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    Electrochemical cell and method of making an electrochemical cell
    21.
    发明授权
    Electrochemical cell and method of making an electrochemical cell 有权
    电化学电池和制造电化学电池的方法

    公开(公告)号：US09329150B2

    公开(公告)日：2016-05-03

    申请号：US14291990

    申请日：2014-05-30

    Applicant: AgaMatrix, Inc.

    Inventor： Ian Harding ,  Sridhar G. Iyengar

    IPC: G01N27/327 ,  G01N27/403 ,  C12Q1/00 ,  G01N27/30

    CPC classification number: G01N27/403 ,  C12Q1/004 ,  G01N27/30 ,  G01N27/3272 ,  Y10T29/49002 ,  Y10T29/49114 ,  Y10T29/49117 ,  Y10T156/1052 ,  Y10T156/1062 ,  Y10T156/1074

    Abstract: Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet.

    Abstract translation: 通过将具有结合开口的电阻片粘附到第一导电片上，精确地和精确地制造电化学测试电池。 然后通过电阻片和第一导电片冲切开切口。 开槽开口与电阻薄片中的第一个开口相交，并将第一个结合开口转变成电阻薄片中的凹口。 第二导电片被冲压成具有与第一导电片相对应的开槽开口，并且其粘接到电阻片的另一侧，使得开槽开口对准。 这种结构从周围的材料上被切割成一个电化学电池，该电化学电池具有用于接收由第一和第二导电片和电阻片中的凹口限定的样品的样品空间。

    Method and apparatus for assay of electrochemical properties
    23.
    发明授权
    Method and apparatus for assay of electrochemical properties 有权

    公开(公告)号：US09164054B2

    公开(公告)日：2015-10-20

    申请号：US14503529

    申请日：2014-10-01

    Applicant: AgaMatrix, Inc.

    Inventor： Sridhar G. Iyengar ,  Ian Harding

    IPC: G01N27/26 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/00 ,  G01N27/416 ,  G01N27/327

    CPC classification number: G01N27/26 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/001 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3274 ,  G01N27/4168

    Abstract: The presence of a select analyte in the sample is evaluated in an an electrochemical system using a conduction cell-type apparatus. A potential or current is generated between the two electrodes of the cell sufficient to bring about oxidation or reduction of the analyte or of a mediator in an analyte-detection redox system, thereby forming a chemical potential gradient of the analyte or mediator between the two electrodes After the gradient is established, the applied potential or current is discontinued and an analyte-independent signal is obtained from the relaxation of the chemical potential gradient. The analyte-independent signal is used to correct the analyte-dependent signal obtained during application of the potential or current. This correction allows an improved measurement of analyte concentration because it corrects for device-specific and test specific factors such as transport (mobility) of analyte and/or mediator, effective electrode area, and electrode spacing (and as a result, sample volume), without need for separate calibration values. The analysis can be performed using disposable test strips in a hand held meter, for example for glucose testing.

    Method and apparatus for monitoring alteration of flow characteristics in a liquid sample
    24.
    发明授权
    Method and apparatus for monitoring alteration of flow characteristics in a liquid sample 有权
    监测液体样品中流动特性变化的方法和装置

    公开(公告)号：US08999242B2

    公开(公告)日：2015-04-07

    申请号：US14092228

    申请日：2013-11-27

    Applicant: AgaMatrix, Inc.

    Inventor： Ian Harding ,  Sridhar G. Iyengar ,  Ha Nguyen ,  Richard Williams ,  Anoop Rao

    IPC: G01N33/49 ,  G01N27/26 ,  G01N33/86

    CPC classification number: G01N27/26 ,  G01N33/4905 ,  G01N33/86

    Abstract: A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes. Changes in observed current are indicative of flow through the device, and a cessation of flow indicates coagulation.

    Abstract translation: 用于测量凝血时间的装置由第一基底形成; 第二基板; 间隔层，其设置在所述第一和第二基板之间，所述间隔层具有形成在其中的开口，所述隔离件限定了样品接收室，通气的宿室和形成用于液体在样品接收室和宿室之间移动的导管的细长储存器; 设置在所述第一基板上的第一电极，所述第一电极通过所述间隔层中的第一开口暴露在所述储存部分中; 以及设置在所述第二基板上的第二电极，所述第二电极通过所述间隔层中的第二开口暴露在所述储存部分中。 本发明的装置与连接到第一和第二电极的装置组合使用，用于测量第一和第二电极之间的电流。 观察到的电流的变化表示通过该装置的流动，并且停止流动表示凝结。

    Analyte Determination Method and Analyte Meter
    25.
    发明申请
    Analyte Determination Method and Analyte Meter 有权
    分析物测定方法和分析计

    公开(公告)号：US20140326616A1

    公开(公告)日：2014-11-06

    申请号：US14278299

    申请日：2014-05-15

    Applicant: AgaMatrix, Inc.

    Inventor： Ian Harding ,  Richard Williams ,  Sridhar Iyengar

    IPC: G01N27/30

    CPC classification number: G01N27/3274 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/327 ,  G01N27/3272 ,  G01N27/3273

    Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.

    Abstract translation: 在施加到使用还原介体的电化学测试条的样品中的氧或红细胞的存在通过作为样品的温度的函数确定的添加剂校正因子来校正，并且反映 样品的氧气承载能力。 测量的氧气承载能力也可用于确定血细胞比容并区分血液样本和应用于测试条的对照溶液。

    Method and apparatus for monitoring alteration of flow characteristics in a liquid sample
    27.
    发明申请
    Method and apparatus for monitoring alteration of flow characteristics in a liquid sample 有权

    公开(公告)号：US20140116894A1

    公开(公告)日：2014-05-01

    申请号：US14092228

    申请日：2013-11-27

    Applicant: AgaMatrix, Inc.

    Inventor： Ian Harding ,  Sridhar G. Iyengar ,  Ha Nguyen ,  Richard Williams ,  Anoop Rao

    IPC: G01N27/26

    CPC classification number: G01N27/26 ,  G01N33/4905 ,  G01N33/86

    Abstract: A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes. Changes in observed current are indicative of flow through the device, and a cessation of flow indicates coagulation.

    Test Strip Coding and Quality Measurement
    29.
    发明申请
    Test Strip Coding and Quality Measurement 审中-公开

    公开(公告)号：US20180088071A1

    公开(公告)日：2018-03-29

    申请号：US15830897

    申请日：2017-12-04

    Applicant: AgaMatrix, Inc.

    Inventor： Steven Diamond ,  Martin Forest ,  Baoguo Wei ,  Ian Harding ,  Sridhar Iyengar

    IPC: G01N27/327 ,  B01L3/00

    CPC classification number: G01N27/3272 ,  B01L3/5023 ,  B01L3/545 ,  B01L2300/02

    Abstract: A test strip and analytical apparatus have pin connections permitting the definition of geographic regions or of particular customers. A test strip made for use in a particular region or for a particular customer will have pin connections matching features of the apparatus made for use in that region or by that customer. Insertion of the strip into the apparatus does not merely turn on the apparatus, but provides the regional or customer coding. Analog switches within the apparatus allow coding of a larger number of distinct regions or customers than would otherwise be possible, all without degrading the quality of the measurements made of the fluid being tested. Conductive paths in the strips permit testing the strips during manufacture so as to detect quality lapses regarding the printing or deposition of the paths.

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