公开(公告)号：US09470674B2

公开(公告)日：2016-10-18

申请号：US14174964

申请日：2014-02-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Darko Klinec

IPC: G01N33/49 ,  G01N21/25 ,  G01N21/31 ,  G01N21/51 ,  G01N35/10 ,  G01N15/06 ,  G01N35/02 ,  G01N21/13 ,  G01N15/04 ,  G01N35/04

CPC classification number: G01N33/491 ,  G01N15/06 ,  G01N21/13 ,  G01N21/253 ,  G01N21/3151 ,  G01N21/51 ,  G01N35/02 ,  G01N35/1016 ,  G01N2015/045 ,  G01N2015/0693 ,  G01N2035/0406 ,  G01N2035/1018 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/0668

Abstract: A method for detecting clots in a liquid is presented. The liquid is in a sample container. Light is irradiated having a first wavelength to the sample container by a first light source at a changeable vertical irradiating position (P_0 to P_n) such that the light irradiated by the first light source passes through the sample container along a first measurement path. An intensity of light having the first wavelength passing along the first measurement path and exiting the sample container is measured. Clots are detected in response to the measured intensity.

Abstract translation: 提出了一种用于检测液体中凝块的方法。 液体在样品容器中。 通过第一光源以可变的垂直照射位置（P_0至P_n）将第一波长的光照射到样品容器，使得由第一光源照射的光沿着第一测量路径通过样品容器。 测量具有沿着第一测量路径通过并离开样品容器的第一波长的光的强度。 根据测量的强度检测到凝块。

公开(公告)号：US09308306B2

公开(公告)日：2016-04-12

申请号：US14188193

申请日：2014-02-24

Applicant: Fresenius Medical Care Holdings, Inc.

Inventor： Louis Lee Barrett ,  Perry N. Law

IPC: A61M1/14 ,  G01N21/59 ,  G01N33/72 ,  A61M1/36

CPC classification number: A61M1/14 ,  A61B5/14535 ,  A61B5/14557 ,  A61M1/3609 ,  A61M1/3621 ,  A61M1/367 ,  A61M2202/0413 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/50 ,  A61M2205/70 ,  A61M2205/702 ,  A61M2230/20 ,  A61M2230/205 ,  A61M2230/207 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/59 ,  G01N33/4925 ,  G01N33/721 ,  G01N2201/062 ,  G01N2201/0668

Abstract: An optical blood monitoring system and corresponding method avoid the need to obtain a precise intensity value of the light impinging upon the measured blood layer during the analysis. The system is operated to determine at least two optical measurements through blood layers of different thickness but otherwise substantially identical systems. Due to the equivalence of the systems, the two measurements can be compared so that the bulk extinction coefficient of the blood can be calculated based only on the known blood layer thicknesses and the two measurements. Reliable measurements of various blood parameters can thereby be determined without certain calibration steps.

Abstract translation: 光学血液监测系统和相应的方法避免了在分析期间获得在测量血液层上入射的光的精确强度值的需要。 该系统被操作以通过不同厚度的血液层但是基本相同的系统来确定至少两个光学测量。 由于系统的等效性，可以比较两个测量值，使得可以仅基于已知血液层厚度和两次测量来计算血液的体积消光系数。 因此可以在没有某些校准步骤的情况下确定各种血液参数的可靠测量。

公开(公告)号：US20150053862A1

公开(公告)日：2015-02-26

申请号：US13975693

申请日：2013-08-26

Applicant: John Magie COFFIN

Inventor： John Magie COFFIN

IPC: G01J3/02

CPC classification number: G01N21/35 ,  G01J3/0237 ,  G01N21/0303 ,  G01N21/15 ,  G01N2201/0668

Abstract: The present invention is thus directed to an automated system of varying the optical path length in a sample that a light from a spectrophotometer must travel through. Such arrangements allow a user to easily vary the optical path length while also providing the user with an easy way to clean and prepare a transmission cell for optical interrogation. Such path length control can be automatically controlled by a programmable control system to quickly collect and stores data from different path lengths as needed for different spectrographic analysis. Moreover, the system utilizes configured wedge shaped windows to best minimize the reflections of light which cause periodic variation in transmission at different wave lengths (commonly described as “channel spectra”). Such a system, as presented herein, is able to return best-match spectra with far fewer computational steps and greater speed than if all possible combinations of reference spectra are considered.

Abstract translation: 因此，本发明涉及一种自动化系统，其改变来自分光光度计必须穿过的光的样品中的光程长度。 这样的布置允许用户容易地改变光路长度，同时还为用户提供了清洁和准备用于光询问的传输单元的简单方法。 这种路径长度控制可以由可编程控制系统自动控制，以便根据不同光谱分析的需要快速收集和存储来自不同路径长度的数据。 此外，该系统利用配置的楔形窗口来最大程度地最小化导致在不同波长（通常被描述为“通道光谱”）的传输中周期性变化的光的反射。 如本文所提出的，如果考虑到所有可能的参考光谱组合，这样一个系统就能够以更少的计算步骤和更高的速度返回最佳匹配光谱。

公开(公告)号：US20140367591A1

公开(公告)日：2014-12-18

申请号：US14376040

申请日：2013-02-01

Applicant: ECOLE POLYTECHNIQUE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIQUE

Inventor： Pierre Mahou ,  Emmanuel Jean Marc Beaurepaire ,  Delphine Debarre ,  Willy Supatto ,  Jean Louis Martin

IPC: G01N21/64

CPC classification number: G01N21/6456 ,  G01N21/3151 ,  G01N21/6402 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2201/06113 ,  G01N2201/0668 ,  G01N2201/0697 ,  G02B17/023 ,  G02B21/16

Abstract: A module is provided for a multi-photon imaging system for simultaneously exciting chromophores of a specimen. A first femtosecond laser source emits a first pulsed excitation beam having a repetition rate 1/T and a wavelength λ1 exciting a first chromophores, the absorbed photons originating from the first excitation beam. A second femtosecond laser source emits a second pulsed excitation beam with a wavelength λ2 exciting a second chromophores, the absorbed photons originating from the second beam; the first beam including an “excitation” part exciting the specimen and a “pumping” part acting as a pump beam for exciting the second laser source to synchronize the second laser source with the first laser source. An optical delay line superimposes spatially and temporally the second beam and the excitation part of the first beam to excite at least a third chromophore, the absorbed photons originating from the first and second excitation beams.

Abstract translation: 提供了用于同时激发样品的发色团的多光子成像系统的模块。 第一飞秒激光源发射具有重复频率1 / T和激发第一发色团的波长λ1的第一脉冲激励光束，所述第一发色团是源自第一激发光束的吸收的光子。 第二飞秒激光源发射具有激发第二发色团的波长λ2的第二脉冲激励光束，所述吸收的光子源自第二光束; 所述第一光束包括激发所述样本的“激发”部分和用作激发所述第二激光源以使所述第二激光源与所述第一激光源同步的泵浦光束的“泵浦”部分。 光学延迟线在空间上和时间上叠加第一光束和第一光束的激发部分，以激励至少第三发色团，所述第三发色团来自第一和第二激发光束的吸收的光子。

公开(公告)号：US08049884B2

公开(公告)日：2011-11-01

申请号：US12444308

申请日：2007-09-27

Applicant: Yasuo Tsukuda

Inventor： Yasuo Tsukuda

IPC: G01J3/02 ,  G01J3/28 ,  G01N21/27

CPC classification number: G01N21/251 ,  G01N21/0303 ,  G01N21/31 ,  G01N2021/035 ,  G01N2201/0668

Abstract: A liquid sample is dropped onto the upper surface of a transparent and cylindrical light-transmitting body (22), and the liquid sample is maintained as a droplet by the surface tension. From above the liquid sample, a transparent cover plate (25) is lowered down to the position where the lower surface thereof touches a spacer (23) in order that the liquid sample is held in the small gap formed between the upper surface of the light-transmitting body (22) and the lower surface of the transparent cover plate (25). A measurement light is provided into the liquid sample held in this manner from immediately above it, and passes through the liquid sample. The transmitted light emitted downwards through the light-transmitting body (22) is introduced into a spectro-detecting unit to be spectro-measured. The measurement optical path length can be adjusted by the height of the spacer (23). This enables an easy transmission spectro-measurement of an extremely small amount of liquid sample.

Abstract translation: 将液体样品滴在透明圆柱形透光体（22）的上表面上，并通过表面张力将液体样品保持为液滴。 从液体样品的上方，将透明盖板（25）向下降到其下表面接触间隔件（23）的位置，以使液体样品保持在形成在光的上表面之间的小间隙 - 透射体（22）和透明盖板（25）的下表面。 将测量光从其上方以这种方式提供到液体样品中，并通过液体样品。 通过透光体（22）向下发射的透射光被引入光谱检测单元进行光谱测量。 测量光路长度可以通过间隔物（23）的高度来调节。 这使得能够容易地透射光谱测量极少量的液体样品。

公开(公告)号：US20110233406A1

公开(公告)日：2011-09-29

申请号：US12731909

申请日：2010-03-25

Applicant: Alexander Majewski ,  Robert Noll ,  Malcolm J. MacFarlane

Inventor： Alexander Majewski ,  Robert Noll ,  Malcolm J. MacFarlane

IPC: G01J5/00 ,  G01T1/00

CPC classification number: G01N21/3504 ,  G01N21/031 ,  G01N21/3581 ,  G01N2201/0668

Abstract: An apparatus is provided that includes a field reflector and a plurality of pairs of object reflectors. The apparatus also includes a plurality of source and detector port pairs, where each source port is configured to pass a beam of radiation, and each detector port is configured to receive a beam of radiation. The source and detector ports of each pair are positioned proximate an outer edge of the field reflector such that an optical axis of the field reflector lies between the respective source port and detector port. The object reflectors and source and detector port pairs are arranged such that each source and detector port pair is associated with a respective pair of object reflectors forming a distinct channel, where the source and detector port pair, and centers of the associated pair of object reflectors, of each channel lie in a distinct plane.

Abstract translation: 提供了一种包括场反射器和多对物体反射器的装置。 该装置还包括多个源和检测器端口对，其中每个源端口被配置为通过辐射束，并且每个检测器端口被配置为接收辐射束。 每对的源极和检测器端口位于场反射器的外边缘附近，使得场反射器的光轴位于相应的源极端口和检测器端口之间。 对象反射器和源和检测器端口对被布置成使得每个源极和检测器端口对与形成不同通道的相应对物体反射器相关联，其中源极和检测器端口对以及相关联的物体反射体对的中心 ，每个通道位于一个不同的平面。

公开(公告)号：US06611333B1

公开(公告)日：2003-08-26

申请号：US09936946

申请日：2001-09-20

Applicant: Kiyoji Uehara ,  Naohiro Yoshida ,  Tomoyuki Kikugawa

Inventor： Kiyoji Uehara ,  Naohiro Yoshida ,  Tomoyuki Kikugawa

IPC: G01N2135

CPC classification number: G01N21/031 ,  G01N21/3103 ,  G01N21/3504 ,  G01N21/39 ,  G01N2201/0668

Abstract: An isotopomer absorption spectral analyzing apparatus and its method for precisely measuring the isotope ratio by substantially equalizing the absorption signal levels of different species of isotopes. In an isotopomer absorption spectral analyzing apparatus, a sample cell (21) capable of providing optical paths of different optical lengths is installed, optical beams A, B are caused to enter the sample cell (21) and travel along paths of different optical lengths, thereby determining the abundance ratio between species of isotopes in molecules from the ratio between intensities of signals corresponding to the species of isotopes.

Abstract translation: 同位素吸收光谱分析装置及其通过基本均衡不同种类的同位素吸收信号水平来精确测量同位素比的方法。 在同位素吸收光谱分析装置中，安装能够提供不同光学长度的光路的样品池（21），使光束A，B进入样品池（21），沿着不同光程长度的路径行进， 从而从同位素种类的信号强度之间的比值确定分子中同位素种类之间的丰度比。

公开(公告)号：US5925881A

公开(公告)日：1999-07-20

申请号：US943712

申请日：1997-10-03

Applicant: Gunter Wahlbrink

Inventor： Gunter Wahlbrink

IPC: G01N21/03 ,  G01N21/61

CPC classification number: G01N21/031 ,  G01N2201/0668

Abstract: A measuring cell (1) for the analysis of a gas sample by infrared absorption, with a measuring path (2) accommodating the gas sample, which has opposite limiting surfaces (7, 9) enclosing the gas sample, wherein a focusing optical component (8) is present at the first limiting surface (7) and an infrared radiation source and a radiation receiver (4) are arranged in the area of the second limiting surface (9) such that a measuring beam (13) emitted by the radiation source (3) is directed onto the radiation receiver (4) through the optical component, shall be improved such that it be suitable for the detection of gases with a long absorption path. A mirror surface (12) active for the measuring path (2) is present in the area of the second limiting surface (9), and the geometry of the optical component (8) is dimensioned such that there is an at least fourfold pass of the measuring beam (13) in the measuring path (2), utilizing the reflection of the beam on the mirror surface (12).

Abstract translation: 一种用于通过红外吸收分析气体样品的测量单元（1），其具有容纳气体样品的测量路径（2），其具有包围气体样品的相对限制表面（7,9），其中聚焦光学部件 8）存在于第一限制表面（7）处，并且红外辐射源和辐射接收器（4）布置在第二限制表面（9）的区域中，使得由辐射源发射的测量光束（13） （3）通过光学部件被引导到辐射接收器（4）上，应该被改进，使其适于检测具有长吸收路径的气体。 在第二限制表面（9）的区域中存在用于测量路径（2）的镜面（12），并且光学部件（8）的几何尺寸被设计成使得存在至少四倍的 测量光束（13）在测量路径（2）中，利用光束在镜面（12）上的反射。

公开(公告)号：US5602647A

公开(公告)日：1997-02-11

申请号：US562785

申请日：1995-11-27

Applicant: Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

Inventor： Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

IPC: G01N21/27 ,  G01J3/42 ,  G01N21/03 ,  G01N21/31 ,  G01N21/39 ,  G01N21/59 ,  G01N21/00

CPC classification number: G01N21/0303 ,  G01N21/31 ,  G01J3/42 ,  G01N2021/3129 ,  G01N21/39 ,  G01N21/59 ,  G01N2201/066 ,  G01N2201/0668

Abstract: An apparatus and method for optically measuring concentrations of components allow enhancement in measurement accuracy of concentration. The apparatus includes a cell, a light irradiator, a photodetector, and an arithmetic unit. The cell presents different optical path lengths at different locations and is to contain a sample therein. The light irradiator, which includes a variable-wavelength laser generator and a measuring system composed of convex lenses, outputs a collimated, enlarged laser beam, and makes the laser beam incident upon the cell. The photodetector comprises a multiplicity of photodetectors arranged in parallel to the surface of the cell, so that it can detect intensity of rays of transmitted light that have traveled over different optical path lengths at positions of an equal distance from the cell. The arithmetic unit, receiving a signal from the individual photodetectors, calculates concentrations of components in the sample based on optimum optical path lengths for different wavelengths and values of transmitted light at positions of the optimum optical path lengths, and further outputs calculation results.

Abstract translation: 用于光学测量组分浓度的装置和方法允许增强浓度的测量精度。 该装置包括单元，光照射器，光电检测器和运算单元。 细胞在不同位置呈现不同的光程长度，并且其中包含样品。 包括可变波长激光发生器和由凸透镜组成的测量系统的光照射器输出准直的，放大的激光束，并使激光束入射到电池上。 光电检测器包括与电池表面平行设置的多个光电检测器，使得其可以检测在距离电池相等距离的位置处已经在不同光程长度上行进的透射光的光强。 运算单元接收来自各个光电检测器的信号，根据最佳光程长度的不同波长的最佳光路长度和最佳光路长度位置处的透射光值，计算样品中的成分浓度，并进一步输出计算结果。

公开(公告)号：US4488814A

公开(公告)日：1984-12-18

申请号：US306206

申请日：1981-09-28

Applicant: Leighton C. Johnson

Inventor： Leighton C. Johnson

IPC: G01N21/11 ,  G01N21/64 ,  G01N35/10 ,  G01J3/50 ,  G01N21/03

CPC classification number: G01N35/1004 ,  G01N21/11 ,  G01N21/645 ,  G01N2021/6482 ,  G01N2035/1062 ,  G01N2201/0668

Abstract: Apparatus and method for biological fluid analysis involving radiation measurement. The apparatus includes a pipetting dispenser having means for directing radiation from the piston thereof generally axially through the liquid in the pipette tube such that the pipetting dispenser serves not only as a means for measuring and mixing liquids, but also serves as a cuvette. The apparatus and method provide maximum radiation path length to accommodate liquids of different optical density. Still another feature of the apparatus and method is the provision of means for removing liquid from the outer surface of a pipette tube, which means are readily adapted to automated procedures. The apparatus in one embodiment is adapted for absorbance measurement of analyte samples, and in another embodiment is adapted for measurement of fluorescent radiation from analyte samples.

Abstract translation: 涉及辐射测量的生物流体分析装置和方法。 该装置包括移液分配器，其具有用于将来自其活塞的辐射大致轴向地引导通过移液管中的液体的装置，使得移液分配器不仅用作用于测量和混合液体的装置，而且用作比色皿。 该装置和方法提供最大辐射路径长度以适应不同光密度的液体。 该装置和方法的另一个特征是提供了用于从移液管的外表面去除液体的装置，这意味着容易适应于自动化程序。 一个实施例中的装置适用于分析物样品的吸光度测量，并且在另一个实施例中适用于测量来自分析物样品的荧光辐射。