公开(公告)号：US11940375B2

公开(公告)日：2024-03-26

申请号：US17535978

申请日：2021-11-26

Applicant: STATE GRID ANHUI ELECTRIC POWER RESEARCH INSTITUTE ,  Dalian University of Technology

Inventor： Fengxiang Ma ,  Ke Chen ,  Yue Zhao ,  Feng Zhu ,  Min Guo ,  Yu Tian ,  Xiaofang Yuan ,  Yabin Ma ,  Chen Hang

IPC: G01N33/00 ,  G01N21/17

CPC classification number: G01N21/1702 ,  G01N33/0027 ,  G01N2021/1704 ,  G01N2201/06113 ,  G01N2201/08

Abstract: The present disclosure relates to the technical field of fiber-optic gas sensing and laser photoacoustic spectroscopy, and reliability of a gas detection system is improved by actively selecting a working frequency of low noise interference combined with an optical fiber photoacoustic sensing probe capable of isolating high-frequency noise. A gas enters a photoacoustic microcavity through gaps on a sound-sensitive diaphragm after diffusing into a miniature air chamber through a plurality of micropores. Photoacoustic excitation light is incident into the photoacoustic microcavity through a fiber-optic collimator and then excited to generate a photoacoustic pressure wave to cause the sound-sensitive diaphragm to vibrate periodically. An end face of a single-mode optical fiber and the sound-sensitive diaphragm constitutes a fiber-optic Fabry-Perot interferometer. The interferometer measures a deflection of the diaphragm and inverts a concentration of the to-be-measured gas.

公开(公告)号：US20240053268A1

公开(公告)日：2024-02-15

申请号：US18379289

申请日：2023-10-12

Applicant: 1DROP SA

Inventor： Luc Gervais ,  Jörg ZIEGLER ,  Nicolas DESCHARMES

IPC: G01N21/64 ,  B01L3/00 ,  G01N21/77 ,  G01N33/543

CPC classification number: G01N21/648 ,  B01L3/502715 ,  G01N21/7746 ,  G01N21/7703 ,  G01N21/6428 ,  G01N33/54306 ,  G01N2021/6439 ,  G01N2021/7786 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/0654 ,  B01L2300/0877 ,  G01N2021/7736 ,  B01L2300/0627 ,  G01N2201/08

Abstract: An assay unit for carrying-out fluorescence-detected assays having a microfluidic chip with a microfluidic system to convey a sample or analyte solution through one or more microfluidic channels arranged on the chip, and a photonic system with two or more rectangular waveguide structures. The microfluidic channels and the waveguide structures cross each other at a detection site. In an assay area, where a certain microfluidic channel and a certain waveguide structure cross each other, one or more lateral surfaces of the core of the waveguide structure at least partially face an inner volume of the microfluidic channel, such that an evanescent field of light guided within the waveguide structure overlaps with a certain part of the inner volume of the microfluidic channel.

公开(公告)号：US20240044786A1

公开(公告)日：2024-02-08

申请号：US18491236

申请日：2023-10-20

Applicant: S4 Mobile Laboratories, LLC

Inventor： Lamalani SUAREZ ,  David PERRY ,  Linda BARRETT

IPC: G01N21/3563 ,  G01N21/359 ,  G01N33/24

CPC classification number: G01N21/3563 ,  G01N21/359 ,  G01N33/24 ,  G01N2201/0638 ,  G01N2201/0636 ,  G01N2201/08

Abstract: A spectrometer probe is disclosed herein including a shaft having a first end and a second end, a fiberoptic bundle located within the shaft, the fiberoptic bundle having a first end and a second end, a mirror, a transparent window, a prism, a prism support, an elastically deformable material, an index-matching elastomer, wherein the prism is completely encompassed by the index-matching elastomer, and a penetration cone operatively attached to the second end of the fiberoptic bundle, the mirror located within the second end of the shaft, wherein the transparent window is substantially parallel with the fiberoptic bundle and the shaft, wherein the prism is angled at approximately a 45 degree angle in relation to the window and the fiberoptic bundle, wherein the prism is flush with the prism support, wherein the elastically deformable material is biasly connected to the prism support.

公开(公告)号：US11892438B2

公开(公告)日：2024-02-06

申请号：US17115792

申请日：2020-12-09

Applicant: Asahi Kasei Microdevices Corporation

Inventor： Takaaki Furuya ,  Tatsushi Yagi ,  Toshiro Sakamoto

IPC: G01N33/00 ,  G01N21/552 ,  G02B6/42 ,  G01N21/59 ,  G02B6/122 ,  G02B6/12 ,  G02B6/124

CPC classification number: G01N33/0027 ,  G01N21/552 ,  G01N21/5907 ,  G02B6/122 ,  G02B6/12002 ,  G02B6/124 ,  G02B6/4215 ,  G01N2201/0635 ,  G01N2201/08

Abstract: Provided is an optical densitometer for measuring a density of a gas or liquid of interest, the optical densitometer comprising: a light source capable of introducing light into a core layer; a detector capable of receiving the light that has propagated through the core layer; and an optical waveguide, the optical waveguide comprising: a substrate; and the core layer comprising a light propagation portion capable of propagating the light in an extending direction of the light propagation portion, and a diffraction grating portion, the diffraction grating portion comprising a diffraction grating region and an extension region connected to the diffraction grating region, and a first optical coupling region included in the extension region and a second optical coupling region included in the light propagation portion being optically coupled with respect to the light propagating through the core layer.

公开(公告)号：US11892397B2

公开(公告)日：2024-02-06

申请号：US17316467

申请日：2021-05-10

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jing Yong Ye ,  Jonathan D. Scudder

IPC: G01N21/31

CPC classification number: G01N21/31 ,  G01N2201/0633 ,  G01N2201/0636 ,  G01N2201/0638 ,  G01N2201/06113 ,  G01N2201/08

Abstract: A pyrogenicity test method and assay of endotoxins allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay monitored with a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by detecting shifts in the resonant condition of an open microcavity affected by the changes in the refractive index of the analyte solutions used.

公开(公告)号：US11892279B2

公开(公告)日：2024-02-06

申请号：US17291034

申请日：2019-11-04

Applicant: trinamiX GmbH

Inventor： Sebastian Valouch ,  Celal Mohan Oeguen ,  Robert Send ,  Ingmar Bruder

IPC: G01B11/00 ,  G01N21/25

CPC classification number: G01B11/002 ,  G01N21/25 ,  G01N2201/08

Abstract: Described herein is a detector (110) for determining a position of at least one object (112). The detector (110) includes:



at least one transfer device (114) with chromatic aberration;
at least one aperture element (118), wherein the aperture element (118) is configured to block edge components of a light beam (120) propagating from the object (112) to the detector (110) and having passed the transfer device (114);
at least one first optical sensor (126) positioned in a direction of propagation of the light beam (120) behind the aperture element (118); and
at least one second optical sensor (128), wherein the second optical sensor (128) is configured to determine at least one second intensity information of the edge components of the light beam (120).

公开(公告)号：US20240035978A1

公开(公告)日：2024-02-01

申请号：US18356979

申请日：2023-07-21

Applicant: FEI DEUTSCHLAND GMBH

Inventor： Rainer DAUM ,  Xaver VOEGELE

IPC: G01N21/64 ,  G02B21/16 ,  G02B21/00 ,  G02B21/24

CPC classification number: G01N21/6458 ,  G02B21/16 ,  G02B21/0032 ,  G02B21/0036 ,  G02B21/0076 ,  G02B21/24 ,  G01N2201/08 ,  G01N2201/06113 ,  G01N2201/105

Abstract: Disclosed are confocal microscope systems capable of spectral multiplexing. The systems beneficially provide multiple excitation spots on a sample plane simultaneously, and each spot can provide a different wavelength of excitation light. Scanning the excitation spots across a sample can therefore provide multispectral fluorescence imaging at a faster rate than through the sequential process of conventional laser scanning confocal microscopes. A method of generating a distribution from multiplexed spectral fluorescence data is also disclosed.

公开(公告)号：US20240035964A1

公开(公告)日：2024-02-01

申请号：US18224135

申请日：2023-07-20

Applicant: Stichting Imec Nederland

Inventor： Mark ZENTILE ,  Xu Zhang ,  Peter Offermans ,  David Young ,  Arjan Tibbe

IPC: G01N21/41

CPC classification number: G01N21/4133 ,  G01N2201/08

Abstract: According to an aspect of the present inventive concept there is provided a probe for analysis of a liquid in a mixture of the liquid and solid substance. The probe comprises: a tube comprising a sample end configured to be inserted into the mixture; a cap configured to come into contact with the mixture at the sample end, the cap comprising one or more openings configured for allowing passage of the liquid therethrough, and for preventing passage of the solid substance therethrough; and an optical measurement head arranged in the tube and configured to come into contact with the liquid having passed the one or more openings, wherein the optical measurement head is configured to collect measurement information for analysis of the liquid.

公开(公告)号：US20230417674A1

公开(公告)日：2023-12-28

申请号：US18343719

申请日：2023-06-28

Applicant: EDAN INSTRUMENTS, INC.

Inventor： Gaoxiang HUANG ,  Zhixiang ZHAO

IPC: G01N21/64 ,  G01N33/72 ,  G01N35/10

CPC classification number: G01N21/6428 ,  G01N33/726 ,  G01N35/1016 ,  G01N2201/08

Abstract: An in-vitro medical diagnostic system includes a host (1), a removable test card (2) and a removable reagent pack (3). The reagent pack (3) includes a calibrating liquid needed in a process for calibrating the test card (2); the reagent pack (3) is clamped to the host (1), with only first power drive and valve control transmission being provided between the host (1) and the reagent pack (3); and the test card (2) is mounted on the host (1) during the entire test process, with only second power drive and an optical conduction path being provided between the host (1) and the test card (2). No liquid path is present in the host (1) of the in-vitro diagnostic system, thus eliminating hidden medical dangers. Tests for blood gas, hemoglobin and derivatives thereof can be achieved in a single test card.

公开(公告)号：US20230392178A1

公开(公告)日：2023-12-07

申请号：US18449087

申请日：2023-08-14

Applicant: International Business Machines Corporation

Inventor： Amos Cahan ,  Guy M. Cohen ,  Theodore G. van Kessel ,  Sufi Zafar

IPC: C12Q1/02 ,  C12Q1/18 ,  G01N21/59 ,  G01N27/04 ,  G01N15/06 ,  C12M1/12 ,  C12M1/34 ,  C12M1/00 ,  C12M3/00 ,  C12M1/18

CPC classification number: C12Q1/02 ,  C12Q1/18 ,  G01N21/59 ,  G01N27/04 ,  G01N15/0656 ,  C12M25/14 ,  C12M41/36 ,  C12M1/3453 ,  C12M23/34 ,  C12M3/00 ,  C12M1/18 ,  C12M31/02 ,  G01N2201/08 ,  C12N2533/76 ,  G01N27/02

Abstract: A structure for culturing cells includes growth medium regions on a surface of the structure. Each of the growth medium regions includes a growth medium surface configured to receive and promote growth in a cell that is being cultured. The structure includes a non-growth medium. The non-growth medium includes a non-growth medium surface configured to receive the cell that is being cultured.