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21.发明授权Optical tomography for microscopy, cell cytometry, microplate array instrumentation, crystallography, and other applications 有权光学断层扫描显微镜，细胞计数仪，微孔板阵列仪，晶体学等应用公开(公告)号：US09594019B1
公开(公告)日：2017-03-14
申请号：US13963931
申请日：2013-08-09
Applicant: Lester F. Ludwig
Inventor： Lester F. Ludwig , Karen Hao , Frank Hu , Alice Huang , Pooncharas Tipgunlakant
IPC: G01N21/59
CPC classification number: G01N21/59 , G01N15/0227 , G01N15/1434 , G01N15/1459 , G01N15/1475 , G01N15/1484 , G01N21/253 , G01N21/51 , G01N21/534 , G01N21/6452 , G01N21/6458 , G01N2015/0294 , G01N2015/1006 , G01N2015/1445 , G01N2015/1493 , G01N2015/1497 , G01N2021/1787 , G01N2201/062 , G01N2201/0626 , G01N2201/0628
Abstract: An optical tomography system including a light emitting array having one or more light emitting diodes (LEDs), a sample holding module and a light sensing array comprising one or more light emitting diodes (LEDs), wherein the light sensing array is configured to sense light emitted from the light emitting array, which has passed through the sample holding module.
Abstract translation: 一种光学断层摄影系统，包括具有一个或多个发光二极管（LED）的发光阵列，样品保持模块和包括一个或多个发光二极管（LED）的光感测阵列，其中光感测阵列被配置为感测光 从已经通过样品保持模块的发光阵列发射。
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公开(公告)号：US20160178521A1
公开(公告)日：2016-06-23
申请号：US14997832
申请日：2016-01-18
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael R. GAMBINI , Edward J. LAKATOS , Anthony L. CERRONE , Eugene F. YOUNG , John G. ATWOOD
IPC: G01N21/64
CPC classification number: G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.
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公开(公告)号：US20150322488A1
公开(公告)日：2015-11-12
申请号：US14730989
申请日：2015-06-04
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael R. GAMBINI , John G. ATWOOD , Anthony L. CERRONE , Edward J. LAKATOS , Eugene F. YOUNG
CPC classification number: G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.
Abstract translation: 光学仪器监测具有温度循环阻滞的反应装置中DNA的PCR复制，所述反应装置具有小瓶反应成分，包括在双链DNA存在下发荧光的染料。 分束器将激发光束传递到小瓶以使染料发荧光。 来自染料的发射光束通过分束器传递到CCD检测器，处理器从该CCD检测器计算DNA浓度。 具有多个参考发射器的参考条发射不同强度的参考光束，处理器从该参考光束选择用于补偿漂移的最佳发射器。 自动调整曝光时间以保持CCD和处理器的最佳动态范围。 分束器和相关的滤光器的模块与选定的染料相关联，并且可替代不同的染料。
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公开(公告)号：US20150107993A1
公开(公告)日：2015-04-23
申请号：US14396218
申请日：2013-04-18
Applicant: Transfert Plus, s.e.c.
Inventor： Ricardo Izquierdo , Philippe Juneau , Florent Lefèvre
CPC classification number: G01N33/1866 , C12M21/02 , C12M23/16 , C12Q1/02 , G01N21/64 , G01N21/6486 , G01N27/30 , G01N33/1893 , G01N2033/184 , G01N2201/0628 , G01N2201/068 , G01N2520/00
Abstract: There are provided methods and apparatuses for evaluating water pollution. The apparatus comprises at least one light source for exciting or causing activity of at least one type of microorganism or biological material; at least one photodetector for detecting a level of fluorescent light; and a chip disposed between the at least one light source and the detector, the chip comprising at least one microfluidic channel disposed for being exposed to light from the at least one light source and dimensioned for receiving a composition comprising the at least one type of microorganism or biological material and a water sample to be evaluated.
Abstract translation: 提供了评估水污染的方法和设备。 该装置包括用于激发或引起至少一种类型的微生物或生物材料的活性的至少一个光源; 用于检测荧光水平的至少一个光电检测器; 以及设置在所述至少一个光源和所述检测器之间的芯片，所述芯片包括至少一个微流体通道，所述至少一个微流体通道被设置用于暴露于来自所述至少一个光源的光，并被设计成用于接收包含所述至少一种类型的微生物 或生物材料和要评估的水样。
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公开(公告)号：US08492138B2
公开(公告)日：2013-07-23
申请号：US13611462
申请日：2012-09-12
Applicant: Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
Inventor： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
CPC classification number: G01N21/6486 , B01L7/52 , C12Q2545/101 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.
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Patent Agency Ranking
公开(公告)号：US08454894B2
公开(公告)日：2013-06-04
申请号：US11662321
申请日：2005-08-24
Applicant: Franz Padinger , Klaus G. Schröter
Inventor： Franz Padinger , Klaus G. Schröter
IPC: G01N27/00
CPC classification number: G01N21/78 , G01N21/75 , G01N2201/0628 , H01L27/146
Abstract: Described is a device for evaluating biochemical samples (1), with a sample carrier (2), with an image recording means having a light-sensitive layer (3) connected to an evaluation circuit (10), and with a means for illuminating the samples (1). In order to provide simple design conditions, it is proposed that the light-sensitive layer (3), provided on the sample carrier (2), of the image recording means comprise a photoactive layer (4) based on organic semiconductors between two electrode layers (5, 6), of which the electrode layer (6) between the photoactive layer (4) and the samples (1) is translucent at least in certain regions.
Abstract translation: 描述了一种用于用样品载体（2）评价生物化学样品（1）的装置，具有连接到评估电路（10）的具有感光层（3）的图像记录装置，以及用于照亮 样品（1）。 为了提供简单的设计条件，提出了设置在图像记录装置的样品载体（2）上的感光层（3）包括基于两个电极层之间的有机半导体的光活性层（4） （5,6），其中光活性层（4）和样品（1）之间的电极层（6）至少在某些区域是半透明的。
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公开(公告)号：US08361785B2
公开(公告)日：2013-01-29
申请号：US12321830
申请日：2009-01-26
Applicant: Mark F. Oldham , Eugene F. Young
Inventor： Mark F. Oldham , Eugene F. Young
CPC classification number: G01N21/6486 , B01L3/5085 , B01L7/52 , C12Q2545/101 , G01N21/274 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
Abstract: An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.
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公开(公告)号：US20110008210A1
公开(公告)日：2011-01-13
申请号：US12918843
申请日：2009-02-23
Applicant: Marika Kurkinen , Jukka Hast , Markus Tuomikoski , Markku Kansakoski , Harri Kopola
Inventor： Marika Kurkinen , Jukka Hast , Markus Tuomikoski , Markku Kansakoski , Harri Kopola
CPC classification number: G01N21/648 , G01N2021/056 , G01N2201/0628
Abstract: A biosensor platform for a biosensor adapted to detect one or more predetermined target analytes in a sample, includes a waveguide for transporting light emitted by a light source, at least one light source including an OLED, for incoupling light to the waveguide, the light source being arranged on the waveguide, a binding site including immobilized biorecognition material capable of binding to the target analytes, the binding site positioned relative to the waveguide such that evanescent field triggered by the light propagating in the waveguide extend to the binding site, a microfluidic layer including one or more microfluidic cavities for conveying the sample past the binding site to enable at least part of the target analytes of the sample to bind to the immobilized biorecognition material. The biosensor platform is configured to enable, when least part of the target analytes are bound to the immobilized biorecognition material, fluorescent markers associated with the bound target or other analytes to be excited by the evanescent field so as to emit fluorescence detectable by a detector.
Abstract translation: 一种用于检测样品中的一种或多种预定目标分析物的生物传感器的生物传感器平台，包括用于传输由光源发射的光的波导，至少一个包括OLED的光源，用于将光耦合到波导，光源 布置在波导上的结合位点，包括能够结合靶分析物的固定化生物识别材料的结合位点，相对于波导定位的结合位点使得由在波导中传播的光触发的消逝场延伸到结合位点，微流体层 包括用于将样品传送通过结合位点的一个或多个微流体腔，以使至少部分样品的目标分析物与固定的生物识别材料结合。 生物传感器平台被配置为使得当目标分析物的至少一部分与固定的生物识别材料结合时，与结合的靶标相关联的荧光标记或其它分析物将被ev逝场激发，以便发射由检测器检测到的荧光。
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公开(公告)号：US07387891B2
公开(公告)日：2008-06-17
申请号：US10440719
申请日：2003-05-19
Applicant: Steven J. Boege , Mark F. Oldham , Eugene F. Young
Inventor： Steven J. Boege , Mark F. Oldham , Eugene F. Young
CPC classification number: G01N21/6452 , B01L7/52 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0628 , G01N2201/0635 , Y10S435/808
Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with an excitation beam generated by a light source. A collimating lens can be disposed along a beam path between the light source and the reaction regions to form bundles of collimated excitation beams, wherein each bundle corresponds to a respective reaction region. Methods of analysis using the optical instrument are also provided.
Abstract translation: 提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多间隔开的反应区域。 准直透镜可以沿着光源和反应区域之间的光束路径设置，以形成准直激励束的束，其中每个束对应于相应的反应区域。 还提供了使用光学仪器的分析方法。
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公开(公告)号：US20070292307A1
公开(公告)日：2007-12-20
申请号：US11662321
申请日：2005-08-24
Applicant: Franz Padinger , Klaus Klaus
Inventor： Franz Padinger , Klaus Klaus
IPC: B01J19/00
CPC classification number: G01N21/78 , G01N21/75 , G01N2201/0628 , H01L27/146
Abstract: Described is a device for evaluating biochemical samples (1), with a sample carrier (2), with an image recording means having a light-sensitive layer (3) connected to an evaluation circuit (10), and with a means for illuminating the samples (1). In order to provide simple design conditions, it is proposed that the light-sensitive layer (3), provided on the sample carrier (2), of the image recording means comprise a photoactive layer (4) based on organic semiconductors between two electrode layers (5, 6), of which the electrode layer (6) between the photoactive layer (4) and the samples (1) is translucent at least in certain regions.
Abstract translation: 描述了一种用于用样品载体（2）评价生物化学样品（1）的装置，具有连接到评估电路（10）的具有感光层（3）的图像记录装置，以及用于照亮 样品（1）。 为了提供简单的设计条件，提出了设置在图像记录装置的样品载体（2）上的感光层（3）包括基于两个电极层之间的有机半导体的光活性层（4） （5,6），其中光活性层（4）和样品（1）之间的电极层（6）至少在某些区域是半透明的。
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