公开(公告)号：US10191065B2

公开(公告)日：2019-01-29

申请号：US15939030

申请日：2018-03-28

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel Clarke ,  Zhaohui Chen

IPC: G01N33/68 ,  G01N33/487 ,  G01N30/72 ,  G01N33/74 ,  G01N30/02 ,  H01J49/00 ,  H01J49/16 ,  H01J49/40

Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

公开(公告)号：US09835606B2

公开(公告)日：2017-12-05

申请号：US15284248

申请日：2016-10-03

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Nigel Clarke

IPC: G01N33/94 ,  G01N33/15 ,  G01N33/49 ,  G01N30/72 ,  H01J49/00 ,  H01J49/10 ,  G01N33/48

CPC classification number: G01N33/15 ,  G01N30/7233 ,  G01N33/48 ,  G01N33/49 ,  G01N33/94 ,  H01J49/00 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/10 ,  Y10T436/17 ,  Y10T436/24 ,  Y10T436/25125 ,  Y10T436/25375

Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.

公开(公告)号：US09506937B2

公开(公告)日：2016-11-29

申请号：US14715153

申请日：2015-05-18

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett Holmquist ,  Nigel Clarke

IPC: G01N33/82 ,  H01J49/00 ,  G01N33/68

CPC classification number: G01N33/82 ,  G01N33/6848 ,  G01N33/6851 ,  G01N2560/00 ,  H01J49/00 ,  H01J49/0027 ,  Y10T436/212

Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

公开(公告)号：US12066446B2

公开(公告)日：2024-08-20

申请号：US18142153

申请日：2023-05-02

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Brett Holmquist ,  Nigel Clarke ,  Anne Caston ,  Richard E. Reitz

IPC: G01N33/82

CPC classification number: G01N33/82 ,  Y10T436/10 ,  Y10T436/20 ,  Y10T436/203332 ,  Y10T436/24

Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.

公开(公告)号：US11852636B2

公开(公告)日：2023-12-26

申请号：US18091726

申请日：2022-12-30

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett Holmquist ,  Nigel Clarke

IPC: G01N33/82 ,  G01N30/72 ,  H01J49/00 ,  H01J49/14 ,  G01N30/00 ,  G01N30/88 ,  G01N30/02

CPC classification number: G01N33/82 ,  G01N30/7233 ,  H01J49/004 ,  H01J49/145 ,  G01N2030/009 ,  G01N2030/027 ,  G01N2030/8813

Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.

公开(公告)号：US11650216B2

公开(公告)日：2023-05-16

申请号：US16748234

申请日：2020-01-21

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Brett Holmquist ,  Nigel Clarke ,  Anne Caston ,  Richard E. Reitz

IPC: G01N27/62 ,  G01N33/82

CPC classification number: G01N33/82 ,  Y10T436/10 ,  Y10T436/20 ,  Y10T436/203332 ,  Y10T436/24

Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.

公开(公告)号：US11549954B2

公开(公告)日：2023-01-10

申请号：US17700320

申请日：2022-03-21

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett Holmquist ,  Nigel Clarke

IPC: G01N33/82 ,  G01N30/72 ,  H01J49/00 ,  H01J49/14 ,  G01N30/00 ,  G01N30/88 ,  G01N30/02

Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.

公开(公告)号：US20210041462A1

公开(公告)日：2021-02-11

申请号：US16857628

申请日：2020-04-24

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Cory Bystrom ,  Shijun Sheng ,  Nigel Clarke ,  Richard E. Reitz

IPC: G01N33/74 ,  G01N33/68

Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.

公开(公告)号：US20180128841A1

公开(公告)日：2018-05-10

申请号：US15602764

申请日：2017-05-23

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Cory Bystrom ,  Shijun Sheng ,  Nigel Clarke ,  Richard E. Reitz

IPC: G01N33/74 ,  G01N33/68

CPC classification number: G01N33/74 ,  G01N33/6848

Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.

公开(公告)号：US12181484B2

公开(公告)日：2024-12-31

申请号：US18132009

申请日：2023-04-07

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Cory Bystrom ,  Shijun Sheng ,  Nigel Clarke ,  Richard Reitz

IPC: G01N33/74 ,  G01N33/68

Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.