Abstract:
A problem is to provide a monolithic structure that is a porous body formed of a polysaccharide being a naturally-occurring polymer, and has continuous pores having an average pore diameter suitable for biomolecule separation to allow formation into an arbitrary shape, and a manufacturing method therefor. A solution is to manufacture the polysaccharide monolithic structure by a method including a first step for dissolving a polysaccharide into a mixed solvent including a solvent into which the polysaccharide is soluble and a solvent into which the polysaccharide is insoluble, at a temperature lower than a boiling point of the mixed solvent, to give a polysaccharide solution, and a second step for cooling the polysaccharide solution to give the polysaccharide monolithic structure. The polysaccharide monolithic structure obtained is a porous body having continuous pores having an average pore diameter of 0.01 to 20 micrometers and a thickness of 100 micrometers or more.
Abstract:
Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase separation technique. In a preferred embodiment, a second liquid is added to a polymer solution, the second liquid causing the solution to increase in viscosity. With sufficient polymer and second liquid present, the increase in viscosity can be up to that of a gel. The gel can then be shaped as needed. Subsequent solvent extraction leaves the porous polymeric body of defined shape. The porous polymers have utility as medical prostheses, the porosity permitting ingrowth of neighboring tissue. A second material may be incorporated into the chambers, thereby creating a microstructure filling the voids of the macrostructure. A porous polymeric body manufactured by this process may incorporate biologically active agents, and which agents may be delivered in a time-staged delivery manner, where differing drugs may be delivered over differing periods.
Abstract:
Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase separation technique. In a preferred embodiment, a second liquid is added to a polymer solution, the second liquid causing the solution to increase in viscosity. With sufficient polymer and second liquid present, the increase in viscosity can be up to that of a gel. The gel can then be shaped as needed. Subsequent solvent extraction leaves the porous polymeric body of defined shape. The porous polymers have utility as medical prostheses, the porosity permitting ingrowth of neighboring tissue. A second material may be incorporated into the chambers, thereby creating a microstructure filling the voids of the macrostructure. A porous polymeric body manufactured by this process may incorporate biologically active agents, and which agents may be delivered in a time-staged delivery manner, where differing drugs may be delivered over differing periods.
Abstract:
A method for preparing a highly porous, high surface area non-degradable material, comprises the steps of mixing a non-degradable polymer with a solvent or mixture of solvents; gelling the mixture; and treating the gel under conditions whereby a substantially solvent free porous structure is created having a porosity greater than about 80%. The resultant material is mechanically strong and has an architecture comprising at least one of nano fibrous, micro fibrous, non fibrous, complex porous structure with nano fibrous architecture, and mixtures thereof.
Abstract:
Cellulose acetate is formed into porous, spherical particles, having an acetylation degree of 49 to 60%, a particle diameter of 0.05 to 10 mm, a sphericity of 0.7 or larger, a pore volume of 0.4 cc/g or larger and a collapsing strength of 9 kg or higher.
Abstract:
Low-density microcellular foam having a cell size of not greater than 2 .mu.m and method of making by dissolving cellulose acetate in an acetone-based solvent, gelling the solution in a water bath maintained at 0.degree.-10.degree. C for a selected period of time to allow impurities to diffuse out, freezing the gel, and then freeze-drying wherein water and solvents sublime and the gel structure solidifies into low-density microcellular foam. The foam has a density of 0.065 to 0.6.times.10.sup.3 kg/m.sup.3 and cell size of about 0.3 to 2 .mu.m. The small cell size foam is particularly applicable for encapsulation of laser targets.
Abstract translation:细胞尺寸不大于2μm的低密度微孔泡沫体和通过将乙酸纤维素溶解在丙酮类溶剂中制备的方法,将溶液凝胶保持在0-10℃的水浴中选定的时间 的时间以允许杂质扩散出来,冷凝凝胶,然后冷冻干燥,其中水和溶剂升华,凝胶结构固化成低密度微孔泡沫。 泡沫体的密度为0.065〜0.6×10 3 kg / m 3,电池尺寸为0.3〜2μm左右。 小泡沫泡沫特别适用于激光靶材的封装。
Abstract:
POROUS OPEN-CELL THERMOSETTING RESIN AND PROCESS FOR PREPARING SAME. THE PROCESS INVOLVES THE INITIAL FORMATION OF AN EMULSION HAVING A LIQUID RESIN BLEND AS THE CONTINUOUS PHASE AND A HARDENER SOLUTION OR DISPERSION AS THE DISCONTINUOUS PHASE. THE RESIN BLEND PHASE INITIALLY CONTAINS AN AMOUNT OF HARDENER LESS THAN THAT REQUIRED FOR A STOICHIOMETRIC CURE OF THE RESIN. THE HARDENER SOLUTION OR DISPERSION INITIALLY CONTAINS AN ADDITIONAL AMOUNT OF HARDENER TO SUPPLEMENT THE BLEND AND CURE THE RESIN. THE LIQUID OF THE NON-RESIN PHASE IS SELECTED TO BE SUBSTNTIALLY A NON-SOLVENT WITH RESPECT TO THE RESIN. AS THE POLYMERIZATION OF THE EMULSION PROCEEDS HARDENER IS LEACHED OUT OF THE SOLUTION PHASE WHICH IS THE DISCONTINUOUS PHASE,
RESULTING IN A PHASE INVERSION AFTER PARTIAL GELATION WITH THE NON-RESIN LIQUID SOLUTION PHASE BECOMING THE CONTINUOUS PHASE ND THE NON-GELLED RESIN BLEND BECOMING THE DISCONTINUOUS PHASE. AFTER POLYMERIZATION IS COMPLETED AND THE RESIN SOLIDIFIED, THE LIQUID OF THE NON-RESIN PHASE IS REMOVED BY EXTRACTION OR EVAPORATION. THE RESULT IS A RESIN HAVING A NETWORK OF INTERCONNECTED PORES. AN IMPORTANT ASPECT OF THE INVENTION IS THAT IT PERMITS CONTROL OF THE PORE SIZE OF THE PRODUCT.
Abstract:
A semicrystalline poly ketone powder useful for additive manufacturing may be made by dissolving a polyketone having differential scanning calorimetry (DSC) monomodal melt peak, at a temperature above 50° C. to below the melt temperature of the polyketone, precipitating the dissolved polyketone by cooling, addition of a nonsolvent or combination thereof. The method may be used to form polyketones having a DSC melt peak with an enthalpy greater than the starting polyketone.
Abstract:
A manufacturing method of an aerogel powder of the present invention includes: a mixing process of mixing a silicon alkoxide (TEOS (tetraethoxysilane)) and a solvent (methanol) to form a sol on hydrolysis; a gelling process of gelling the sol obtained in the mixing process; an aging process of aging the gel obtained in the gelling process to obtain a wet gel (alkogel); a solvent exchanging process of replacing the solvent of the wet gel with a predetermined replacement solvent (hexane); a modifying process of modifying a surface of a network structure of the wet gel with a predetermined organic group using TMCS; a process of washing the modified wet gel obtained in the wet gel generating process; drying the washed and modified wet gel; and crushing the dried, washed and modified wet gel. It is possible to provide aerogel powder with reduced manufacturing cost per unit bulk volume and excellent in thermal insulation.
Abstract:
Biocompatible and biodegradable, three-dimensional structures containing hyaluronic acid derivatives, obtained by the technique of precipitation induced by supercritical antisolvent (SAS), can be used in the field of medicine and surgery.