公开(公告)号：US12019227B2

公开(公告)日：2024-06-25

申请号：US16977820

申请日：2019-02-20

Applicant: Leica Microsystems CMS GmbH

Inventor： Florian Fahrbach ,  Werner Knebel ,  Peter Pott ,  Wernher Fouquet

IPC: G02B21/00 ,  G01N21/47 ,  G01N21/64 ,  G02B21/24 ,  G02B21/33

CPC classification number: G02B21/0032 ,  G01N21/47 ,  G01N21/6458 ,  G02B21/0064 ,  G02B21/0076 ,  G02B21/24 ,  G02B21/33 ,  G01N2201/0633

Abstract: An optical device for illuminating a sample located in a sample volume with illumination light and for detecting scattered and/or fluorescent light from the sample includes an optical illumination assembly, an optical detection assembly and at least one attachment element. The optical illumination assembly is configured to transmit the illumination light along an illumination path into the sample volume. The optical detection assembly is configured to collect and relay the scattered and/or fluorescent light from the sample volume along a detection path. At least portions of the illumination path and/or of the detection path extend in the at least one attachment element.

公开(公告)号：US11965827B2

公开(公告)日：2024-04-23

申请号：US17936161

申请日：2022-09-28

Applicant: Chongqing Institute of East China Normal University ,  East China Normal University ,  Yunnan Huapu Quantum Material Co., Ltd ,  ROI Optoelectronics Technology CO, LTD. ,  Chongqing Huapu New Energy Co., Ltd. ,  Chongqing Huapu Information Technology Co., Ltd. ,  Nanjing ROI Optoelectronics Technology Co., Ltd.

Inventor： Heping Zeng ,  Jianan Fang ,  Kun Huang ,  Mengyun Hu

IPC: G01N21/35

CPC classification number: G01N21/35 ,  G01N2201/06113 ,  G01N2201/0633

Abstract: A hyperspectral imaging method includes: providing time-domain synchronous mid-infrared ultrashort pulse and near-infrared ultrashort pulse as pump light and signal light, respectively; subjecting the signal light to optical time-stretching to broaden a pulse width of the signal light; directing the time-stretched signal light to a target sample to be detected; directing the pump light to a time delayer to adjust the time when the pump light reaches a silicon-based camera; spatially combining the time-stretched signal light from the target sample with the pump light from the time delayer; directing combined light to a silicon-based camera where the signal light is detected through non-degenerate two-photon absorption of the signal light under the action of the pump light to acquire hyperspectral imaging data; and obtaining an image of the target sample based on the hyperspectral imaging data.

公开(公告)号：US11893728B2

公开(公告)日：2024-02-06

申请号：US16928974

申请日：2020-07-14

Applicant: FUJIFILM Corporation

Inventor： Sohichiro Nakamura ,  Ryusuke Osaki ,  Sho Onozawa ,  Akihiro Asakura

IPC: G06T7/00 ,  G06T7/62 ,  C12Q1/02 ,  G01N15/06 ,  G01N21/45 ,  G02B21/16 ,  G03H1/04

CPC classification number: G06T7/0012 ,  C12Q1/02 ,  G01N15/06 ,  G01N21/453 ,  G06T7/62 ,  G01N2015/0693 ,  G01N2201/0633 ,  G01N2201/06113 ,  G02B21/16 ,  G03H1/0443 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30024

Abstract: Provided is a determination method capable of non-destructively and simply determining a state of a sphere that is an aggregate of a plurality of cells. A phase difference image of a sphere that is an aggregate of a plurality of cells is generated from a hologram obtained by imaging the sphere, and a state of the sphere is determined on the basis of the phase difference image and a shape index value corresponding to a shape of the sphere.

公开(公告)号：US11879846B2

公开(公告)日：2024-01-23

申请号：US16968754

申请日：2019-02-08

Applicant: Answeray Inc.

Inventor： Seong Ho Cho

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01N2201/0631 ,  G01N2201/0633 ,  G01N2201/0636 ,  G01N2201/0638

Abstract: Disclosed is a method of processing a Raman spectroscopy signal. The method includes: obtaining a first resolution of Raman spectroscopy by irradiating a target sample with broadband excitation light; calculating a Raman spectroscopy signal corresponding to the Raman spectroscopy of the first resolution; and calculating a signal corresponding to a second resolution of Raman spectroscopy that is higher than the first resolution by deconvoluting a Raman light signal.

公开(公告)号：US11861897B2

公开(公告)日：2024-01-02

申请号：US18012230

申请日：2022-01-14

Applicant: Jiangsu University

Inventor： Aichen Wang ,  Huadong Cao ,  Binjie Gao ,  Lin Li ,  Xinhua Wei ,  Kun Tao

IPC: G06V20/10 ,  G06V10/774 ,  G06V10/46 ,  H04N23/51 ,  H04N23/54 ,  H04N23/56 ,  G01N21/84 ,  G03B17/02 ,  G06T5/00 ,  G06T7/00 ,  H01S5/024

CPC classification number: G06V20/188 ,  G01N21/84 ,  G03B17/02 ,  G06T5/001 ,  G06T7/0002 ,  G06V10/46 ,  G06V10/774 ,  H01S5/02415 ,  H04N23/51 ,  H04N23/54 ,  H04N23/56 ,  G01N2021/8466 ,  G01N2201/0633 ,  G01N2201/0636 ,  G01N2201/06113 ,  G06T2207/20081 ,  G06T2207/30188

Abstract: The present disclosure provides a portable apparatus for detecting early crop diseases based on spatial frequency domain imaging. The apparatus includes an end cover, a spatial frequency domain imaging apparatus, a dark box body, a telescopic section, and an opening-and-closing apparatus connected in sequence. The detection method includes: putting a crop sample to be detected into the dark box body from a bottom; projecting structured light of sine grey scale patterns with different spatial frequencies to the crop sample; after the sine gray scale pattern is switched each time, acquiring, by a camera, a diffuse reflection image of a surface of the crop sample once; after capturing all diffuse reflection images, performing uniformity correction on the images, demodulating the images, and extracting an alternating current component; and inputting an alternating current component image to a trained disease detection model, and determining whether the crop sample has a disease.

公开(公告)号：US11788967B2

公开(公告)日：2023-10-17

申请号：US16963679

申请日：2019-01-23

Applicant: DANMARKS TEKNISKE UNIVERSITET

Inventor： Oleksii Ilchenko ,  Tomas Rindzevicius ,  Anja Boisen ,  Roman Slipets

IPC: G01J3/02 ,  G01J3/44 ,  G01N21/65

CPC classification number: G01N21/65 ,  G01J3/0229 ,  G01J3/0297 ,  G01J3/44 ,  G01N2201/0612 ,  G01N2201/0631 ,  G01N2201/0633 ,  G01N2201/0635

Abstract: An apparatus for carrying out Raman spectroscopy on a sample includes a light source for providing a beam of excitation radiation, and an optical system including a spectrograph. The spectrograph includes a grating that divides a beam of scattered light into a spectrum of spatially separated wavelength components and to direct a portion of the spectrum to a detector. The spectrograph includes: 1) a first lens system for focusing the portion of the spectrum onto the detector and 2) a second lens system-configured to provide a focal plane with focal point in the optical path for focusing the beam of excitation radiation and/or the beam of scattered radiation at the focal point. The apparatus including a reference sample arranged in the focal plane, in particular at the focal point, for obtaining a reference spectrum from the reference sample.

公开(公告)号：US20230175973A1

公开(公告)日：2023-06-08

申请号：US17999777

申请日：2021-05-31

Applicant: VIENEX CORPORATION

Inventor： Yukihiro KAGAWA ,  Osamu IWASAKI

IPC: G01N21/88 ,  G01N21/47

CPC classification number: G01N21/88 ,  G01N21/4738 ,  G01N2201/062 ,  G01N2201/10 ,  G01N2201/0633

Abstract: According to the present invention, a light source and one pixel unit formed of at least one light reception element among a light reception element array (photodiode array) are provided in a one-to-one correspondence, and a light beam is detected from at least one light reception element (one pixel unit) corresponding to the light source, only when the light source emits light. Therefore, only one collimated or further substantially condensed light beam is incident into “a foreign substance/defect” in an object to be inspected, and only scattered light can be separated by the light reception element and be detected. Accordingly, even when an object to be inspected has a light scattering property and is thick, “a foreign substance/defect” can be detected with a good signal to noise ratio (crosstalk is extremely low).

公开(公告)号：US20190250389A1

公开(公告)日：2019-08-15

申请号：US16387842

申请日：2019-04-18

Applicant: The USA, as represented by the Secretary, Dept. of Health and Human Services

Inventor： Hari Shroff ,  Andrew York

IPC: G02B21/00 ,  G01N21/64

CPC classification number: G02B21/0072 ,  G01N21/6458 ,  G01N2021/6478 ,  G01N2201/0633 ,  G02B21/0032 ,  G02B21/0036 ,  G02B21/004 ,  G02B21/0076

Abstract: A structured illumination microscopy (SIM) system for generating single focal point patterns of a sample is disclosed. The SIM system performs a focusing, scaling and summing operation on each single focal point that completely scan the sample to produce a high resolution composite image.

公开(公告)号：US20180127805A1

公开(公告)日：2018-05-10

申请号：US15611433

申请日：2017-06-01

Applicant: Delta Electronics Int'l (Singapore) Pte Ltd

Inventor： Bo Ma ,  Song-Bin Huang ,  Jei-Yin Yiu ,  Hui Wang

IPC: C12Q1/68 ,  G01N21/64 ,  B01L7/00

CPC classification number: C12Q1/686 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2300/0654 ,  B01L2300/1822 ,  G01N21/0332 ,  G01N21/6428 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6471 ,  G01N2201/062 ,  G01N2201/0633 ,  G01N2201/0638 ,  G01N2201/068

Abstract: The multi-channel fluorescence detection device includes an illumination module, plural heating chambers, a detection module and a transmission module. The illumination module includes at least one light source, plural different types of excitation filters, and a first rotational drum, wherein the light source provides a broad band illumination, each of the excitation filters passes light at a particular band width for exciting a targeted fluorescent probe, and the first rotational drum drives the excitation filters. The plural heating chambers are adapted for accommodating PCR tubes having samples and the targeted fluorescent probes. The detection module includes plural different types of emission filters, a second rotational drum and at least one photo-detector, wherein each of the emission filters passes light at a particular band width, the second rotational drum drives the emission filters, and the photo-detector receives fluorescent signals and converts the fluorescent signals to electrical signals. The transmission module includes an actuator connecting with the first and the second rotational drums to drive rotations of the first and the second rotational drum simultaneously for switching and synchronizing the excitation filters and the emission filters to match specific wavelengths of the targeted fluorescent probes.

公开(公告)号：US09945776B2

公开(公告)日：2018-04-17

申请号：US15315604

申请日：2015-09-14

Applicant: CHINA COMMUNICATION TECHNOLOGY CO.,LTD. ,  SHENZHEN VICTOOTH TERAHERTZ TECHNOLOGY CO.,LTD.

Inventor： Guangsheng Wu ,  Yandong Zhang ,  Qing Ding

IPC: G01N21/3581 ,  B07C1/00

CPC classification number: G01N21/3581 ,  B07C1/00 ,  B07C2201/006 ,  G01B9/02 ,  G01N2201/0633 ,  G01N2201/068 ,  G01N2201/12

Abstract: The present invention discloses a mail detection device and method. The device comprises a broad-band terahertz generator, a collimator, a beam splitter, a fixed reflector, a movable reflector, a wave buncher, a matrix detector, an acquisition card and an information processing module; wherein the information processing module is used for generating a terahertz image of a mail to be detected according to the electric signals sent by the acquisition card when the movable reflector is motionless; and when finding suspicious articles according to the terahertz image of a mail to be detected, the information processing module controls the movable reflector to move, and generates spectral information of the suspicious articles according to an electric signal sequence sent by the acquisition card during the movement of the movable reflector.