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公开(公告)号：US20090118805A1
公开(公告)日：2009-05-07
申请号：US12168740
申请日：2008-07-07
Applicant: Robert J. Greenberg , Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Kelly H. McClure , Brian V. Mech , Rongqing Dai , David Daomin Zhou , Gaillard R. Nolan
Inventor： Robert J. Greenberg , Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Kelly H. McClure , Brian V. Mech , Rongqing Dai , David Daomin Zhou , Gaillard R. Nolan
CPC classification number: A61N1/0543 , A61N1/36046 , H05K1/118
Abstract: In a visual prosthesis electrodes stimulate retinal tissue to induce the perception of light to a user implanted with the prosthesis. The prosthesis must have a return, or common, electrode to make a complete circuit with the retinal tissue. To avoid stimulating tissue with the return electrode, it is advantageous if the electrode is large.The invention involver a flexible circuit electrode array comprising a polymer base layer, metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue a polymer top layer deposited on said polymer base layer and said metal traces, and a return electrode separate from said stimulating electrodes.The flexible circuit electrode array comprises a secondary coil for receiving visual data; an electronics package electrically coupled to said receiving coil, and a plurality of stimulating electrode electrically coupled to said electronics package.
Abstract translation: 在视觉假体中，电极刺激视网膜组织以诱导植入假体的使用者对光的感知。 假体必须具有返回或常见的电极以与视网膜组织形成完整的电路。 为了避免用返回电极刺激组织，如果电极很大，则是有利的。 本发明涉及柔性电路电极阵列，其包括聚合物基底层，沉积在所述聚合物基底层上的金属迹线，包括适于刺激沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层的神经组织的电极和分离的回流电极 从所述刺激电极。 柔性电路电极阵列包括用于接收视觉数据的次级线圈; 电耦合到所述接收线圈的电子封装，以及电耦合到所述电子封装的多个刺激电极。
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公开(公告)号：US10188853B2
公开(公告)日：2019-01-29
申请号：US12044830
申请日：2008-03-07
Applicant: Rajat Agrawal , Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Brian V. Mech , Jordan Matthew Neysmith , Neil Hamilton Talbot , Dao Min Zhou
Inventor： Rajat Agrawal , Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Brian V. Mech , Jordan Matthew Neysmith , Neil Hamilton Talbot , Dao Min Zhou
Abstract: The present invention is a flexible circuit electrode array with a polymer base layer, metal traces deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue, a polymer top layer deposited on the polymer base layer and the metal traces, and a soft polymer filling a void through both the polymer base layer and polymer top layer, the soft polymer forming drum stress relief around an attachment point.
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23.发明授权公开(公告)号：US09220169B2
公开(公告)日：2015-12-22
申请号：US11821327
申请日：2007-06-21
Applicant: Dao Min Zhou , James Singleton Little , Robert J. Greenberg
Inventor： Dao Min Zhou , James Singleton Little , Robert J. Greenberg
IPC: A61N1/36 , H05K3/36 , A61N1/02 , C25D3/62 , C25D5/02 , C25D5/18 , C25D5/56 , H05K3/32 , C25D3/56
CPC classification number: H05K3/361 , A61N1/02 , A61N1/36046 , C25D3/567 , C25D3/62 , C25D5/02 , C25D5/18 , C25D5/56 , H05K3/32 , H05K2203/0723
Abstract: Device is a hermetically sealed electronics package bonded to an electrode or flexible circuit that is suitable for implantation such as for a retinal or cortical electrode array. The hermetically sealed electronics package is bonded to the electrode or flexible circuit by electroplating a biocompatible material, such as platinum or gold, forming a plated connection, bonding the flexible circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation. The device comprises a substrate containing a contact, a flexible assembly containing a pad, and electroplated bonding between said contact and said pad that bonds said substrate and said flexible assembly together.
Abstract translation: 器件是密封的电子封装，其结合到适合于植入的电极或柔性电路，例如用于视网膜或皮质电极阵列。 电气密封的电子封装通过电镀生物相容性材料（例如铂或金）而结合到电极或柔性电路上，形成电镀连接，将柔性电路接合到电子封装。 所得到的电子器件是生物相容的并且适用于长期植入。 该装置包括含有接触件的基板，包含焊盘的柔性组件以及在所述接触件和所述焊盘之间的电镀接合，将所述基板和所述柔性组件接合在一起。
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公开(公告)号：US08510939B2
公开(公告)日：2013-08-20
申请号：US11924696
申请日：2007-10-26
Applicant: Robert J. Greenberg , Matthew J. McMahon , James Singleton Little , Kelly H. McClure , Brian V. Mech , Neil Hamilton Talbot , Jordan M. Neysmith
Inventor： Robert J. Greenberg , Matthew J. McMahon , James Singleton Little , Kelly H. McClure , Brian V. Mech , Neil Hamilton Talbot , Jordan M. Neysmith
IPC: H01K3/22
CPC classification number: A61N1/36046 , A61N1/0543 , A61N1/37223 , H05K1/028 , H05K1/0281 , H05K1/118 , H05K3/0014 , H05K3/28 , H05K2201/0133 , H05K2201/09018 , H05K2201/09145 , H05K2201/09909 , H05K2201/2009 , H05K2203/1105 , H05K2203/1476 , H05K2203/302 , Y10T29/49158
Abstract: Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, and cortical stimulation, and many related purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
Abstract translation: 聚合物材料可用作神经刺激的电极阵列体。 它们特别有用于视网膜刺激以产生人造视觉，耳蜗刺激以产生人造听觉和皮质刺激以及许多相关目的。 通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。 太小的压力会导致电阻增加以及电场分散。 太大的压力可能会阻止血液流动。 通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。 由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。 此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。 通过将适量的热应用于完整的阵列，可以引起曲线。 对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。 此外，沿着边缘添加材料是有利的。 在柔性电路阵列中提供折叠或扭曲是更有利的。 可以在折叠内部和外部添加附加材料以促进与组织的良好密封。
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公开(公告)号：US08412339B2
公开(公告)日：2013-04-02
申请号：US11924709
申请日：2007-10-26
Applicant: Jerry Ok , Robert J. Greenberg , Neil Hamilton Talbot , James Singleton Little , Rongqing Dai , Jordan Matthew Neysmith , Kelly H. McClure
Inventor： Jerry Ok , Robert J. Greenberg , Neil Hamilton Talbot , James Singleton Little , Rongqing Dai , Jordan Matthew Neysmith , Kelly H. McClure
IPC: A61N1/18
CPC classification number: A61N1/36046 , A61F15/001 , A61N1/0529 , A61N1/0543 , A61N1/36125 , A61N1/375 , H01L23/055 , H01L23/06 , H01L23/08 , H01L23/10 , H01L24/16 , H01L24/48 , H01L25/18 , H01L2224/16225 , H01L2224/45144 , H01L2224/48091 , H01L2224/48106 , H01L2224/48225 , H01L2924/00011 , H01L2924/00014 , H01L2924/00 , H01L2224/0401
Abstract: The present invention is an improved hermetic package for implantation in the human body. The implantable device comprises an electrically non-conductive substrate; a plurality of electrically conductive vias through said electrically non-conductive substrate; a flip-chip circuit attached to said electrically non-conductive substrate using conductive bumps and electrically connected to a first subset of said plurality of electrically conductive vias, wherein said flip-chip circuit contains one or more stacks or a folded stack; a wire bonded circuit attached to said electrically non-conductive substrate and electrically connected to a second subset of said electrically conductive vias; and a cover bonded to said electrically non-conductive substrate, said cover, said electrically non-conductive substrate and said electrically conductive vias forming a hermetic package.
Abstract translation: 本发明是用于植入人体的改进的密封包装。 可植入装置包括非导电基底; 通过所述非导电衬底的多个导电通孔; 使用导电凸块连接到所述非导电衬底并电连接到所述多个导电通孔的第一子集的倒装芯片电路，其中所述倒装芯片电路包含一个或多个堆叠或折叠堆叠; 连接到所述非导电衬底并电连接到所述导电通孔的第二子集的引线键合电路; 以及盖，其结合到所述非导电衬底，所述盖，所述非导电衬底和所述导电通孔形成气密封装。
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Patent Agency Ranking
公开(公告)号：US08150534B2
公开(公告)日：2012-04-03
申请号：US13029955
申请日：2011-02-17
Applicant: Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Jordan Matthew Neysmith
IPC: A61N1/00
CPC classification number: A61N1/0543 , A61N1/0558
Abstract: An electrode array attached to neural tissue, such as the retina, necessarily has graded pressure exerted on the tissue, with higher pressure near the attachment point. Greater pressure improves contact between the electrodes and neural tissue while too much pressure may damage neural tissue. Hence it is advantageous to obtain equal pressure across the array field. In the present invention multiple and selective attachment points are provided on an electrode array allowing a surgeon to select the attachment points providing the best electrode tissue contact.
Abstract translation: 附着到神经组织（例如视网膜）上的电极阵列必须具有施加在组织上的分级压力，附近点附近具有更高的压力。 更大的压力改善了电极和神经组织之间的接触，而太多的压力可能损伤神经组织。 因此，有利的是在阵列场上获得相等的压力。 在本发明中，在电极阵列上提供多个选择性附着点，允许外科医生选择提供最佳电极组织接触的附着点。
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27.发明授权Flexible circuit electrode array device and a method for backside processing of a flexible circuit electrode device 有权柔性电路电极阵列器件及柔性电路电极器件的背面处理方法公开(公告)号：US08145322B1
公开(公告)日：2012-03-27
申请号：US12177038
申请日：2008-07-21
Applicant: Qingfang Yao , Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
Inventor： Qingfang Yao , Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
IPC: A61N1/04
CPC classification number: A61N1/05 , A61N1/0541 , A61N1/0543 , B23K26/361 , B23K26/362
Abstract: The invention involves a flexible circuit electrode array device comprising: a polymer layer; wherein the polymer layer includes one or more metal traces, an electrode array; one or more bond pads; and the electrode array is located on the opposite side of the polymer layer.The invention further involves a method for backside processing of a flexible circuit electrode device, comprising: applying polymer film on a substrate; processing the front side; releasing the polymer film from substrate; flipping over the polymer film and fixing it onto the substrate; processing the backside; and final releasing of the polymer film from the substrate.The invention further involves a method for backside processing of a flexible circuit electrode device, comprising: processing the front side without releasing the polymer; processing the backside by sacrificial substrate method, or by laser drilling method; and releasing the polymer film from the substrate.
Abstract translation: 本发明涉及一种柔性电路电极阵列器件，包括：聚合物层; 其中所述聚合物层包括一个或多个金属迹线，电极阵列; 一个或多个接合垫; 并且电极阵列位于聚合物层的相对侧上。 本发明还涉及一种用于柔性电路电极器件的背面处理的方法，包括：在基底上施加聚合物膜; 正面加工; 从基材中释放聚合物膜; 翻转在聚合物膜上并将其固定在基底上; 处理背面; 并从基底中最终释放聚合物膜。 本发明还涉及一种用于柔性电路电极器件的背面处理的方法，包括：处理前侧而不释放聚合物; 通过牺牲基板方法或通过激光钻孔方法处理背面; 并从基板上释放聚合物膜。
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公开(公告)号：US08034229B2
公开(公告)日：2011-10-11
申请号：US12708358
申请日：2010-02-18
Applicant: Dao Min Zhou , Amy Hines , James Singleton Little , Robert J. Greenberg
Inventor： Dao Min Zhou , Amy Hines , James Singleton Little , Robert J. Greenberg
IPC: C23F13/04
Abstract: The invention is a process for cathodic protection of electrodes wherein negative bias is applied on the electrode. The negative bias is obtained by asymmetric current pulse, which is obtained by negative phase pulsing with higher amplitude than that of the anodic phase. The asymmetric current pulse is obtained by negative phase pulsing with wider pulse width than that of the anodic phase. The asymmetric current pulse may also be obtained by negative phase pulsing with both higher amplitude and wider pulse width than that of the anodic phase. The invention further relates to a process for cathodic protection of electrodes, wherein negative bias is applied on the electrode, and the negative bias is obtained by asymmetric current pulse, where the asymmetric current pulse is obtained by negative phase pulsing with wider pulse width than that of the anodic phase. The wider pulse width is obtained by pulse trains.
Abstract translation: 本发明是用于对电极进行负偏压的电极的阴极保护方法。 通过不对称电流脉冲获得负偏压，其通过负相脉冲以比阳极相高的幅度获得。 非对称电流脉冲通过脉冲宽度大于阳极相的脉冲宽度相位来获得。 也可以通过负相位脉冲获得不对称电流脉冲，同时具有比阳极相更高的幅度和更宽的脉冲宽度。 本发明还涉及一种用于对电极进行阴极保护的方法，其中对电极施加负偏压，并且通过不对称电流脉冲获得负偏压，其中通过具有较宽脉冲宽度的负相脉冲获得非对称电流脉冲， 的阳极相。 通过脉冲串获得更宽的脉冲宽度。
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公开(公告)号：US07638032B2
公开(公告)日：2009-12-29
申请号：US11924349
申请日：2007-10-25
Applicant: Dao Min Zhou , Amy Hines , James Singleton Little , Robert J. Greenberg
Inventor： Dao Min Zhou , Amy Hines , James Singleton Little , Robert J. Greenberg
IPC: C23F13/04
Abstract: The present invention relates to a process for cathodic protection of electrode or electrode materials wherein negative bias is applied on the electrode. the negative bias is obtained by asymmetric current pulse. The asymmetric current pulse is obtained by performing negative phase with higher amplitude. The asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The asymmetric current pulse is obtained by performing negative phase with higher amplitude and with wider pulse width than that of the anodic phase. The present invention further relates to a process for cathodic protection of electrode or electrode materials, wherein negative bias is applied on the electrode, wherein the negative bias is obtained by asymmetric current pulse, wherein the asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The wider pulse width is obtained by pulse trains.
Abstract translation: 本发明涉及对电极或电极材料进行阴极保护的方法，其中负电极施加在电极上。 负偏压通过不对称电流脉冲获得。 通过执行具有较高振幅的负相来获得非对称电流脉冲。 通过执行具有比阳极相宽的脉冲宽度的负相来获得非对称电流脉冲。 通过执行具有更高幅度和宽于脉冲宽度的阳极相的负相位获得非对称电流脉冲。 本发明还涉及一种用于对电极或电极材料进行阴极保护的方法，其中在电极上施加负偏压，其中通过不对称电流脉冲获得负偏压，其中非对称电流脉冲通过执行具有更宽的负相 脉冲宽度大于阳极相。 通过脉冲串获得更宽的脉冲宽度。
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公开(公告)号：US20090143848A1
公开(公告)日：2009-06-04
申请号：US12267489
申请日：2008-11-07
Applicant: Robert J. Greenberg , David Daomin Zhou , Jordan Matthew Neysmith , Kelly H. McClure , Jianing Wei , Neil Hamilton Talbot , James Singleton Little
Inventor： Robert J. Greenberg , David Daomin Zhou , Jordan Matthew Neysmith , Kelly H. McClure , Jianing Wei , Neil Hamilton Talbot , James Singleton Little
IPC: A61N1/05
CPC classification number: A61N1/0541 , A61N1/0472
Abstract: A cochlear stimulation device comprising an electrode array designed to provide enhanced charge injection capacity necessary for neural stimulation. The electrode array comprises electrodes with high surface area or a fractal geometry and correspondingly high electrode capacitance and low electrical impedance. The resultant electrodes have a robust surface and sufficient mechanical strength to withstand physical stress vital for long term stability. The device further comprises wire traces having a multilayer structure which provides a reduced width for the conducting part of the electrode array. The cochlear prosthesis is attached by a grommet to the cochleostomy that is made from a single piece of biocompatible polymer. The device, designed to achieve optimum neural stimulation by appropriate electrode design, is a significant improvement over commercially available hand-built devices.
Abstract translation: 耳蜗刺激装置包括设计成提供神经刺激所需的增强的电荷注入能力的电极阵列。 电极阵列包括具有高表面积或分形几何形状的电极以及相当高的电极电容和低的电阻抗。 所得电极具有坚固的表面和足够的机械强度以抵抗对于长期稳定性至关重要的物理应力。 该装置还包括具有多层结构的导线迹线，其为电极阵列的导电部分提供减小的宽度。 耳蜗假体通过索环连接到由单一生物相容性聚合物制成的耳蜗切开术。 该设备旨在通过适当的电极设计实现最佳神经刺激，这是相对于市售的手工设备的显着改进。
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