公开(公告)号：US20210309622A1

公开(公告)日：2021-10-07

申请号：US17352382

申请日：2021-06-21

Applicant: Versitech Limited

Inventor： Yi Tsun Richard KAO ,  Peng GAO ,  Xuechen LI ,  Ming LIU

IPC: C07D295/08 ,  A61K9/00 ,  C07D215/58 ,  C07D217/06 ,  A61P31/04

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

公开(公告)号：US20220378751A1

公开(公告)日：2022-12-01

申请号：US17870855

申请日：2022-07-22

Applicant: VERSITECH LIMITED

Inventor： Yi Tsun Richard KAO ,  Hin Cheung Bill YAM ,  Peng GAO ,  Ho Ting IU

IPC: A61K31/426 ,  A61K31/427 ,  A61K31/7008 ,  A61K31/357 ,  A61P31/04

Abstract: The present invention can inhibit dihydrofolate reductase in a microorganism. In some aspects, it may also suppress pigment formation in gram negative bacteria. The suppression of pigment formation can also mediate virulence suppression on other Gram negative bacteria. As such, the compounds may be used for microbial infections. The compounds can potentiate the effects of one or more antimicrobial agents when co-administered. Compositions including the compounds are provided. The composition can further include at least one antibiotic.

公开(公告)号：US20200261438A1

公开(公告)日：2020-08-20

申请号：US16867540

申请日：2020-05-05

Applicant: Versitech Limited

Inventor： Yi Tsun Richard KAO ,  Peng GAO ,  Xuechen LI ,  Ming LIU

IPC: A61K31/4545 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/404 ,  A61K31/47 ,  A61K31/472 ,  A61K31/18 ,  A61K31/4458 ,  A61K31/4462 ,  A61K31/496 ,  A61P31/04

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

公开(公告)号：US20200069642A1

公开(公告)日：2020-03-05

申请号：US16679313

申请日：2019-11-11

Applicant: Versitech Limited

Inventor： Yi Tsun Richard KAO ,  Peng GAO ,  Xuechen LI ,  Ming LIU

IPC: A61K31/40 ,  A61K31/496 ,  A61K31/47 ,  A61K31/454 ,  A61K31/4453 ,  A61K31/444 ,  A61K31/4406 ,  A61K31/4402 ,  A61K31/404 ,  A61K31/18 ,  A61K31/167 ,  A61K31/357 ,  A61P31/04 ,  C07D317/60 ,  C07D295/26

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): The present methods include administering to a subject an effective amount of one or more compounds of Formula (I). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

公开(公告)号：US20230041593A1

公开(公告)日：2023-02-09

申请号：US17949184

申请日：2022-09-20

Applicant: Versitech Limited

Inventor： Yi Tsun Richard KAO ,  Peng GAO ,  Xuechen LI ,  Ming LIU

IPC: A61K31/40 ,  C07D295/26 ,  C07D317/60 ,  A61P31/04 ,  A61K31/357 ,  A61K31/167 ,  A61K31/18 ,  A61K31/404 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/444 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/47 ,  A61K31/496

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

公开(公告)号：US20190307729A1

公开(公告)日：2019-10-10

申请号：US16309516

申请日：2017-06-12

Applicant: VERSITECH LIMITED

Inventor： Yi Tsun Richard KAO ,  Hin Cheung Bill YAM ,  Peng GAO ,  Ho Ting IU

IPC: A61K31/426 ,  A61P31/04

Abstract: Compounds, pharmaceutical compositions, and methods for treatment of microbial infections are provided. The compounds can potentiate the therapeutic effects of one or more antimicrobial agents when co-administered. The compounds have antivirulence properties. Pharmaceutical compositions including the compounds and a pharmaceutically acceptable carrier are provided. The pharmaceutical composition can further include at least one antibiotic, such as, Gentamicin, amikacin, kanamycin, neomycin, spectinomycin, neamine or any combination thereof. The compounds and compositions can be used to treat or prevent microbial infections.

公开(公告)号：US20230278971A1

公开(公告)日：2023-09-07

申请号：US18316254

申请日：2023-05-12

Applicant: Versitech Limited

Inventor： Yi Tsun Richard KAO ,  Peng GAO ,  Xuechen LI ,  Ming LIU

IPC: C07D295/08 ,  A61K9/00 ,  C07D215/58 ,  C07D217/06 ,  A61P31/04

CPC classification number: C07D295/08 ,  A61K9/0095 ,  C07D215/58 ,  C07D217/06 ,  A61P31/04

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II):




The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.