-
公开(公告)号：US20210325254A1
公开(公告)日：2021-10-21
申请号：US17224466
申请日：2021-04-07
Applicant: IMEC VZW , Katholieke Universiteit Leuven, KU LEUVEN R&D
Inventor： Niels Verellen , Dmitry Kouznetsov , Pol Van Dorpe
Abstract: Example embodiments relate to methods and devices for generating (quasi-) periodic interference patterns. One embodiment includes a method for generating an interference pattern using multi-beam interference of electromagnetic radiation. The method includes computing a set of grid points in a complex plane representing a grid with a desired symmetry. The method also includes selecting a radius of a virtual circle. Additionally, the method includes selecting a set of grid points in the complex plane that lies on the virtual circle centered around a virtual center point. Further, the method includes associating an argument of each grid point of the selected set of grid points in the complex plane with a propagation direction of plane waves or quasi plane waves or parallel wave fronts. In addition, the method includes obtaining the interference pattern that is a superposition of the plane waves or quasi plane waves or parallel wave fronts.
-
公开(公告)号：US11096608B2
公开(公告)日：2021-08-24
申请号：US15100067
申请日：2014-12-03
Applicant: IMEC VZW
Inventor： Pol Van Dorpe , Peter Peumans
Abstract: The present disclosure relates to devices and methods for non-invasive measuring of analytes. At least one embodiment relates to a wearable system for non-invasive measuring of a concentration of an analyte in skin tissue. The wearable system includes an integrated circuit that includes a first optical unit. The first optical unit includes a Raman spectrometer. The first optical unit also includes an OCT spectrometer and an interferometer optically coupled to the OCT spectrometer or an infrared (IR) spectrometer. The first optical unit additionally includes a light coupler. The wearable system further includes a first light source for performing Raman spectroscopy. The wearable system additionally includes a second light source for performing OCT spectroscopy or IR spectroscopy. Still further, the wearable system includes read-out electronics to determine an optical model of the skin tissue based on the spectroscopic data and to determine the concentration of the analyte.
-
公开(公告)号：US10928305B2
公开(公告)日：2021-02-23
申请号：US15736399
申请日：2016-06-30
Applicant: IMEC VZW
Inventor： Peter Peumans , Liesbet Lagae , Willem Van Roy , Tim Stakenborg , Pol Van Dorpe
Abstract: A sensor device for quantifying luminescent targets comprises a light source, a detector, a modulator, and a processor. The light source is adapted for exciting the luminescent target. The detector is adapted for detecting the luminescence of the luminescent target resulting in a measured signal which comprises a desired signal originating from the luminescent target and a background signal. The modulator is adapted for modulating a physical parameter resulting in a modulation of the desired signal which is different from the modulation of the background signal. The processor is configured to correlate the modulation of the physical parameter with the modulation of the desired signal and/or the modulation of the background signal.
-
公开(公告)号：US10267998B2
公开(公告)日：2019-04-23
申请号：US15538572
申请日：2015-12-28
Applicant: IMEC VZW
Inventor： Dries Vercruysse , Pol Van Dorpe , Xavier Rottenberg , Tom Claes , Richard Stahl
Abstract: Embodiments described herein relate to an imaging device, a method for imaging an object, and a photonic integrated circuit. The imaging device includes at least one photonic integrated circuit. The photonic integrated circuit includes an integrated waveguide for guiding a light signal. The photonic integrated circuit also includes a light coupler optically coupled to the integrated waveguide. The light coupler is adapted for directing the light signal out of a plane of the integrated waveguide as a light beam. The imaging device also includes a microfluidic channel for containing an object immersed in a fluid medium. The microfluidic channel is configured to enable, in operation of the imaging device, illumination of the object by the light beam. In addition, the imaging device includes at least one imaging detector positioned for imaging the object illuminated by the light beam.
-
公开(公告)号：US20180188156A1
公开(公告)日：2018-07-05
申请号：US15736399
申请日：2016-06-30
Applicant: IMEC VZW
Inventor： Peter Peumans , Liesbet Lagae , Willem Van Roy , Tim Stakenborg , Pol Van Dorpe
CPC classification number: G01N21/1717 , G01N21/645 , G01N21/648 , G01N2021/1731
Abstract: A sensor device for quantifying luminescent targets comprises a light source, a detector, a modulator, and a processor. The light source is adapted for exciting the luminescent target. The detector is adapted for detecting the luminescence of the luminescent target resulting in a measured signal which comprises a desired signal originating from the luminescent target and a background signal. The modulator is adapted for modulating a physical parameter resulting in a modulation of the desired signal which is different from the modulation of the background signal. The processor is configured to correlate the modulation of the physical parameter with the modulation of the desired signal and/or the modulation of the background signal.
-
Patent Agency Ranking
公开(公告)号：US20170351034A1
公开(公告)日：2017-12-07
申请号：US15538572
申请日：2015-12-28
Applicant: IMEC VZW
Inventor： Dries Vercruysse , Pol Van Dorpe , Xavier Rottenberg , Tom Claes , Richard Stahl
CPC classification number: G02B6/34 , G01N15/1436 , G01N15/1484 , G02B6/12 , G02B2006/12107 , G03H1/0443 , G03H2001/0447
Abstract: Embodiments described herein relate to an imaging device, a method for imaging an object, and a photonic integrated circuit. The imaging device includes at least one photonic integrated circuit. The photonic integrated circuit includes an integrated waveguide for guiding a light signal. The photonic integrated circuit also includes a light coupler optically coupled to the integrated waveguide. The light coupler is adapted for directing the light signal out of a plane of the integrated waveguide as a light beam. The imaging device also includes a microfluidic channel for containing an object immersed in a fluid medium. The microfluidic channel is configured to enable, in operation of the imaging device, illumination of the object by the light beam. In addition, the imaging device includes at least one imaging detector positioned for imaging the object illuminated by the light beam.
-
27.发明授权公开(公告)号：US09068891B2
公开(公告)日：2015-06-30
申请号：US13734600
申请日：2013-01-04
Inventor： Masahiko Shioi , Kristof Lodewijks , Pol Van Dorpe , Hilde Jans
CPC classification number: G01J3/4412 , G01N21/658
Abstract: A method for measuring a concentration of a biogenic substance in a living body includes steps of: preparing an apparatus including a light source, a substrate which has periodic metal structures and generates surface enhanced Raman scattering light by being irradiated with light from the light source, and spectroscopic means which disperses and detects the light, wherein the periodic metal structure is arranged with first and second distances in first and second direction respectively, the first distance is set to generate surface plasmon by matching a phase of the light from the light source, and the second distance is smaller than the first distance and is set between 300 nm and 350 nm; irradiating the substrate with the light from the light source to generate the surface enhanced Raman scattering; detecting the scattering with the spectroscopic means; and calculating the concentration of the biogenic substance based on the scattering.
Abstract translation: 一种测定生物体的生物体浓度的方法，其特征在于，包括以下步骤：制备包括光源，具有周期性金属结构的基板并通过照射来自光源的光而产生表面增强的拉曼散射光的装置， 以及分散和检测光的分光装置，其中周期性金属结构分别在第一和第二方向上以第一和第二距离布置，第一距离被设置为通过匹配来自光源的光的相位来产生表面等离子体， 并且第二距离小于第一距离并且设置在300nm和350nm之间; 用来自光源的光照射基板以产生表面增强的拉曼散射; 用分光装置检测散射; 并基于散射计算生物源物质的浓度。
-
公开(公告)号：US20190383743A1
公开(公告)日：2019-12-19
申请号：US16442484
申请日：2019-06-15
Applicant: IMEC VZW
Inventor： Pol Van Dorpe , Niels Verellen
Abstract: An imaging apparatus comprises: (i) an illumination waveguide configured to propagate light by total internal reflection, wherein an evanescent field illuminates an object in close relation to the illumination waveguide; an array of light-sensitive areas arranged on a common substrate with the illumination waveguide for detecting light from the object; and (iii) a controller configured to control forming of an interference pattern in the illumination waveguide, wherein the interference pattern comprises at least one element of constructive interference for selectively illuminating a portion of the object, the at least one element having a dimension with a size in a range of 100 nm-10 μm; wherein the controller is configured to sequentially change the interference pattern in relation to the object such that different portions are illuminated and light from different portions is sequentially detected.
-
公开(公告)号：US10359363B2
公开(公告)日：2019-07-23
申请号：US15736414
申请日：2016-06-22
Applicant: IMEC VZW
Inventor： Peter Peumans , Liesbet Lagae , Willem Van Roy , Tim Stakenborg , Pol Van Dorpe
Abstract: A sensor device for quantifying luminescent targets. The device comprises a light source for exciting the targets, thus generating luminescence signals, and a detector for detecting these signals of the targets in a cell, resulting in a detected signal comprising a desired signal and a background signal. The detector has a spatial cell resolution and/or a time resolution that is so high that only a limited number of targets will be present in the cell when measuring at low concentration and/or that only a limited number of targets add to the cell in between two measurements. A change in the number of targets in the cell can be observed in the detected signal. The device comprises a processor configured to distinguish the desired and the background signal, and to combine the detected signals of the different cells and/or moments in time, to quantify the targets.
-
公开(公告)号：US10267733B2
公开(公告)日：2019-04-23
申请号：US15312116
申请日：2015-05-22
Applicant: IMEC VZW
Inventor： Pol Van Dorpe , Liesbet Lagae , Peter Peumans , Andim Stassen , Philippe Helin , Bert Du Bois , Simone Severi
Abstract: The present disclosure relates to semiconductor devices for detecting fluorescent particles. At least one embodiment relates to an integrated semiconductor device for detecting fluorescent tags. The device includes a first layer, a second layer, a third layer, a fourth layer, and a fifth layer. The first layer includes a detector element. The second layer includes a rejection filter. The third layer is fabricated from dielectric material. The fourth layer is an optical waveguide configured and positioned such that a top surface of the fourth layer is illuminated with an evanescent tail of excitation light guided by the optical waveguide when the fluorescent tags are present. The fifth layer includes a microfluidic channel. The optical waveguide is configured and positioned such that the microfluidic channel is illuminated with the evanescent tail. The detector element is positioned such that light from activated fluorescent tags can be received.
-
-
-
-
-
-
-
-
-
Search Results
37
records
(took 0.018 seconds)
