公开(公告)号：US20170296112A1

公开(公告)日：2017-10-19

申请号：US15418485

申请日：2017-01-27

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/157 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/15 ,  A61B5/153 ,  A61B5/155 ,  G01N33/49 ,  G01N21/07 ,  G01N21/03 ,  A61M5/172 ,  G06F19/00 ,  A61M5/14 ,  A61M5/142 ,  A61M5/168 ,  G01N21/35

CPC classification number: A61B5/157 ,  A61B5/0059 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/412 ,  A61B5/6866 ,  A61B2560/0228 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61M5/1415 ,  A61M5/142 ,  A61M5/16827 ,  A61M5/1723 ,  A61M39/10 ,  A61M39/1011 ,  A61M2005/14208 ,  A61M2039/1033 ,  A61M2205/12 ,  A61M2205/128 ,  G01N21/03 ,  G01N21/07 ,  G01N21/35 ,  G01N33/491 ,  G01N2021/0346 ,  G06F19/00 ,  G06F19/3468

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

公开(公告)号：US20170188943A1

公开(公告)日：2017-07-06

申请号：US15236831

申请日：2016-08-15

Applicant: OptiScan Biomedical Corporation

Inventor： James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/1495 ,  G06F19/00 ,  A61B5/155 ,  A61B5/157 ,  A61M5/168 ,  A61B5/145 ,  A61B5/15

Abstract: Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.

公开(公告)号：US20150119663A1

公开(公告)日：2015-04-30

申请号：US14589867

申请日：2015-01-05

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/157 ,  A61B5/15 ,  A61B5/1455

CPC classification number: A61B5/157 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/6866 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61M5/1415 ,  A61M5/142 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/12 ,  A61M2205/128 ,  G01N21/03 ,  G01N21/07 ,  G01N21/35 ,  G01N33/491 ,  G01N2021/0346 ,  G06F19/00 ,  G06F19/3468

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

Abstract translation: 公开了用于确定流体（例如血液）中分析物浓度的系统和方法。 该系统可以从患者抽取血液并将血液输送到样品池。 流体（例如，等离子体）的特定组分可以被分离和/或定位，使得在流体的特定组分（例如，等离子体）中测量分析物的浓度。 样品池可以包括具有两个窗件的样品容器。 该系统可以具有流体通道，其具有构造成与多腔导管配合而不泄漏的顶端。 多腔导管可以具有近端和远端端口。 流体压力系统可以被配置成周期性地从脉管系统中抽取流体通过近端血管内开口和近端口，同时保持低压和/或流速，从而降低反转容器中的流体流动的风险，并将输注物上游到另一个 血管内开放。

公开(公告)号：US20180263555A1

公开(公告)日：2018-09-20

申请号：US15853249

申请日：2017-12-22

Applicant: OptiScan Biomedical Corporation

Inventor： Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/00

CPC classification number: A61B5/4839 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/157 ,  A61B5/6866 ,  A61M5/1415 ,  A61M5/1452 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/201

Abstract: Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can include an automated blood withdrawal system that is configured to withdraw blood from the patient's vasculature at low pressure and/or withdrawal rates so as to reduce or prevent contamination of the withdrawn fluid from the infusion fluids.

公开(公告)号：US20180259420A1

公开(公告)日：2018-09-13

申请号：US15863630

申请日：2018-01-05

Applicant: OptiScan Biomedical Corporation

Inventor： Peter Rule ,  James D. Causey

IPC: G01M3/28 ,  A61M5/14 ,  A61B5/15 ,  A61B5/145 ,  A61M5/168 ,  A61B5/157

CPC classification number: G01M3/2846 ,  A61B5/14532 ,  A61B5/15 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150854 ,  A61B5/150862 ,  A61B5/15087 ,  A61B5/157 ,  A61M5/1413 ,  A61M5/16831 ,  A61M5/16854 ,  A61M2205/15

Abstract: Various embodiments disclosed herein relate to detecting leaks in a patient monitoring system. The system can include a fluid handling network configured to receive a fluid sample drawn from a patient and to deliver at least a portion of the fluid sample to an analyte measurement system. The system can isolate at least a portion of the fluid handling network, can apply pressure to the at least a portion of the fluid handling network, can measure the pressure in the at least a portion of the fluid handling network, and can determine whether a leak is present in the at least a portion of the fluid handling network based at least in part on the measured pressure.

公开(公告)号：US09907504B2

公开(公告)日：2018-03-06

申请号：US15225079

申请日：2016-08-01

Applicant: OptiScan Biomedical Corporation

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: G01N33/48 ,  A61B5/157 ,  G01N21/3577 ,  G01N21/03 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/15 ,  A61B5/151 ,  A61B5/00 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

公开(公告)号：US10660557B2

公开(公告)日：2020-05-26

申请号：US16271653

申请日：2019-02-08

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/157 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/153 ,  A61B5/155 ,  A61M39/10 ,  A61B5/15 ,  A61B5/1459 ,  A61M5/172 ,  G01N21/03 ,  G01N21/07 ,  G01N33/49 ,  G06F19/00 ,  G16H20/17 ,  A61M5/14 ,  A61M5/142 ,  A61M5/168 ,  G01N21/35

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

公开(公告)号：US20190336678A1

公开(公告)日：2019-11-07

申请号：US16270471

申请日：2019-02-07

Applicant: OptiScan Biomedical Corporation

Inventor： Peter Rule

IPC: A61M5/142 ,  A61B5/157 ,  A61M5/172 ,  A61B5/15 ,  A61B5/1468 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/145

Abstract: Systems for rapid and accurate analyte measurement are described. For example, periodic glucose measurements can be achieved with high accuracy in a critical care environment by drawing blood into a device more than once per hour, analyzing blood (for example using infrared radiation through plasma). Safety and accuracy can be achieved by improved fluid control and avoidance of clotting. Data can be conveyed (e.g., displayed) to a user. A user can be allowed to annotate the data. For example, a touchscreen or other interface can allow addition of notes on a running graph of data, indicating events or other items of interest that may correspond to data readings or to particular times.

公开(公告)号：US10201303B2

公开(公告)日：2019-02-12

申请号：US15418485

申请日：2017-01-27

Applicant: OptiScan Biomedical Corporation

Inventor： Eugene Lim ,  Roger Tong ,  Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/157 ,  A61B5/00 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/153 ,  A61M39/10 ,  A61B5/15 ,  A61B5/1459 ,  A61M5/172 ,  G01N21/03 ,  G01N21/07 ,  G01N33/49 ,  G06F19/00 ,  A61M5/14 ,  A61M5/142 ,  A61M5/168 ,  G01N21/35

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

公开(公告)号：US09913604B2

公开(公告)日：2018-03-13

申请号：US14954869

申请日：2015-11-30

Applicant: OptiScan Biomedical Corporation

Inventor： James R. Braig ,  Peter Rule

IPC: A61B5/15 ,  A61B5/145 ,  A61B5/157 ,  A61B5/1455 ,  A61B5/00 ,  A61M5/172 ,  G01N21/27 ,  G06F19/00 ,  A61B5/153 ,  A61B5/155 ,  A61B5/1486 ,  A61M5/142 ,  A61M5/168 ,  A61M5/36 ,  A61M5/38 ,  G01N21/35

CPC classification number: A61B5/150992 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1486 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150854 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/274 ,  G01N21/35 ,  G01N2201/1293 ,  G06F19/00 ,  G06F19/3468 ,  G16H10/40 ,  G16H20/17

Abstract: In certain embodiments, a sampling assembly is for use with a main analyzer. The main analyzer is configured to sense an analyte in a body fluid obtained from a patient through a first fluid passageway extending from the main analyzer. The sampling assembly includes an instrument portion separate from the main analyzer and including at least one sensor. The instrument portion is removably engaged with the first fluid passageway. The at least one sensor is in sensing engagement with the first fluid passageway such that the at least one sensor can sense a property of a fluid within the first fluid passageway.