公开(公告)号：US20230079737A1

公开(公告)日：2023-03-16

申请号：US17940883

申请日：2022-09-08

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： Joshua LaBaer ,  Jie Wang ,  Ji Qiu ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC: G01N33/574 ,  G01N33/564 ,  C07K16/30 ,  C12Q1/6886

Abstract: Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

公开(公告)号：US11543407B2

公开(公告)日：2023-01-03

申请号：US15308330

申请日：2015-05-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joseph Smith ,  Jennifer Blain Christen ,  Karen Anderson ,  Benjamin Katchman

IPC: G01N33/543 ,  B01L3/00 ,  G01N21/64 ,  G01N21/05 ,  A61B5/00

Abstract: A fully integrated miniaturized optical biosensor and methods of making the same are disclosed. The biosensor may include a fluid transport system and an optical system.

公开(公告)号：US20200182874A1

公开(公告)日：2020-06-11

申请号：US16743906

申请日：2020-01-15

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  NATIONAL CANCER INSTITUTE

Inventor： Joshua LaBaer ,  Jie Wang ,  Ji Qui ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC: G01N33/574 ,  C12Q1/6886 ,  C07K16/30 ,  G01N33/564

Abstract: Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

公开(公告)号：US10591474B2

公开(公告)日：2020-03-17

申请号：US15579038

申请日：2016-05-06

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Benjamin Katchman ,  Karen Anderson ,  Joseph Smith ,  Jennifer Blain Christen

IPC: G01N33/543 ,  G01N33/58 ,  B01L3/00 ,  G01N21/64 ,  G01N33/68

Abstract: Systems and methods for low-cost point-of-care immunoassay are provided. The system comprises an emitter, two optical interference filters, a microscope slide, a photodiode detector, a circuit, and a measuring unit. The detector is placed upon the second filter, the slide, the first filter, and then the emitter. The emitter comprises non-organic light emitting diodes (LEDs) or organic light emitting diodes (OLEDs) that emits light of a first color. The slide is spotted with biofluid from a patient. Biomarkers in the biofluid is bound with immobilized fluorophores that emit light of a second color when stimulated by the light of the first color. The first and second filters band-pass the light of the first and second colors, respectively. The detector detects light of the second color. The current outputted from the detector is converted into a relatively-large output voltage by a circuit. A measuring unit measures the ramp time of the output voltage. The ramp time is to be used to determine the concentration of the fluorophores, which in turn is related to the concentration of the biomarkers.

公开(公告)号：US20180172681A1

公开(公告)日：2018-06-21

申请号：US15579038

申请日：2016-05-06

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Benjamin Katchman ,  Karen Anderson ,  Joseph Smith ,  Jennifer Blain Christen

IPC: G01N33/543 ,  G01N33/58 ,  G01N33/68 ,  B01L3/00 ,  G01N21/64

CPC classification number: G01N33/54373 ,  B01L3/502715 ,  G01N21/6428 ,  G01N33/54386 ,  G01N33/58 ,  G01N33/582 ,  G01N33/6857 ,  G01N2333/025

Abstract: Systems and methods for low-cost point-of-care immunoassay are provided. The system comprises an emitter, two optical interference filters, a microscope slide, a photodiode detector, a circuit, and a measuring unit. The detector is placed upon the second filter, the slide, the first filter, and then the emitter. The emitter comprises non-organic light emitting diodes (LEDs) or organic light emitting diodes (OLEDs) that emits light of a first color. The slide is spotted with biofluid from a patient. Biomarkers in the biofluid is bound with immobilized fluorophores that emit light of a second color when stimulated by the light of the first color. The first and second filters band-pass the light of the first and second colors, respectively. The detector detects light of the second color. The current outputted from the detector is converted into a relatively-large output voltage by a circuit. A measuring unit measures the ramp time of the output voltage. The ramp time is to be used to determine the concentration of the fluorophores, which in turn is related to the concentration of the biomarkers.

公开(公告)号：US20170177788A1

公开(公告)日：2017-06-22

申请号：US15128405

申请日：2015-03-18

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Karen Anderson ,  Immanuel Purushothaman

IPC: G06F19/22 ,  G06F17/30 ,  G06F19/28

CPC classification number: G16B30/00 ,  G06F16/2455 ,  G06F16/285 ,  G16B20/00 ,  G16B50/00

Abstract: A computer-based bioinformatics method for identifying protein sequence differences between sets of sequences grouped into different phenotype data sets that involves querying a database to identify common sequence motifs within a first phenotype data set and another phenotype data set of protein sequences, computing a pairwise correlation among motifs for each data set, and computing the variation between the data sets to identify one or more motifs that are conserved in a given data set and thus correlate with that data set's phenotype.

公开(公告)号：US20170045515A1

公开(公告)日：2017-02-16

申请号：US15307112

申请日：2015-03-16

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Karen Anderson ,  Marshall Posner ,  Joshua LaBaer

IPC: G01N33/569 ,  G01N33/574

CPC classification number: G01N33/56983 ,  G01N33/57411 ,  G01N2333/025 ,  G01N2469/20

Abstract: Provided herein are methods for the rapid detection of HPV types, such as HPV 16- and HPV18-specific antibodies, in patient samples that contain antibodies. For example, patients with head and neck cancers have detectable antibodies to multiple early genes derived from HPV. These antibodies also are useful as biomarkers for HPV-associated malignancies and premalignant states, for diagnosis and prognosis, and for methods of assessing treatment and cancer-recurrence prediction.

Abstract translation: 本文提供了用于在含有抗体的患者样品中快速检测HPV类型（例如HPV16-和HPV18-特异性抗体）的方法。 例如，患有头颈部癌症的患者对来自HPV的多个早期基因具有可检测的抗体。 这些抗体还可用作HPV相关恶性肿瘤和恶化前状态的生物标志物，用于诊断和预后，以及评估治疗和癌症复发预测的方法。