公开(公告)号：US20140220173A1

公开(公告)日：2014-08-07

申请号：US14241975

申请日：2012-09-04

Applicant: Carlo Joseph Quinonez

Inventor： Carlo Joseph Quinonez

IPC: B81C99/00 ,  B29C45/17 ,  B29C45/40

CPC classification number: B81C99/0085 ,  B01L1/025 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0645 ,  B01L2400/0481 ,  B01L2400/0487 ,  B29C45/1753 ,  B29C45/34 ,  B29C45/401 ,  B29C2045/0094 ,  B81C2201/034 ,  F04B19/006 ,  F04B43/043 ,  F04B49/065 ,  G01N2035/00158 ,  G05D7/0694 ,  Y10T137/8376

Abstract: A microfluidic device platform may include a valve manifold adapted to deliver a programmable pressure to a plurality of ports, a cell chamber having programmable environmental control, and a chip-to-world interface.

Abstract translation: 微流体装置平台可以包括适于将可编程压力递送到多个端口的阀歧管，具有可编程环境控制的电池室和芯片到世界接口。

公开(公告)号：US20140065347A1

公开(公告)日：2014-03-06

申请号：US14016683

申请日：2013-09-03

Applicant: Carnegie Mellon University, Center for Technology Transfer and Enterprise Creation

Inventor： Metin Sitti ,  Seok Kim

IPC: C09J7/02

CPC classification number: C09J7/00 ,  A44B18/0049 ,  B29C33/3842 ,  B29C33/424 ,  B29C33/52 ,  B29C39/34 ,  B29C39/36 ,  B29C39/42 ,  B29L2031/756 ,  B81B2203/0361 ,  B81C99/0085 ,  B81C2201/034 ,  C09J9/00 ,  C09J2201/626 ,  Y10T428/23957 ,  Y10T428/2933 ,  Y10T428/2935 ,  Y10T428/2976

Abstract: A dry adhesive and a method of forming a dry adhesive. The method includes forming an opening through an etch layer and to a barrier layer, expanding the opening in the etch layer at the barrier layer, filling the opening with a material, removing the barrier layer from the material in the opening, and removing the etch layer from the material in the opening.

Abstract translation: 干燥粘合剂和形成干燥粘合剂的方法。 该方法包括通过蚀刻层和阻挡层形成开口，在阻挡层处扩展蚀刻层中的开口，用材料填充开口，从开口中的材料移除阻挡层，以及去除蚀刻 从开口的材料层。

公开(公告)号：US20140010988A1

公开(公告)日：2014-01-09

申请号：US14016700

申请日：2013-09-03

Applicant: Carnegie Mellon University, Center for Technology Transfer and Enterprise Creation

Inventor： Metin Sitti ,  Seok Kim

IPC: C09J9/00 ,  C09J7/02

CPC classification number: C09J7/00 ,  A44B18/0049 ,  B29C33/3842 ,  B29C33/424 ,  B29C33/52 ,  B29C39/34 ,  B29C39/36 ,  B29C39/42 ,  B29L2031/756 ,  B81B2203/0361 ,  B81C99/0085 ,  B81C2201/034 ,  C09J9/00 ,  C09J2201/626 ,  Y10T428/23957 ,  Y10T428/2933 ,  Y10T428/2935 ,  Y10T428/2976

Abstract: A dry adhesive and a method of forming a dry adhesive. The method includes forming an opening through an etch layer and to a barrier layer, expanding the opening in the etch layer at the barrier layer, filling the opening with a material, removing the barrier layer from the material in the opening, and removing the etch layer from the material in the opening.

公开(公告)号：US20130237034A1

公开(公告)日：2013-09-12

申请号：US13415376

申请日：2012-03-08

Applicant: Alexander Breymesser ,  Andre Brockmeier ,  Carsten von Koblinski ,  Francisco Javier Santos Rodriguez

Inventor： Alexander Breymesser ,  Andre Brockmeier ,  Carsten von Koblinski ,  Francisco Javier Santos Rodriguez

IPC: H01L21/78 ,  C03B19/00 ,  B32B3/30 ,  C03B23/02

CPC classification number: B81C99/008 ,  B81C2201/034 ,  C03B11/082 ,  C03B40/02 ,  C03B2215/07 ,  C03B2215/79 ,  G02B2006/12038 ,  H01L21/56 ,  H01L23/291 ,  H01L23/3178 ,  H01L2924/0002 ,  Y10T428/24479 ,  H01L2924/00

Abstract: A source material, which is based on a glass, is arranged on a working surface of a mold substrate. The mold substrate is made of a single-crystalline material. A cavity is formed in the working surface. The source material is pressed against the mold substrate. During pressing a temperature of the source material and a force exerted on the source material are controlled to fluidify source material. The fluidified source material flows into the cavity. Re-solidified source material forms a glass piece with a protrusion extending into the cavity. After re-solidifying, the glass piece may be bonded to the mold substrate. On the glass piece, protrusions and cavities can be formed with slope angles less than 80 degrees, with different slope angles, with different depths and widths of 10 micrometers and more.

Abstract translation: 基于玻璃的源材料被布置在模具基板的工作表面上。 模具基材由单晶材料制成。 在工作面上形成空腔。 源材料被压靠在模具基底上。 在压制源材料的温度期间，并且控制施加在源材料上的力以使原料流体化。 流化的原料流入空腔。 再固化的源材料形成具有延伸到空腔中的突起的玻璃片。 重新固化后，玻璃片可以结合到模制基底上。 在玻璃片上，可以形成倾斜角度小于80度的倾斜角度，具有不同的倾斜角度，不同的深度和宽度为10微米等。

公开(公告)号：US08268446B2

公开(公告)日：2012-09-18

申请号：US10572764

申请日：2004-09-23

Applicant: Joseph M. DeSimone ,  Jason P. Rolland ,  Stephen R. Quake ,  Derek A. Schorzman ,  Jason Yarbrough ,  Michael Van Dam

Inventor： Joseph M. DeSimone ,  Jason P. Rolland ,  Stephen R. Quake ,  Derek A. Schorzman ,  Jason Yarbrough ,  Michael Van Dam

IPC: C28J5/20 ,  H01M4/88 ,  H01M8/10 ,  B05D5/12

CPC classification number: B01L3/502707 ,  B01L3/0268 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2400/0481 ,  B01L2400/0655 ,  B81B1/006 ,  B81B2201/058 ,  B81B2203/0323 ,  B81C2201/034 ,  B82Y10/00 ,  B82Y40/00 ,  C08G18/5015 ,  C08G18/8116 ,  C08G65/007 ,  C08G65/33348 ,  C08G2650/48 ,  C09D163/00 ,  C09D171/02 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0034 ,  F16K99/0036 ,  F16K99/0042 ,  F16K99/0046 ,  F16K99/0051 ,  F16K99/0059 ,  F16K99/0061 ,  F16K99/0065 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0086 ,  G03F7/0002 ,  Y10T137/0396 ,  Y10T428/24479 ,  Y10T428/249954 ,  Y10T428/3154

Abstract: The use of a photocurable perfluoropolyether (PFPE) material for fabricating a solvent-resistant PFPE-based microfluidic device, methods of flowing a material and performing a chemical reaction in a solvent-resistant PFPE-based microfluidic device, and the solvent-resistant PFPE-based microfluidic devices themselves are described. In an embodiment, a method is described for preparing a patterned layer of a photocured perfluoropolyether, the method comprising: (a) providing a substrate, wherein the substrate comprises a patterned surface; (b) contacting a perfluoropolvether precursor with the patterned surface of the substrate; and (c) photocuring the perfluoropolyether precursor to form a patterned layer of a photocured perfluoropolyether.

Abstract translation: 使用光固化全氟聚醚（PFPE）材料制造耐溶剂PFPE基微流体装置，使材料流动并在耐溶剂型PFPE基微流体装置中进行化学反应的方法，以及耐溶剂PFPE- 描述了基于微流体的微流体装置本身。 在一个实施方案中，描述了一种制备光固化全氟聚醚的图案化层的方法，所述方法包括：（a）提供基材，其中所述基材包含图案化表面; （b）使全氟聚醚醚前体与基底的图案化表面接触; 和（c）光固化全氟聚醚前体以形成光固化全氟聚醚的图案化层。

公开(公告)号：US08142700B2

公开(公告)日：2012-03-27

申请号：US12448242

申请日：2007-12-14

Applicant: Metin Sitti ,  Michael Murphy ,  Burak Aksak

Inventor： Metin Sitti ,  Michael Murphy ,  Burak Aksak

IPC: B29C37/02

CPC classification number: G03F7/2014 ,  B29C33/3842 ,  B29C33/424 ,  B29C39/26 ,  B29L2031/756 ,  B81C99/0085 ,  B81C2201/034 ,  C09J7/38 ,  C09J2201/28 ,  G03F7/00 ,  G03F7/0017 ,  G03F7/201

Abstract: Dry adhesives and methods for forming dry adhesives. A method of forming a dry adhesive structure on a substrate, comprises: forming a template backing layer of energy sensitive material on the substrate; forming a template layer of energy sensitive material on the template backing layer; exposing the template layer to a predetermined pattern of energy; removing a portion of the template layer related to the predetermined pattern of energy, and leaving a template structure formed from energy sensitive material and connected to the substrate via the template backing layer.

Abstract translation: 干燥粘合剂和干燥粘合剂的形成方法。 在基材上形成干燥粘合剂结构的方法包括：在基材上形成能量敏感材料的模板背衬层; 在模板背衬层上形成能量敏感材料的模板层; 将模板层暴露于预定的能量模式; 去除与预定能量图案相关的模板层的一部分，并留下由能量敏感材料形成的模板结构，并通过模板背衬层连接到基板。

公开(公告)号：US07981346B2

公开(公告)日：2011-07-19

申请号：US11661113

申请日：2005-08-30

Applicant: Patrick Griss ,  Göran Stemme

Inventor： Patrick Griss ,  Göran Stemme

IPC: B28B1/14 ,  B28B1/48 ,  A61M35/00

CPC classification number: B29C45/2628 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B29C2045/0094 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C99/0085 ,  B81C2201/034

Abstract: Method of hollow micro-projections having side walls and at least one opening in a side wall, by a molding technique. The hollow micro-projections are defined by a first, negative mold defining the exterior shape of the micro-projections and a second, positive mold defining the hollow interior shape of the micro-projections. The method includes injecting a moldable material into the space between the two molds, in a state where they have been brought together. The positive and negative molds each have an essentially cylindrical geometry. In the process of bringing the molds together, the mold halves are laterally off-set with respect to each other, such that the distance between an inner wall of the negative mold and the positive mold in the area, ranges from zero to a finite distance. Micro-projections and arrays of micro-projections are also disclosed.

Abstract translation: 通过成型技术的具有侧壁和侧壁中的至少一个开口的中空微型突起的方法。 中空微突起由限定微突起的外部形状的第一负模具和限定微突起的中空内部形状的第二正模定义。 该方法包括将可模塑材料注入到两个模具之间的空间中，并将它们合并在一起。 正负模具各自具有基本上圆柱形的几何形状。 在将模具合在一起的过程中，半模相对于彼此横向偏移，使得阴模的内壁和该区域中的正模之间的距离从零到有限距离 。 还公开了微突起和微突起的阵列。

公开(公告)号：US07763203B2

公开(公告)日：2010-07-27

申请号：US10727124

申请日：2003-12-03

Applicant: Francisco Arias ,  Faiz Feisal Sherman ,  Grover David Owens

Inventor： Francisco Arias ,  Faiz Feisal Sherman ,  Grover David Owens

IPC: B29C35/08

CPC classification number: A61B5/1411 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150419 ,  A61B5/150984 ,  A61M37/0015 ,  A61M2037/0038 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C1/00111 ,  B81C2201/034

Abstract: A method for manufacturing microneedle structures is disclosed using soft lithography and photolithography, in which micromold structures made of a photoresist material or PDMS are created. The micromold manufacturing occurs quite quickly, using inexpensive materials and processes. Once the molds are available, using moldable materials such as polymers, microneedle arrays can be molded or embossed in relatively fast procedures. In some cases a sacrificial layer is provided between the forming micromold and its substrate layer, for ease of separation. The microneedles themselves can be solid projections, hollow “microtubes,” or shallow “microcups.” Electrodes can be formed on the microneedle arrays, including individual electrodes per hollow microtube.

Abstract translation: 公开了使用软光刻和光刻技术制造微针结构的方法，其中制造由光致抗蚀剂材料或PDMS制成的微型结构。 使用廉价的材料和工艺，微型制造相当快速地发生。 一旦模具可用，使用可模塑材料如聚合物，微针阵列可以以相对较快的程序模制或压花。 在一些情况下，为了易于分离，在成形微胶体与其基底层之间提供牺牲层。 微针本身可以是固体突起，中空“微管”或浅“微杯”。电极可以形成在微针阵列上，包括每个中空微管的单个电极。

公开(公告)号：US20100136281A1

公开(公告)日：2010-06-03

申请号：US12448243

申请日：2007-12-14

Applicant: Metin Sitti ,  Seok Kim

Inventor： Metin Sitti ,  Seok Kim

IPC: B32B5/02 ,  C23F1/00 ,  D02G3/22

CPC classification number: C09J7/00 ,  A44B18/0049 ,  B29C33/3842 ,  B29C33/424 ,  B29C33/52 ,  B29C39/34 ,  B29C39/36 ,  B29C39/42 ,  B29L2031/756 ,  B81B2203/0361 ,  B81C99/0085 ,  B81C2201/034 ,  C09J9/00 ,  C09J2201/626 ,  Y10T428/23957 ,  Y10T428/2933 ,  Y10T428/2935 ,  Y10T428/2976

Abstract: A dry adhesive and a method of forming a dry adhesive. The method includes forming an opening through an etch layer and to a barrier layer, expanding the opening in the etch layer at the barrier layer, filling the opening with a material, removing the barrier layer from the material in the opening, and removing the etch layer from the material in the opening.

Abstract translation: 干燥粘合剂和形成干燥粘合剂的方法。 该方法包括通过蚀刻层和阻挡层形成开口，在阻挡层处扩展蚀刻层中的开口，用材料填充开口，从开口中的材料移除阻挡层，以及去除蚀刻 从开口的材料层。

公开(公告)号：US07718420B2

公开(公告)日：2010-05-18

申请号：US11697140

申请日：2007-04-05

Applicant: Dong-Sung Kim ,  Tai-Hun Kwon

Inventor： Dong-Sung Kim ,  Tai-Hun Kwon

IPC: C12M3/00

CPC classification number: C12M3/00 ,  B01F5/0641 ,  B01F13/0059 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  B81C1/00119 ,  B81C2201/034

Abstract: The present invention is directed to a microfluidic biochip based on an agglutination reaction that is frequently used in qualitative typing in the diagnostic medicine field by realizing a specimen inlet, a reagent inlet, a split microchannel, transfer microchannels, a chaos micromixer, a reaction microchamber, a microfilter, a passive microvalve, and an outlet on a plastic microchip. Particularly, the biochip of the present invention is characterized in that portability thereof is superior and a small amount (about 1 μl) of each of a specimen and a reagent is used. In addition, the biochip of the present invention can be cheaply made through conventional photolithography, electroplating, injection molding, and bonding. Therefore, by utilizing the microfluidic biochip for blood typing according to the present invention, a point-of-care diagnosis for performing blood typing based on an agglutination reaction at any place becomes possible.

Abstract translation: 本发明涉及一种基于凝集反应的微流体生物芯片，其通过实现样品入口，试剂入口，分离微通道，转移微通道，混沌微混合器，反应微室，经常用于诊断医学领域的定性分型 ，微型过滤器，被动微型阀和塑料微芯片上的出口。 特别地，本发明的生物芯片的特征在于其便携性优异，并且使用每个样本和试剂的少量（约1μl）。 此外，本发明的生物芯片可以通过常规的光刻，电镀，注射成型和粘合来廉价制造。 因此，通过利用根据本发明的用于血型分离的微流体生物芯片，可以在任何地方进行基于凝集反应进行血液分型的护理点诊断。