08 ,  C08F220/54 ,  C09D133/26

CPC classification number: C09D133/24 ,  B29D11/00865 ,  C07D205/04 ,  C08F20/00 ,  C08F26/00 ,  C08F220/54 ,  C08F220/56 ,  C08F224/00 ,  C08F283/124 ,  C08F2500/26 ,  C09D133/26 ,  C09D137/00 ,  C09D139/04 ,  C09D151/085

Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.

公开(公告)号：US08944592B2

公开(公告)日：2015-02-03

申请号：US13948206

申请日：2013-07-23

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: G02C7/00 ,  G02C7/02 ,  G02B1/04 ,  G02C7/04

CPC classification number: C09D177/06 ,  B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  G02B1/043 ,  G02B1/10 ,  G02B1/18 ,  G02C7/049 ,  G02C2202/06 ,  G02C2202/16 ,  C08L101/14

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

Abstract translation: 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜 在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成， 和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。

公开(公告)号：US20130250234A1

公开(公告)日：2013-09-26

申请号：US13900136

申请日：2013-05-22

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Sibichen J. Thekveli ,  Robert Carey Tucker ,  Jared Nelson

IPC: G02C7/04

CPC classification number: C09D177/06 ,  B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  G02B1/043 ,  G02B1/10 ,  G02B1/18 ,  G02C7/049 ,  G02C2202/06 ,  G02C2202/16 ,  C08L101/14

Abstract: The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

公开(公告)号：US20190179055A1

公开(公告)日：2019-06-13

申请号：US16204641

申请日：2018-11-29

Applicant: Novartis AG

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  C08L83/04 ,  C08L33/02 ,  C09D133/02 ,  C08L79/04

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.