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公开(公告)号：US11128098B2
公开(公告)日：2021-09-21
申请号：US16384335
申请日：2019-04-15
Applicant: Quantum-Si Incorporated
Inventor： Jonathan C. Schultz , Andrey V. Okishev , Craig Wenger , Brittany Lathrop , Faisal R. Ahmad
Abstract: A method and apparatus for characterizing an optical element. The optical element is part of a laser and is mounted on a translation stage to scan the optical element transverse to an intracavity laser beam. A performance characteristic of the laser is recorded as a function of position of the optical element.
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公开(公告)号：US20200335933A1
公开(公告)日：2020-10-22
申请号：US16916277
申请日：2020-06-30
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife , Benjamin Cipriany
Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument. The mode-locked laser can produce sub-50-ps optical pulses at a repetition rates between 200 MHz and 50 MHz, rates suitable for massively parallel data-acquisition. The optical pulses can be used to generate a reference clock signal for synchronizing data-acquisition and signal-processing electronics of the portable instrument.
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公开(公告)号：US20200220317A1
公开(公告)日：2020-07-09
申请号：US16362830
申请日：2019-03-25
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife , Benjamin Cipriany
Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument. The mode-locked laser can produce sub-50-ps optical pulses at a repetition rates between 200 MHz and 50 MHz, rates suitable for massively parallel data-acquisition. The optical pulses can be used to generate a reference clock signal for synchronizing data-acquisition and signal-processing electronics of the portable instrument.
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公开(公告)号：US20190249240A1
公开(公告)日：2019-08-15
申请号：US16277113
申请日：2019-02-15
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife
IPC: C12Q1/6869 , H01S3/00 , G01N21/64 , H01L27/146 , H01S3/101 , H01S3/13 , H01S3/105 , H01S3/081 , H01S3/11 , H01S3/0941 , H01S3/10
CPC classification number: C12Q1/6869 , G01N21/6408 , G01N21/645 , G01N21/6458 , G01N2021/6439 , G01N2021/6441 , G01S7/4814 , H01L27/14603 , H01S3/0071 , H01S3/0405 , H01S3/0817 , H01S3/0941 , H01S3/10061 , H01S3/101 , H01S3/105 , H01S3/1115 , H01S3/1118 , H01S3/1305 , H01S3/1611 , H01S3/1673
Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.
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公开(公告)号：US20250093670A1
公开(公告)日：2025-03-20
申请号：US18817108
申请日：2024-08-27
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Paul E. Glenn , Jonathan C. Schultz , Benjamin Cipriany
Abstract: Apparatus and methods for coupling an optical beam from an optical source to a hi-tech system are described. A compact, low-cost beam-shaping and steering assembly may be located between the optical source and hi-tech system and provide automated adjustments to beam parameters such as beam position, beam rotation, and beam incident angles. The beam-shaping and steering assembly may be used to couple an elongated beam to a plurality of optical waveguides.
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Patent Agency Ranking
公开(公告)号：US20240209434A1
公开(公告)日：2024-06-27
申请号：US18431313
申请日：2024-02-02
Applicant: Quantum-Si Incorporated
Inventor： Guojun Chen , Jeremy Lackey , Alexander Goryaynov , Gerard Schmid , Ali Kabiri , Jonathan M. Rothberg , Todd Rearick , Jonathan C. Schultz , Farshid Ghasemi , Keith G. Fife
IPC: C12Q1/6869 , B01L3/00 , C08L1/02 , C12Q1/6806 , G01N21/64 , G01N27/447 , G01N30/86 , G01N30/88
CPC classification number: C12Q1/6869 , B01L3/502761 , B01L3/50857 , C08L1/02 , C12Q1/6806 , G01N21/6428 , G01N21/6454 , G01N27/44743 , G01N27/44782 , G01N30/86 , B01L2200/0647 , B01L2300/0645 , B01L2300/0829 , B01L2300/0864 , B01L2400/0415 , B01L2400/0421 , G01N27/447 , G01N30/88
Abstract: Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.
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公开(公告)号：US20240079843A1
公开(公告)日：2024-03-07
申请号：US18505039
申请日：2023-11-08
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife , Benjamin Cipriany
IPC: H01S3/1115 , G02F1/37 , H01S3/02 , H01S3/08 , H01S3/081 , H01S3/0941 , H01S3/16
CPC classification number: H01S3/1115 , G02F1/37 , H01S3/025 , H01S3/08072 , H01S3/0813 , H01S3/09415 , H01S3/1611 , H01S3/1673 , H01S3/10046
Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument. The mode-locked laser can produce sub-50-ps optical pulses at a repetition rates between 200 MHz and 50 MHz, rates suitable for massively parallel data-acquisition. The optical pulses can be used to generate a reference clock signal for synchronizing data-acquisition and signal-processing electronics of the portable instrument.
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公开(公告)号：US20230152224A1
公开(公告)日：2023-05-18
申请号：US18094312
申请日：2023-01-06
Applicant: Quantum-SI Incorporated
Inventor： Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Brendan Huang , Paul E. Glenn , Jonathan C. Schultz , Jose Camara
IPC: G01N21/64 , H01S5/042 , H01L27/146 , G01S7/484 , H05B47/16 , H05B45/335
CPC classification number: G01N21/6408 , G01N21/645 , G01S7/484 , H01L27/14603 , H01S5/0428 , H05B45/335 , H05B47/16 , G01N2021/6439 , G01N2201/0612 , G01N2201/0621 , G01N2201/0697 , G01S7/4863
Abstract: Compact optical sources and methods for producing short and ultrashort optical pulses are described. A semiconductor laser or LED may be driven with a bipolar waveform to generate optical pulses with FWHM durations as short as approximately 85 ps having suppressed tail emission. The pulsed optical sources may be used for fluorescent lifetime analysis of biological samples and time-of-flight imaging, among other applications.
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公开(公告)号：US20220341959A1
公开(公告)日：2022-10-27
申请号：US17725127
申请日：2022-04-20
Applicant: Quantum-Si Incorporated
Inventor： Xiaoxiao Ma , Jonathan C. Schultz , Caixia Lv , Brittany Lathrop
IPC: G01N35/10 , C12Q1/6874 , B01L3/00
Abstract: Aspects of this disclosure relate to systems, devices, and methods for the transfer of fluid to fluidic receptacles. In some embodiments, the fluid contains one or more molecules (e.g., one or more peptides, proteins, and/or nucleic acids) of interest, and the fluidic receptacle includes an integrated device. In certain embodiments, the one or more molecules can be immobilized on the integrated device for subsequent analysis (e.g., sequencing). Certain aspects of the present disclosure are directed towards systems and methods that can, in some instances, enhance the immobilization of the one or more molecules on the integrated device, e.g., by improving a rate of sample interaction with the integrated device. Through the use of systems, devices, and methods of the instant disclosure, target molecules may be more readily sequenced or prepared for sequencing. For example, in some embodiments, systems, devices, and methods of the instant disclosure allow automated loading of the fluidic receptacle using a fluidic device.
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公开(公告)号：US20220243265A9
公开(公告)日：2022-08-04
申请号：US16277113
申请日：2019-02-15
Applicant: Quantum-Si Incorporated
Inventor： Jonathan M. Rothberg , Jason W. Sickler , Lawrence C. West , Faisal R. Ahmad , Paul E. Glenn , Jack Jewell , John Glenn , Jose Camara , Jeremy Christopher Jordan , Todd Rearick , Farshid Ghasemi , Jonathan C. Schultz , Keith G. Fife
IPC: C12Q1/6869 , H01S3/00 , G01N21/64 , H01L27/146 , H01S3/101 , H01S3/13 , H01S3/105 , H01S3/081 , H01S3/11 , H01S3/0941 , H01S3/10
Abstract: Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.
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