公开(公告)号：US09566024B2

公开(公告)日：2017-02-14

申请号：US13610256

申请日：2012-09-11

Applicant: Zhi Xu

Inventor： Zhi Xu

IPC: A61B5/1455 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/7225 ,  A61B2562/0238 ,  A61B2576/00 ,  G06F19/00

Abstract: Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area of the sample from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor, calculating the attenuance attributable to blood with a ratio factor based on the received output signal, and determining a blood glucose level based on the calculated attenuance.

Abstract translation: 公开了基于光谱数据非生物地测量生物样品中的血糖水平的系统和方法。 这包括利用至少一个被配置成撞击样本的目标区域的光源，利用至少一个光过滤器，其被定位成通过至少一个光检测器接收透射来自所述至少一个光源的样品的目标区域的光 定位成从所述至少一个光源接收光并被所述至少一个滤光器滤波，并且产生具有时间相关电流的输出信号，所述时间相关电流指示所检测的光的功率，从所述至少一个光滤波器接收来自所述至少一个光滤波器的输出信号 具有处理器的至少一个光检测器，基于所接收的输出信号以比例因子计算归因于血液的衰减，以及基于所计算的衰减来确定血糖水平。

公开(公告)号：US20130245405A1

公开(公告)日：2013-09-19

申请号：US13610423

申请日：2012-09-11

Applicant: Zhi Xu

Inventor： Zhi Xu

IPC: A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/7225 ,  A61B2562/0238 ,  A61B2576/00 ,  G06F19/00

Abstract: Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, a processor configured to receive the output signal from the at least one light detector based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area with a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and then determine a blood glucose level with a sample present in target area based on the calculated attenuance with the processor.

Abstract translation: 公开了基于光谱数据非生物地测量生物样品中的血糖水平的系统和方法。 这包括配置成撞击样品的目标区域的至少一个光源，至少一个光检测器，定位成接收来自至少一个光源的光并产生具有时间相关电流的输出信号，其指示 检测到的光的功率，被配置为基于接收到的输出信号从至少一个光检测器接收输出信号的处理器以比例因子计算归因于目标区域中存在的样本中的血液的衰减，消除效果 由至少一个光检测器的温度依赖性检测器响应引起的不确定性，然后基于与处理器计算的衰减，使用存在于目标区域中的样本来确定血糖水平。

公开(公告)号：US20120209107A1

公开(公告)日：2012-08-16

申请号：US13337713

申请日：2011-12-27

Applicant: Jianjun Guo ,  Zhi Xu ,  Feng Lin ,  Menachem Halmann ,  Mirsaid Seyed-Bolorforosh

Inventor： Jianjun Guo ,  Zhi Xu ,  Feng Lin ,  Menachem Halmann ,  Mirsaid Seyed-Bolorforosh

IPC: A61B8/13

CPC classification number: A61B8/0841 ,  A61B8/54 ,  A61B10/0233 ,  A61B2017/3413 ,  A61B2090/378 ,  A61B2090/3925 ,  G01S7/52046 ,  G01S7/52085 ,  G06T5/008 ,  G06T2207/10132 ,  G06T2207/30021

Abstract: A method of enhancing needle visualization in ultrasound imaging is provided. The method includes reducing overall gain in needle frames, and applying a nonlinear mapping to the needle frames, wherein the nonlinear mapping is configured to make strong signals stronger and make weak signals weaker after mapping.

Abstract translation: 提供了一种在超声成像中增强针头可视化的方法。 该方法包括降低针框的总体增益，以及对针框施加非线性映射，其中非线性映射被配置为使得强信号变得更强并且使得弱信号在映射之后较弱。

公开(公告)号：US08193075B2

公开(公告)日：2012-06-05

申请号：US12757341

申请日：2010-04-09

Applicant: Zhi Xu

Inventor： Zhi Xu

IPC: H01L21/322

CPC classification number: H01L21/3105 ,  H01J37/32357 ,  H01L21/3003 ,  H01L21/321 ,  H01L21/425 ,  H01L31/03685 ,  H01L31/03762 ,  H01L31/075 ,  H01L31/1824 ,  H01L31/1868 ,  H01L31/202 ,  Y02E10/545 ,  Y02E10/548 ,  Y02P70/521

Abstract: Apparatus and methods for repairing silicon dangling bonds resulting from semiconductor processing are disclosed. The silicon dangling bonds can be repaired by introducing hydrogen radicals with substantially no hydrogen ions into the processing chamber to react with the silicon dangling bonds, eliminating them.

Abstract translation: 公开了用于修复由半导体加工产生的硅悬挂键的装置和方法。 可以通过将基本上没有氢离子的氢自由基引入处理室来与硅悬挂键反应来修复硅悬挂键，从而消除它们。

公开(公告)号：US20110079718A1

公开(公告)日：2011-04-07

申请号：US12898879

申请日：2010-10-06

Applicant: Zhi Xu

Inventor： Zhi Xu

IPC: G01J5/02 ,  G01J3/42

CPC classification number: G01J3/4535

Abstract: A Fourier Transfer Infrared (FTIR) spectrophotometer having reduced baseline noise. The system and method include internal or external optical adapters having a moveable beamsplitter for splitting the source light beam into a reference beam and a sample beam, and may include a variable bandpass filter, variable preamplifier and reversed biased photodiodes.

Abstract translation: 具有降低的基线噪声的傅立叶转移红外（FTIR）分光光度计。 该系统和方法包括具有可移动分束器的内部或外部光学适配器，用于将源光束分成参考光束和采样光束，并且可以包括可变带通滤波器，可变前置放大器和反向偏置光电二极管。

公开(公告)号：US20100288026A1

公开(公告)日：2010-11-18

申请号：US12517951

申请日：2007-12-06

Applicant: Zhi Xu

Inventor： Zhi Xu

IPC: G01N30/26 ,  G01N30/00

CPC classification number: G01N30/74 ,  G01N30/84 ,  G01N2030/847 ,  G01N2030/8494

Abstract: A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector

Abstract translation: 用于液相色谱检测器的流量控制器。 流量控制器包括流动通道，其包括入口部分，与入口部分连通的控制通道部分和与所述控制通道部分连通的出口部分。 控制通道部分的横截面积小于液相色谱检测器的漂移管的横截面面积，用于将液滴流通过较小的横截面积。 流量控制器的形状和尺寸可以减小液相色谱检测器液滴流中的压力波动和湍流

公开(公告)号：US20080228083A1

公开(公告)日：2008-09-18

申请号：US10586272

申请日：2005-01-18

Applicant: Jinguang Wu ,  Yuanfu Zhang ,  Yizhuang Xu ,  Qingbo Li ,  Shifu Weng ,  Limin Yang ,  Li Zhang ,  Weijin Zhou ,  Zhanian Yang ,  Weihong Li ,  Huizhong Wu ,  Rongye Gong ,  Xuejun Gao ,  Duanfu Xu ,  Ying Zhao ,  Zhi Xu ,  Nengwei Zhang ,  Lixin Wang ,  Kaihua Sun ,  Xin Peng ,  Yufeng Liu ,  Xuejun Sun ,  Xiaofeng Ling ,  Su Zhou ,  Zhi Liu ,  Guoqiao Lai ,  Jianxiong Jiang ,  Qinghua Pan ,  Qiguang Wu ,  Guangyan Yu ,  Bingbing Wang

Inventor： Jinguang Wu ,  Yuanfu Zhang ,  Yizhuang Xu ,  Qingbo Li ,  Shifu Weng ,  Limin Yang ,  Li Zhang ,  Weijin Zhou ,  Zhanian Yang ,  Weihong Li ,  Huizhong Wu ,  Rongye Gong ,  Xuejun Gao ,  Duanfu Xu ,  Ying Zhao ,  Zhi Xu ,  Nengwei Zhang ,  Lixin Wang ,  Kaihua Sun ,  Xin Peng ,  Yufeng Liu ,  Xuejun Sun ,  Xiaofeng Ling ,  Su Zhou ,  Zhi Liu ,  Guoqiao Lai ,  Jianxiong Jiang ,  Qinghua Pan ,  Qiguang Wu ,  Guangyan Yu ,  Bingbing Wang

IPC: A61B6/00 ,  G01J5/02

CPC classification number: A61B5/0059 ,  A61B5/6848 ,  A61B5/7257

Abstract: The invention relates to a non-invasive method to diagnose the changes of molecular structures of organism tissues from body surface and a dedicated apparatus. The apparatus is comprised of a Fourier Transform infrared spectrometer and a set of additional accessories. Said additional accessories include a mid-IR fiber optics sampling attachment, a fiber coupling part, and an infrared detector part. The detection method is comprised of placing the ATR probe of the dedicated apparatus on the skin surface of a region to be tested, and scanning more than one time in which the resolution of the apparatus is 1-32 cm−1 and the range of the spectrum is 800-4000 cm−1. It is possible to detect changes in molecular structures of living biological tissues in the early stages of cancer, and testees will not feel uncomfortable during testing. The method is easy to operate, quick, accurate, and it doesn't harm the body.

Abstract translation: 本发明涉及用于诊断来自身体表面的生物体组织的分子结构的变化的非侵入性方法和专用设备。 该装置由傅里叶变换红外光谱仪和一组附加附件组成。 所述附加附件包括中红外光纤采样附件，光纤耦合部件和红外探测器部件。 检测方法包括将专用装置的ATR探针放置在待测试区域的皮肤表面上，扫描多于一次，其中装置的分辨率为1-32cm -1， SUP>，光谱范围为800-4000cm -1。 在癌症早期阶段可以检测生物体组织的分子结构变化，受试者在测试过程中不会感到不适。 该方法易于操作，快速，准确，不伤身体。

公开(公告)号：US20070291255A1

公开(公告)日：2007-12-20

申请号：US11845580

申请日：2007-08-27

Applicant: David Larsen ,  Zhi Xu

Inventor： David Larsen ,  Zhi Xu

IPC: G01N21/00

CPC classification number: G01J3/02 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/42 ,  G01J3/45 ,  G01J2003/425 ,  G01N21/274 ,  G01N21/31 ,  G01N2021/3137 ,  G01N2201/0227 ,  G01N2201/127

Abstract: Increasing signal to noise ratio in optical spectra obtained by spectrophotometers. An interferometer introduces interference effects into a source light beam. A dual beam configuration splits the source beam having the interference effects into a reference beam and a sample beam. The reference beam interacts with a reference substance and is detected by a reference detector. The sample beam interacts with a sample substance and is detected by a sample detector. An optical spectra of the sample is based on the difference between the detected reference beam and the detected sample beam.

Abstract translation: 通过分光光度计获得的光谱增加信噪比。 干涉仪将干扰效应引入源光束。 双光束配置将具有干涉效应的源光束分解成参考光束和样本光束。 参考光束与参考物质相互作用，并由参考检测器检测。 样品束与样品物质相互作用，并由样品检测器检测。 样品的光谱基于检测到的参考光束和检测到的样品光束之间的差异。

公开(公告)号：US20070104614A1

公开(公告)日：2007-05-10

申请号：US11317559

申请日：2005-12-22

Applicant: Wei Wang ,  Chuanfen Xie ,  Quan Li ,  Zhi Xu

Inventor： Wei Wang ,  Chuanfen Xie ,  Quan Li ,  Zhi Xu

IPC: G01N35/00

CPC classification number: G01N35/025 ,  G01N35/00594 ,  G01N2035/00425

Abstract: The present invention relates to an automatic chemistry analyzer comprising a reaction disk assembly (1), a sample and reagent disk assembly (2), a probe assembly (3) and a stirring assembly (4). A single probe (5) is used to dispense both the reagent and the sample into the reaction vessels. A pre-heating device disposed in the mechanical arm (6) for supporting the probe (5) pre-heats the reagent sucked into the probe to an appropriate temperature. The reaction vessels are disposable and may be replaced manually. The automatic chemistry analyzer may run single-reagent tests or double-reagent tests. According to the automatic chemistry analyzer of the present invention, the interval between injecting the first reagent of a test and injecting the sample of the same test may be 5.5 operation periods so that the first reagent in the reaction vessel may be maintained at or near an appropriate reaction temperature (37° C.). In a process of running a double-reagent test, the incubation time between injecting the sample and injecting the second reagent is set freely by the operator according to the requirements of the test. The automatic chemistry analyzer and the analyzing method according to the present invention may improve the test correctness.

Abstract translation: 本发明涉及一种包括反应盘组件（1），样品和试剂盘组件（2），探针组件（3）和搅拌组件（4）的自动化学分析仪。 使用单个探针（5）将试剂和样品分配到反应容器中。 设置在用于支撑探针（5）的机械臂（6）中的预热装置将吸入探针的试剂预加热到适当的温度。 反应容器是一次性的，可以手动更换。 自动化学分析仪可以运行单试剂测试或双试剂测试。 根据本发明的自动化学分析装置，注射试验的第一试剂与同一试验样品的注射间隔可以为5.5个操作时间，以使反应容器中的第一试剂维持在或接近 适当的反应温度（37℃）。 在运行双试剂测试的过程中，注射样品和注射第二试剂之间的孵育时间由操作者根据测试要求自由设定。 根据本发明的自动化学分析仪和分析方法可以提高测试正确性。

公开(公告)号：US09788764B2

公开(公告)日：2017-10-17

申请号：US13610342

申请日：2012-09-11

Applicant: Zhi Xu

Inventor： Zhi Xu

IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/7225 ,  A61B2562/0238 ,  A61B2576/00 ,  G06F19/00

Abstract: Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, and a processor configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area and eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determine a blood glucose level associated with a sample present in the target area.