公开(公告)号：US20210309622A1

公开(公告)日：2021-10-07

申请号：US17352382

申请日：2021-06-21

Applicant: Versitech Limited

Inventor： Yi Tsun Richard KAO ,  Peng GAO ,  Xuechen LI ,  Ming LIU

IPC: C07D295/08 ,  A61K9/00 ,  C07D215/58 ,  C07D217/06 ,  A61P31/04

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

公开(公告)号：US20230278971A1

公开(公告)日：2023-09-07

申请号：US18316254

申请日：2023-05-12

Applicant: Versitech Limited

Inventor： Yi Tsun Richard KAO ,  Peng GAO ,  Xuechen LI ,  Ming LIU

IPC: C07D295/08 ,  A61K9/00 ,  C07D215/58 ,  C07D217/06 ,  A61P31/04

CPC classification number: C07D295/08 ,  A61K9/0095 ,  C07D215/58 ,  C07D217/06 ,  A61P31/04

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II):




The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

公开(公告)号：US20220017462A1

公开(公告)日：2022-01-20

申请号：US17296088

申请日：2019-11-21

Applicant: Wuxi Biologics Ireland Limited ,  Versitech Limited

Inventor： Xuechen LI ,  Mingzhi JIN ,  Yue ZHANG ,  Li YIN ,  Jun WANG

IPC: C07D207/452 ,  C07C235/78 ,  C07D241/04 ,  C07C233/61 ,  C07K1/113 ,  A61K47/68

Abstract: Provided herein are novel ortho-Phthalaldehyde (OPA) containing linkers (OPA-L) and the use of OPA-L for the preparation of Antibody-drug conjugate (ADC) via the formation of Phthalimidine through the reaction of primary amine on antibody (e.g., residue of Lysine) and ortho-Phthalaldehyde. The advantage of this OPA-L is high reactivity and can be applied in different types of antibodies to form stably-linked conjugates. The use of OPA-L for the preparation of ADC is advantageous for mild and wide condition of conjugation, for instance, low percentage of organic solvent required, wide range of pH and temperature can be used.

公开(公告)号：US20200261438A1

公开(公告)日：2020-08-20

申请号：US16867540

申请日：2020-05-05

Applicant: Versitech Limited

Inventor： Yi Tsun Richard KAO ,  Peng GAO ,  Xuechen LI ,  Ming LIU

IPC: A61K31/4545 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/404 ,  A61K31/47 ,  A61K31/472 ,  A61K31/18 ,  A61K31/4458 ,  A61K31/4462 ,  A61K31/496 ,  A61P31/04

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

公开(公告)号：US20200069642A1

公开(公告)日：2020-03-05

申请号：US16679313

申请日：2019-11-11

Applicant: Versitech Limited

Inventor： Yi Tsun Richard KAO ,  Peng GAO ,  Xuechen LI ,  Ming LIU

IPC: A61K31/40 ,  A61K31/496 ,  A61K31/47 ,  A61K31/454 ,  A61K31/4453 ,  A61K31/444 ,  A61K31/4406 ,  A61K31/4402 ,  A61K31/404 ,  A61K31/18 ,  A61K31/167 ,  A61K31/357 ,  A61P31/04 ,  C07D317/60 ,  C07D295/26

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): The present methods include administering to a subject an effective amount of one or more compounds of Formula (I). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

公开(公告)号：US20230041593A1

公开(公告)日：2023-02-09

申请号：US17949184

申请日：2022-09-20

Applicant: Versitech Limited

Inventor： Yi Tsun Richard KAO ,  Peng GAO ,  Xuechen LI ,  Ming LIU

IPC: A61K31/40 ,  C07D295/26 ,  C07D317/60 ,  A61P31/04 ,  A61K31/357 ,  A61K31/167 ,  A61K31/18 ,  A61K31/404 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/444 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/47 ,  A61K31/496

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

公开(公告)号：US20250121045A1

公开(公告)日：2025-04-17

申请号：US18685422

申请日：2022-06-21

Applicant: Versitech Limited ,  City University of Hong Kong

Inventor： Xuechen LI ,  Ruohan WEI ,  Han LIU ,  Sheng CHEN ,  Xuemei YANG

IPC: A61K39/104 ,  A61K39/00 ,  A61K39/385 ,  A61K47/64 ,  A61P31/04

Abstract: Provided are compositions comprising chemically synthesized pseudaminic acid (Pse) conjugated to a carrier protein using the OPA chemistry, methods of using said compositions to stimulate immune responses in subjects and protect the vaccinated subjects from infections caused by Pse-producing A. baumannii.

公开(公告)号：US20210060121A1

公开(公告)日：2021-03-04

申请号：US16958028

申请日：2018-12-20

Applicant: VERSITECH LIMITED ,  THE HONG KONG POLYTECHNIC UNIVERSITY

Inventor： Xuechen LI ,  Kang JIN ,  Sheng CHEN ,  Kathy Hiu Laam PO

IPC: A61K38/15

Abstract: The invention pertains to a new class of cyclic peptides as antibiotics. The antibiotics of the invention are derivatives of teixobactin. Teixobactin is modified to develop teixobactin analogues with improved antibacterial and therapeutic properties. Pharmaceutical compositions comprising the antibiotics of the invention and pharmaceutically acceptable carriers or excipients are also provided. Further provided are methods of treating an infection by an agent in a subject by administering to the subject the antibiotics described herein.