公开(公告)号：US07737145B2

公开(公告)日：2010-06-15

申请号：US11644244

申请日：2006-12-22

Applicant: Damian Arnaiz ,  Greg Brown ,  Emmanuel Claret ,  Arwed Cleve ,  David Davey ,  William Guilford ,  Seock-Kyu Khim ,  Thomas Kirkland ,  Monica J. Kochanny ,  Amy Liang ,  David Light ,  John Parkinson ,  David Vogel ,  Guo Ping Wei ,  Bin Ye

Inventor： Damian Arnaiz ,  Greg Brown ,  Emmanuel Claret ,  Arwed Cleve ,  David Davey ,  William Guilford ,  Seock-Kyu Khim ,  Thomas Kirkland ,  Monica J. Kochanny ,  Amy Liang ,  David Light ,  John Parkinson ,  David Vogel ,  Guo Ping Wei ,  Bin Ye

IPC: A01N43/60 ,  A61K31/495 ,  C07D241/36 ,  C07D271/00 ,  C07D487/00 ,  C07D491/00 ,  C07D495/00 ,  C07D497/00 ,  C07D498/00 ,  C07D513/00

CPC classification number: C07D487/08 ,  C07B2200/07 ,  C07C217/58 ,  C07C229/08 ,  C07C229/38 ,  C07C233/78 ,  C07C255/57 ,  C07C271/20 ,  C07C2601/14 ,  C07D207/04 ,  C07D207/09 ,  C07D207/16 ,  C07D211/26 ,  C07D211/34 ,  C07D211/58 ,  C07D243/08 ,  C07D263/14 ,  C07D263/32 ,  C07D277/22 ,  C07D277/68 ,  C07D295/04 ,  C07D295/096 ,  C07D295/16 ,  C07D401/10 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D451/02 ,  C07D451/04

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract translation: 本发明涉及式（I）化合物：其中r，q，R，R2，R3，R4，R5a，R5b，R5c，R6a，R6b，R6c，R7，R8和R9在本文中描述为单立体异构体 或作为立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药的混合物; 其是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。

公开(公告)号：US20080176833A1

公开(公告)日：2008-07-24

申请号：US11955777

申请日：2007-12-13

Applicant: Marc Adler ,  Stefan Baeurle ,  Judi Bryant ,  Ming Chen ,  Yuo-Ling Chou ,  Paul Hrvatin ,  Seock-Kyu Khim ,  Monica Kochanny ,  Wheeseong Lee ,  Michael Mamounas ,  Janet Meurer Ogden ,  Gary Bruce Phillips ,  Victor Selchau ,  Christopher West ,  Bin Ye ,  Shendong Yuan ,  Martin Krueger

Inventor： Marc Adler ,  Stefan Baeurle ,  Judi Bryant ,  Ming Chen ,  Yuo-Ling Chou ,  Paul Hrvatin ,  Seock-Kyu Khim ,  Monica Kochanny ,  Wheeseong Lee ,  Michael Mamounas ,  Janet Meurer Ogden ,  Gary Bruce Phillips ,  Victor Selchau ,  Christopher West ,  Bin Ye ,  Shendong Yuan ,  Martin Krueger

IPC: A61K31/55 ,  C07D213/02 ,  A61K31/4427 ,  C07D455/02 ,  A61K31/4375 ,  C07D295/00 ,  A61K31/5377 ,  A61P35/00 ,  C07D239/24 ,  A61K31/506 ,  C07D221/00 ,  A61K31/496 ,  C07D223/02

CPC classification number: C07D401/04 ,  C07D211/90 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04

Abstract: This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.

Abstract translation: 本发明提供具有蛋白酪氨酸激酶抑制活性的新颖的具有蛋白酪氨酸激酶抑制活性的二氢吡啶衍生物，其制备方法及其用于治疗c-Met介导的疾病或c-Met介导的病症的用途。

公开(公告)号：US20070155727A1

公开(公告)日：2007-07-05

申请号：US11644822

申请日：2006-12-22

Applicant: Ming Chen ,  Emmanuel Claret ,  Arwed Cleve ,  David Davey ,  William Guilford ,  Seock-Kyu Khim ,  Thomas Kirkland ,  Monica Kochanny ,  Amy Liang ,  David Light ,  John Parkinson ,  David Vogel ,  Guo Wei ,  Bin Ye ,  Hong Ye

Inventor： Ming Chen ,  Emmanuel Claret ,  Arwed Cleve ,  David Davey ,  William Guilford ,  Seock-Kyu Khim ,  Thomas Kirkland ,  Monica Kochanny ,  Amy Liang ,  David Light ,  John Parkinson ,  David Vogel ,  Guo Wei ,  Bin Ye ,  Hong Ye

IPC: A61K31/551 ,  A61K31/407 ,  C07D487/02 ,  C07D243/08

CPC classification number: C07D207/04 ,  C07C237/04 ,  C07C237/06 ,  C07C237/30 ,  C07C255/58 ,  C07C275/40 ,  C07C275/42 ,  C07C275/62 ,  C07C311/05 ,  C07C311/08 ,  C07C311/09 ,  C07C311/37 ,  C07C2601/08 ,  C07C2601/14 ,  C07D211/06 ,  C07D243/08 ,  C07D295/04 ,  C07D295/16 ,  C07D487/02 ,  C07D487/08

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4a, R4b, R4c, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, R9 and R10 are described herein, or pharmaceutically acceptable salts, solvates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and which are therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of using and preparing the compounds of the invention are also disclosed.

Abstract translation: 本发明涉及式（I）化合物：其中r，q，R，R 2，R 3，R 4a，R 4， R 4b，R 4c，R 5a，R 5b，R 5c，R 5，R 5， R 6b，R 6b，R 6，R 7，R 8，R 8，R 8， 本文描述了本发明的其它药学上可接受的盐，溶剂合物，多晶型物，铵离子，N-氧化物或前体药物; 其是白三烯A 4水解酶抑制剂，因此其可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和使用和制备本发明化合物的方法。

公开(公告)号：US20070032438A1

公开(公告)日：2007-02-08

申请号：US11194676

申请日：2005-08-02

Applicant: Yu-Fang Hu ,  Yao-Kun Huang ,  Shian-Bin Ye

Inventor： Yu-Fang Hu ,  Yao-Kun Huang ,  Shian-Bin Ye

IPC: A61K31/70 ,  A61K31/337 ,  A61K47/00

CPC classification number: A61K9/08 ,  A61K31/337 ,  A61K31/70 ,  A61K47/10 ,  A61K47/24

Abstract: Pharmaceutical compositions containing taxanes having about 5 to about 75% phospholipid, about 0.01 to about 50% of a surfactant of an HLB value greater than 10, about 0.01 to about 50% alcohol and about 0.01 to about 40% taxane(s) or a derivative thereof.

Abstract translation: 含有紫杉烷的药物组合物，其具有约5至约75％的磷脂，约0.01至约50％的HLB值大于10的表面活性剂，约0.01至约50％的醇和约0.01至约40％的紫杉烷或一种或多种 其衍生物。

公开(公告)号：US06864368B2

公开(公告)日：2005-03-08

申请号：US10122006

申请日：2002-04-12

Applicant: Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

Inventor： Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

IPC: C07D403/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/547 ,  A61P1/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/02 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P21/00 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07D213/00 ,  C07D233/00 ,  C07D239/00 ,  C07D241/02 ,  C07D265/00 ,  C07D279/00 ,  C07D317/44 ,  C07D319/00 ,  C07D333/02 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D521/00

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

公开(公告)号：US06864263B2

公开(公告)日：2005-03-08

申请号：US10121659

申请日：2002-04-12

Applicant: Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

Inventor： Damian O. Arnaiz ,  John J. Baldwin ,  David D. Davey ,  James J. Devlin ,  Roland Ellwood Dolle, III ,  Shawn David Erickson ,  Kirk McMillan ,  Michael M. Morrissey ,  Michael H. J. Ohlmeyer ,  Gonghua Pan ,  Vidyadhar Madhav Paradkar ,  John Parkinson ,  Gary B. Phillips ,  Bin Ye ,  Zuchun Zhao

IPC: C07D403/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/547 ,  A61P1/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/02 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P21/00 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07D213/00 ,  C07D233/00 ,  C07D239/00 ,  C07D241/02 ,  C07D265/00 ,  C07D279/00 ,  C07D317/44 ,  C07D319/00 ,  C07D333/02 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D521/00

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

公开(公告)号：US6140351A

公开(公告)日：2000-10-31

申请号：US187459

申请日：1998-11-05

Applicant: Damian O. Arnaiz ,  Yuo-Ling Chou ,  Brian D. Griedel ,  Rushad E. Karanjawala ,  Monica J. Kochanny ,  Wheeseong Lee ,  Amy Mei Liang ,  Michael M. Morrissey ,  Gary B. Phillips ,  Karna Lyn Sacchi ,  Steven T. Sakata ,  Kenneth J. Shaw ,  R. Michael Snider ,  Shung C. Wu ,  Bin Ye ,  Zuchun Zhao

Inventor： Damian O. Arnaiz ,  Yuo-Ling Chou ,  Brian D. Griedel ,  Rushad E. Karanjawala ,  Monica J. Kochanny ,  Wheeseong Lee ,  Amy Mei Liang ,  Michael M. Morrissey ,  Gary B. Phillips ,  Karna Lyn Sacchi ,  Steven T. Sakata ,  Kenneth J. Shaw ,  R. Michael Snider ,  Shung C. Wu ,  Bin Ye ,  Zuchun Zhao

IPC: C07D333/38 ,  C07D333/70 ,  C07D401/04 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D473/06 ,  C07D473/34 ,  A61K31/44 ,  C07D409/00 ,  C07D411/00

CPC classification number: C07D401/04 ,  C07D333/38 ,  C07D333/70 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D473/06 ,  C07D473/34

Abstract: This invention is directed to compounds of formula (III): ##STR1## wherein B, C, D, E, R.sup.1, R.sup.2 and R.sup.3 are disclosed herein. These compounds are disclosed as being useful as anti-coagulants.

Abstract translation: 本发明涉及式（III）化合物：其中B，C，D，E，R 1，R 2和R 3在本文中公开。 这些化合物被公开用作抗凝剂。

公开(公告)号：US09008269B2

公开(公告)日：2015-04-14

申请号：US13598643

申请日：2012-08-30

Applicant: Jian Wang ,  Bin Ye ,  Yannan Huang ,  Yonghui Han

Inventor： Jian Wang ,  Bin Ye ,  Yannan Huang ,  Yonghui Han

IPC: A61B6/08 ,  A61B6/00 ,  A61B6/06

CPC classification number: A61B6/52 ,  A61B6/06 ,  A61B6/08 ,  A61B6/4021 ,  A61B6/469 ,  A61B6/548

Abstract: A method for adjusting a field of view for exposure of an X-ray system is provided. The method comprises: capturing an image of a patient on an examining table of the system by an image sensor, wherein the image sensor is placed at a predetermined position in the system; displaying the captured image on a display for selection of a region of interest or a point of interest by a user on the image; automatically determining a target position of an X-ray source in response to the selection of the region of interest or the point of interest on the image, wherein a desired field of view for exposure covering the region of interest or the point of interest is obtained when the X-ray source is located at the target position; and automatically locating the X-ray source at the target position in response to the determination of the target position.

Abstract translation: 提供了一种用于调整用于X射线系统的曝光的视场的方法。 该方法包括：通过图像传感器在系统的检查表上捕获患者的图像，其中图像传感器被放置在系统中的预定位置; 在显示器上显示所捕获的图像，以便在图像上选择用户感兴趣的区域或兴趣点; 响应于对图像上的感兴趣区域或兴趣点的选择，自动确定X射线源的目标位置，其中获得覆盖感兴趣区域或感兴趣点的曝光的期望视场 当X射线源位于目标位置时; 并且响应于目标位置的确定，将X射线源自动定位在目标位置。

公开(公告)号：US20140242612A1

公开(公告)日：2014-08-28

申请号：US14131853

申请日：2012-07-16

Applicant: Shuqi Wang ,  Utkan Demirci ,  Bin Ye ,  Ragip Akbas

Inventor： Shuqi Wang ,  Utkan Demirci ,  Bin Ye ,  Ragip Akbas

IPC: G01N33/543 ,  G01N33/569 ,  G01N33/574

CPC classification number: G01N33/54386 ,  C12Q1/00 ,  G01N21/253 ,  G01N21/274 ,  G01N21/29 ,  G01N21/6452 ,  G01N21/78 ,  G01N33/53 ,  G01N33/56916 ,  G01N33/56972 ,  G01N33/57449 ,  G01N35/00

Abstract: A system and method for analyzing a biomarker in a biological sample is provided. A biological sample is loaded onto a microchip and an enzyme-linked immunosorbent assay specific to the biomarker is performed on the microchip. A color image of the microchip is generated using a mobile device and a color intensity of a selected portion of the color image is determined. The color intensity is correlated with a biomarker concentration using a baseline curve calculation and the concentration of the biomarker is then reported.

Abstract translation: 提供了用于分析生物样品中生物标志物的系统和方法。 将生物样品加载到微芯片上，并在微芯片上进行对生物标志物特异性的酶联免疫吸附测定。 使用移动设备生成微芯片的彩色图像，并且确定彩色图像的选定部分的颜色强度。 使用基线曲线计算，颜色强度与生物标志物浓度相关，然后报告生物标志物的浓度。

公开(公告)号：US08569303B2

公开(公告)日：2013-10-29

申请号：US12771659

申请日：2010-04-30

Applicant: Damian O Arnaiz ,  Greg Brown ,  Emmanuel Claret ,  Arwed Cleve ,  David Davey ,  William Guilford ,  Seock-Kyu Khim ,  Thomas Kirkland ,  Monica J Kochanny ,  Amy Liang ,  David Light ,  John Parkinson ,  David Vogel ,  Guo Ping Wei ,  Bin Ye

Inventor： Damian O Arnaiz ,  Greg Brown ,  Emmanuel Claret ,  Arwed Cleve ,  David Davey ,  William Guilford ,  Seock-Kyu Khim ,  Thomas Kirkland ,  Monica J Kochanny ,  Amy Liang ,  David Light ,  John Parkinson ,  David Vogel ,  Guo Ping Wei ,  Bin Ye

IPC: A61K31/495 ,  C07D241/36

CPC classification number: C07D487/08 ,  C07B2200/07 ,  C07C217/58 ,  C07C229/08 ,  C07C229/38 ,  C07C233/78 ,  C07C255/57 ,  C07C271/20 ,  C07C2601/14 ,  C07D207/04 ,  C07D207/09 ,  C07D207/16 ,  C07D211/26 ,  C07D211/34 ,  C07D211/58 ,  C07D243/08 ,  C07D263/14 ,  C07D263/32 ,  C07D277/22 ,  C07D277/68 ,  C07D295/04 ,  C07D295/096 ,  C07D295/16 ,  C07D401/10 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D451/02 ,  C07D451/04

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract translation: 本发明涉及式（I）化合物：其中r，q，R，R2，R3，R4，R5a，R5b，R5c，R6a，R6b，R6c，R7，R8和R9在本文中描述为单立体异构体 或作为立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药的混合物; 其是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。 还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。