公开(公告)号：US20200261438A1

公开(公告)日：2020-08-20

申请号：US16867540

申请日：2020-05-05

Applicant: Versitech Limited

Inventor： Yi Tsun Richard KAO ,  Peng GAO ,  Xuechen LI ,  Ming LIU

IPC: A61K31/4545 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/404 ,  A61K31/47 ,  A61K31/472 ,  A61K31/18 ,  A61K31/4458 ,  A61K31/4462 ,  A61K31/496 ,  A61P31/04

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

公开(公告)号：US10647746B2

公开(公告)日：2020-05-12

申请号：US15093950

申请日：2016-04-08

Applicant: Versitech Limited

Inventor： Xuechen Li

IPC: C07K7/54 ,  C07K7/08 ,  A61K38/00

Abstract: Described are design and generation of a set of novel cyclic lipopeptides as potential antibacterial agents. New daptomycin analogues are generated by chemical synthesis, which makes introduction of an unnatural amino acid and any modification into daptomycin possible.

公开(公告)号：US20200069642A1

公开(公告)日：2020-03-05

申请号：US16679313

申请日：2019-11-11

Applicant: Versitech Limited

Inventor： Yi Tsun Richard KAO ,  Peng GAO ,  Xuechen LI ,  Ming LIU

IPC: A61K31/40 ,  A61K31/496 ,  A61K31/47 ,  A61K31/454 ,  A61K31/4453 ,  A61K31/444 ,  A61K31/4406 ,  A61K31/4402 ,  A61K31/404 ,  A61K31/18 ,  A61K31/167 ,  A61K31/357 ,  A61P31/04 ,  C07D317/60 ,  C07D295/26

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): The present methods include administering to a subject an effective amount of one or more compounds of Formula (I). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

公开(公告)号：US10547852B2

公开(公告)日：2020-01-28

申请号：US15441530

申请日：2017-02-24

Applicant: Versitech Limited

Inventor： Shing Chow Chan ,  Zhouchi Lin ,  An Ling Liu

IPC: H04N7/18 ,  H04N11/02 ,  H04N11/04 ,  H04N19/159 ,  H04N19/13 ,  H04N19/14 ,  H04N19/182

Abstract: The present invention relate to methods and codecs for image and video compression. Embodiments of the present invention include a novel shape-adaptive model-based codec (SAM) that supports binary shapes as well as matte and soft segmentation image compression by decomposing input shapes into deterministic and stochastic components for flexible lossy and lossless coding. The present invention can provide inter/intra prediction and flexibly adapts between lossy and lossless modes with various parameters for compression quality control. The compression module can also be adapted with numerous other compression techniques.

公开(公告)号：US20190320998A1

公开(公告)日：2019-10-24

申请号：US16458660

申请日：2019-07-01

Applicant: VERSITECH LIMITED

Inventor： Alfred Cheuk Hang YU ,  Yat Shun YIU

IPC: A61B8/06 ,  A61B8/02 ,  A61B8/08 ,  A61B8/00 ,  G01S15/89 ,  G06T7/20 ,  G01S15/58 ,  G01S7/52

Abstract: Apparatus and methods of use are provided for complex flow imaging and analysis that is non-invasive, accurate, and time-resolved. It is particularly useful in imaging of vascular flow with spatiotemporal fluctuations. This apparatus is an ultrasound-based framework called vector projectile imaging (VPI) that can dynamically render complex flow patterns over an imaging view at millisecond time resolution. The VPI apparatus and methods comprise: (i) high-frame-rate broad-view data acquisition (based on steered plane wave firings); (ii) flow vector estimation derived from multi-angle Doppler analysis (coupled with data regularization and least-squares fitting); and (iii) dynamic visualization of color-encoded vector projectiles (with flow speckles displayed as adjunct).

公开(公告)号：US20180369453A1

公开(公告)日：2018-12-27

申请号：US16119633

申请日：2018-08-31

Applicant: VERSITECH LIMITED ,  City University of Hong Kong

Inventor： HOI MAN, KAREN WONG ,  WAI KWOK, KELVIN YEUNG ,  MAN CHEE, KENNETH CHEUNG ,  DIP KEI, KEITH LUK ,  KIN ON, JOHN LAM ,  KIM HO, PAUL CHU

IPC: A61L27/58 ,  A61L27/44 ,  C08L67/04

Abstract: Novel hybrid materials and fabrication methods thereof are provided. The novel hybrid materials can include a biodegradable polymer and a biodegradable metallic material. The hybrid material can also include a coupling agent between the biodegradable metallic material and the biodegradable polymer. A method of fabricating a hybrid material can include performing a surface treatment process on the biodegradable metallic material, and then either performing a solvent formation method or a thermal formation method.

公开(公告)号：US20180323384A1

公开(公告)日：2018-11-08

申请号：US16035793

申请日：2018-07-16

Applicant: VERSITECH LIMITED

Inventor： Chi Ming Che ,  Chi Fai Kui ,  Chi Chung Kwok

IPC: H01L51/00 ,  C09K11/06 ,  C07F15/00 ,  H01L51/50

CPC classification number: H01L51/0087 ,  C07F15/0086 ,  C09K11/06 ,  C09K2211/1029 ,  C09K2211/185 ,  H01L51/5012 ,  H01L51/5016

Abstract: Described herein are novel platinum(II) emitters. These materials show high emission quantum efficiency, a low self-quenching constant and are stable in thermal deposition process. Organic light-emitting diodes (OLEDs) fabricated from these materials can have pure green emission, high efficiency and low efficiency roll-off. The OLEDs can have a chemical structure of:

公开(公告)号：US20180312564A1

公开(公告)日：2018-11-01

申请号：US16030180

申请日：2018-07-09

Applicant: VERSITECH LIMITED

Inventor： ZHIWEI CHEN ,  LIN CHENG ,  ALLEN KA LOON CHEUNG ,  JINGYING ZHOU

IPC: C07K14/705 ,  A61K39/12 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K14/70503 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/55516 ,  C07K14/70521 ,  C07K16/2818 ,  C12N2740/16234

Abstract: The present invention pertains to antibodies against a novel isoform of human PD1 protein (Δ42PD1) that contains a 42-nucleotide in-frame deletion in exon 2. The invention also pertains to methods of using the antibodies against Δ42PD1 for the treatment for autoimmune disorders. In certain embodiments, the antibodies against Δ42PD1 are monoclonal.

公开(公告)号：US10080997B2

公开(公告)日：2018-09-25

申请号：US13839072

申请日：2013-03-15

Applicant: VERSITECH LIMITED

Inventor： Ho Cheung Shum ,  Alban Sauret ,  Zida Li ,  Yang Song

IPC: B01F3/08 ,  B01F17/00 ,  G01H3/04 ,  B01F13/00 ,  B01F15/02

CPC classification number: B01F3/0819 ,  B01F3/0807 ,  B01F13/0062 ,  B01F15/024 ,  B01F17/00 ,  G01H3/04

Abstract: A method and apparatus for generating droplets with a high level of uniformity in liquid systems that present a low interfacial tension. This method and apparatus utilize the breakup of the dispersed phase in a controlled fashion by periodically varying the pressure that drives the fluids so as to successfully generate emulsions with a good control over the size. The method and apparatus can be used for the formation of simple emulsion or double emulsion where a larger droplet contains one or more smaller droplets.

公开(公告)号：US10047137B2

公开(公告)日：2018-08-14

申请号：US14246811

申请日：2014-04-07

Applicant: VERSITECH LIMITED

Inventor： Zhiwei Chen ,  Lin Cheng ,  Allen Ka Loon Cheung ,  Jingying Zhou

IPC: C07K16/28 ,  C07K14/705 ,  A61K39/12 ,  A61K39/00

Abstract: The present invention pertains to antibodies against a novel isoform of human PD1 protein (Δ42PD1) that contains a 42-nucleotide in-frame deletion in exon 2. The invention also pertains to methods of using the antibodies against Δ42PD1 for the treatment for autoimmune disorders. In certain embodiments, the antibodies against Δ42PD1 are monoclonal.