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公开(公告)号：US20230330686A1
公开(公告)日：2023-10-19
申请号：US18134629
申请日：2023-04-14
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters
CPC classification number: B04B13/00 , G01N21/31 , G01N33/491 , B04B5/0442 , G01N2001/4083
Abstract: Systems and methods are provided for determining and controlling the location of an interface between separated fluid components within a channel of a centrifugal separation chamber being rotated about a rotational axis. Light from a light source is received by a collimator, which directs collimated light through the channel in a direction substantially parallel to the rotational axis. At least a portion of the collimated light exiting the channel is received by a light detector configured as a photodetector array. A signal emitted by the light detector is received by a controller, which determines the location of an interface between separated fluid components within the channel based at least in part on the signal. When the controller determines that the interface is not at a target location within the channel, the controller controls a centrifugal separator and/or a pump system to move the interface to the target location.
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公开(公告)号：US20230226264A1
公开(公告)日：2023-07-20
申请号：US18154949
申请日：2023-01-16
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters
IPC: A61M1/36
CPC classification number: A61M1/3693
Abstract: A device and method for separating whole blood includes flowing whole blood to a centrifuge, separating whole blood into blood components within the centrifuge, and flowing separated blood components out of the centrifuge. The device and method include a flow rate stoppage phase executed one or more times during the method. The flow rate stoppage phase includes (i) stopping the flow of whole blood to the centrifuge and stopping the flow of separated blood components out of the centrifuge; (ii) spinning the centrifuge at a selected rate; and (iii) after a selected time ending the flow rate stoppage phase and resuming the flow of whole blood to the centrifuge and the flow of separated blood components out of the centrifuge.
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公开(公告)号：US20220314237A1
公开(公告)日：2022-10-06
申请号：US17712531
申请日：2022-04-04
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Richard I. Brown , Kyungyoon Min
Abstract: Fluid separation chambers are provided with a central hub, with generally annular low- and high-G walls extending about the hub to define therebetween a separation channel. A plurality of radial walls extend from the hub to the channel to define an inlet passage and two outlet passages. The low-G wall may include an air drain taper and/or a decreased radius adjacent to an associated outlet passage. The radius of the low-G wall and (optionally) the high-G wall may gradually decrease from an upstream end of the channel to a downstream end for improved separation. A ramp may extend across the channel, with a bottom end positioned adjacent to the bottom end of the channel, where the outlet passages open into the channel. The outlet passage associated with the high-G wall may open into the channel at an upstream end of the ramp or at the upstream end of the channel.
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24.发明授权公开(公告)号：US10682611B2
公开(公告)日：2020-06-16
申请号：US15894307
申请日：2018-02-12
Applicant: Fenwal, Inc.
Inventor： Richard I. Brown , Benjamin E. Kusters , Kyungyoon Min
Abstract: A system for separating a suspension of biological cells is disclosed comprising a single-use fluid circuit and a durable hardware component. The fluid circuit comprises a separator having a housing that includes an inlet for introducing the suspension of biological cells into the gap, a first outlet in communication with the gap for flowing a first type of cells from the separator, and a second outlet in communication with the second side of the filter membrane for flowing a second type of cells from the separator. The hardware component comprises a pump for flowing the suspension of biological cells to the inlet of the separator and at least one flow control device associated with the first outlet and the second outlet of the separator for selectively opening and closing the outlets so as to permit one of the first type of cells and the second type of cells to flow out of the separator in accordance with a predetermined duty cycle equal to the ratio of a target flow rate of first type of cells through the first outlet to the predetermined inlet flow rate.
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公开(公告)号：US10300189B2
公开(公告)日：2019-05-28
申请号：US15122060
申请日：2014-04-30
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min , Christopher J. Wegener , Daniel R. Boggs
Abstract: A system and method are provided for controlling fouling and complement protein activation during separation of plasma from whole blood using a spinning membrane separator. The separator includes a pair of relatively rotating surfaces spaced apart to define a gap therebetween, with at least one of the surfaces comprising a membrane that allows plasma to pass therethrough but substantially prevents the passage of red cells. In accordance with the method, the membrane material and membrane fabrication technique are selected so as that the resulting membrane both resists fouling and complement protein activation. In a specific embodiment, the membrane is has a smooth surface and substantially linear pores. The pores have a nominal diameter of less than 2 microns (so as to exclude platelets) and preferably a diameter of from 0.6 microns to 0.8 microns, as may be obtained by use of track-etching. In addition, the membrane material preferably is polycarbonate, as it has been determined that polycarbonate does not activate complement proteins.
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Patent Agency Ranking
公开(公告)号：US20190070354A1
公开(公告)日：2019-03-07
申请号：US16124796
申请日：2018-09-07
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min
Abstract: A system for controlling a fluid procedure comprising a reusable separation apparatus controlled by a microprocessing controller. A sterile circuit is configured to associate with the reusable separation apparatus and provide a first fluid flow path in association with a pressure sensor in communication with the controller and a first pump configured to transmit pulsatile pressure signals to the pressure sensor during operation in association with the first fluid flow path. The reusable apparatus and the controller are configured to receive from the pressure sensor pressure signals comprising the pulsatile pressure signals, perform a frequency analysis of the pressure signals received by the pressure sensor over a time duration, derive a first rotation rate of the first pump or a first fluid flow rate at the first pump from the frequency analysis, and provide a response action based on the first rotation rate or the first fluid flow rate.
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公开(公告)号：US20190046710A1
公开(公告)日：2019-02-14
申请号：US16101185
申请日：2018-08-10
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min
Abstract: A computer-implemented method comprises providing a fluid circuit comprising fluid pathways configured to mount and associate with a durable processing device comprising a pressure sensor in communication with a controller and a fluid pathway. A container is connected to the pressure sensor and may receive a volume of fluid. A change in pressure values between a first and second time is measured from when the volume of fluid is not in communication with the pressure sensor to when the volume of fluid is in communication with the pressure sensor, the volume of fluid within the container or a presence or absence of a fluid connection to the fluid pathway based on the change in pressure values is determined, and a response action is executed if the volume of fluid within the container is not within an authorized volume range for the time period, or if a fluid connection is unauthorized.
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公开(公告)号：US20180354202A1
公开(公告)日：2018-12-13
申请号：US15978487
申请日：2018-05-14
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Kyungyoon Min
CPC classification number: A61M39/14 , A61M39/146 , A61M39/18 , B29C65/02 , B29C66/032 , B29C66/5221 , B29C66/73921 , B29C66/857
Abstract: Method and apparatus are disclosed for mechanically opening a heat-bonded connection site between two hollow, flexible, thermoplastic segments of a medical fluid flow path, the heat-bonded connection site having an axis. The connection site is compressed between two facing surfaces, and the facing surfaces are relatively moved to rotate the connection site about the connection site axis and to apply force to the connection site substantially perpendicular to the connection site axis.
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公开(公告)号：US20180311430A1
公开(公告)日：2018-11-01
申请号：US15768140
申请日：2016-10-13
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Mark J. Brierton
CPC classification number: A61M1/265 , A61M1/0281 , A61M1/3633 , A61M2205/121 , A61M2209/086
Abstract: A fluid flow circuit assembly for a fluid processing device, comprising a housing having a plurality of openings, a separator disposed at least partially within the housing, and a plurality of flow paths communicating between an interior and an exterior of the housing via the plurality of openings, wherein the separator is disposed substantially at the center of the plurality of flow paths.
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30.发明申请公开(公告)号：US20180303997A1
公开(公告)日：2018-10-25
申请号：US16025432
申请日：2018-07-02
Applicant: Fenwal, Inc.
Inventor： Benjamin E. Kusters , Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min , William H. Cork , Daryl R. Calhoun , Bryan Blickman , Daniel Lynn
CPC classification number: A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
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