公开(公告)号：US20160151785A1

公开(公告)日：2016-06-02

申请号：US14806438

申请日：2015-07-22

Applicant: Keck Graduate Institute

Inventor： Robert W. Doebler, II ,  Christopher Cooney ,  Anna Hickerson ,  James D. Sterling ,  Ali Nadim

IPC: B01L7/00 ,  G01N21/64

CPC classification number: B01L7/52 ,  B01L2200/147 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/18 ,  B01L2300/1805 ,  B01L2300/1827 ,  C12Q1/6844 ,  G01N21/0332 ,  G01N21/6428 ,  G01N21/6486 ,  G01N2201/06153 ,  Y10T436/12 ,  Y10T436/25

Abstract: An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.

Abstract translation: 等温反应和分析系统可以包括用于接收样品架的接收器，用于控制接收器的温度的热控制子系统，激励子系统，检测子系统和分析子系统。 定位激励源和/或检测器以增强数据收集。 样品保持器可以包括滤光器，选择性地阻挡和通过电磁辐射的波长或带。

公开(公告)号：US20160123892A1

公开(公告)日：2016-05-05

申请号：US14984833

申请日：2015-12-30

Applicant: KLA-Tencor Corporation

Inventor： Filip Cauwenberghs ,  Johan DeGreeve ,  Pauline Begoc ,  Koen Goorman

IPC: G01N21/88 ,  H04N5/225 ,  F21V14/00 ,  F21V5/04 ,  F21V23/00

CPC classification number: G01N21/8806 ,  G01N2021/8835 ,  G01N2201/06126 ,  G01N2201/06153 ,  H04N5/2256

Abstract: An illumination system, an inspection tool and a method for inspecting an object are disclosed. A configurable area light source is arranged in an illumination optical axis of an illumination beam path, wherein the configurable area light source is configured such that different beam diameters are settable. At least one illumination lens is positioned in the illumination beam path for directing a collimated beam at least onto a field of view on a surface of the object, wherein a value of an angle of incidence of the illumination optical axis of the illumination beam path equals a value of an angle of reflectance of the imaging optical axis of the imaging beam path. The invention allows the combination of the functionality of a wide angle coaxial illumination and a collimated coaxial illumination in one illumination system.

Abstract translation: 公开了一种照明系统，检查工具和用于检查物体的方法。 可配置区域光源被布置在照明光束路径的照明光轴中，其中可配置区域光源被配置为使得可以设置不同的光束直径。 至少一个照明透镜被定位在照明光束路径中，用于将准直光束至少引导到物体表面上的视野上，其中照明光束路径的照明光轴的入射角值等于 成像光束路径的摄像光轴的反射角度的值。 本发明允许在一个照明系统中组合广角同轴照明和准直同轴照明的功能。

公开(公告)号：US09297749B2

公开(公告)日：2016-03-29

申请号：US13836627

申请日：2013-03-15

Applicant: Innovative Science Tools, Inc.

Inventor： Ronald H Micheels ,  Don J Lee

IPC: G01J3/28 ,  G01N21/359 ,  G01N21/3563 ,  G01N21/3577 ,  G01J3/10 ,  G01J3/02 ,  G01J3/42 ,  G01N21/95

CPC classification number: G01N21/359 ,  G01J3/0205 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/42 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/9508 ,  G01N2201/06153 ,  G01N2201/0627 ,  G01N2201/0631

Abstract: A device and method for identifying solid and liquid materials use near-infrared transmission spectroscopy combined with multivariate calibration methods for analysis of the spectral data. Near-infrared transmission spectroscopy is employed within either the 700-1100 nm or the 900-1700 nm wavelength range to identify solid or liquid materials and determine whether they match specific known materials. Uses include identifying solid (including powdered) and liquid materials with a fast measurement cycle time of about 2 to 15 seconds and with a method that requires no sample preparation, as well as quantitative analysis to determine the concentration of one or more chemical components in a solid or liquid sample that consists of a mixture of components. A primary application of such analysis includes detection of counterfeit drug tablets, capsules and liquid medications.

Abstract translation: 用于识别固体和液体材料的装置和方法使用近红外透射光谱与多变量校准方法结合用于分析光谱数据。 在700-1100nm或900-1700nm波长范围内采用近红外透射光谱法来识别固体或液体材料，并确定它们是否与特定的已知材料相匹配。 用途包括以大约2至15秒的快速测量周期时间识别固体（包括粉末）和液体材料，并且使用不需要样品制备的方法以及定量分析来确定一种或多种化学成分的浓度 固体或液体样品，由组分的混合物组成。 这种分析的主要应用包括检测假药片，胶囊和液体药物。

公开(公告)号：US09151943B2

公开(公告)日：2015-10-06

申请号：US13360260

申请日：2012-01-27

Applicant: Christian K. Sieracki ,  William H. Nelson ,  Robert M. Grimm ,  Scott Ellis

Inventor： Christian K. Sieracki ,  William H. Nelson ,  Robert M. Grimm ,  Scott Ellis

IPC: H04N9/47 ,  H04N7/18 ,  G02B21/36 ,  G01N21/05 ,  G01N21/23

CPC classification number: G02B21/365 ,  G01N21/05 ,  G01N21/23 ,  G01N2201/06153 ,  G01N2201/0627

Abstract: An imaging system with an imaging mechanism which includes polarization analyzers, which may be crossed polarization analyzers, positioned to provide birefringence images of particles in the fluid passing through the flow chamber. Captured images are of high resolution and may be used in comparison to known images of a library of images. The system and related method enhance the accuracy and sensitivity of particle monitoring by utilizing birefringence imaging combined with particle analysis and the detection of each particle's characteristic features, such as crystalline features. The system includes a scatter detector used to trigger backlighting of the flow chamber and capture images of particles therein.

Abstract translation: 具有成像机构的成像系统包括可以是交叉偏振分析器的偏振分析器，其被定位成在通过流动室的流体中提供颗粒的双折射图像。 捕获的图像具有高分辨率，并且可以与图像库的已知图像进行比较。 该系统和相关方法通过利用双折射成像结合粒子分析和检测每个粒子的特征，如晶体特征，提高了粒子监测的准确度和灵敏度。 该系统包括用于触发流动室的背光并捕获颗粒图像的散射检测器。

公开(公告)号：US08792094B2

公开(公告)日：2014-07-29

申请号：US13508038

申请日：2010-10-25

Applicant: Massimo Balducci

Inventor： Massimo Balducci

IPC: G01N21/00 ,  G01N21/88

CPC classification number: G01N21/8806 ,  G01N21/909 ,  G01N2021/8816 ,  G01N2021/8845 ,  G01N2201/06153

Abstract: An apparatus for detecting defects of elements to be subjected to examination, particularly metallic lids, with means for lighting an element to be subjected to examination, an image acquisition unit, and a unit for processing images acquired by said image acquisition unit is described.

Abstract translation: 描述用于检测要检查的元件的缺陷的装置，特别是金属盖，具有用于点亮被检查元件的装置，图像获取单元和用于处理由所述图像获取单元获取的图像的单元。

公开(公告)号：US20110132077A1

公开(公告)日：2011-06-09

申请号：US12737693

申请日：2009-07-22

Applicant: Kevin P. Killeen ,  Karsten Kraiczek ,  Hubert Kuderer

Inventor： Kevin P. Killeen ,  Karsten Kraiczek ,  Hubert Kuderer

IPC: G01N30/00 ,  G01N30/74 ,  F21V11/00

CPC classification number: G01N30/74 ,  G01J2003/102 ,  G01N21/05 ,  G01N21/31 ,  G01N2021/0346 ,  G01N2021/3129 ,  G01N2021/3133 ,  G01N2021/3148 ,  G01N2021/317 ,  G01N2030/027 ,  G01N2201/06153 ,  G01N2201/0627 ,  G01N2201/0638

Abstract: A fluid separation system (10) for separating compounds of a sample fluid in a mobile phase comprises a detector (50) adapted to detect separated compounds by providing an optical stimulus signal to the sample fluid and receiving a response signal to the optical stimulus signal. The detector (50) comprises a light source (100) adapted to provide an output light beam (230) as the optical stimulus signal. The light source (100) comprises a plurality of light emitting elements (200, 200A, 200Z) each adapted to emit a light beam (210, 210A1, 210A2, 210Z1, 210Z2) having a respective wavelength, and a diffracting element (220). The plurality of light emitting elements (200, 200A, 200Z) are arranged that emitted light beams (210, 210A1, 210A2, 210Z1, 210Z2) impinging, on the diffracting element (220) are diffracted by the diffracting element (220) to form the output light beam (230).

Abstract translation: 用于分离流动相中的样品流体的化合物的流体分离系统（10）包括适于通过向样品流体提供光学刺激信号并且接收对光学刺激信号的响应信号来检测分离的化合物的检测器（50）。 检测器（50）包括适于提供输出光束（230）作为光学刺激信号的光源（100）。 光源（100）包括多个发光元件（200,200A，200Z），每个发光元件适于发射具有相应波长的光束（210,210A1,210A2,210Z1,210Z2​​）和衍射元件（220）， 。 多个发光元件（200,200A，200Z）被布置成入射到衍射元件（220）上的发射光束（210,210A1,210A2,210Z1,210Z2​​）被衍射元件（220）衍射以形成 输出光束（230）。

公开(公告)号：US20240019368A1

公开(公告)日：2024-01-18

申请号：US18251471

申请日：2021-11-03

Applicant: Insplorion Sensor Systems AB

Inventor： Per Klockar

IPC: G01N21/552

CPC classification number: G01N21/554 ,  G01N2201/06106 ,  G01N2201/06153

Abstract: The present invention relates to a method and device for determining a property of an ambient environment. The device comprises a plasmonic sensing element; a first light source for illuminating a first and a second light sensor, the first sensor via the plasmonic sensing element; a second light source for illuminating the light sensors; circuitry for executing: a control function controlling light sources, a function receiving a measurement from the first sensor, and a first signal from the second sensor, a function receiving a reference from the first sensor, and a second signal from the second sensor, a function determining the property by comparing the measurement and reference signals, and the control function further controlling light sources such that a relation of intensities of light emitted by the light sources is constant over time.

公开(公告)号：US20170257923A1

公开(公告)日：2017-09-07

申请号：US15510744

申请日：2015-09-15

Applicant: Marc BREIT

Inventor： Marc BREIT

IPC: H05B33/08 ,  G01N21/88

CPC classification number: H05B33/0857 ,  F21L2001/00 ,  F21V29/70 ,  G01N21/8803 ,  G01N21/8806 ,  G01N21/91 ,  G01N2021/8835 ,  G01N2201/06153 ,  H05B33/0893

Abstract: A light, in particular for testing workpiece surfaces using a fluorescent marking device, which light has at least two lighting elements that emit electromagnetic radiation with different wavelength ranges. The intensity with which the lighting element irradiates can be adjusted separately for at least one of the lighting elements. Expediently, the light is configured to increase or reduce the intensity of at least one of the lighting elements and at the same time to keep the intensity of at least one other of the lighting elements constant, or to reduce it or increase it in the opposite way to the first-mentioned lighting element. The light is configured to adjust the intensity at such a speed that the human eye can adapt to a change in the intensity during the adjustment without adverse effects on the person's sight.

公开(公告)号：US20160363568A1

公开(公告)日：2016-12-15

申请号：US15241786

申请日：2016-08-19

Applicant: Agilent Technologies, Inc.

Inventor： Kevin P. Killeen ,  Hubert Kuderer ,  Karsten Kraiczek

IPC: G01N30/74 ,  G01N21/05 ,  G01N21/31

CPC classification number: G01N30/74 ,  G01J2003/102 ,  G01N21/05 ,  G01N21/31 ,  G01N2021/0346 ,  G01N2021/3129 ,  G01N2021/3133 ,  G01N2021/3148 ,  G01N2021/317 ,  G01N2030/027 ,  G01N2201/06153 ,  G01N2201/0627 ,  G01N2201/0638

Abstract: A fluid separation system for separating compounds of a sample fluid in a mobile phase comprises a detector adapted to detect separated compounds by providing an optical stimulus signal to the sample fluid and receiving a response signal on the optical stimulus signal. The detector comprises a light source adapted to provide an output light beam as the optical stimulus signal. The light source comprises a plurality of light emitting elements each adapted to emit a light beam having a respective wavelength, and a diffracting element. The plurality of light emitting elements are arranged that emitted light beams impinging on the diffracting element in a respective angle dependent on the respective wavelength are diffracted by the diffracting element into the output light beam.

Abstract translation: 用于分离流动相中样品流体的化合物的流体分离系统包括适于通过向样品流体提供光刺激信号并且在光刺激信号上接收响应信号来检测分离的化合物的检测器。 检测器包括适于提供输出光束作为光刺激信号的光源。 光源包括多个适于发射具有各自波长的光束的发光元件和衍射元件。 多个发光元件被布置成使得衍射元件以相应的角度照射在衍射元件上的发射光束被衍射元件衍射成输出光束。

公开(公告)号：US09115393B2

公开(公告)日：2015-08-25

申请号：US14307253

申请日：2014-06-17

Applicant: Keck Graduate Institute

Inventor： Robert W. Doebler, II ,  Christopher Cooney ,  Anna Hickerson ,  James D. Sterling ,  Ali Nadim

IPC: G01N21/64 ,  C12Q1/68 ,  B01L7/00 ,  G01N21/03

CPC classification number: B01L7/52 ,  B01L2200/147 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/18 ,  B01L2300/1805 ,  B01L2300/1827 ,  C12Q1/6844 ,  G01N21/0332 ,  G01N21/6428 ,  G01N21/6486 ,  G01N2201/06153 ,  Y10T436/12 ,  Y10T436/25

Abstract: An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.

Abstract translation: 等温反应和分析系统可以包括用于接收样品架的接收器，用于控制接收器的温度的热控制子系统，激励子系统，检测子系统和分析子系统。 定位激励源和/或检测器以增强数据收集。 样品保持器可以包括滤光器，选择性地阻挡和通过电磁辐射的波长或带。