公开(公告)号：US3790554A

公开(公告)日：1974-02-05

申请号：US3790554D

申请日：1971-09-24

Applicant: ABBOTT LAB

Inventor： FLOURET G

IPC: C07K7/23 ,  C07C103/52 ,  C07G7/00 ,  C08H1/00

CPC classification number: C07K7/23 ,  Y10S930/13

Abstract: THE SYNTHESIS OF THE HEPTAPEPTIDE SER-TYR-CLY-LEUARG-PRO-GLY-AMIDE CARRYING EASILY REMOVABLE PROTECTIVE GROUPS ON THE SER, TYR AND ARG MOIETIES IS DESCRIBED; THE CORRESPONDINGLY PROTECTED HEXAPEPTIDE IS USED AS THE STATING MATERIAL. THE HEPTAPEPTIDE, UPON REMOVAL OF ANY PROTECTIVE GROUP ON THE AMINO-N OF THE SERINE MOIETY, IS AN IMPORTANT INTERMEDIATE FOR THE PEPARATION OF THE GONADOTROPIN-RELEASING HORMONE.

公开(公告)号：US3784702A

公开(公告)日：1974-01-08

申请号：US3784702D

申请日：1972-01-14

Applicant: ABBOTT LAB

Inventor： KIMURA E ,  ANDERSON D

IPC: A61K31/13 ,  A61K31/14 ,  A61K31/19 ,  A61K27/00

CPC classification number: A61K31/19 ,  A61K31/13 ,  A61K31/14 ,  Y10S514/85 ,  A61K2300/00

Abstract: COVERS A METHOD OF TREATING PATIENTS REQUIRING ANTITUSSIVE THERAPY BY ADMINISTERING TO SAID PATIENT AN EFFECTIVE DOSE OF A COMPOSITION SELECTED FROM THE GROUP CONSISTING OF 2-PHENYLBUTYRIC ACID, DIETHYLAMINOETHOXYETHANOL, MIXTURES OF 2-PHENYLBUTYRIC ACID, AND DIETHYLAMINOETHOXY-ETHANOL, AND MEDICINALLY ACCEPTABLE ACID OR BASE ADDITION SALTS OF THE FOREGOING, AND A PHARMACEUTICAL CARRIER.

公开(公告)号：US3780737A

公开(公告)日：1973-12-25

申请号：US3780737D

申请日：1971-03-09

Applicant: ABBOTT LAB

Inventor： BANFORD J

IPC: A61D7/00 ,  A61M31/00

CPC classification number: A61D7/00

Abstract: A method of treating bovine mastitis by injecting through the teat orifice of an infected quarter a solution of erythromycin in a fatty acid triglyceride having an iodine value of less than 42. This method, by virtue of the unique solution offers not only effective mastitis control, but also the distinct advantage of a shorter period of detactable drug residue in the milk than heretofore obtainable. Milk taken after the third milking following the last treatment is free from detectable erythromycin residue.

Abstract translation: 通过感染季度的乳头孔注射红霉素在碘值小于42的脂肪酸甘油三酸酯中的方法来治疗牛乳腺炎的方法。该方法凭借独特的解决方案不仅提供有效的乳腺炎控制， 而且还具有比以前可获得的更短的可消除药物残留时间的明显优点。 在最后一次治疗后第三次挤奶后摄取的牛奶不含可检测的红霉素残留物。

公开(公告)号：US3778427A

公开(公告)日：1973-12-11

申请号：US3778427D

申请日：1971-11-02

Applicant: ABBOTT LAB

Inventor： FLOURET G

IPC: C07K7/23 ,  C07C103/52

CPC classification number: C07K7/23 ,  Y10S930/13

Abstract: THE SYNTHESIS OF THE HEXAPEPTIDE TYR-GLY-LEU-ARG-PROGLY-AMIDE CARRYING EASILY REMOVABLE PROTECTIVE GROUPS ON THE TYR AND ARG MOIETIES IS DESCIRBED; THE CORRESPONDINGLY PROTECTED PENTAPEPTIDE IS USED AS THE STARTING MATERIAL. THE HEXAPEPTIDE, UPON REMOVAL OF ANY PROTECITVE GROUP ON THE NITROGEN OF THE TYROSINE MOEITY, IS AN IMPORTANT INTERMEDIATE FOR THE PREPARATION OF THE GONADOTROPIN-RELEASING HORMONE.

公开(公告)号：US3767850A

公开(公告)日：1973-10-23

申请号：US3767850D

申请日：1972-02-22

Applicant: ABBOTT LAB

Inventor： MC MILLIAN L ,  HUTCHISON A ,  GARD L

IPC: G01T1/166 ,  G01T1/20 ,  H04N5/84

CPC classification number: G01T1/166 ,  G01T1/1663

Abstract: The disclosure describes apparatus for preventing scalloping the photographic film image produced by a scintillation scanner. The described scanner comprises a detector which can be scanned along parallel paths over an area of interest in a patient. The detector is directly coupled to a light-emitting tube that simultaneously is scanned in a similar manner over a photographic film. Gamma rays emitted by the patient are received by the detector and are converted into corresponding electrical event pulses and bits of event information which are sequentially shifted through shift registers in response to periodic clock pulses. A stepping motor moves the detector and light-producing tube a predetermined distance in response to the receipt of each clock pulse so that the concentration of gamma ray events occuring along any particular segment of the detector scan path can be precisely determined. An individual event pulse is transmitted to the light-producing tube after is has been shifted halfway through the shift register, so that the information stored in the shift register represents gamma ray events occurring before and after the gamma ray event resulting in the event pulse. A counter continuously analyzes the information flowing into and out of the shift register so that an accurate count of the information bits stored in the shift register is continuously available. Additional means are provided for controlling the intensity of the light produced by the tube in response to the value of the information stored in the shift register. As a result, the light intensity produced in response to any single gamma ray event depends on the concentration of gamma ray events occurring on either side of the single event along the detector scan path.

Abstract translation: 本公开描述了用于防止扇形闪烁扫描仪产生的摄影胶片图像的装置。 所描述的扫描器包括可以沿着平行路径扫描患者感兴趣区域的检测器。 检测器直接耦合到发光管，同时在照相胶片上以类似的方式扫描。 由患者发射的γ射线由检测器接收，并被转换成对应的电事件脉冲和事件信息的位，响应于周期性时钟脉冲而顺序地移位移位寄存器。 响应于每个时钟脉冲的接收，步进电机将检测器和发光管移动预定距离，使得可以精确地确定沿检测器扫描路径的任何特定段发生的伽马射线事件的浓度。 在通过移位寄存器移动中途之后，单个事件脉冲被传送到发光管，使得存储在移位寄存器中的信息表示在导致事件脉冲的伽马射线事件之前和之后发生的伽马射线事件。 计数器连续分析流入和移出移位寄存器的信息，从而可以连续地获得存储在移位寄存器中的信息位的精确计数。 提供附加装置，用于响应于存储在移位寄存器中的信息的值来控制由管产生的光的强度。 结果，响应于任何单个伽马射线事件产生的光强度取决于沿着检测器扫描路径的单个事件的任一侧上发生的伽马射线事件的浓度。

公开(公告)号：US3755584A

公开(公告)日：1973-08-28

申请号：US3755584D

申请日：1972-04-03

Applicant: ABBOTT LAB

Inventor： PLOTNIKOO N

IPC: C07D471/04 ,  A61K27/00

CPC classification number: C07D471/04

Abstract: Y-CARBOLINES CARRYING FLUORINE IN THE 6-OR 8-POSITION AND A SPECIFIC P-SUBSTITUTED PHENYLALKYL MOIETY AT THE 2POSITION WERE FOUND TO BE MAJOR TRANQUILIZERS AT LOW DOSES IN WARM-BLOODED ANIMALS.

公开(公告)号：US3748044A

公开(公告)日：1973-07-24

申请号：US3748044D

申请日：1971-04-12

Applicant: ABBOTT LAB

Inventor： LISTON M

IPC: G01J1/16 ,  G01N1/00 ,  G01N21/27 ,  G01N33/483 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01J3/46 ,  G01N1/10 ,  G01N33/16

CPC classification number: G01N35/025 ,  G01J1/16 ,  G01N21/27 ,  G01N21/272 ,  G01N2035/00396 ,  G01N2035/0448

Abstract: The disclosure describes an improved system for evaluating rates of reactions and end point determinations that take place within a plurality of individaul secimens. The system includes a cuvette for holding each of the specimens in an individual compartment. Analyzing apparatus is used to generate and sequentially transmit a beam of radiant energy through each of the specimens. The analysis apparatus also produces an analysis signal having a value proportional to a property of a particular specimen each time the beam passes through that specimen. Cycling apparatus causes the beam to sequentially and separately pass through each of the specimens during multiple cycles of operation. During the first cycle of operation, a first set of analysis signals having a first set of values corresponding to the specimens is created. Likewise, during a second cycle of operation, a second set of analysis signals having a second set of values corresponding to the specimens is created. In order to determine the rate at which the reactions take place within each of the specimens, a memory is used to store at least the first set of values. Then, during the second cycle of operation, a processing circuit compares the values of the first and second sets of values which correspond to the same specimen. In this way, the rate of reaction of each specimen is automatically determined. By a similar technique, values can be created and compared in seconds in order to determine rates of reactions that proceed rapidly. In order to analyze end joint determinations, one of the specimens comprises a known concentration of a substance, and other specimens contain unknown concentrations of the substance. The value corresponding to the known concentration is stored in the memory, and other values correspndingly to the unknown concentration are compared with the value stored in the memory. Improved components of the system such as a cuvette, a specimen dispenser, and an analyzing apparatus are also disclosed in the specification. The analyzing apparatus preferably comprises apparatus for instantaneously determining the concentration of a predetermined substance that absorbs radiant energy within a predetermined band of wavelengths in the presence of other interfering substances that also absorb radiant energy in the region of the predetermined band. The determination is made by generating multiple wavelengths of radiant energy. The radiant energy is then sequentially transmitted in a single path through the substances, and the transmission is periodically interrupted by means which prevent the transmission of any radiation. The intensities of the radiant energy transmitted through the substances at the various wavelengths are then compared by electronic apparatus.

Abstract translation: 本公开描述了一种改进的系统，用于评估在多个个体中发生的反应速率和终点测定。 该系统包括用于将每个样本保持在单独隔室中的比色皿。 分析装置用于通过每个样本产生并依次传送辐射能束。 分析装置还产生一个分析信号，该分析信号在每次束通过该样本时具有与特定样品的性质成比例的值。 循环装置在多个操作周期期间使光束顺序并分别通过每个样本。 在第一操作周期期间，产生具有与样本对应的第一组值的第一组分析信号。 类似地，在第二操作周期期间，产生具有对应于样本的第二组值的第二组分析信号。

公开(公告)号：US3737549A

公开(公告)日：1973-06-05

申请号：US3737549D

申请日：1972-03-20

Applicant: ABBOTT LAB

Inventor： PLOTNIKOFF N

IPC: A61K31/00 ,  A61K27/00

CPC classification number: A61K31/00

Abstract: AN IMPROVED METHOD OF TREATING DEPRESSION USING THYROTROPIN RELEASING AGENT OR L-PYROGLUTAMYL-L-HISTIDYLL-PROLINAMIDE AS THE ANTI-DEPRESSANT AGENG.

公开(公告)号：US3736313A

公开(公告)日：1973-05-29

申请号：US3736313D

申请日：1971-02-26

Applicant: ABBOTT LAB

Inventor： JONES P ,  PERUN T

IPC: C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: THE 2'',4"-DI-O-ALKANOYL AND THE 2'',4",11-TRI-O-ALKANOYL DERIVATIVES OR ERYTHROMYCIN ARE PREPARED BY ESTERFICATION OF ERYTHROMYCIN WITH AN APPROPRIATE ACID ANHYDRIDE. THESE RESULTING ESTER DERIVATIVES ARE INITIALLY DE-ESTERFIED IN THE 2''-POSITION TO PROPARE THE 4"-O-ALKANOYL OR THE 4",11-DI-O-ALKANOYL ERYTHORMYCIN, AND THEN, IF DESIRED, THESE DE-ESTERFICATION PRODUCTS ARE REACTED WITH ANOTHER ACID ANHYDRIDE TO PREPARE A DISSIMILARLY DI-SUBSTITUTED OR TRI-SUBSTITUTED ESTER. THROUGH REPETITIVE ESTERFICATION AND DE-ESTERFICATION, COMBINATIONS OF THE MONO SUBSTITUTED AND THE SIMILARLY OR DISSIMILARLY MULTIPLE SUBSTITUTED ERYTHROMYCIN ESTERS ARE PREPARED. THESE COMPOUNDS HAVE ANTIBIOTIC ACTIVITY.

公开(公告)号：US3728343A

公开(公告)日：1973-04-17

申请号：US3728343D

申请日：1971-10-04

Applicant: ABBOTT LAB

Inventor： HWANG K ,  RATAJCZYK J

IPC: C07D513/04 ,  C07D99/10

CPC classification number: C07D513/04 ,  Y10S514/927

Abstract: NOVEL SUBSTITUTED 1H - PYRIDO(2,3-B)(1,4)THIAZINES-2 (3H)-THIONES REPRESENTED BY THE FORMULA

2-(S=),3-R,X-2,3-DIHYDRO-1H-PYRIDO(2,3-B)(1,4)THIAZINE

WHEREIN X IS HYDROGEN, HYDROXY, MERCAPTO, LOWER ALKYL, LOWER ALKOXY OR HALO AND R IS HYDROGEN, HYDROXY, LOWER ALKYL, LOWER ALKOXY ORHALO. THE COMPOUNDS EXHIBIT ANTIINFLAMMATORY AND ANTI-SECRETORY ACTIVITY.