公开(公告)号：US20080095200A1

公开(公告)日：2008-04-24

申请号：US11871389

申请日：2007-10-12

Applicant: Volker Seyfried ,  Rafael Storz

Inventor： Volker Seyfried ,  Rafael Storz

IPC: H01S3/10 ,  H01S3/30

CPC classification number: H01S3/02 ,  G01N21/6458 ,  G01N2201/024 ,  G02B21/0032 ,  H01S3/2383

Abstract: A device for generating a laser light beam includes a module. The module includes at least one laser light source, and a mechanical, an electrical and/or an optical interface defined towards an outside of the module.

Abstract translation: 用于产生激光束的装置包括模块。 该模块包括至少一个激光光源，以及朝向模块的外部限定的机械，电和/或光学接口。

公开(公告)号：US07198755B2

公开(公告)日：2007-04-03

申请号：US10241451

申请日：2002-09-12

Applicant: Eugene Tokhtuev ,  Anatoly Skirda ,  Viktor Slobodyan ,  Christopher Owen

Inventor： Eugene Tokhtuev ,  Anatoly Skirda ,  Viktor Slobodyan ,  Christopher Owen

IPC: G01N21/00 ,  G01N21/75 ,  G01N21/62 ,  G01N21/76 ,  B32B5/02

CPC classification number: G01N21/8507 ,  G01N21/15 ,  G01N21/274 ,  G01N21/276 ,  G01N21/645 ,  G01N33/1886 ,  G01N2021/6417 ,  G01N2021/6421 ,  G01N2021/6478 ,  G01N2201/0218 ,  G01N2201/024 ,  G01N2201/0627 ,  G01N2201/0693 ,  Y10T436/11

Abstract: A multichannel fluorosensor includes an optical module and an electronic module combined in a watertight housing with an underwater connector. The fluorosensor has an integral calibrator for periodical sensitivity validation of the fluorosensor. The optical module has one or several excitation channels and one or several emission channels that use a mutual focusing system. To increase efficiency, the excitation and emission channels each have a micro-collimator made with one or more ball lenses. Each excitation channel has a light emitting diode and an optical filter. Each emission channel has a photodiode with a preamplifier and an optical filter. The electronic module connects directly to the optical module and includes a lock-in amplifier, a power supply and a controller with an A/D converter and a connector. The calibrator provides a response proportional to the excitation intensity, and matches with spectral parameter of fluorescence for the analyzed fluorescent substance.

Abstract translation: 多通道氟传感器包括光学模块和组合在具有水下连接器的防水壳体中的电子模块。 氟传感器具有用于氟传感器周期灵敏度验证的积分校准器。 光学模块具有一个或多个激发通道和使用相互聚焦系统的一个或多个发射通道。 为了提高效率，激发和发射通道各自具有由一个或多个球透镜制成的微型准直器。 每个激励通道都有一个发光二极管和一个滤光器。 每个发射通道具有带有前置放大器和光学滤波器的光电二极管。 电子模块直接连接到光模块，包括锁定放大器，电源和带有A / D转换器和连接器的控制器。 校准器提供与激发强度成比例的响应，并与分析的荧光物质的荧光光谱参数相匹配。

公开(公告)号：US20060223169A1

公开(公告)日：2006-10-05

申请号：US11174754

申请日：2005-07-05

Applicant: William Bedingham ,  Peter Ludowise ,  Barry Robole

Inventor： William Bedingham ,  Peter Ludowise ,  Barry Robole

IPC: C12M1/34 ,  G01J3/42

CPC classification number: G01N35/00069 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/024

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules. Each of the removable optical modules is optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector.

公开(公告)号：US06580081B1

公开(公告)日：2003-06-17

申请号：US09630043

申请日：2000-08-01

Applicant: Guenter Thorwirth

Inventor： Guenter Thorwirth

IPC: G01N2164

CPC classification number: G01N21/6452 ,  B01L2300/0893 ,  G01N21/6428 ,  G01N2201/024

Abstract: An arrangement for the detection of the fluorescence radiation of matrix-shaped specimen carriers with a large number of individual specimens, in particular, for the analysis of chemical and biological specimen carriers is disclosed. The object of the invention, to find a new possibility for detection of fluorescence radiation of matrix-shaped specimen carriers with a large number of individual specimens which permits a highly sensitive quantitative readout of the fluorescence radiation which is characteristically influenced by the individual specimen substances, is met in that, while simultaneously exciting the fluorescence radiation of a large number of substrate pixels, the transmitting optics for transmitting the fluorescence radiation emitted by individual substrate pixels to a multi-element receiver contain an imaging objective by which every substrate pixel is correlated with a determined group of receiver elements of the multi-element receiver and which is outfitted with an additional aperture stop for limiting the angular area of the recorded fluorescence radiation, so that the receiver elements which are correlated respectively with a determined substrate pixel receive substantially no fluorescent light of neighboring substrate pixels, and a darkfield illumination is provided for exciting a large number of substrate pixels with an excitation beam bundle which cuts out the aperture of the objective as well as a substantial angular area surrounding the objective aperture.

Abstract translation: 公开了一种用于检测具有大量单个样本的基体样本载体的荧光辐射的装置，特别是用于分析化学和生物样本载体的装置。 本发明的目的是为了发现具有大量单独标本的基体样本载体的荧光辐射检测的新可能性，其允许对由各个样本物质特征性影响的荧光辐射的高灵敏度定量读数， 满足的是，在同时激发大量基板像素的荧光辐射的同时，用于将由各个基板像素发射的荧光辐射传输到多元件接收器的发射光学器件包含成像目标，每个衬底像素与 多组件接收器的确定的一组接收器元件，其配备有用于限制记录的荧光辐射的角度区域的附加孔径光阑，使得与确定的衬底像素分别相关的接收器元件基本上不接收荧光 光o f相邻的衬底像素，并且提供暗场照明，用于激发大量衬底像素，其中激发束束切除物镜的孔径以及围绕物镜孔的实质角区域。

公开(公告)号：US6043506A

公开(公告)日：2000-03-28

申请号：US1254

申请日：1997-12-30

Applicant: David M. Heffelfinger ,  Rebecca Ann Batterson ,  Renato Salgado

Inventor： David M. Heffelfinger ,  Rebecca Ann Batterson ,  Renato Salgado

IPC: G01N21/64 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/68 ,  G01N21/75 ,  G01N21/78 ,  G01N33/53 ,  G01N37/00 ,  G03B42/00 ,  G03B42/02

CPC classification number: G03B42/00 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/024

Abstract: An apparatus capable of measuring quantities of biological or other types of samples that have been labeled using any of a variety of techniques including fluorescence, radioisotopes, enzyme activated light emitting chemicals, and enzyme activated fluorescent materials is provided. The apparatus allows for either simultaneous or sequential acquisition of signals from multiple sample types. The apparatus is not restricted to a particular source or wavelength of excitation or readout light, nor is the apparatus restricted to a particular emission wavelength. The provided scanner includes a source module that preferably contains an internal laser emitting two different wavelengths of approximately the same intensity. An optional external light source may be coupled to the source module, thus adding further flexibility through the addition of other wavelengths (e.g., V, visible, mid-IR, and IR). The scanner also includes a detection module. Within the detection module are two detectors, thus allowing the simultaneous detection of multiple wavelengths. A bifurcated optical cable is used to transfer the excitation and/or readout light from the source module to the sample and subsequently transfer the emitted and/or scattered light from the sample to the detection module. The scanning stage of the scanner is designed to accommodate a variety of samples, ranging from phosphor screens, gels, and fluorescent samples to microtiter plates. An internal microprocessor is used to control the various aspects of the scanner, preferably including translation stage control, source filters, and detection filters. The internal microprocessor may be coupled to an external computer. The external computer may be used to change the programming of the microprocessor, provide a user interface to the microprocessor, process and store test results, and display sample images.

Abstract translation: 提供了一种能够测量使用包括荧光，放射性同位素，酶活化的发光化学物质和酶激活的荧光材料在内的各种技术中的任何一种进行标记的生物样品或其他类型样品的量的装置。 该装置允许同时或顺序地采集来自多个样本类型的信号。 该装置不限于激发或读出光的特定源或波长，也不限于特定发射波长的装置。 所提供的扫描器包括源模块，其优选地包含发射具有大致相同强度的两个不同波长的内部激光器。 可选的外部光源可以耦合到源模块，从而通过添加其它波长（例如，V，可见，中IR和IR）来增加更多的灵活性。 扫描仪还包括检测模块。 在检测模块内是两个检测器，从而允许同时检测多个波长。 使用分叉光缆将激励和/或读出光从源模块传送到样品，随后将发射和/或散射的光从样品转移到检测模块。 扫描仪的扫描阶段设计为适应各种样品，从荧光屏，凝胶和荧光样品到微量滴定板。 内部微处理器用于控制扫描仪的各个方面，最好包括平移台控制，源滤波器和检测滤波器。 内部微处理器可以耦合到外部计算机。 外部计算机可用于改变微处理器的编程，向微处理器提供用户界面，处理和存储测试结果以及显示样本图像。

公开(公告)号：US5107133A

公开(公告)日：1992-04-21

申请号：US576604

申请日：1990-08-31

Applicant: Stanley M. Klainer

Inventor： Stanley M. Klainer

IPC: C12M1/34 ,  G01N21/01 ,  G01N21/03 ,  G01N21/25 ,  G01N21/75 ,  G01N21/77 ,  G01N21/80 ,  G01N33/543

CPC classification number: G01N21/75 ,  G01N21/253 ,  G01N2021/0193 ,  G01N2021/0325 ,  G01N2021/0385 ,  G01N2021/1738 ,  G01N21/77 ,  G01N21/80 ,  G01N2201/024 ,  G01N2201/0415

Abstract: A reservoir chemical sensor has a sensor body containing a reservoir cell channel around which source and detector are positioned within the cell body. A replaceable modular reservoir cell which contains sensing solution fits snugly and removably in the channel in the sensor body. Different reservoir cells can be easily inserted and removed from the sensor body.

Abstract translation: 储存器化学传感器具有包含储存器单元通道的传感器主体，源和检测器围绕该储存器单元通道定位在单元体内。 包含传感解决方案的可替换的模块化储存器单元紧密地和可拆卸地配合在传感器主体的通道中。 可以容易地从传感器主体中插入和移除不同的储存器单元。

公开(公告)号：US4657390A

公开(公告)日：1987-04-14

申请号：US703762

申请日：1985-02-21

Applicant: Walter M. Doyle

Inventor： Walter M. Doyle

IPC: G01J3/453 ,  G01N21/03 ,  G01N21/25 ,  G01N21/55 ,  G01B9/02 ,  G01J3/45 ,  G01N21/13

CPC classification number: G01N21/253 ,  G01J3/453 ,  G01N2021/0339 ,  G01N21/552 ,  G01N2201/0233 ,  G01N2201/024 ,  G01N2201/0415

Abstract: A spectrometer system is disclosed in which the sample-containing chamber is a separately constructed, enclosed modular unit which is readily attachable to, and detachable from, one wall of a housing which constitutes the basic unit of the spectrometer, and which contains an interferometer, one or more detectors, and other portions of the system. Various examples of the essentially unlimited types of sampling modules are disclosed. Also, automatic sample loading and unloading devices are disclosed, which are feasible because of the modular construction. And means of loading and unloading samples without purge loss are disclosed, which are feasible because of the modular construction.

Abstract translation: 公开了一种光谱仪系统，其中样品容纳室是单独构造的封闭的模块化单元，其容易地附接到构成所述光谱仪的基本单元的壳体的一个壁上并可拆卸，并且其包含干涉仪， 一个或多个检测器和系统的其它部分。 公开了基本上无限类型的采样模块的各种示例。 此外，公开了自动样品装载和卸载装置，这是因为模块化结构是可行的。 并且公开了无吹扫损失的装载和卸载样品，这是因为模块化构造是可行的。

公开(公告)号：US4437004A

公开(公告)日：1984-03-13

申请号：US295485

申请日：1981-08-24

Applicant: Robert E. Passaro ,  Irvin G. Burough

Inventor： Robert E. Passaro ,  Irvin G. Burough

IPC: G01N21/35 ,  G01J1/04 ,  G01N21/01

CPC classification number: G01N21/3504 ,  G01N2201/024

Abstract: An infrared gas analyzer is described wherein infrared energy is directed through a sample cell from a source at one end thereof. A detector at the opposite end of the sample tube monitors infrared energy of at least one pre-selected wavelength in order to produce a signal representative of the infrared energy passing through the sample cell. The analyzer is of modular construction including a disposable sample cell, an infrared source housing, a detector housing and printed circuit boards mounting signal processing components for the analyzer. A mounting base is adapted for receiving the sample tube, housings and printed circuit boards in operating alignment and interconnection with each other, detents positively securing the components in place.

Abstract translation: 描述了红外气体分析仪，其中红外能量在其一端通过来自源的样品池。 在样品管的相对端的检测器监测至少一个预选波长的红外能量，以产生表示通过样品池的红外能量的信号。 分析仪具有模块化结构，包括一次性样品池，红外源壳体，检测器壳体和用于分析仪的信号处理组件的印刷电路板。 安装基座适于接收样品管，壳体和印刷电路板，其操作对准并彼此互连，制动器将组件正确地固定在适当的位置。

公开(公告)号：US4082459A

公开(公告)日：1978-04-04

申请号：US690627

申请日：1976-05-27

Applicant: Court Lone Wolfe

Inventor： Court Lone Wolfe

IPC: G01N21/64 ,  G01N21/52

CPC classification number: G01N21/645 ,  G01N2021/6482 ,  G01N2201/024

Abstract: An analytical cell assembly comprising a base with a radiation source mounted on one end, an enclosure on the other end, and a cell proper, with cell heating means, within the enclosure. The enclosure and cell have cooperative fluid flow connections whereby the cell is modular and may be simply lifted out of the enclosure. The enclosure also includes a collimating lens assembly interposed between the cell within the enclosure and the source outside the enclosure on the base. The entire assemblage of source, enclosure and cell can be moved as a unit, making it modular, or just the cell can be moved as a module leaving the enclosure and the source in place in an instrument using the invention cell assembly.

公开(公告)号：US3977786A

公开(公告)日：1976-08-31

申请号：US463975

申请日：1974-04-25

Applicant: Jurgen Gast

Inventor： Jurgen Gast

IPC: G01J3/453 ,  G01J3/42 ,  G01N21/16

CPC classification number: G01J3/453 ,  G01N2201/024

Abstract: A modular system for performing optical spectroscopy measurements comprising enclosed modules with ports through which optical beams may pass into and out of the modules. The modules may be joined together with the ports aligned and are interchangeable in the sense that the focal point of the optical beam directed out of any output port has the same location relative to the output port.

Abstract translation: 用于执行光谱测量的模块化系统包括具有端口的封闭模块，光束可以通过该端口进入和离开模块。 这些模块可以连接在一起，端口对准，并且在从任何输出端口引出的光束的焦点相对于输出端口具有相同位置的意义上可互换。