公开(公告)号：US10830697B2

公开(公告)日：2020-11-10

申请号：US16037841

申请日：2018-07-17

Applicant: Block Engineering, LLC

Inventor： Petros Kotidis ,  Erik Deutsch ,  Ninghui Zhu ,  Dan Cavicchio

IPC: G01N21/39 ,  B82Y20/00 ,  G01N21/35 ,  H01S5/00 ,  H01S5/14 ,  H01S5/34 ,  G01J3/433 ,  G01J3/10 ,  G01J3/45 ,  G02B21/06 ,  H01S5/40 ,  G01J3/26 ,  G01N21/27 ,  G02B21/00 ,  G01N21/17 ,  G01N21/3504 ,  G01N21/3563 ,  G01N21/3577

Abstract: A spectroscopy system comprising at least two laser modules, each of the laser modules including a laser cavity, a quantum cascade gain chip for amplifying light within the laser cavity, and a tuning element for controlling a wavelength of light generated by the modules. Combining optics are used to combine the light generated by the at least two laser modules into a single beam and a sample detector detects the single beam returning from a sample.

公开(公告)号：US10823616B2

公开(公告)日：2020-11-03

申请号：US16290219

申请日：2019-03-01

Applicant: The Boeing Company

Inventor： Robert A. Smith ,  David K. Mefford

IPC: G01J3/433 ,  G01N33/53 ,  G01N21/39

Abstract: A dual sensor, includes: one or more analyte detectors, each having an analyte-specific binding site for interacting with a specific analyte; an optical source generating a first frequency comb spectrum directed to an environment to be scanned, the first frequency comb spectrum having multiple optical frequencies at a first frequency range; an optical spectrum analyzer analyzing an optical spectrum resulting from interaction of the first frequency comb spectrum with the environment; and a controller that is configured, where an analyte detector indicates presence of a specific analyte, to adjust the first frequency comb spectrum to increase sensitivity for detecting the specific analyte.

公开(公告)号：US10801950B2

公开(公告)日：2020-10-13

申请号：US15751095

申请日：2016-08-29

Applicant: Apple Inc.

Inventor： Miikka M. Kangas ,  Mark Alan Arbore ,  David I. Simon ,  Michael J. Bishop ,  James W. Hillendahl ,  Robert Chen

IPC: G01N21/27 ,  G01N21/35 ,  G01N21/47 ,  G01J3/32 ,  G01J3/36 ,  G01J3/433 ,  G01J3/447 ,  G01J3/02 ,  G01J3/42 ,  G01N21/49 ,  G01N21/21

Abstract: This relates to systems and methods for measuring a concentration and type of substance in a sample at a sampling interface. The systems can include a light source, optics, one or more modulators, a reference, a detector, and a controller. The systems and methods disclosed can be capable of accounting for drift originating from the light source, one or more optics, and the detector by sharing one or more components between different measurement light paths. Additionally, the systems can be capable of differentiating between different types of drift and eliminating erroneous measurements due to stray light with the placement of one or more modulators between the light source and the sample or reference. Furthermore, the systems can be capable of detecting the substance along various locations and depths within the sample by mapping a detector pixel and a microoptics to the location and depth in the sample.

公开(公告)号：US10746655B2

公开(公告)日：2020-08-18

申请号：US15832690

申请日：2017-12-05

Applicant: SpectraSensors, Inc.

Inventor： Xiang Liu ,  Alfred Feitisch ,  Xin Zhou

IPC: G01J3/433 ,  G01J3/02 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/39 ,  G01N21/03 ,  G01N21/27 ,  G01N21/05

Abstract: Detector data representative of an intensity of light that impinges on a detector after being emitted from a light source and passing through a gas over a path length can be analyzed using a first analysis method to obtain a first calculation of an analyte concentration in the volume of gas and a second analysis method to obtain a second calculation of the analyte concentration. The second calculation can be promoted as the analyte concentration upon determining that the analyte concentration is out of a first target range for the first analysis method.

公开(公告)号：US20200240910A1

公开(公告)日：2020-07-30

申请号：US16656045

申请日：2019-10-17

Applicant: Shimadzu Corporation

Inventor： Kazune Mano

IPC: G01N21/39 ,  G01N21/3504 ,  G01J3/433

Abstract: A gas absorption spectrometer is provided that is capable of measuring a gas concentration and the like with high accuracy even when a measurement target gas is mixed with a gas other than the measurement target gas. A gas absorption spectrometer includes: a wavelength tunable light source; a light source control unit to change a wavelength of the light source; a gas cell to have a measurement object gas introduced thereto, the measurement object gas containing a measurement target gas and a mixed gas other than the measurement target gas; a photodetector to detect intensity of light having passed through the gas cell; a spectrum preparation unit to prepare an absorption spectrum of the measurement object gas from a change in the light intensity relative to the change in the wavelength; a physical quantity measurement unit to measure at least one of a temperature and a concentration of the measurement target gas based on an absorption spectrum of the measurement target gas; a gas concentration measurement unit to measure a concentration of the mixed gas; and a physical quantity correction unit to correct at least one of the temperature and the concentration of the measurement target gas measured by the physical quantity measurement unit based on the concentration of the mixed gas.

公开(公告)号：US10718664B2

公开(公告)日：2020-07-21

申请号：US14508986

申请日：2014-10-07

Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS

Inventor： Kishan Dholakia ,  Phillip Ronald Thomas Jess ,  Michael Mazilu

IPC: G01J3/28 ,  G01J3/44 ,  G01N21/65 ,  G01J3/02 ,  G01J3/433 ,  B01L3/00

Abstract: A micro-fluidic system comprising means for optically trapping a particle and a Raman excitation source for causing Raman scatter from the particle whilst it is in the optical trap.

公开(公告)号：US10677727B2

公开(公告)日：2020-06-09

申请号：US16057594

申请日：2018-08-07

Applicant: University Court of the University of St Andrews

Inventor： Robert J H Hammond ,  Mario E. Giardini ,  Stephen H. Gillespie

IPC: G01N21/51 ,  G01N21/47 ,  C12Q1/18 ,  C12Q1/02 ,  G01N21/17 ,  G01J3/433 ,  G01N15/06 ,  G01J3/02 ,  C12Q1/00 ,  G01N21/03 ,  G01N21/53 ,  G01N15/02 ,  C12Q1/06 ,  G01N15/00 ,  G01N21/11 ,  G01N21/64

Abstract: A system for measuring a liquid sample comprising biological material, the system comprising an integrating light collector for collecting light and for at least partially containing the sample; a light source for introducing light in the integrating light collector; a signal generator or modulator configured to cause a known modulation of the light output by the light source; a phase-sensitive detector for detecting scattered light in the integrating light collector; at least one of an exit port to allow un-scattered light to exit the integrating light collector, a beam dump, or a baffle arranged to absorb unscattered light; and a processor configured to analyse the detected modulated light to determine changes in the detected modulated light as a function of time thereby to determine at least one of: drug susceptibility of the biological material; a change in a number of cells in the sample; a change in cell state; a change in the biological material.

公开(公告)号：US10656083B2

公开(公告)日：2020-05-19

申请号：US16307253

申请日：2017-06-06

Applicant: The Trustees of Princeton University

Inventor： Genevieve Plant ,  Yifeng Chen ,  Gerard Wysocki

IPC: G01N21/45 ,  G01N21/59 ,  G01J3/433 ,  G02F1/35 ,  G01B9/02 ,  G01J3/45

Abstract: A sensitivity boosted laser dispersion spectroscopy system for sensing a sample in a sample cell or in an open path crossing the sample. The system includes a local oscillator arm and a sample arm containing the sample cell or the open path crossing the sample. A laser source is configured to generate a first light beam directed along the sample arm and a second light beam, the second light beam being frequency shifted and directed along the local oscillator arm. An intensity modulator/phase modulator/frequency shifter is disposed in the sample arm configured to generate a multi-frequency beam having known frequency spacing which is then passed through the sample cell to generate a sample arm output. A beam combiner is configured to combine the sample arm output and the second light beam from the local oscillator arm and generate a combined beam. A photodetector is configured to detect the combined beam for sensing the sample in the sample cell.

公开(公告)号：US10656012B2

公开(公告)日：2020-05-19

申请号：US16229355

申请日：2018-12-21

Applicant: Amir H. Atabaki ,  Rajeev J. Ram ,  William F. Herrington

Inventor： Amir H. Atabaki ,  Rajeev J. Ram ,  William F. Herrington

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/10 ,  G01J3/28 ,  G01J3/18 ,  G01N21/65 ,  G01J1/42 ,  G01J3/433 ,  G02B6/293

Abstract: In swept source Raman (SSR) spectroscopy, a swept laser beam illuminates a sample, which inelastically scatters some of the incident light. This inelastically scattered light is shifted in wavelength by an amount called the Raman shift. The Raman-shifted light can be measured with a fixed spectrally selective filter and a detector. The Raman spectrum can be obtained by sweeping the wavelength of the excitation source and, therefore, the Raman shift. The resolution of the Raman spectrum is determined by the filter bandwidth and the frequency resolution of the swept source. An SSR spectrometer can be smaller, more sensitive, and less expensive than a conventional Raman spectrometer because it uses a tunable laser and a fixed filter instead of free-space propagation for spectral separation. Its sensitivity depends on the size of the collection optics. And it can use a nonlinearly swept laser beam thanks to a wavemeter that measures the beam's absolute wavelength during Raman spectrum acquisition.

公开(公告)号：US10591417B2

公开(公告)日：2020-03-17

申请号：US16448670

申请日：2019-06-21

Applicant: Verily Life Sciences LLC

Inventor： Charles Santori ,  Supriyo Sinha ,  Cheng-Hsun Wu ,  James Higbie ,  Seung Ah Lee

IPC: G01J3/18 ,  G01N21/64 ,  G01J3/44 ,  G02B21/00 ,  G02B21/16 ,  G01J3/10 ,  G01J3/28 ,  G01J3/433 ,  G01J3/02 ,  A61B5/00 ,  G01J3/32 ,  G01J3/12

Abstract: Systems and methods for hyperspectral imaging are described. In one implementation, a hyperspectral imaging system includes a sample holder configured to hold a sample, an illumination system, and a detection system. The illumination system includes a light source configured to emit excitation light having one or more wavelengths and a diffractive element. The illumination system is configured to structure the excitation light into a predetermined two-dimensional pattern at a conjugate plane of a focal plane in the sample, spectrally disperse the structured excitation light in a first lateral direction, and illuminate the sample in an excitation pattern with the one or more wavelengths dispersed in the first lateral direction.