公开(公告)号：US11780984B2

公开(公告)日：2023-10-10

申请号：US16895617

申请日：2020-06-08

Applicant: University of Maryland, College Park

Inventor： Eric L. Kendall ,  Erik Wienhold ,  Omid Rahmanian ,  Don L. Devoe

IPC: B01L3/00 ,  C08J3/24 ,  C08J9/224 ,  B01J19/24 ,  B01J20/32 ,  C08J9/28 ,  B01J20/30 ,  C08J9/36 ,  C08F220/32 ,  C08F222/10

CPC classification number: C08J9/36 ,  B01J19/2485 ,  B01J20/3242 ,  B01J20/3255 ,  B01L3/502 ,  B01L3/5023 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/502753 ,  C08J3/246 ,  C08J9/224 ,  B01D2253/342 ,  B01J20/3007 ,  B01J2219/2402 ,  B01J2219/2433 ,  B01J2220/82 ,  B01L2200/0631 ,  B01L2200/12 ,  B01L2300/16 ,  B01L2300/165 ,  C08F220/325 ,  C08F222/102 ,  C08F222/103 ,  C08J9/286 ,  C08J2201/026 ,  C08J2205/022 ,  C08J2205/024 ,  C08J2207/00 ,  C08J2333/10 ,  C08J2333/14 ,  C08J2335/02

Abstract: Bare porous polymer monoliths, fluidic chips, methods of incorporating bare porous polymer monoliths into fluidic chips, and methods for functionalizing bare porous polymer monoliths are described. Bare porous polymer monoliths may be fabricated ex situ in a mold. The bare porous polymer monoliths may also be functionalized ex situ. Incorporating the bare preformed porous polymer monoliths into the fluidic chips may include inserting the monoliths into channels of channel substrates of the fluidic chips. Incorporating the bare preformed porous polymer monoliths into the fluidic chips may include bonding a capping layer to the channel substrate. The bare porous polymer monoliths may be mechanically anchored to channel walls and to the capping layer. The bare porous polymer monoliths may be functionalized by ex situ immobilization of capture probes on the monoliths. The monoliths may be functionalized by direct attachment of chitosan.

公开(公告)号：US10024828B2

公开(公告)日：2018-07-17

申请号：US14894633

申请日：2014-05-07

Applicant: Hitachi High-Technologies Corporation

Inventor： Jun Nunoshige ,  Shinya Ito ,  Hiroshi Nakano

IPC: B01J20/281 ,  B01J20/28 ,  B01D15/08 ,  G01N30/52 ,  B01J20/288 ,  B01J20/32 ,  G01N30/72 ,  G01N30/00 ,  G01N30/02

CPC classification number: G01N30/482 ,  B01D15/08 ,  B01J20/28019 ,  B01J20/28042 ,  B01J20/288 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3248 ,  B01J20/3253 ,  B01J2220/54 ,  B01J2220/82 ,  G01N30/52 ,  G01N30/72 ,  G01N2030/009 ,  G01N2030/027 ,  G01N2030/484

Abstract: An adsorbent which enables solid phase extraction of water-soluble molecules with high efficiency and excellent selectivity and an analysis system using the adsorbent, the adsorbent containing a structure represented by the formula I wherein R is a carrier component, the moiety other than R is a side-chain functional group, R and the benzene ring in the side-chain functional group are bonded directly or bonded through one or more atoms, R′ is selected from the group consisting of hydroxy group, alkoxy group, amino group, alkylamino group, thiol group and alkyl sulfide group, R″ is independently selected from the group consisting of hydroxy group, alkoxy group, alkyl group, amino group, alkylamino group, dialkylamino group, trialkylamino group, thiol group, alkyl sulfide group and hydrogen atom, x is an integer of zero or more and three or less, and n is the number of the side-chain functional groups contained in the carrier component.

公开(公告)号：US09950280B2

公开(公告)日：2018-04-24

申请号：US15299411

申请日：2016-10-20

Applicant: Porvair Filtration Group Limited

Inventor： Igor Chernukhin ,  Elena Klenova ,  David Cowieson ,  Samantha Brown

IPC: B01D15/38 ,  G01N33/543 ,  C12Q1/68 ,  B01J20/286

CPC classification number: B01D15/3809 ,  B01J20/286 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3274 ,  B01J2220/82 ,  C12Q1/6804 ,  G01N33/54306 ,  G01N33/54366

Abstract: The invention provides methods and devices for isolating chromatin from liquid samples. The devices have a rigid porous matrix on which a ligand is immobilized, with the ligand binding to a protein associated with the chromatin.

公开(公告)号：US20160184800A1

公开(公告)日：2016-06-30

申请号：US15063196

申请日：2016-03-07

Applicant: Francois Parmentier

Inventor： Francois Parmentier

IPC: B01J20/283 ,  B01J20/30 ,  B01J20/281 ,  B01J20/284

CPC classification number: B01J20/283 ,  B01J20/28045 ,  B01J20/28095 ,  B01J20/284 ,  B01J20/305 ,  B01J20/3078 ,  B01J2220/82 ,  G01N30/482 ,  G01N30/6043 ,  G01N2030/484 ,  G01N2030/528

Abstract: The invention relates to a monolithic porous material made of amorphous silica or activated alumina, comprising substantially rectilinear capillary channels that are parallel to one another, wherein: the channels have a substantially uniform cross-section relative to each other, the cross-section of each channel is regular over its entire length, the channels pass through the material from end to end, the length of the channels is equal to or more than 10 mm. The invention also relates to an annular, radial or axial chromatographic apparatus, the packing of which consists of at least one said monolithic material.The invention also relates to processes for manufacturing such a monolithic material.

公开(公告)号：US09321866B2

公开(公告)日：2016-04-26

申请号：US14406202

申请日：2013-06-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Pei Yuin Keng ,  Rehana Ismail ,  Ariella Machness ,  Kyoung-Joo Jenny Park

IPC: C08F2/46 ,  C08G61/04 ,  C08F212/14 ,  A61B5/15 ,  B01J19/00 ,  C07B59/00 ,  C07H13/04 ,  C08F236/20 ,  A61B5/151

CPC classification number: C08F212/14 ,  A61B5/1405 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150229 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1514 ,  B01D15/363 ,  B01J19/0093 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/328 ,  B01J2219/00831 ,  B01J2219/00844 ,  B01J2219/00846 ,  B01J2219/00905 ,  B01J2219/00918 ,  B01J2219/00936 ,  B01J2219/00943 ,  B01J2220/82 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0883 ,  C07B59/005 ,  C07H13/04 ,  C08F236/20

Abstract: The present disclosure relates to the novel multistep procedure for preparation of polymer monoliths for use in solvent exchange, such as methods to exchange and activate fluoride ions on a flow through microfluidic chip for subsequent chemical synthesis. Methods according to the present disclosure include the application of such microfluidic platforms for rapid F18 radiosynthesis on a flow through microfluidic chip with high efficiency, followed by a subsequent nucleophilic fluorination reaction. Various other methods of exchanging and activating fluoride ions on a flow through microfluidic chip are also disclosed. Methods incorporating features of the present invention can be applicable to any flow through microfluidic device in any field, such as radiosyntheses, chemical syntheses, concentration of ions for environmental analyzes and sample preparation such as concentrating minute amounts of analyte to improve the downstream detection.

Abstract translation: 本公开涉及用于制备用于溶剂交换的聚合物整料的新型多步骤方法，例如在通过微流体芯片的流动上交换和活化氟离子以用于随后的化学合成的方法。 根据本公开的方法包括将这种微流体平台用于快速F18放射合成在高效率流过微流控芯片的流体上，随后进行亲核氟化反应。 还公开了在流过微流体芯片的流动上交换和激活氟离子的各种其它方法。 结合本发明的特征的方法可以适用于任何领域中的任何流过微流体装置的流体，例如放射合成，化学合成，用于环境分析的离子浓度和样品制备，例如浓缩微量分析物以改善下游检测。

公开(公告)号：US09303098B2

公开(公告)日：2016-04-05

申请号：US12994914

申请日：2009-05-05

Applicant: Matthias Joehnck

Inventor： Matthias Joehnck

IPC: C08F4/52 ,  B01J20/285 ,  B01J20/32 ,  C08F257/02 ,  C08F265/00 ,  C08F271/00 ,  C08F271/02 ,  C08F283/06 ,  C08F290/06 ,  C08F291/00 ,  C08L51/00

CPC classification number: C08F4/52 ,  B01J20/285 ,  B01J20/3278 ,  B01J2220/82 ,  C08F257/02 ,  C08F265/00 ,  C08F271/00 ,  C08F271/02 ,  C08F283/06 ,  C08F290/06 ,  C08F291/00 ,  C08L51/003 ,  C08L2666/02

Abstract: The invention relates to a process for the preparation of a separating material having improved binding capacity, and to materials prepared and to the use thereof for the separation of charged or uncharged biopolymers from liquids.

Abstract translation: 本发明涉及一种制备具有改善的结合能力的分离材料的方法，以及制备的材料及其用于从带液体或不带电荷的生物聚合物分离液体的用途。

公开(公告)号：US20150377847A1

公开(公告)日：2015-12-31

申请号：US14843762

申请日：2015-09-02

Applicant: BRIGHAM YOUNG UNIVERSITY

Inventor： Matthew R. Linford ,  Robert C. Davis ,  Richard Vanfleet ,  David S. Jensen ,  Li Yang ,  Jun Song

IPC: G01N30/92 ,  B01J20/282 ,  B01J20/28 ,  G01N30/93 ,  B01D15/20

CPC classification number: G01N30/92 ,  B01D15/20 ,  B01J20/28007 ,  B01J20/282 ,  B01J20/286 ,  B01J2220/82 ,  B82Y30/00 ,  G01N30/93

Abstract: In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. At least a portion of the elongated nanostructures may be removed after being coated. Embodiments for TLC plates and related methods are also disclosed.

Abstract translation: 在一个实施方案中，公开了薄层色谱（“TLC”）板的制造方法。 该方法包括形成细长的纳米结构层（例如，碳纳米管），并且用涂层至少部分地涂覆细长的纳米结构。 涂层包括用于色谱法的固定相和/或固定相的前体。 至少一部分细长的纳米结构可以在被涂覆之后被去除。 还公开了TLC板的实施例和相关方法。

公开(公告)号：US09212271B2

公开(公告)日：2015-12-15

申请号：US14379913

申请日：2012-02-28

Applicant: Klaus Gregorius ,  Ian Alan Nicholls ,  Nicolas Otto Krogh

Inventor： Klaus Gregorius ,  Ian Alan Nicholls ,  Nicolas Otto Krogh

IPC: C08G6/00 ,  C08J9/36 ,  B01D15/38 ,  B01J20/26 ,  B01J20/285 ,  B01J20/30 ,  B82Y30/00

CPC classification number: C08J9/36 ,  B01D15/3804 ,  B01D15/3852 ,  B01J20/268 ,  B01J20/285 ,  B01J20/3007 ,  B01J20/3057 ,  B01J20/3085 ,  B01J2220/82 ,  B82Y30/00 ,  C08J2300/00

Abstract: Provided is an improved method for preparation of insoluble molecular imprinted polymers (MIPs), the method comprising: a) providing soluble or semi-soluble MIPs that 1) substantially all bind template agents and 2) have sizes which enable their separation in a chromatographic step utilizing packed bed chromatography, b) cross-linking the template agent binding soluble MIPs provided in step a so as to obtain insoluble template agent binding MIPs, and c) optionally isolating, concentrating or purifying the MIPs obtained by the cross-linking in step b. In an interesting embodiment, step a includes an affinity purification procedure, which ensures that the MIPs provided in step a are indeed all binders of the template.

Abstract translation: 提供了一种用于制备不溶性分子印迹聚合物（MIP）的改进方法，所述方法包括：a）提供可溶性或半溶性MIP，其1）基本上全部结合模板剂和2）具有使其能够在色谱步骤中分离的尺寸 使用填充床层析法，b）交联在步骤a中提供的结合可溶性MIP的模板剂，以获得结合MIP的不溶性模板剂，以及c）任选分离，浓缩或纯化通过步骤b中的交联获得的MIP 。 在有趣的实施方案中，步骤a包括亲和纯化程序，其确保步骤a中提供的MIP确实是模板的所有结合物。

公开(公告)号：US09211524B2

公开(公告)日：2015-12-15

申请号：US14206538

申请日：2014-03-12

Applicant: Waters Technologies Corporation

Inventor： Zhiping Jiang ,  John E. O'Gara ,  Raymond P. Fisk ,  Kevin D. Wyndham ,  Darryl W. Brousmiche

IPC: B32B27/30 ,  B01J20/285 ,  B01J20/26 ,  B01J20/28 ,  B01J20/286 ,  C08F230/08 ,  C08G77/442 ,  C08L53/00

CPC classification number: C08J9/35 ,  B01J20/26 ,  B01J20/265 ,  B01J20/28019 ,  B01J20/28042 ,  B01J20/285 ,  B01J20/286 ,  B01J2220/82 ,  C08F230/08 ,  C08G77/442 ,  C08J2329/04 ,  C08J2383/06 ,  C08L53/00 ,  C08L53/005 ,  Y10T428/2982 ,  C08L2666/02

Abstract: The present invention relates to porous inorganic/organic homogenous copolymeric hybrid material materials, including particulates and monoliths, methods for their manufacture, and uses thereof, e.g., as chromatographic separations materials.

Abstract translation: 本发明涉及多孔无机/有机均相共聚混合材料材料，包括颗粒和整料，其制造方法及其用途，例如作为色谱分离材料。

公开(公告)号：US09181282B2

公开(公告)日：2015-11-10

申请号：US14368046

申请日：2012-12-21

Applicant: UNIVERSITEIT GENT

Inventor： Matthias Ide ,  Pascal Van Der Voort ,  Patrick Sandra ,  Frederic Lynen

IPC: C07F7/08 ,  C07F7/18 ,  B01J20/283 ,  B01J20/286

CPC classification number: C07F7/1804 ,  B01J20/283 ,  B01J20/286 ,  B01J2220/82

Abstract: The present invention relates to novel silica materials, precursors thereof and the preparation thereof. The compounds may be used for a variety of applications, including chromatography and catalysis.

Abstract translation: 本发明涉及新型二氧化硅材料及其前体及其制备方法。 该化合物可用于各种应用，包括色谱和催化。