公开(公告)号：US20220265172A1

公开(公告)日：2022-08-25

申请号：US17692613

申请日：2022-03-11

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: A61B5/1477 ,  A61B10/00 ,  H01J49/04 ,  A61M11/00 ,  A61M25/00 ,  H01J49/00 ,  H01J49/16 ,  H01J49/34 ,  G01N33/483

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US20200381239A1

公开(公告)日：2020-12-03

申请号：US16985553

申请日：2020-08-05

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Yue Ren ,  Ziqing Lin

IPC: H01J49/16 ,  C12Q1/6806

Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

公开(公告)号：US10777402B2

公开(公告)日：2020-09-15

申请号：US16293017

申请日：2019-03-05

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Yue Ren ,  Ziqing Lin

IPC: H01J49/16 ,  C12Q1/6806

Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

公开(公告)号：US20190221418A1

公开(公告)日：2019-07-18

申请号：US16293017

申请日：2019-03-05

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Yue Ren ,  Ziqing Lin

IPC: H01J49/16 ,  C12Q1/6806

CPC classification number: H01J49/167 ,  C12Q1/6806 ,  Y10T436/24 ,  Y10T436/255

Abstract: The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides methods that involve introducing a solvent into a capillary, introducing the capillary into a vessel including a sample such that a portion of the sample is introduced into the capillary, moving the sample and the solvent within the capillary to induce circulation within the sample and the solvent, thereby causing the analyte to be extracted from the sample and into the solvent, analyzing the analyte that has been extracted from the sample, and quantifying the analyte. In certain embodiments, the quantifying step is performed without knowledge of a volume of the sample and/or solvent.

公开(公告)号：US20180279927A1

公开(公告)日：2018-10-04

申请号：US15989706

申请日：2018-05-25

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-Hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: A61B5/1477 ,  G01N33/483 ,  A61B10/00 ,  A61M11/00 ,  A61M25/00 ,  H01J49/00 ,  H01J49/04 ,  H01J49/16

CPC classification number: A61B5/1477 ,  A61B5/1405 ,  A61B5/145 ,  A61B5/150015 ,  A61B5/150992 ,  A61B5/157 ,  A61B10/0045 ,  A61M11/00 ,  A61M25/00 ,  A61M2202/0468 ,  G01N33/4833 ,  G01N2001/028 ,  H01J49/0022 ,  H01J49/0404 ,  H01J49/0445 ,  H01J49/167 ,  H01J49/34

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US10004440B2

公开(公告)日：2018-06-26

申请号：US15617013

申请日：2017-06-08

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-Hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: H01J49/00 ,  A61B5/1477 ,  H01J49/16 ,  H01J49/34 ,  A61M25/00 ,  G01N33/483 ,  H01J49/04 ,  A61M11/00

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

公开(公告)号：US20170135613A1

公开(公告)日：2017-05-18

申请号：US15400358

申请日：2017-01-06

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-Hsun Chen ,  Ziqing Lin ,  Livia Schiavinato Eberlin

IPC: A61B5/1477 ,  A61M25/00 ,  H01J49/34 ,  H01J49/00 ,  H01J49/04 ,  H01J49/16 ,  A61M11/00 ,  G01N33/483

CPC classification number: A61B5/1477 ,  A61B5/1405 ,  A61B5/145 ,  A61B5/150015 ,  A61B5/150992 ,  A61B5/157 ,  A61B10/0045 ,  A61M11/00 ,  A61M25/00 ,  A61M2202/0468 ,  G01N33/4833 ,  G01N2001/028 ,  H01J49/0022 ,  H01J49/0404 ,  H01J49/0445 ,  H01J49/167 ,  H01J49/34

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.