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公开(公告)号：US20180017487A1
公开(公告)日：2018-01-18
申请号：US15590745
申请日：2017-05-09
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Vadim Backman , Ji Yi
CPC classification number: G01N21/4795 , A61B5/0066
Abstract: A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo α defined as the ratio of scattering coefficient μs, and the back-scattering coefficient μb), the RI correlation function can be inversely deduced and the full set of optical scattering properties can be obtained.
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22.发明授权公开(公告)号：US09830501B2
公开(公告)日：2017-11-28
申请号：US14339239
申请日：2014-07-23
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Vadim Backman , Hariharan Subramanian , John E. Chandler , Craig White , Jeremy D. Rogers , Lusik Cherkezyan
IPC: G06K9/00 , G02B21/36 , H04N5/235 , H04N5/232 , G01J3/44 , G01J3/12 , G01J3/28 , G02B21/06 , G02B21/16 , G01N21/47
CPC classification number: G06K9/00127 , G01J3/1256 , G01J3/2823 , G01J3/44 , G01N21/47 , G01N2021/4709 , G02B21/06 , G02B21/16 , G02B21/365 , H04N5/23212 , H04N5/2354
Abstract: The present technology provides methods, systems, and apparatuses to achieve high throughput and high speed acquisition of partial wave spectroscopic (PWS) microscopic images. In particular, provided herein are high-throughput, automated partial wave spectroscopy (HT/A-PWS) instruments and systems capable of rapid acquisition of PWS Microscopic images and clinical, diagnostic, and research applications thereof.
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公开(公告)号：US20170188818A1
公开(公告)日：2017-07-06
申请号：US15465285
申请日：2017-03-21
Applicant: Northwestern University
Inventor： Ji Yi , Wenzhong Liu , Vadim Backman , Hao F. Zhang , Kieren J. Patel
IPC: A61B3/10 , G01B9/02 , A61B5/1455 , G06F17/13 , A61B5/145 , A61B5/0205 , A61B1/04 , G06T7/00 , A61B3/12
CPC classification number: A61B3/102 , A61B1/04 , A61B3/1233 , A61B5/0066 , A61B5/0073 , A61B5/0205 , A61B5/0261 , A61B5/14507 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14542 , A61B5/14551 , G01B9/02091 , G06F17/10 , G06F17/13 , G06T7/0012 , G06T7/0014 , G06T11/003 , G06T2207/10028 , G06T2207/10101
Abstract: The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.
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24.发明申请HIGH THROUGHPUT PARTIAL WAVE SPECTROSCOPIC MICROSCOPY AND ASSOCIATED SYSTEMS AND METHODS 有权高通量部分波光谱显微镜及相关系统及方法公开(公告)号：US20150029326A1
公开(公告)日：2015-01-29
申请号：US14339239
申请日：2014-07-23
Applicant: NORTHWESTERN UNIVERSITY
Inventor： Vadim Backman , Hariharan Subramanian , John E. Chandler , Craig White , Jeremy D. Rogers , Lusik Cherkezyan
CPC classification number: G06K9/00127 , G01J3/1256 , G01J3/2823 , G01J3/44 , G01N21/47 , G01N2021/4709 , G02B21/06 , G02B21/16 , G02B21/365 , H04N5/23212 , H04N5/2354
Abstract: The present technology provides methods, systems, and apparatuses to achieve high throughput and high speed acquisition of partial wave spectroscopic (PWS) microscopic images. In particular, provided herein are high-throughput, automated partial wave spectroscopy (HT/A-PWS) instruments and systems capable of rapid acquisition of PWS Microscopic images and clinical, diagnostic, and research applications thereof.
Abstract translation: 本技术提供方法，系统和设备，以实现部分波谱（PWS）显微镜图像的高吞吐量和高速采集。 特别地，本文提供了能够快速获取PWS显微镜图像及其临床，诊断和研究应用的高通量，自动部分波谱（HT / A-PWS）仪器和系统。
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公开(公告)号：US20230340047A1
公开(公告)日：2023-10-26
申请号：US18151166
申请日：2023-01-06
Applicant: Northwestern University
Inventor： Hemant K. Roy , Vadim Backman
IPC: C07K14/475 , A61K31/282 , C07K14/47
CPC classification number: C07K14/475 , A61K31/282 , C07K14/4703 , A61K38/00
Abstract: Disclosed are compositions comprising myokines and their methods of preparation and use. The disclosed myokine compositions and methods may comprise myokines having a molecular weight of greater than about 10 kDa such as myostatin and metrnl. The disclosed myokine compositions and methods may be utilized for treating and/or preventing cell proliferative and metabolic diseases and disorders. In particular, the disclosed myokine compositions and methods may be utilized for treating and/or preventing cell proliferative and metabolic diseases and disorders, such as cancer, and metabolic diseases and disorders, such as diabetes, non-alcoholic fatty liver disease, and heart disease.
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Patent Agency Ranking
公开(公告)号：US11525666B2
公开(公告)日：2022-12-13
申请号：US17055908
申请日：2019-05-17
Applicant: Northwestern University
Inventor： James Arthur Winkelmann, Jr. , Vadim Backman
IPC: G01B11/02 , G01B9/02091 , A61B3/10 , G01B9/02
Abstract: In an aspect, a method for imaging a target comprises steps of: performing optical coherence tomography (OCT) scanning on the target with one or more beams of source light, the one or more beams of source light comprising a plurality of wavelengths; wherein performing OCT scanning comprises: providing the source light to a reference optical path and to a sample optical path, wherein providing the source light to a sample optical path comprises illuminating the target with the source light; and recording interference data corresponding to an interaction of a light from the reference optical path and a light from the sample optical path; processing the interference data; and identifying blood or one or more blood-features in the target based on an optical attenuation of light in or associated with the sample optical path by the blood or the one or more blood-features.
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公开(公告)号：US20210007673A1
公开(公告)日：2021-01-14
申请号：US16319669
申请日：2017-06-21
Inventor： Vadim Backman , David S. Mueller , Andrew J. Cittadine , Sarah Ruderman , Hemant Roy , Bradley Gould
IPC: A61B5/00 , A61B5/1459
Abstract: Methods and apparatus initiate a procedure performed by a probe on tissue. A signal is obtained from the probe, the signal varying with changes in a proximity of the probe to the tissue. The obtained signal is analyzed by a controller to determine whether the probe is within a predetermined distance of the tissue. The controller initiates the procedure when it is determined that the probe is within the predetermined distance of the tissue. The obtaining and analyzing may be repeated until the probe is determined to be within the predetermined distance of the tissue. The analyzing may include comparing the obtained signal to a predetermined threshold.
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公开(公告)号：US10881273B2
公开(公告)日：2021-01-05
申请号：US14638714
申请日：2015-03-04
Applicant: NORTHWESTERN UNIVERSITY , AMERICAN BIOOPTICS LLC
Inventor： Vadim Backman , Bradley Gould , Andrew J. Cittadine , Nikhil Mutyal
Abstract: A pre-fabricated, on-demand interface provides optical coupling between disposable and reusable portions of a fiber-optic probe. The interface uses a pre-cured, compressible optically-transmissive gel in a cavity of the disposable portion, which can be a disposable insertion tip of the fiber optic probe. The disposable portion includes an elongated housing, or sheath, and the cavity is located within and proximal of a distal end of the elongated housing. A proximal end of an optical assembly of the disposable portion is located within the cavity and contacts the gel. A first coupling, provided at a proximal end of the elongated housing, detachably couples to a mating, second coupling of the probe reusable portion. When the disposable and reusable portions are coupled together, the gel is compressed between the proximal end of the optical assembly of the disposable portion and a distal optical member of an optical assembly of the reusable portion.
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29.发明授权公开(公告)号：US10684417B2
公开(公告)日：2020-06-16
申请号：US15886431
申请日：2018-02-01
Applicant: NORTHWESTERN UNIVERSITY , AMERICAN BIOOPTICS, LLC
Inventor： Vadim Backman , Jeremy D. Rogers , Nikhil N. Mutyal , Bradley Gould , Andrew J. Radosevich , The Quyen Nguyen
Abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.
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公开(公告)号：US20180088048A1
公开(公告)日：2018-03-29
申请号：US15584018
申请日：2017-05-01
Applicant: Northwestern University
Inventor： Biqin Dong , Janel L. Davis , Cheng Sun , Hao F. Zhang , Kieren J. Patel , Ben Urban , Vadim Backman , Luay Almassalha , Yolanda Stypula-Cyrus , The-Quyen Nguyen
IPC: G01N21/64 , C12Q1/6825 , G01N33/53
CPC classification number: G01N21/6428 , C12Q1/6825 , C12Q1/6841 , G01N21/6458 , G01N33/5302 , G01N2021/6441
Abstract: The devices, methods, and systems of the present disclosure provide for spectroscopic super-resolution microscopic imaging. In some examples, spectroscopic super-resolution microscopic imaging may be referred to or comprise spectroscopic photon localization microscopy (SPLM), a method which may employ the use of extrinsic labels or tags in a test sample suitable for imaging. In some examples spectroscopic super-resolution microscopic or spectroscopic photon localization microscopy (SPLM) may not employ extrinsic labels and be performed using the intrinsic contrast of the test sample or test sample material.Generally, spectroscopic super-resolution microscopic imaging may comprise resolving one or more non-diffraction limited images of an area of a test sample by acquiring both localization information of a subset of molecules using microscopic methods known in the art, and simultaneously or substantially simultaneously, acquiring spectral data about the same or corresponding molecules in the subset. This method maybe useful to detect a variety of features in cellular material for the molecular characterization of cells and disease.
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