公开(公告)号：US20200225197A1

公开(公告)日：2020-07-16

申请号：US16833181

申请日：2020-03-27

Applicant: Agilent Technologies, Inc.

Inventor： Daniel Thielsch ,  Thomas Ortmann ,  Sam Wouters

IPC: G01N30/20 ,  G01N30/32

Abstract: An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. A control unit controls a pressure of the fluid and/or the further fluid during injecting.

公开(公告)号：US10473632B2

公开(公告)日：2019-11-12

申请号：US15525674

申请日：2014-11-10

Applicant: Agilent Technologies, Inc.

Inventor： Daniel Thielsch ,  Thomas Ortmann

IPC: G01N30/20 ,  B01D15/12 ,  B01D15/14 ,  B01D15/16 ,  B01D15/26 ,  G01N30/02

Abstract: A sample injector configured to introduce a sample fluid into a mobile phase, wherein the mobile phase is to be driven by a mobile phase drive through a separation unit for separating compounds of the sample fluid in the mobile phase, wherein the sample injector comprises a metering device being operable for displacing fluid and for intaking a metered amount of the sample fluid into the sample injector, an injector valve being switchable for operating the sample injector selectively in a sample intake mode in which the metering device is operable to intake the sample fluid from a sample container, or a separation mode in which intaken sample fluid is driven between the mobile phase drive and the separation unit for separating the compounds, and a flow direction controller configured for defining an enabled flow direction of fluid displaced by the metering device and for defining a disabled flow direction.

公开(公告)号：US20170343518A1

公开(公告)日：2017-11-30

申请号：US15608903

申请日：2017-05-30

Applicant: Agilent Technologies, Inc.

Inventor： Daniel Thielsch ,  Thomas Ortmann

IPC: G01N30/06 ,  G01N30/20 ,  G01N30/22

CPC classification number: G01N30/06 ,  F16K11/074 ,  G01N30/20 ,  G01N30/22 ,  G01N30/32 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

Abstract: An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. A control unit controls a pressure of the fluid and/or the further fluid during injecting.

公开(公告)号：US20240201143A1

公开(公告)日：2024-06-20

申请号：US18430447

申请日：2024-02-01

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Martin Seifried ,  Sam Wouters ,  Irina Spuling

IPC: G01N30/20 ,  G01N30/02 ,  G01N30/14 ,  G01N30/32

CPC classification number: G01N30/20 ,  G01N30/14 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/326

Abstract: A sample separation device includes a separation path and a control unit. The separation path is between a fluid drive and a sample separation unit, and is configured to inject a fluidic sample in an injector path into a mobile phase in the separation path driven by the fluid drive to the sample separation unit for chromatographically separating the fluidic sample. The control unit is configured to control blocking the injector path or at least a partial path thereof, generating an overpressure in the blocked injector path or the partial path thereof by a pressure source, and subsequently fluidically coupling the injector path or the partial path thereof to a region of lower pressure than the overpressure to generate an expansion stroke for releasing unwanted components from the injector path.

公开(公告)号：US11921093B2

公开(公告)日：2024-03-05

申请号：US17584250

申请日：2022-01-25

Applicant: Agilent Technologies, Inc.

Inventor： Daniela Loraing ,  Lena Höninger ,  Uwe Effelsberg ,  Andreas Otto ,  Ansgar Waldbaur ,  Armin Steinke ,  Thomas Ortmann ,  Michael Lang

IPC: G01N30/60

CPC classification number: G01N30/6047

Abstract: A mounting device for mounting a sample separation unit configured for separating, preferably chromatographically separating, compounds in a fluidic sample includes a first fluid connector configured for being mechanically and fluidically coupled with a first fluid interface of the sample separation unit, a second fluid connector configured for being mechanically and fluidically coupled with a second fluid interface of the sample separation unit, and a swivel mechanism configured for swivelling the first fluid connector between a mounting orientation for mounting the first fluid interface of the sample separation unit at the first fluid connector and an alignment orientation for aligning the second fluid interface of the mounted sample separation unit with the second fluid connector for subsequently coupling the second fluid interface with the second fluid connector.

公开(公告)号：US11835495B2

公开(公告)日：2023-12-05

申请号：US17566330

申请日：2021-12-30

Applicant: Agilent Technologies, Inc.

Inventor： Daniel Thielsch ,  Thomas Ortmann ,  Sam Wouters

IPC: G01N30/20 ,  G01N30/32 ,  G01N30/02

CPC classification number: G01N30/20 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/328

Abstract: An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the separation unit and further fluid driven by the fluid drive and flowing from the fluid drive to the separation unit are combined at a fluidic connection upstream of the separation unit. A control unit controls a pressure of the fluid and/or the further fluid during injecting.

公开(公告)号：US20230296571A1

公开(公告)日：2023-09-21

申请号：US18018540

申请日：2021-07-29

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Blasius Nocon ,  Armin Steinke ,  Christian Daniel Ruf

IPC: G01N30/20

CPC classification number: G01N30/20 ,  G01N2030/027

Abstract: A valve may be utilized in a high-performance chromatography system for separating components of a sample liquid introduced into a mobile phase. The valve has a first valve element and a second valve element. By a movement of one valve element relative to the other, a first effective surface of the first valve element is brought into connection with a second effective surface of the second valve element, and a flow path may be produced or suppressed. The second valve element has an elastic region to compensate for an axial angle between the first valve element and the second valve element, such that the first effective surface and the second effective surface may be oriented parallel to each other. This may favorably influence a fluidic leak tightness and/or longevity of the valve.

公开(公告)号：US11567040B2

公开(公告)日：2023-01-31

申请号：US16760429

申请日：2018-10-26

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Konstantin Shoykhet

IPC: G01N30/08 ,  G01N30/20 ,  G01N30/32 ,  G01N30/36

Abstract: Injector (40) for injecting a fluidic sample into a mobile phase in a sample separation apparatus (10), the injector (40) comprising a main flow path (100) between a fluid drive (20) and a sample separation device (30), wherein the fluid drive (20) is adapted to drive the mobile phase and the sample separation device (30) is adapted to separate the fluidic sample that is injected into the mobile phase, a discharge device (104) for discharging an, in particular predetermined, amount of the mobile phase from the main flow path (100), and a supply device (102) for supplying an, in particular predetermined, amount of the fluidic sample and/or of a solvent into the main flow path (100), wherein the discharged amount and the supplied amount compensate each other at least partially.

公开(公告)号：US20220341897A1

公开(公告)日：2022-10-27

申请号：US17730553

申请日：2022-04-27

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Martin Seifried ,  Sam Wouters ,  Irina Spuling

IPC: G01N30/20 ,  G01N30/14 ,  G01N30/32

Abstract: An injector is configured for injecting a fluidic sample from an injector path into a mobile phase in a separation path between a fluid drive and a sample separation unit of a sample separation device. The injector includes a control unit configured for generating a first overpressure in a blocked first partial path of the injector path by a first pressure source, for generating a second overpressure in a blocked second partial path of the injector path by a second pressure source, for subsequently fluidically coupling the first partial path with the second partial path for generating an expansion stroke for releasing a gas bubble in the injector path, and for rinsing the released gas bubble from the injector path.

公开(公告)号：US20220283129A1

公开(公告)日：2022-09-08

申请号：US17631924

申请日：2020-07-30

Applicant: Agilent Technologies, Inc.

Inventor： Dwight Robert Stoll ,  Konstantin Shoykhet ,  Thomas Ortmann ,  Stephan Buckenmaier ,  Sascha Lege

IPC: G01N30/46

Abstract: A fluid processing apparatus includes a first fluid processing unit and a second fluid processing unit. A fluid unit is fluidically coupled to the first fluid processing unit and includes a first buffering unit configured for buffering fluid, and/or a mask flow source configured for providing a mask fluid or a flow thereof. A first coupling point is fluidically coupled between the first fluid processing unit and the fluid unit. A modulation unit is configured, selectively, for withdrawing fluid from the first coupling point, or for transferring withdrawn fluid into the second fluid processing unit. The apparatus may be utilized for chromatography.