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21.发明授权公开(公告)号：US07943088B2
公开(公告)日：2011-05-17
申请号：US11972708
申请日：2008-01-11
Applicant: Jeong-gun Lee , Yong-moo Shin , Kui-hyun Kim , Jin-han Chung
Inventor： Jeong-gun Lee , Yong-moo Shin , Kui-hyun Kim , Jin-han Chung
CPC classification number: B01L7/52 , B01L3/5027 , B01L9/527 , B01L2300/0681 , B01L2300/0806 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2300/1883 , B01L2400/0409 , G01N35/00069 , G01N2035/00346 , Y10T436/11 , Y10T436/25
Abstract: Provided is a biochemical analyzer in which a microfluidic biochemical assay may be performed. The analyzer includes: a microfluidic device loading space including a microfluidic device supporting unit detachably supporting a microfluidic device including an energy application region in which an energy is applied; an energy source loading space including an energy source applying the energy to the radiation application region; and an isolation wall isolating the microfluidic device loading space and the energy source loading space to prevent heat transfer between the microfluidic device loading space and the energy source loading space and including a window through which the energy can be transmitted. A method of controlling an internal temperature of the biochemical analyzer is also provided.
Abstract translation: 提供了可以进行微流体生化测定的生化分析仪。 该分析仪包括：微流体装置装载空间，其包括微流体装置支撑单元，其可拆卸地支撑包括其中施加能量的能量施加区域的微流体装置; 能量源装载空间，其包括将能量施加到所述辐射施加区域的能量源; 隔离壁隔离微流体装置加载空间和能量源装载空间，以防止微流体装置加载空间与能量源装载空间之间的热传递并且包括能够传输能量的窗口。 还提供了一种控制生化分析仪内部温度的方法。
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公开(公告)号：US07901633B2
公开(公告)日：2011-03-08
申请号：US11491825
申请日：2006-07-24
Applicant: Nam Huh , Jeong-gun Lee
Inventor： Nam Huh , Jeong-gun Lee
CPC classification number: B01L3/0241 , B01L2200/0647 , B01L2200/0673 , B01L2200/143 , B01L2300/0819 , B01L2300/089 , B01L2400/027 , B01L2400/0427 , G01N2035/00237 , Y10T436/2575
Abstract: Provided is a quantitative cell dispensing apparatus using liquid droplet manipulation, for quantitatively dispensing cells from hydrophilic suspension containing a plurality of cells. The quantitative cell dispensing apparatus includes hydrophilic suspension, a liquid droplet manipulation unit, a dispensing unit, a sensing unit, and a control unit. The hydrophilic suspension includes a plurality of cells and electrolyte, and the liquid droplet manipulation unit. The liquid droplet manipulation unit includes an inlet and a liquid droplet outlet portion. The dispensing unit discharges a liquid droplet received from the liquid droplet outlet portion to a target portion. The sensing unit optically senses liquid droplets distributed on a panel of the liquid droplet manipulation unit. The control unit analyses the number of cells contained in each liquid droplet using a single sensed by the sensing unit, and controls the liquid droplet manipulation unit to transfer a liquid droplet containing a predetermined number of cells to the liquid droplet outlet portion.
Abstract translation: 提供了一种使用液滴操作的定量细胞分配装置，用于从含有多个细胞的亲水性悬浮液定量分配细胞。 定量细胞分配装置包括亲水性悬浮液，液滴操作单元，分配单元，感测单元和控制单元。 亲水性悬浮液包括多个细胞和电解质，以及液滴操作单元。 液滴操作单元包括入口和液滴出口部分。 分配单元将从液滴出口部分接收的液滴排放到目标部分。 感测单元光学地感测分布在液滴操作单元的面板上的液滴。 控制单元使用感测单元检测到的单个分析每个液滴中包含的细胞的数量，并且控制液滴操作单元将含有预定数量的细胞的液滴转移到液滴出口部分。
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23.发明授权公开(公告)号：US07892491B2
公开(公告)日：2011-02-22
申请号：US11533961
申请日：2006-09-21
Applicant: Su Hyeon Kim , Jeong Gun Lee , Seung Yeon Yang
Inventor： Su Hyeon Kim , Jeong Gun Lee , Seung Yeon Yang
IPC: G01N15/06
Abstract: An apparatus for disruption of cells or viruses using a laser and magnetic beads includes a cell lysis chip including a sample inlet hole into which a sample and the magnetic beads are introduced, a vibrator fixing the cell lysis chip and transferring vibrations in a prescribed direction, a laser generator supplying the laser to the cell lysis chip and a controller controlling operations of the vibrator and the laser generator.
Abstract translation: 使用激光和磁珠对细胞或病毒进行破坏的装置包括细胞裂解芯片，其包括样品入口孔和样品入口孔，样品和磁珠被引入其中，振动器固定细胞裂解芯片并沿规定方向传递振动， 将激光器提供给细胞裂解芯片的激光发生器和控制振动器和激光发生器的操作的控制器。
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24.发明申请APPARATUS AND METHOD FOR EJECTING DROPLETS USING CHARGE CONCENTRATION AND LIQUID BRIDGE BREAKUP 有权使用充气浓度和液桥破坏进行喷射的装置和方法公开(公告)号：US20110015094A1
公开(公告)日：2011-01-20
申请号：US12888927
申请日：2010-09-23
Applicant: Beom-seok LEE , Jeong-gun LEE , Hye-jung CHO , In-seok KANG , Jae-suk MOON , Jin-seok HONG
Inventor： Beom-seok LEE , Jeong-gun LEE , Hye-jung CHO , In-seok KANG , Jae-suk MOON , Jin-seok HONG
CPC classification number: B01L3/0262 , B01J19/0046 , B01J2219/00369 , B01J2219/00371 , B01J2219/00527 , B01J2219/00605 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01J2219/00743 , B01L2300/0819 , B01L2300/0838 , B01L2400/027 , Y10T436/11 , Y10T436/118339 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
Abstract: Disclosed is an apparatus and method for ejecting droplets using charge concentration and liquid bridge breakup. The droplet ejection apparatus includes a reservoir storing a liquid; a capillary nozzle having a lower end submerged in the liquid stored in the reservoir and an upper end exposed outside the surface of the liquid, the capillary nozzle transferring the liquid to the upper end using capillary force; a potentiostat for applying a voltage to the liquid; a substrate mount on which a substrate is disposed to face the upper end of the capillary nozzle; and a distance adjusting unit for reciprocatingly moving the substrate between first and second positions with respect to the capillary nozzle, wherein the first position denotes a position where a distance between the upper end of the capillary nozzle and the surface of the substrate is less than a effective distance.
Abstract translation: 公开了一种使用电荷浓度和液桥分解喷射液滴的装置和方法。 液滴喷射装置包括储存液体的储液器; 毛细喷嘴，其下端浸没在存储在储存器中的液体中，上端暴露在液体表面之外，毛细喷嘴使用毛细管力将液体传送到上端; 用于向液体施加电压的恒电位仪; 基板安装件，基板设置在其上面对毛细管喷嘴的上端; 以及距离调节单元，用于使所述基板相对于所述毛细管喷嘴在第一位置和所述第二位置之间往复移动，其中所述第一位置表示所述毛细管喷嘴的上端与所述基板的表面之间的距离小于 有效距离。
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25.发明授权Apparatus and method for ejecting droplets using charge concentration and liquid bridge breakup 有权使用电荷浓度和液桥破裂喷射液滴的装置和方法公开(公告)号：US07824621B2
公开(公告)日：2010-11-02
申请号：US11970301
申请日：2008-01-07
Applicant: Beom-seok Lee , Jeong-gun Lee , Hye-jung Cho , In-seok Kang , Jae-suk Moon , Jin-seok Hong
Inventor： Beom-seok Lee , Jeong-gun Lee , Hye-jung Cho , In-seok Kang , Jae-suk Moon , Jin-seok Hong
CPC classification number: B01L3/0262 , B01J19/0046 , B01J2219/00369 , B01J2219/00371 , B01J2219/00527 , B01J2219/00605 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01J2219/00743 , B01L2300/0819 , B01L2300/0838 , B01L2400/027 , Y10T436/11 , Y10T436/118339 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
Abstract: Disclosed is an apparatus and method for ejecting droplets using charge concentration and liquid bridge breakup. The droplet ejection apparatus includes a reservoir storing a liquid; a capillary nozzle having a lower end submerged in the liquid stored in the reservoir and an upper end exposed outside the surface of the liquid, the capillary nozzle transferring the liquid to the upper end using capillary force; a potentiostat for applying a voltage to the liquid; a substrate mount on which a substrate is disposed to face the upper end of the capillary nozzle; and a distance adjusting unit for reciprocatingly moving the substrate between first and second positions with respect to the capillary nozzle, wherein the first position denotes a position where a distance between the upper end of the capillary nozzle and the surface of the substrate is less than a effective distance.
Abstract translation: 公开了一种使用电荷浓度和液桥分解喷射液滴的装置和方法。 液滴喷射装置包括储存液体的储存器; 毛细喷嘴，其下端浸没在存储在储存器中的液体中，上端暴露在液体表面之外，毛细喷嘴使用毛细管力将液体传送到上端; 用于向液体施加电压的恒电位仪; 基板安装件，基板设置在其上面对毛细管喷嘴的上端; 以及距离调节单元，用于使所述基板相对于所述毛细管喷嘴在第一位置和所述第二位置之间往复移动，其中所述第一位置表示所述毛细管喷嘴的上端与所述基板的表面之间的距离小于 有效距离。
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Patent Agency Ranking
26.发明授权公开(公告)号：US07794054B2
公开(公告)日：2010-09-14
申请号：US11746299
申请日：2007-05-09
Applicant: Beom-seok Lee , Jeong-gun Lee , In-seok Kang , Jin-seok Hong , Dustin Moon
Inventor： Beom-seok Lee , Jeong-gun Lee , In-seok Kang , Jin-seok Hong , Dustin Moon
IPC: B41J2/06
CPC classification number: B41J2/06
Abstract: A droplet printing apparatus using capillary electric charge concentration includes a reservoir which contains a solution, a capillary nozzle comprising a back-end part and a front-end part disposed substantially opposite the back-end part, a target member spaced apart from the front-end part of the capillary nozzle at a predetermined distance, and a voltage supplier which supplies a voltage to the solution, wherein the back-end part is immersed in the solution and transmits the solution to the front-end part.
Abstract translation: 使用毛细管电荷浓度的液滴印刷装置包括：包含溶液的储存器，包括后端部分的毛细管喷嘴和基本上与后端部分相对设置的前端部分，与前端部分间隔开的目标部件， 在预定距离的毛细管喷嘴的端部，以及向溶液提供电压的电压供给器，其中后端部分浸入溶液中并将溶液传输到前端部分。
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27.发明授权Optical detection apparatus, optical detection method, and microfluidic system including the optical detection apparatus 有权光学检测装置，光学检测方法和包括光学检测装置的微流体系统公开(公告)号：US07692794B2
公开(公告)日：2010-04-06
申请号：US11972266
申请日：2008-01-10
Applicant: Su-hyeon Kim , Jeong-gun Lee
Inventor： Su-hyeon Kim , Jeong-gun Lee
IPC: G01N21/25
CPC classification number: G01N21/07 , G01N21/253 , G01N21/276 , G01N21/314
Abstract: Provided are an optical detection apparatus, a microfluidic system including the same, and an optical detection method. The optical detection apparatus including: at least one light emission unit which emits light of a predetermined wavelength band; at least one light receiving unit which is disposed such that the light receiving unit receives the light emitted from the light emission unit and generates an electrical signal according to the intensity of the light received, wherein the number of light receiving units is the same as the number of light emission units; a rotation operating unit which rotates a disk-type microfluidic apparatus comprising at least one detection chamber in which a sample is to be loaded such that the detection chamber is disposed in a light pathway between the light emission unit and the light receiving unit; and a processor which measures a property of the sample contained in the detection chamber using the electrical signal generated by the light receiving unit.
Abstract translation: 提供了一种光学检测装置，包括该光学检测装置的微流体系统和光学检测方法。 所述光学检测装置包括：发射预定波长带的光的至少一个发光单元; 至少一个光接收单元，其设置成使得所述光接收单元接收从所述发光单元发射的光并根据所接收的光的强度产生电信号，其中所述光接收单元的数量与 发光单位数量; 旋转操作单元，其旋转盘式微流体装置，其包括至少一个检测室，其中样品将被装载，使得所述检测室设置在所述发光单元和所述光接收单元之间的光路径中; 以及处理器，其使用由光接收单元生成的电信号来测量包含在检测室中的样品的性质。
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28.发明申请CENTRIFUGAL-BASED MICROFLUIDIC APPARATUS, METHOD OF FABRICATING THE SAME, AND METHOD OF TESTING SAMPLES USING THE MICROFLUIDIC APPARATUS 有权基于离心的微流体装置，其制造方法和使用微流控装置测试样品的方法公开(公告)号：US20100081213A1
公开(公告)日：2010-04-01
申请号：US12569437
申请日：2009-09-29
Applicant: Beom Seok LEE , Ji Won KIM , Jeong Gun LEE , Kui Hyun KIM
Inventor： Beom Seok LEE , Ji Won KIM , Jeong Gun LEE , Kui Hyun KIM
CPC classification number: B01L3/50273 , B01L3/502738 , B01L3/545 , B01L2200/0621 , B01L2200/0689 , B01L2200/10 , B01L2300/021 , B01L2300/0806 , B01L2300/0816 , B01L2300/0861 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , B01L2400/0409 , B01L2400/0677 , G01N21/07 , G01N33/54386 , G01N35/00069
Abstract: Provided is a microfluidic apparatus including: a microfluidic structure for providing spaces for receiving a fluid and for forming channels, through which the fluid flows; and valves for controlling the flow of fluid through the channels in the microfluidic apparatus. The microfluidic structure includes: a sample chamber; a sample separation unit receiving the sample from the sample chamber and separating a supernatant from the sample by using a centrifugal force; a testing unit receiving the supernatant from the sample separation unit for detecting a specimen from the supernatant using an antigen-antibody reaction, and a quality control chamber for identifying reliability of the test.
Abstract translation: 提供了一种微流体装置，包括：微流体结构，用于提供用于接收流体的空间和用于形成流体流过的通道; 以及用于控制通过微流体装置中的通道的流体流动的阀。 微流体结构包括：样品室; 样品分离单元，从样品室接收样品，并通过离心力从样品中分离上清液; 接收来自样品分离单元的上清液的测试单元，用于使用抗原 - 抗体反应从上清液检测样品;以及质量控制室，用于识别测试的可靠性。
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29.发明申请OPTICAL DETECTION APPARATUS, OPTICAL DETECTION METHOD, AND MICROFLUIDIC SYSTEM INCLUDING THE OPTICAL DETECTION APPARATUS 有权光学检测装置，光学检测方法和包括光学检测装置的微流体系统公开(公告)号：US20090021741A1
公开(公告)日：2009-01-22
申请号：US11972266
申请日：2008-01-10
Applicant: Su-hyeon KIM , Jeong-gun LEE
Inventor： Su-hyeon KIM , Jeong-gun LEE
IPC: G01N21/00
CPC classification number: G01N21/07 , G01N21/253 , G01N21/276 , G01N21/314
Abstract: Provided are an optical detection apparatus, a microfluidic system including the same, and an optical detection method. The optical detection apparatus including: at least one light emission unit which emits light of a predetermined wavelength band; at least one light receiving unit which is disposed such that the light receiving unit receives the light emitted from the light emission unit and generates an electrical signal according to the intensity of the light received, wherein the number of light receiving units is the same as the number of light emission units; a rotation operating unit which rotates a disk-type microfluidic apparatus comprising at least one detection chamber in which a sample is to be loaded such that the detection chamber is disposed in a light pathway between the light emission unit and the light receiving unit; and a processor which measures a property of the sample contained in the detection chamber using the electrical signal generated by the light receiving unit.
Abstract translation: 提供了一种光学检测装置，包括该光学检测装置的微流体系统和光学检测方法。 所述光学检测装置包括：发射预定波长带的光的至少一个发光单元; 至少一个光接收单元，其设置成使得所述光接收单元接收从所述发光单元发射的光并根据所接收的光的强度产生电信号，其中所述光接收单元的数量与 发光单位数量; 旋转操作单元，其使包括至少一个检测室的盘式微流体装置旋转，其中样品将被装载，使得检测室设置在发光单元和光接收单元之间的光通路中; 以及处理器，其使用由光接收单元生成的电信号来测量包含在检测室中的样品的性质。
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公开(公告)号：US20080305006A1
公开(公告)日：2008-12-11
申请号：US12053656
申请日：2008-03-24
Applicant: Yoon-kyoung Cho , Beom-seok Lee , Jeong-gun Lee
Inventor： Yoon-kyoung Cho , Beom-seok Lee , Jeong-gun Lee
IPC: B01J19/00
CPC classification number: B01L3/502738 , B01L3/50273 , B01L2200/028 , B01L2300/0803 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , Y10T436/11 , Y10T436/25 , Y10T436/255 , Y10T436/2575
Abstract: A microfluidic apparatus having a substrate including a channel through which a fluid is conveyed, a fluid container in which at least one kind of fluid is accommodated and which is disposed on the substrate so as to allow the fluid to flow toward the channel, and a fluid flow controller which controls a flow of the fluid toward the channel from the fluid container.
Abstract translation: 一种微流体装置，其具有包括流体被输送的通道的基板，容纳有至少一种流体的流体容器，并且设置在所述基板上以允许流体朝向所述流路流动， 流体流量控制器，其控制流体朝向来自流体容器的通道的流动。
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