公开(公告)号：US3764679A

公开(公告)日：1973-10-09

申请号：US3764679D

申请日：1972-03-20

Applicant: ABBOTT LAB

Inventor： JONES P ,  SOMANI P

IPC: A61K31/495 ,  A61K27/00

CPC classification number: A61K31/495

Abstract: A method of reducing blood pressure in hypertensive patients by administering a therapeutically effective amount of iodinin to said patients.

Abstract translation: 一种通过向所述患者施用治疗有效量的碘汀来降低高血压患者血压的方法。

公开(公告)号：US3842069A

公开(公告)日：1974-10-15

申请号：US37238773

申请日：1973-06-21

Applicant: ABBOTT LAB

Inventor： JONES P ,  MARTIN J ,  TADANIER J ,  MCALPINE J ,  PAUVLIK J

IPC: C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: 1. A 4"-DEOXY-4"-OXOERYTHROMYCIN COMPOUND SELECTED FROM THE GROUP CONSISTING OF

2,10-DI(O=),4,5,7,9,11,13,-HEXA(H3C-),4-((4,6-DI(H3C-),

4-(H3C-O-),5-(O=),6-(H3C-)-TETRAHYDROPYR-2-YL)-O-),6-

((3-(R1-O-),4-((H3C)2-N-),6-(H3C-)-TETRAHYDROPYR-2-YL)-

O-),7-(HO-),12-(R-O-),14-(H5C2-)-OXACYCLOTETRADECANE

WHERE R IS -CHR2SR3 WHERE R'' IS HYDROGEN OR LOWERALKYL, R3 IS LOWERALKYL AND R1 IS HYDROGEN OR LOWERALKANOYL AND;

2-(O=),3,5,7,9,11,13-HEXA(H3C-),4-((4,6-DI(H3C-),

4-(H3C-O-),5-(O=),6-(H3C-)-TETRAHYDROPYR-2-YL)-O-),6-

((3-(R1-O-),4-((H3C)2-N-),6-(H3C-)-TETRAHYDROPYR-2-YL)-

O-),7,10-(-O-),10,12-(-O-CH(-R2)-O-),12-(H5C2-)-

OXACYCLOTETRADECANE

WHERE R1 AND R2 ARE AS BEFORE DEFINED.

公开(公告)号：US3840663A

公开(公告)日：1974-10-08

申请号：US23752772

申请日：1972-03-23

Applicant: ABBOTT LAB

Inventor： JONES P ,  SOMANI P

IPC: A61K31/445 ,  A61K27/00

CPC classification number: A61K31/445

Abstract: WHEREIN R IS C1-C8 ALKYL OR A SALT THEREOF TO SAID PATIENT.

2-(HOOC-),5-R1-PIPERIDINE

1. A METHOD OF LOWERING BLOOD PRESSURE IN HYPERTENSIVE PATIENT COMPRISING ADMINISTERING A THERAPEUTICALLY EFFECTIVE AMOUNT OF A COMPOUND SELECTED FROM THE GROUP CONSISTING OF THE TRANS ISOMER AND A MIXTURE OF THE TRANS AND CIS ISOMERS REPRESENTED BY THE FORMULA

公开(公告)号：US3736313A

公开(公告)日：1973-05-29

申请号：US3736313D

申请日：1971-02-26

Applicant: ABBOTT LAB

Inventor： JONES P ,  PERUN T

IPC: C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: THE 2'',4"-DI-O-ALKANOYL AND THE 2'',4",11-TRI-O-ALKANOYL DERIVATIVES OR ERYTHROMYCIN ARE PREPARED BY ESTERFICATION OF ERYTHROMYCIN WITH AN APPROPRIATE ACID ANHYDRIDE. THESE RESULTING ESTER DERIVATIVES ARE INITIALLY DE-ESTERFIED IN THE 2''-POSITION TO PROPARE THE 4"-O-ALKANOYL OR THE 4",11-DI-O-ALKANOYL ERYTHORMYCIN, AND THEN, IF DESIRED, THESE DE-ESTERFICATION PRODUCTS ARE REACTED WITH ANOTHER ACID ANHYDRIDE TO PREPARE A DISSIMILARLY DI-SUBSTITUTED OR TRI-SUBSTITUTED ESTER. THROUGH REPETITIVE ESTERFICATION AND DE-ESTERFICATION, COMBINATIONS OF THE MONO SUBSTITUTED AND THE SIMILARLY OR DISSIMILARLY MULTIPLE SUBSTITUTED ERYTHROMYCIN ESTERS ARE PREPARED. THESE COMPOUNDS HAVE ANTIBIOTIC ACTIVITY.

公开(公告)号：US3720768A

公开(公告)日：1973-03-13

申请号：US3720768D

申请日：1971-11-22

Applicant: ABBOTT LAB

Inventor： JONES P ,  MARTIN Y

IPC: A61K31/445 ,  C07D213/89 ,  C07D241/18 ,  A61K27/00

CPC classification number: C07D213/89 ,  A61K31/445 ,  C07D241/18

Abstract: METHOD OF TREATING HYPERTENSION BY ADMINISTERING TO A HYPERTENSIVE PATIENT A THERAPWUTICALLY EFFECTIVE AMOUNT OF A COMPOUND OF THE FORMULA

O=N
HO-N
WHEREIN X IIS C OR N; AND R1, R2, R3 AND R4 EACH ARE HYDROGEN, ALKYL, CYCLOALKYL OR ARYL, WITH THE LIMITATION THAT R4 IS PRESENT ONLY WHEN X IS C.