公开(公告)号：US20170144961A1

公开(公告)日：2017-05-25

申请号：US15300010

申请日：2015-04-08

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Teruki TAKAHASHI ,  Kazuya UEKI ,  Yuta NAGASHIMA

IPC: C07C201/12 ,  C07C205/11 ,  C07C209/68

CPC classification number: C07C201/12 ,  C07C205/11 ,  C07C209/68 ,  C07C211/29

Abstract: A compound represented by formula (1): can be produced by: a step wherein a compound represented by formula (2): is reacted with a compound represented by formula (3): thereby obtaining a compound represented by formula (4): a step wherein a compound represented by formula (4) is reacted with hypohalogenous acid or a salt thereof, thereby obtaining a compound represented by formula (5): and a step wherein a compound represented by formula (5) is reduced.

公开(公告)号：US20170137448A1

公开(公告)日：2017-05-18

申请号：US15312694

申请日：2015-04-23

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： CONOR PRANCKEVICIUS ,  DOUGLAS WADE STEPHAN

IPC: C07F15/00

CPC classification number: C07F15/0046 ,  C07C5/03 ,  C07C29/172 ,  C07C41/22 ,  C07C45/63 ,  C07C67/303 ,  C07C201/12 ,  C07C2531/22 ,  C07C2601/14 ,  C08C19/02 ,  C08L15/005 ,  C07C9/15 ,  C07C9/18 ,  C07C13/18 ,  C07C15/073 ,  C07C205/06 ,  C07C69/34 ,  C07C49/403 ,  C07C35/08 ,  C07C43/184

Abstract: The present invention provides stable, cyclic bent allene metal complexes and methods of conducting chemical processes, preferably olefin hydrogenation, comprising contacting an olefin substrate, preferably an unsaturated polymer, with a cyclic bent allene metal complex as described herein, under hydrogenation conditions.

公开(公告)号：US09637462B2

公开(公告)日：2017-05-02

申请号：US15034751

申请日：2014-11-05

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED

Inventor： Gennady Nisnevich ,  Kseniya Kulbitski ,  Mark Gandelman ,  Alexander Artaryan

IPC: C07D263/26 ,  C07D275/06 ,  C07D233/82 ,  C07C41/22 ,  C07D233/74 ,  C07D263/22 ,  C07D209/48 ,  C07C17/093 ,  C07C29/64 ,  C07C41/05 ,  C07C67/05 ,  C07C201/12 ,  C07D211/38 ,  C07C17/10 ,  C07C17/12 ,  C07C17/14 ,  C07C17/363 ,  C07B39/00 ,  C07D207/46

CPC classification number: C07D263/26 ,  C07B39/00 ,  C07C17/093 ,  C07C17/10 ,  C07C17/12 ,  C07C17/14 ,  C07C17/363 ,  C07C29/64 ,  C07C41/05 ,  C07C41/22 ,  C07C67/05 ,  C07C201/12 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/42 ,  C07D207/46 ,  C07D209/48 ,  C07D211/38 ,  C07D233/74 ,  C07D233/82 ,  C07D263/22 ,  C07D275/06 ,  C07C43/225 ,  C07C35/48 ,  C07C43/192 ,  C07C33/46 ,  C07C43/174 ,  C07C69/63 ,  C07C22/04 ,  C07C25/02 ,  C07C205/12 ,  C07C25/13 ,  C07C205/11 ,  C07C23/10 ,  C07C23/28 ,  C07C23/08 ,  C07C23/14 ,  C07C23/16 ,  C07C19/07

Abstract: The present invention provides new stable crystalline N-iodoamides-1-iodo-3,5,5-trimethylhydantoin (1-ITMH) and 3-iodo-4,4-dimethyl-2-oxazolidinone (IDMO). The present invention further provides a process for the preparation of organic iodides using N-iodoamides of this invention and recovery of the amide co-products from waste water.

公开(公告)号：US20170088494A1

公开(公告)日：2017-03-30

申请号：US15285172

申请日：2016-10-04

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas CHEN

IPC: C07C29/92 ,  C07C29/86 ,  C07C29/78

CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07B2200/07 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07C2601/16 ,  C07C33/14 ,  C07C205/57 ,  C07C69/76 ,  C07C69/92

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US09586883B2

公开(公告)日：2017-03-07

申请号：US14255049

申请日：2014-04-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Zachary K. Wickens ,  Bill Morandi ,  Robert H. Grubbs ,  Kacper Skakuj ,  Sarah M. Bronner

IPC: C07C45/34 ,  C07C249/04 ,  C07C253/00 ,  C07C201/12 ,  C07C205/44 ,  C07C209/60 ,  C07C213/00 ,  C07C227/08 ,  C07C51/373 ,  C07C59/235 ,  C07C211/48 ,  C07C217/48 ,  C07D301/22

CPC classification number: C07C45/34 ,  C07C51/373 ,  C07C201/12 ,  C07C205/44 ,  C07C209/60 ,  C07C213/00 ,  C07C227/08 ,  C07C249/04 ,  C07C253/00 ,  C07D301/22 ,  C07C59/235 ,  C07C211/48 ,  C07C217/48 ,  C07C229/18 ,  C07C47/02 ,  C07C47/11 ,  C07C47/14 ,  C07C47/19 ,  C07C47/198 ,  C07C47/277

Abstract: This disclosure is directed to methods of preparing organic aldehydes, each method comprising contacting a terminal olefin with an oxidizing mixture comprising: (a) a dichloro-palladium complex; (b) a copper complex; (c) a source of nitrite; under aerobic reaction conditions sufficient to convert at least a portion of the terminal olefin to an aldehyde.

Abstract translation: 本公开涉及制备有机醛的方法，每种方法包括使末端烯烃与氧化混合物接触，所述氧化混合物包含：（a）二氯 - 钯络合物; （b）铜络合物; （c）亚硝酸盐源; 在需氧反应条件下，足以将至少一部分末端烯烃转化为醛。

公开(公告)号：US20170057897A1

公开(公告)日：2017-03-02

申请号：US15123252

申请日：2015-03-01

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ronny NEUMANN ,  Amir RUBINSTEIN

IPC: C07C45/28 ,  C07C67/333 ,  B01J31/02

CPC classification number: C07C45/28 ,  B01J23/002 ,  B01J23/8993 ,  B01J27/188 ,  B01J31/0239 ,  B01J31/0271 ,  B01J2231/321 ,  B01J2531/002 ,  C07C67/333 ,  C07C201/12 ,  C07C47/54 ,  C07C49/78 ,  C07C49/786 ,  C07C49/84 ,  C07C47/02 ,  C07C69/716 ,  C07C205/44

Abstract: The present invention relates to a process for preparing aldehydes and ketones by carbon-carbon bond cleavage of alkenes, wherein the process is catalysed by first row transition metal nitro coordinated polyoxometalate catalyst. The catalyst can be prepared by pre-treatment of aqua coordinated polyoxometalates with NO2, or they are formed in situ when the reactions are carried in nitroalkanes under aerobic conditions, or they are formed in situ from nitrosyl (NO) compounds in the presence of O2.

Abstract translation: 本发明涉及通过烯烃的碳 - 碳键裂解制备醛和酮的方法，其中该方法由第一排过渡金属硝基配位多金属氧酸盐催化剂催化。 催化剂可以通过用NO2预处理水配位的多金属氧酸盐来制备，或者当在需氧条件下在硝基烷烃中进行反应时，它们是原位形成的，或者它们是在存在O 2的情况下由亚硝酰基（NO）化合物原位形成的 。

公开(公告)号：US20170037008A1

公开(公告)日：2017-02-09

申请号：US15101385

申请日：2014-11-06

Applicant: Zhiyong ZHANG ,  BEIJING ZHIBO BIO-MEDICAL TECHNOLOGY CO., LTD

Inventor： Zhiyong Zhang ,  Mengchao Cui ,  Chunping Lin ,  Boli Liu ,  Yuzhi Guo

IPC: C07D213/64 ,  C07C201/12 ,  C07C43/205 ,  C07C319/20 ,  C07C217/86 ,  C07C213/02 ,  C07C323/20 ,  C07C205/37 ,  C07C41/18

CPC classification number: C07D213/64 ,  A61K51/04 ,  A61K51/0406 ,  C07B2200/05 ,  C07C41/18 ,  C07C43/2055 ,  C07C43/225 ,  C07C43/23 ,  C07C201/12 ,  C07C205/37 ,  C07C211/53 ,  C07C213/02 ,  C07C217/86 ,  C07C319/20 ,  C07C323/20 ,  C07D213/65 ,  C07F7/2208

Abstract: Parts of compounds, after being labeled by radionuclide, of the phenyl benzyl ether derivative, are used as Aβ plaque imaging agent. The structural formula of the phenyl benzyl ether derivative is shown by formula (I). The present invention develops a kind of brand new phenyl benzyl ether derivative which has high affinity with Aβ plaques in brains of AD patients. The chemical structure of the phenyl benzyl ether derivative is different from that of compounds disclosed in the prior art and the phenyl benzyl ether derivative belongs to a brand new compound for diagnosing and treating AD. The obtained Aβ plaque imaging agent has the advantages that the in-vivo stability is good, the fat solubility is low, the removal speed for the brain is fast, the problem of removing the radionuclide in vivo does not exist, and the application prospect and the market value are great.

Abstract translation: 本发明涉及苯基苄基醚衍生物及其制备方法和用途，一部分化合物在放射性核素标记后作为Aβ斑块显像剂，苯基苄基醚衍生物用于制备 用于诊断和治疗阿尔茨海默病（AD）的药物。 苯基苄基醚衍生物具有式（I）所示的结构式; 本发明开发了一种对AD患者大脑中的Aβ斑块具有高亲和力的全新苯基苄基醚衍生物，其化学结构与现有技术公开的化合物的化学结构不同，属于 用于诊断和治疗阿尔茨海默病的全新化合物; 得到的Aβ噬菌斑显像剂体内稳定性好，脂质溶解度低，使得脑部消除速度快，体内不含放射性核素的去除问题，具有广阔的应用前景， 市场价值。

公开(公告)号：US09561998B2

公开(公告)日：2017-02-07

申请号：US15107872

申请日：2014-12-15

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Yuya Yoshimoto ,  Tatsuya Toriumi ,  Yuta Nagashima

IPC: C07C205/00 ,  C07C201/12 ,  C07C205/34 ,  C07C213/02

CPC classification number: C07C201/12 ,  C07C205/34 ,  C07C213/02 ,  C07C217/76

Abstract: A nitro compound represented by formula (1) which is a raw material for producing a compound represented by formula (7) can be produced by reacting at least one type selected from the group consisting of a compound represented by formula (2), a compound represented by formula (3), and a compound represented by formula (3′) with a compound represented by formula (4). [In the formula, R1, R2, R3, and R4 are each independently a hydrogen atom, etc., X1 and X2 are each independently a chlorine atom, etc., R6, R7, R8, and R9 are a hydrogen atom, etc., provided that X1, X2, R6, R7, R8, and R9 are not all the same, X3, X4, and X5 are a halogen atom, R10 is a nitro group, etc., R5 is an alkyl group having 1 to 12 carbon atoms, etc., and M is an alkali metal atom.]

Abstract translation: 作为用于制备由式（7）表示的化合物的原料的由式（1）表示的硝基化合物可以通过使选自由式（2）表示的化合物，化合物 （3）表示的化合物和式（3'）表示的化合物与式（4）表示的化合物反应。 [式中，R 1，R 2，R 3和R 4各自独立地为氢原子等，X 1和X 2各自独立地为氯原子等，R 6，R 7，R 8 ，R 9为氢原子等，条件是X 1，X 2，R 6，R 7，R 8和R 9不全部相同，X 3，X 4和X 5为卤素 原子，R 10为硝基等，R 5为碳原子数1〜12的烷基等，M为碱金属原子。

公开(公告)号：US09546191B1

公开(公告)日：2017-01-17

申请号：US15081308

申请日：2016-03-25

Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

Inventor： Bassam M. El Ali ,  Mansur Bala Ibrahim ,  Rami K. Suleiman

IPC: C07F15/00 ,  C07C45/68 ,  C07C17/26 ,  C07C253/30 ,  C07F7/08 ,  C07F7/18 ,  C07C29/32 ,  C07C209/68 ,  C07B37/00 ,  B01J31/18 ,  C07C2/86

CPC classification number: C07F15/0066 ,  B01J31/182 ,  B01J2231/4266 ,  B01J2531/824 ,  C07B37/04 ,  C07C2/861 ,  C07C17/269 ,  C07C29/32 ,  C07C45/68 ,  C07C201/12 ,  C07C209/68 ,  C07C253/30 ,  C07C2531/22 ,  C07D263/12 ,  C07F7/083 ,  C07F7/1892 ,  C07C22/08 ,  C07C22/04 ,  C07C49/796 ,  C07C33/30 ,  C07C205/06 ,  C07C255/50 ,  C07C255/56 ,  C07C211/45 ,  C07C211/49 ,  C07C15/54

Abstract: A palladium(II) complex which catalyzes the Sonogashira coupling reaction efficiently under aerobic condition and a method of employing the palladium(II) complex to synthesize internal alkynes. The palladium(II) complex is an effective catalyst for the coupling reactions of aryl iodo and diiodo compounds with unactivated alkyl alkynes and terminal dialkynes to produce various novel symmetrical dialkynes and disubstituted internal alkynes in excellent yields.

Abstract translation: 在需氧条件下有效催化Sonogashira偶联反应的钯（II）络合物和使用钯（II）络合物合成内部炔烃的方法。 钯（II）络合物是芳基碘和二碘化合物与未活化的烷基炔烃和末端二炔烃的偶联反应的有效催化剂，以产生各种新型对称二炔烃和二取代的内炔烃，产率高。

公开(公告)号：US20160339418A1

公开(公告)日：2016-11-24

申请号：US15158238

申请日：2016-05-18

Applicant: Bruce H. Lipshutz ,  Sachin Handa

Inventor： Bruce H. Lipshutz ,  Sachin Handa

IPC: B01J31/24 ,  C07C45/68 ,  C07F9/12 ,  C07D317/46 ,  C07C201/12 ,  C07D317/22 ,  C07D213/64 ,  C07D239/26 ,  C07D213/30 ,  C07D241/18 ,  C07D215/06 ,  C07D471/04 ,  C07D333/60 ,  C07D239/54 ,  C07D211/70 ,  C07D409/04 ,  C07D403/04 ,  C07D401/04 ,  C07D405/14 ,  C07D405/04 ,  B01J31/22 ,  B01J35/00 ,  B01J35/12 ,  C07C41/30

CPC classification number: B01J31/2404 ,  B01J23/8906 ,  B01J31/0202 ,  B01J31/0209 ,  B01J31/068 ,  B01J31/22 ,  B01J35/0013 ,  B01J35/10 ,  B01J35/12 ,  B01J37/16 ,  B01J2231/4211 ,  B01J2231/4227 ,  B01J2231/4266 ,  B01J2231/64 ,  B01J2531/004 ,  B01J2531/007 ,  B01J2531/824 ,  B01J2531/842 ,  B01J2531/96 ,  B01J2531/985 ,  C07B37/04 ,  C07C37/18 ,  C07C41/30 ,  C07C45/68 ,  C07C201/12 ,  C07C205/12 ,  C07C209/325 ,  C07C209/68 ,  C07C211/45 ,  C07C269/06 ,  C07C269/08 ,  C07C319/20 ,  C07C2603/24 ,  C07D211/70 ,  C07D213/30 ,  C07D213/64 ,  C07D215/06 ,  C07D239/26 ,  C07D239/54 ,  C07D241/18 ,  C07D317/22 ,  C07D317/46 ,  C07D333/60 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D471/04 ,  C07F9/12 ,  C07C271/28 ,  C07C321/28 ,  C07C43/215 ,  C07C43/205 ,  C07C43/2055 ,  C07C47/546 ,  C07C47/575 ,  C07C39/21

Abstract: In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle (NP) catalyst, prepared by a reduction of an iron salt in an organic solvent, wherein the catalyst comprises at least one other metal selected from the group consisting of Pd, Pt, Au, Ni, Co, Cu, Mn, Rh, Jr, Ru and Os or mixtures thereof; c) a ligand; and d) a surfactant; wherein the metal or mixtures thereof is present in less than or equal to 50,000 ppm relative to the iron salt.

Abstract translation: 在一个实施方案中，本申请公开了一种催化剂组合物，其包含：a）反应溶剂或反应介质; b）有机金属纳米颗粒，其包含：i）通过在有机溶剂中还原铁盐制备的纳米颗粒（NP）催化剂，其中所述催化剂包含至少一种选自Pd，Pt，Au，Ni ，Co，Cu，Mn，Rh，Jr，Ru和Os或其混合物; c）配体; 和d）表面活性剂; 其中所述金属或其混合物相对于所述铁盐以小于或等于50,000ppm的量存在。