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    Optical detection apparatus for multi-channel multi-color measurement and multi-channel sample analyzer employing the same
    21.
    发明授权
    Optical detection apparatus for multi-channel multi-color measurement and multi-channel sample analyzer employing the same 有权
    用于多通道多色测量的光学检测装置和采用其的多通道样本分析仪

    公开(公告)号：US07274455B2

    公开(公告)日：2007-09-25

    申请号：US11221055

    申请日：2005-09-07

    Applicant: Gyeong-sik Ok ,  Jin-tae Kim ,  Kwang-wook Oh ,  Sang-hyo Kim

    Inventor： Gyeong-sik Ok ,  Jin-tae Kim ,  Kwang-wook Oh ,  Sang-hyo Kim

    IPC: G01N21/25 ,  G01J3/51

    CPC classification number: G01N21/645 ,  G01J3/51 ,  G01N2021/6421 ,  G01N2021/6471

    Abstract: Provided are an optical detection apparatus which can measure multi-channel samples at high speed and various wavelengths using an optical detector and a multi-channel sample analyzer employing the same. The optical detection apparatus includes an optical detector; a filter wheel having at least two color filters connected to each other in the shape of a disk; a plurality of optical channels through which a plurality of beams of light enter the filter wheel; and a mirror unit including a plurality of mirrors for sequentially reflecting the plurality of beams of light transmitted through the filter wheel to the optical detector, wherein the mirror unit rotates together with the filter wheel.

    Abstract translation: 提供了一种光学检测装置，其可以使用光学检测器和使用该多通道样本的多通道样本分析仪来测量高速和各种波长的多通道样本。 光检测装置包括光检测器; 具有至少两个滤色器轮的滤光轮，所述至少两个滤色器以盘的形状彼此连接; 多个光通道，多个光束通过该光通道进入滤光轮; 以及反射镜单元，其包括多个反射镜，用于将透过滤光轮的多个光束顺序地反射到光学检测器，其中反射镜单元与滤光轮一起旋转。

    Polymerase chain reaction module, and multiple polymerase chain reaction system including the module
    22.
    发明申请
    Polymerase chain reaction module, and multiple polymerase chain reaction system including the module 有权
    聚合酶链反应模块，以及多个聚合酶链反应系统，包括该模块

    公开(公告)号：US20060246580A1

    公开(公告)日：2006-11-02

    申请号：US11377793

    申请日：2006-03-16

    Applicant: Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chi-sung Park ,  Yu-jin Seo

    Inventor： Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chi-sung Park ,  Yu-jin Seo

    IPC: C12M1/34

    CPC classification number: B01L7/52 ,  B01L3/5027 ,  B01L9/52 ,  B01L2300/0822 ,  B01L2300/1827 ,  B01L2300/1844 ,  C12Q1/686

    Abstract: Provided are a polymerase chain reaction (PCR) module and a PCR system including the same. The PCR module includes: a detachable PCR chip including a PCR chamber unit in which a PCR solution is accommodated; a heater unit for heating the PCR solution in the PCR chip with a preset temperature; a detecting unit for detecting a PCR signal of the PCR solution; a PCR chip installation unit for mounting/detaching the PCR chip using a one-touch method, in which the heater unit is adhered to the PCR chip with a predetermined pressure when mounting the PCR chip and the heater unit is separated from the PCR chip when detaching the PCR chip; and a housing covering at least the heater unit and the detecting unit so that they are not exposed to the outside.

    Abstract translation: 提供了聚合酶链反应（PCR）模块和包括其的PCR系统。 所述PCR模块包括：可拆卸PCR芯片，其包括其中容纳PCR溶液的PCR室单元; 用于以预设温度加热PCR芯片中的PCR溶液的加热器单元; 用于检测PCR溶液的PCR信号的检测单元; 用于使用一触式方法安装/分离PCR芯片的PCR芯片安装单元，其中当将PCR芯片和加热器单元安装在PCR芯片上时，将加热器单元以预定的压力粘附到PCR芯片上，与PCR芯片分离， 分离PCR芯片; 以及至少覆盖加热器单元和检测单元的壳体，使得它们不暴露于外部。

    Real-time PCR monitoring apparatus and method
    26.
    发明申请
    Real-time PCR monitoring apparatus and method 有权
    实时PCR监测装置及方法

    公开(公告)号：US20050130183A1

    公开(公告)日：2005-06-16

    申请号：US10890350

    申请日：2004-07-13

    Applicant: Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    Inventor： Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    IPC: C12Q1/68 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  G01N21/03 ,  G01N21/64 ,  C12M1/34

    CPC classification number: G01N21/645 ,  B01L3/50851 ,  B01L7/52 ,  B01L2300/0627 ,  B01L2300/18 ,  G01N21/0332

    Abstract: Provided are a real-time PCR monitoring apparatus and method. The real-time PCR monitoring apparatus includes a microchip-type PCR tube that has a PCR solution-containing PCR chamber, a micro-heater that applies heat to the PCR chamber of the PCR tube, a detection unit that detects a PCR product signal based on the amount of a PCR product of the PCR solution, a plurality of modules, each of which includes a cooling fan for lowering the inside air temperature and a control unit for adjusting the temperature of the PCR chamber of the PCR tube by controlling the micro-heater and the cooling fan, and receives the PCR tube, the micro-heater, and the detection unit, a base instrument that includes a power supply unit electrically connected to the modules for power supply and a data communication unit electrically connected to the modules for data communication with the control unit of each of the modules, and a display unit that displays data received from the data communication unit, wherein the control unit of each of the modules independently controls at least one of both the detection unit and the temperature of the PCR chamber of the PCR tube received in each of the modules. Therefore, co-amplification of different samples at different temperature conditions can be carried out and monitored in real time.

    Abstract translation: 提供了一种实时PCR监测装置和方法。 实时PCR监视装置包括具有含PCR溶液的PCR室的微芯片型PCR管，向PCR管的PCR室照射热的微加热器，检测基于PCR产物信号的检测单元 关于PCR溶液的PCR产物的量，多个模块，每个模块包括用于降低内部空气温度的冷却风扇和用于通过控制微管来调节PCR管的PCR室的温度的控制单元 加热器和冷却风扇，并且接收PCR管，微加热器和检测单元，基本仪器包括电连接到用于电源的模块的电源单元和与模块电连接的数据通信单元 用于与每个模块的控制单元的数据通信，以及显示单元，显示从数据通信单元接收的数据，其中每个模块的控制单元独立地控制 在每个模块中接收PCR管的PCR室的检测单元和温度中的至少一个。 因此，不同温度条件下不同样品的共扩增可以进行实时监测。

    Real-time PCR monitoring apparatus and method
    27.
    发明授权
    Real-time PCR monitoring apparatus and method 有权
    实时PCR监测装置及方法

    公开(公告)号：US07767439B2

    公开(公告)日：2010-08-03

    申请号：US10890350

    申请日：2004-07-13

    Applicant: Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    Inventor： Kwang-wook Oh ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

    IPC: C12M1/34 ,  C12M3/00 ,  C12Q1/68 ,  G01N21/25

    CPC classification number: G01N21/645 ,  B01L3/50851 ,  B01L7/52 ,  B01L2300/0627 ,  B01L2300/18 ,  G01N21/0332

    Abstract: A real time polymerase chain reaction (“PCR”) monitoring apparatus includes, a microchip-type PCR tube that has a PCR solution-containing PCR chamber, a micro-heater, a detection unit detecting a PCR product signal based on the PCR solution, a plurality of modules, each of which includes the abovementioned elements in addition to a cooling fan and a control unit controlling the micro-heater and the cooling fan to adjust the temperature of the PCR chamber, a base instrument that comprises a power supply unit connected to the modules and a data communication unit connected to the control unit of each of the modules, and a display unit displaying data from the data communication unit, wherein the control unit of each of the modules independently controls at least one of both the detection unit and the temperature of the PCR chamber of the PCR tube in each of the modules.

    Abstract translation: 实时聚合酶链式反应（“PCR”）监测装置包括：具有含PCR溶液的PCR室的微芯片型PCR管，微加热器，基于PCR溶液检测PCR产物信号的检测单元， 多个模块，每个模块除了冷却风扇之外还包括上述元件，以及控制单元，其控制微加热器和冷却风扇来调节PCR室的温度;基础仪器，包括连接的电源单元 连接到每个模块的控制单元的数据通信单元和从数据通信单元显示数据的显示单元，其中每个模块的控制单元独立地控制检测单元中的至少一个 以及每个模块中PCR管的PCR室的温度。

    Polymerase chain reaction module, and multiple polymerase chain reaction system including the module
    28.
    发明授权
    Polymerase chain reaction module, and multiple polymerase chain reaction system including the module 有权
    聚合酶链反应模块，以及多个聚合酶链反应系统，包括该模块

    公开(公告)号：US07754452B2

    公开(公告)日：2010-07-13

    申请号：US11377793

    申请日：2006-03-16

    Applicant: Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chin-sung Park ,  Yu-jin Seo

    Inventor： Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chin-sung Park ,  Yu-jin Seo

    IPC: C12P19/34 ,  C12M1/36 ,  G01N15/06

    CPC classification number: B01L7/52 ,  B01L3/5027 ,  B01L9/52 ,  B01L2300/0822 ,  B01L2300/1827 ,  B01L2300/1844 ,  C12Q1/686

    Abstract: Provided are a polymerase chain reaction (PCR) module and a PCR system including the same. The PCR module includes: a detachable PCR chip including a PCR chamber unit in which a PCR solution is accommodated; a heater unit for heating the PCR solution in the PCR chip with a preset temperature; a detecting unit for detecting a PCR signal of the PCR solution; a PCR chip installation unit for mounting/detaching the PCR chip using a one-touch method, in which the heater unit is adhered to the PCR chip with a predetermined pressure when mounting the PCR chip and the heater unit is separated from the PCR chip when detaching the PCR chip; and a housing covering at least the heater unit and the detecting unit so that they are not exposed to the outside.

    Abstract translation: 提供了聚合酶链反应（PCR）模块和包括其的PCR系统。 所述PCR模块包括：可拆卸PCR芯片，其包括其中容纳PCR溶液的PCR室单元; 用于以预设温度加热PCR芯片中的PCR溶液的加热器单元; 用于检测PCR溶液的PCR信号的检测单元; 用于使用一触式方法安装/分离PCR芯片的PCR芯片安装单元，其中当将PCR芯片和加热器单元安装在PCR芯片上时，将加热器单元以预定的压力粘附到PCR芯片上，与PCR芯片分离， 分离PCR芯片; 以及至少覆盖加热器单元和检测单元的壳体，使得它们不暴露于外部。

    Cell lysis method using free radical
    29.
    发明授权
    Cell lysis method using free radical 有权
    细胞裂解法使用自由基

    公开(公告)号：US07517690B2

    公开(公告)日：2009-04-14

    申请号：US11291053

    申请日：2005-11-30

    Applicant: Jung-im Han ,  Young-sun Lee ,  Kak Namkoong ,  Kwang-wook Oh

    Inventor： Jung-im Han ,  Young-sun Lee ,  Kak Namkoong ,  Kwang-wook Oh

    IPC: G01N33/48

    CPC classification number: C12N1/06 ,  Y10T436/107497 ,  Y10T436/206664 ,  Y10T436/25 ,  Y10T436/2575

    Abstract: Provided is a method of lysing a cell or a virus using a free radical. The method includes: applying an electric field to a mixture of a metal ion, a peroxide, and a cell or virus solution to increase the free radical generation, thereby lysing a cell or a virus. In the present method, cell lysis may be efficiently performed using a low electrical energy (several mV to several V). When the present method is applied to a microsystem, cell lysis can occur at a desired time and in a desired space by controlling the electrical energy, thus being suitable to realize a lab-on-a-chip (LOC).

    Abstract translation: 提供了使用自由基裂解细胞或病毒的方法。 该方法包括：向金属离子，过氧化物和细胞或病毒溶液的混合物施加电场以增加自由基产生，从而裂解细胞或病毒。 在本方法中，可以使用低电能（几mV至几V）有效地进行细胞裂解。 当本方法应用于微系统时，细胞裂解可以通过控制电能在期望的时间和期望的空间中发生，从而适于实现芯片上的实验室（LOC）。

    Fluid mixing device using cross channels
    30.
    发明申请
    Fluid mixing device using cross channels 有权
    流体混合装置使用交叉通道

    公开(公告)号：US20060262642A1

    公开(公告)日：2006-11-23

    申请号：US11433594

    申请日：2006-05-12

    Applicant: Chin-sung Park ,  Joon-ho Kim ,  Kak Namkoong ,  Kwang-wook Oh

    Inventor： Chin-sung Park ,  Joon-ho Kim ,  Kak Namkoong ,  Kwang-wook Oh

    IPC: B01F5/06

    CPC classification number: B01F13/1013 ,  B01F5/0475 ,  B01F5/0478 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01F13/1019 ,  B01F15/0203 ,  B01F15/0404 ,  B01F2015/0221 ,  G01N1/38

    Abstract: Provided is a fluid mixing device which produces a series of solutions with a concentration gradient. The fluid mixing device includes: a plurality of first channels disposed parallel to each other on a layer, and into which an equal amount of diluent flows from its upstream; a plurality of second channels formed perpendicular to the first channels on an adjacent layer to the layer on which the first channels are formed, and into which an equal amount of sample solution flows from its upstream; and via holes formed at at least one intersection between each of the first channel and a plurality of second channels so that a predetermined amount of sample solution flows from the second channels into corresponding first channels, wherein a series of solutions with different concentrations is produced in the first channels depending on the amount of sample solution that flows into the first channels through the via holes. Thus, a series of solutions with different concentrations is output from the first channels.

    Abstract translation: 提供了一种流体混合装置，其产生具有浓度梯度的一系列溶液。 流体混合装置包括：在层上彼此平行设置的多个第一通道，等量的稀释剂从其上游流入其中; 多个第二通道，其垂直于与形成有第一通道的层相邻的第一通道形成，并且等量的样品溶液从其上游流入其中; 以及形成在每个第一通道和多个第二通道之间的至少一个相交处的通孔，使得预定量的样品溶液从第二通道流入相应的第一通道，其中一系列具有不同浓度的溶液在 第一通道取决于通过通孔流入第一通道的样品溶液的量。 因此，从第一通道输出一系列具有不同浓度的溶液。

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