公开(公告)号：US20110194104A1

公开(公告)日：2011-08-11

申请号：US13023078

申请日：2011-02-08

Applicant: Martina DAUB ,  Jochen Rupp

Inventor： Martina DAUB ,  Jochen Rupp

IPC: G01N21/01 ,  B23P11/00 ,  B23P17/00

CPC classification number: G01N21/645 ,  B01L3/5085 ,  B01L2200/026 ,  B01L2200/141 ,  B01L2300/0654 ,  G01N21/0303 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/064

Abstract: A device and a method for optical parallel analysis of a sample arrangement. The device includes a system of sample areas provided on and/or in a front face of the carrier substrate for receiving a sample substance; a system of detector areas provided on and/or in a back face of the carrier substrate, each detector area being assigned to a corresponding sample area; and a system of optical devices, each optical system being assigned to a corresponding sample area and being designed in such a way that it deflects light beams, which the corresponding sample area in response to an optical excitation does not emit in the direction of a detector area assigned to it, in the direction of the detector area assigned to it and/or in the direction of a detector-free area on the back face of the carrier substrate.

Abstract translation: 用于样本布置的光学并行分析的装置和方法。 该装置包括：设置在载体基板的正面和/或前表面上的用于接收样品物质的样品区域系统; 设置在载体基板的背面和/或背面的检测器区域的系统，每个检测器区域被分配给相应的样品区域; 以及光学装置系统，每个光学系统被分配给对应的采样区域并且被设计成使得其偏转光束，所述光束响应于光学激发而不在检测器的方向上发射 分配给它的区域，分配给它的检测器区域的方向和/或在载体基板的背面上的无检测器区域的方向上。

公开(公告)号：US07961311B2

公开(公告)日：2011-06-14

申请号：US12810838

申请日：2008-12-24

Applicant: Amnon Weichselbaum ,  Jaime De La Zerda ,  Issakhar Regev

Inventor： Amnon Weichselbaum ,  Jaime De La Zerda ,  Issakhar Regev

IPC: G01N21/01

CPC classification number: G01N21/51 ,  G01N21/0303 ,  G01N33/493 ,  G01N2021/0382 ,  G01N2021/4769 ,  G01N2021/479 ,  G01N2021/513 ,  G01N2201/064

Abstract: System and method for detecting and counting bacteria suspended in a biological fluid by means of light scattering measurements is provided. In accordance with the method of the invention the level of signal to noise of the measured intensities of light scattered by a sample of the biological fluid is significantly enhanced for forwardly scattered light within a range of scattering angles which are smaller compared to a predefined maximal scattering angle. The system of the invention includes a cuvette adapted to contain a sample of the biological fluid whose sidewalls and windows are suitably constructed and arranged to significantly reduce the level of reflected light obscuring the scattering patterns measured within the range of scattering angles considered.

Abstract translation: 提供了通过光散射测量来检测和计数悬浮在生物流体中的细菌的系统和方法。 根据本发明的方法，在与预定的最大散射相比较小的散射角范围内的向前散射光显着增强了由生物流体样本散射的光的测量强度的信噪比水平 角度。 本发明的系统包括适于容纳生物流体的样本的比色皿，其侧壁和窗口被适当地构造和布置，以显着降低反射光的水平，遮蔽在所考虑的散射角度范围内测量的散射图案。

公开(公告)号：US20080144012A1

公开(公告)日：2008-06-19

申请号：US11956245

申请日：2007-12-13

Applicant: Alexander F. H. Goetz ,  Leonid G. Feldman ,  Thomas Ciupak ,  Robert J. Faus ,  Brian Curtiss

Inventor： Alexander F. H. Goetz ,  Leonid G. Feldman ,  Thomas Ciupak ,  Robert J. Faus ,  Brian Curtiss

IPC: G01N21/00 ,  G01J3/00

CPC classification number: G01N21/278 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/0291 ,  G01J3/08 ,  G01J3/42 ,  G01N21/255 ,  G01N21/55 ,  G01N2021/8411 ,  G01N2201/0636 ,  G01N2201/064

Abstract: A system and method for optical spectroscopic measurements is described. One embodiment includes a measurement head for optical spectroscopic measurements, the measurement head comprising an illumination source configured to illuminate a sample, a collection optic configured to view the sample, and an internal reference, wherein the internal reference can be illuminated by the illumination source and viewed by the collection optic.

Abstract translation: 描述了用于光谱测量的系统和方法。 一个实施例包括用于光学光谱测量的测量头，测量头包括被配置为照亮样本的照明源，被配置为观察样本的收集光学器件和内部参考，其中内部参考可被照明源照亮，以及 由收集光学器件查看。

公开(公告)号：US20060055930A1

公开(公告)日：2006-03-16

申请号：US10535259

申请日：2003-10-30

Applicant: Kazunori Yamauchi

Inventor： Kazunori Yamauchi

IPC: G01J3/50

CPC classification number: G01N21/78 ,  G01N21/8483 ,  G01N2021/7759 ,  G01N2021/7773 ,  G01N2201/022 ,  G01N2201/0627 ,  G01N2201/064 ,  G01N2201/101

Abstract: A scanning mechanism 6 moves an optical head 5 relative to a mount plate 2 in a scan direction, and light emitting diodes 3A, 3B mounted on the optical head 5 emit their respective beams of measurement light along the scan direction and onto two color regions TP3, TP3, respectively, of an immunochromatographic test strip mounted on the mount plate 2. Photodiodes 4A, 4B mounted on the optical head 5 receive respective beams of reflected light from the two color regions TP3, TP3 perpendicularly to colored lines on the immunochromatographic test strip, thereby implementing simultaneous measurement of color intensities of the colored lines formed in the two color regions TP3, TP3 of the immunochromatographic test strip.

Abstract translation: 扫描机构6在扫描方向上相对于安装板2移动光学头5，并且安装在光学头5上的发光二极管3A，3B沿着扫描方向发射它们各自的测量光束，并且发射到两个颜色 分别安装在安装板2上的免疫层析试片的区域TP 3，TP 3。 安装在光学头5上的光电二极管4A，4B接收来自两个颜色区域TP 3，TP 3的反射光的垂直于免疫色谱测试条上的着色线的反射光束，从而实现形成的着色线的色强度的同时测量 在两个颜色区域TP 3，TP 3的免疫层析试片。

公开(公告)号：US20050036914A1

公开(公告)日：2005-02-17

申请号：US10785411

申请日：2004-02-25

Applicant: Kazunori Yamauchi

Inventor： Kazunori Yamauchi

IPC: G01N21/47 ,  G01N21/78 ,  G01N21/86 ,  G01N21/00

CPC classification number: G01N30/90 ,  G01N21/474 ,  G01N21/78 ,  G01N21/8483 ,  G01N2201/064 ,  G01N2201/0813

Abstract: A measuring device for immunochromatography test piece comprising an irradiation optical system for irradiating measurement light onto an immunochromatography test piece, and a detection optical system for detecting reflected light from the immunochromatography test piece under irradiation with the measurement light. The irradiation optical system comprises a semiconductor light emitting element, a beam shaping member, a lens, a first baffle portion, a second baffle portion, and a third baffle portion. The beam shaping member shapes light from the semiconductor light emitting element, into a beam of a beam section extending in a direction substantially parallel to a colored line formed on the immunochromatography test piece. The lens focuses the beam from the beam shaping member on the immunochromatography test piece. The first baffle portion removes stray light, which is disposed between the semiconductor light emitting element and the beam shaping member. The second baffle portion removes stray light, which is disposed between the beam shaping member and the lens. The third baffle portion removes stray light, which is disposed between the lens and the immunochromatography test piece.

Abstract translation: 一种用于免疫层析试片的测量装置，包括用于将测量光照射到免疫层析试片上的照射光学系统，以及用于在用测量光照射下检测来自免疫层析试片的反射光的检测光学系统。 照射光学系统包括半导体发光元件，光束整形元件，透镜，第一挡板部分，第二挡板部分和第三挡板部分。 光束成形构件将来自半导体发光元件的光成形为沿与免疫层析试片上形成的彩色线基本平行的方向延伸的光束部分的光束。 透镜将来自光束成形构件的光束聚焦在免疫层析试片上。 第一挡板部分去除杂散光，其设置在半导体发光元件和光束成形构件之间。 第二挡板部分去除杂散光，其设置在光束成形构件和透镜之间。 第三挡板部分去除杂散光，其设置在透镜和免疫层析试片之间。

公开(公告)号：US20010007497A1

公开(公告)日：2001-07-12

申请号：US09748170

申请日：2000-12-27

Applicant: SHIMADZU CORPORATION

Inventor： Yoichi Fujiyama

IPC: G01N021/05

CPC classification number: G01N21/05 ,  G01N2021/0346 ,  G01N2201/064

Abstract: A measuring cell is formed of base plates joined together. A passage groove is formed on a joining surface of one base plate. Through-holes for introducing and discharging a fluid sample are formed on the other base plate, and the joining surface is provided with an optically opaque Si film as slits. Further, the joining surfaces of the base plates and the inner surface of the passage groove are covered with SiO2 films. Thus, a measuring cell having a sufficiently small passage sectional area, a high air-tightness, a chemically stable measuring chamber, and a high measuring sensitivity can be obtained.

Abstract translation: 测量单元由连接在一起的基板形成。 在一个基板的接合面上形成通道槽。 在另一个基板上形成用于引入和排出流体样品的通孔，并且接合表面设置有不透光的Si膜作为狭缝。 此外，基板的接合面和通道槽的内表面被SiO 2膜覆盖。 因此，可以获得具有足够小的通道截面积，高气密性，化学稳定的测量室和高测量灵敏度的测量池。

公开(公告)号：US5838429A

公开(公告)日：1998-11-17

申请号：US855918

申请日：1997-05-14

Applicant: Andreas Hahn

Inventor： Andreas Hahn

IPC: G01N21/25 ,  G01N21/31 ,  G01N33/48 ,  G01J1/04

CPC classification number: G01N21/255 ,  G01N21/3151 ,  G01N2021/3144 ,  G01N2201/0224 ,  G01N2201/0612 ,  G01N2201/064 ,  G01N2201/065

Abstract: The invention relates to an apparatus for measuring physiological parameters of blood conveyed within an extracorporeal circulatory system. Two light sources (1a, 1b) emit light of varying wavelength into a spherical cavity (3) that comprises a reflective inner surface (3a). Light sensor means (2) receives part of the light propagating within the cavity (3). A tube portion of the extracorporeal circulation can be inserted into a second cavity (4) such that the light (La, Lb) emitted by the light sources encounters the boundary surface between the blood and an inner wall of the tube. The light returns to the cavity (3) at least to an extent by means of reflection and/or transmission.

Abstract translation: 本发明涉及一种用于测量在体外循环系统内输送的血液的生理参数的装置。 两个光源（1a，1b）将变化波长的光发射到包括反射内表面（3a）的球形腔（3）中。 光传感器装置（2）接收在空腔（3）内传播的一部分光。 体外循环的管部分可以插入第二腔（4）中，使得由光源发射的光（La，Lb）遇到血液和管的内壁之间的边界面。 光通过反射和/或透射至少在一定程度上返回到空腔（3）。

公开(公告)号：US5159412A

公开(公告)日：1992-10-27

申请号：US670040

申请日：1991-03-15

Applicant: David L. Willenborg ,  Allan Rosencwaig ,  Jon Opsal

Inventor： David L. Willenborg ,  Allan Rosencwaig ,  Jon Opsal

IPC: G01B11/06 ,  G01M11/00 ,  G01N21/21 ,  G01N21/55 ,  G01N21/84

CPC classification number: G01N21/55 ,  G01B11/0616 ,  G01N21/211 ,  G01N21/8422 ,  G01N2201/064

Abstract: An approach for increasing the sensitivity of a high resolution measurement device 50 is disclosed. The device includes a laser 52 for generating a probe beam 54 which is tightly focused onto the surface of the sample 58. A detector 66 is provided for monitoring a parameter of the reflected probe beam. In accordance with the subject invention, a spatial filter is provided for reducing the amount of light energy reaching the detector that has been reflected from areas on the surface of the sample beyond the focused spot. The spatial filter includes a relay lens 68 and a blocking member 70 located in the focal plane of the lens. The blocking member 70 includes an aperture 72 dimensioned to block light reflected from the surface of the sample beyond a predetermined distance from the center of the focused spot. In this manner, greater sensitivity to sample characteristics within the highly focused spot is achieved.

公开(公告)号：US5108179A

公开(公告)日：1992-04-28

申请号：US391481

申请日：1989-08-09

Applicant: Stephen A. Myers

Inventor： Stephen A. Myers

IPC: G01N21/64 ,  G01N27/447

CPC classification number: G01N21/6428 ,  G01N21/645 ,  G01N27/44721 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N21/6402 ,  G01N21/6456 ,  G01N2201/064 ,  G01N2201/1042

Abstract: The use of continuous wave (CW) laser excitation to measure small differences in the fluorescence of bands of fluorophore stained nucleic acid fragments present in gels is described.

Abstract translation: 描述了使用连续波（CW）激光激发来测量存在于凝胶中的荧光团染色的核酸片段的荧光的微小差异。

公开(公告)号：US4632559A

公开(公告)日：1986-12-30

申请号：US704767

申请日：1985-02-21

Applicant: Albert Brunsting

Inventor： Albert Brunsting

IPC: G01N21/47 ,  G01J3/51

CPC classification number: G01N21/474 ,  G01N2021/478 ,  G01N2201/064

Abstract: Reflectance apparatus is disclosed for obtaining measurement of nonspecular reflected light in which controlled light rays are directed by means of a lens and transmission path from a light source through a light trap to expose or illuminate a specimen and nonspecular reflected light is passed from the specimen through the light trap along a transmission path to one or more detectors where the nonspecular reflected light is measured.

Abstract translation: 公开了用于获得非限制性反射光的测量的反射装置，其中受控光线通过透镜和来自光源的通过光阱的透射路径被引导以暴露或照亮样本，并且非特异性反射光从样本通过 沿着传输路径到一个或多个检测器的光阱，其中测量非特异性反射光。