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    SAMPLE SEPARATION DEVICE WITH FLUID DRIVE UNIT DECOUPLING
    21.
    发明申请
    SAMPLE SEPARATION DEVICE WITH FLUID DRIVE UNIT DECOUPLING 有权

    公开(公告)号：US20250146984A1

    公开(公告)日：2025-05-08

    申请号：US18932428

    申请日：2024-10-30

    Applicant: Agilent Technologies, Inc.

    Inventor： Blasius Nocon ,  Konstantin Shoykhet ,  Tobias Meier ,  Karsten Lehradt

    IPC: G01N30/36 ,  G01N30/02 ,  G01N30/32

    Abstract: A sample separation apparatus includes a fluid drive arrangement having a first fluid drive unit and a second fluid drive unit for driving a mobile phase along a flow path to a sample separation unit, a sample accommodation volume configured to accommodate the fluidic sample and to be selectively fluidically coupleable with the flow path or fluidically decoupleable from the flow path, and a control unit configured to control respective operations of the fluid drive units, and to control a fluidically decoupling of the second fluid drive unit from the flow path in a decoupled operation mode of the sample separation apparatus. The control unit is further configured to control, in the decoupled operation mode, the decoupled second fluid drive unit for fluidically coupling to the sample accommodation volume, and intaking sample into the sample accommodation volume.

    DEGASSER WITH TWO WEAKLY COUPLED SPACES AND/OR WITH A RESTRICTION ADJUSTMENT DEVICE
    22.
    发明公开
    DEGASSER WITH TWO WEAKLY COUPLED SPACES AND/OR WITH A RESTRICTION ADJUSTMENT DEVICE 审中-公开

    公开(公告)号：US20240033658A1

    公开(公告)日：2024-02-01

    申请号：US18227107

    申请日：2023-07-27

    Applicant: Agilent Technologies, Inc.

    Inventor： Manfred Berndt ,  Konstantin Shoykhet

    IPC: B01D19/00 ,  B01D15/16

    CPC classification number: B01D19/0031 ,  B01D15/166

    Abstract: A degasser for degassing a mobile phase includes a degasser chamber with a degasser volume for receiving a degassing membrane, a delimiting unit for delimiting a first space of the degasser volume with respect to a second space of the degasser volume while maintaining a fluid connection between the first space and the second space. The first space in an operation in an environment of the degassing membrane includes a higher partial pressure of vapor of the mobile phase than the second space with a lower partial pressure of vapor of the mobile phase. The degasser further includes a suction unit for sucking a gas that passed through the degassing membrane from the second space, and/or an associated gas supply unit for supplying an associated gas in the second space or in a fluid conduit that is connected to the second space.

    Multi-dimensional liquid chromatography with second dimension having a variable flow rate
    23.
    发明授权
    Multi-dimensional liquid chromatography with second dimension having a variable flow rate 有权

    公开(公告)号：US11808742B2

    公开(公告)日：2023-11-07

    申请号：US17446096

    申请日：2021-08-26

    Applicant: Agilent Technologies, Inc.

    Inventor： Konstantin Shoykhet ,  Stephan Buckenmaier

    IPC: G01N30/46 ,  G01N30/14 ,  G01N30/32 ,  G01N30/02

    CPC classification number: G01N30/46 ,  G01N30/14 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/324 ,  G01N2030/326

    Abstract: A multi-dimensional liquid chromatography system includes first and second liquid chromatography systems. The first system is configured for providing a first chromatographic separation of a sample fluid comprised in a first mobile phase and to provide a first effluent including at least a portion of the separated sample fluid. The second system is configured for providing a second chromatographic separation of at least a portion of the first effluent comprised in a second mobile phase. A control unit is configured to operate the first liquid chromatography system by maintaining a first flow rate of the first mobile phase substantially constant during the first chromatographic separation, and to operate the second liquid chromatography system during the second chromatographic separation according to a control value different from the second flow rate, so that a variation in the control value can lead to a variation in the second flow rate.

    Injector with fluid supply and mobile phase discharge
    25.
    发明授权
    Injector with fluid supply and mobile phase discharge 有权

    公开(公告)号：US11567040B2

    公开(公告)日：2023-01-31

    申请号：US16760429

    申请日：2018-10-26

    Applicant: Agilent Technologies, Inc.

    Inventor： Thomas Ortmann ,  Konstantin Shoykhet

    IPC: G01N30/08 ,  G01N30/20 ,  G01N30/32 ,  G01N30/36

    Abstract: Injector (40) for injecting a fluidic sample into a mobile phase in a sample separation apparatus (10), the injector (40) comprising a main flow path (100) between a fluid drive (20) and a sample separation device (30), wherein the fluid drive (20) is adapted to drive the mobile phase and the sample separation device (30) is adapted to separate the fluidic sample that is injected into the mobile phase, a discharge device (104) for discharging an, in particular predetermined, amount of the mobile phase from the main flow path (100), and a supply device (102) for supplying an, in particular predetermined, amount of the fluidic sample and/or of a solvent into the main flow path (100), wherein the discharged amount and the supplied amount compensate each other at least partially.

    FLUID PROCESSING WITH WITHDRAW-TRANSFER MODULATION
    26.
    发明申请
    FLUID PROCESSING WITH WITHDRAW-TRANSFER MODULATION 有权

    公开(公告)号：US20220283129A1

    公开(公告)日：2022-09-08

    申请号：US17631924

    申请日：2020-07-30

    Applicant: Agilent Technologies, Inc.

    Inventor： Dwight Robert Stoll ,  Konstantin Shoykhet ,  Thomas Ortmann ,  Stephan Buckenmaier ,  Sascha Lege

    IPC: G01N30/46

    Abstract: A fluid processing apparatus includes a first fluid processing unit and a second fluid processing unit. A fluid unit is fluidically coupled to the first fluid processing unit and includes a first buffering unit configured for buffering fluid, and/or a mask flow source configured for providing a mask fluid or a flow thereof. A first coupling point is fluidically coupled between the first fluid processing unit and the fluid unit. A modulation unit is configured, selectively, for withdrawing fluid from the first coupling point, or for transferring withdrawn fluid into the second fluid processing unit. The apparatus may be utilized for chromatography.

    HPLC sample introduction with bypass channel
    27.
    发明授权
    HPLC sample introduction with bypass channel 有权

    公开(公告)号：US10953345B2

    公开(公告)日：2021-03-23

    申请号：US14252711

    申请日：2014-04-14

    Applicant: AGILENT TECHNOLOGIES, INC.

    Inventor： Klaus Witt ,  Konstantin Shoykhet ,  Dwight Stoll

    IPC: B01D15/14 ,  G01N30/20 ,  G01N30/46

    Abstract: A sample dispatcher is disclosed and is configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a liquid separation system. The liquid separation system is configured for separating compounds of the sample fluids and comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises one or more sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof, and a bypass channel.

    CORRECTED FLOW REPORTING UNDER DYNAMIC CONDITIONS BY SYSTEM MODELING
    28.
    发明申请
    CORRECTED FLOW REPORTING UNDER DYNAMIC CONDITIONS BY SYSTEM MODELING 审中-公开

    公开(公告)号：US20190064124A1

    公开(公告)日：2019-02-28

    申请号：US15691202

    申请日：2017-08-30

    Applicant: Agilent Technologies, Inc.

    Inventor： Klaus Witt ,  Konstantin Shoykhet ,  Philip Herzog ,  Iwan Bouzid

    IPC: G01N30/32 ,  G01N30/20 ,  G01N30/86

    Abstract: To determine a corrected flow rate value of a mobile phase flowing in a liquid chromatography (LC) system, a flow rate of the mobile phase at a selected reference position in the LC system is measured to produce one or more flow rate values. A model of the LC system is applied to the flow rate value(s) to determine the corrected flow rate value(s). The model includes a distribution of capacitive elements and resistive elements arranged according to a topology of the LC system. The capacitive and resistive elements are representative of system and solvent properties affecting flow rate while operating the LC system. The system and solvent properties may be properties affecting the flow rate while operating the LC system under dynamic conditions.

    UNINTERRUPTED FLUID FLOW WHILE MODULATING FLUID
    30.
    发明申请
    UNINTERRUPTED FLUID FLOW WHILE MODULATING FLUID 审中-公开
    调制流体上的不中断流体流动

    公开(公告)号：US20160334031A1

    公开(公告)日：2016-11-17

    申请号：US14975342

    申请日：2015-12-18

    Applicant: Agilent Technologies, Inc.

    Inventor： Konstantin Shoykhet ,  Klaus Witt ,  Stephan Buckenmaier ,  Dwight Stoll

    IPC: F16K99/00 ,  B01D15/10 ,  G01N27/447 ,  B01L3/00

    CPC classification number: F16K99/0028 ,  B01D15/10 ,  B01D15/1878 ,  B01D15/40 ,  B01L3/50273 ,  B01L2400/0475 ,  F16K2099/0084 ,  G01N27/44791 ,  G01N30/32 ,  G01N30/465 ,  G01N2030/202 ,  G01N2030/328

    Abstract: A fluid processing device (10) for processing fluid, wherein the fluid processing device (10) comprises a first fluid drive unit (20) configured for driving a first fluid along a first flow path (85), a second fluid drive unit (20′) configured for driving a second fluid along a second flow path (86), and a fluidic switch (90) fluidically coupled to the first flow path (85) and to the second flow path (86) and configured for being switchable for transferring first fluid from the first flow path (85) into the second flow path (86) without interruption of fluid flow along at least one of the first flow path (85) and the second flow path (86).

    Abstract translation: 一种用于处理流体的流体处理装置（10），其中所述流体处理装置（10）包括构造成沿着第一流动路径（85）驱动第一流体的第一流体驱动单元（20），第二流体驱动单元 被配置为沿着第二流动路径（86）驱动第二流体的流体开关（90）以及流体连接到第一流动路径（85）和第二流动路径（86）的流体开关（90），并被配置为可转换 第一流体从第一流动路径（85）进入第二流动路径（86），而不中断沿着第一流动路径（85）和第二流动路径（86）中的至少一个的流体流动。

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