公开(公告)号：US07899506B2

公开(公告)日：2011-03-01

申请号：US10532669

申请日：2003-09-25

Applicant: Kexin Xu ,  Yiwen Ma ,  Renda Wang

Inventor： Kexin Xu ,  Yiwen Ma ,  Renda Wang

IPC: A61B5/1455

CPC classification number: A61B5/0059 ,  G01J3/10 ,  G01J3/1256 ,  G01N21/359 ,  G01N2021/3144

Abstract: The present invention discloses a spectral measurement method via continuous light source and discrete light source, and a measurement instrument for non-invasive detection of human body tissue components. Said instrument includes an incident unit, a probe, a receiving unit and a data processing unit. Said composite spectral measurement method improves or strengthens the output light intensity at the wavelength that carries information of the target component within human body. It enables the spectral detection in the whole wavelength range, and thus significantly enhances the SNR of the detecting system. In the non-invasive detection instrument, light from both the continuous light source and discrete light source can be firstly selectively light-split by AOTF, or AOTF conducts light-splitting for the continuous light source, while the discrete light source LD is controlled by a spatial chopper. When data of the spectral curves achieved from said continuous light source and discrete light source are processed, data acquired under different measuring modes can be compared.

Abstract translation: 本发明公开了一种通过连续光源和离散光源的光谱测量方法，以及用于人体组织成分非侵入性检测的测量仪器。 所述仪器包括入射单元，探测器，接收单元和数据处理单元。 所述复合光谱测量方法改善或加强了携带人体内目标成分信息的波长处的输出光强度。 它能够在整个波长范围内进行光谱检测，从而显着提高检测系统的信噪比。 在非侵入式检测仪器中，来自连续光源和离散光源的光可以首先被AOTF选择性地光分裂，或者AOTF对连续光源进行光分裂，而离散光源LD由 空中砍刀 当从所述连续光源和离散光源获得的光谱曲线的数据被处理时，可以比较在不同测量模式下获得的数据。

公开(公告)号：US5796482A

公开(公告)日：1998-08-18

申请号：US741261

申请日：1996-10-30

Applicant: Kexin Xu ,  Michio Naka ,  Norihito Suzuki

Inventor： Kexin Xu ,  Michio Naka ,  Norihito Suzuki

IPC: G01N21/21 ,  G01B9/02

CPC classification number: G01N21/21

Abstract: The optical measuring apparatus of this invention for measuring a physical amount of a specific component contained in a substance to be measured by the use of measurement light which passes through the substance to be measured and the use of predetermined reference light includes: a first interfering polarizing plate for obtaining a first light interference signal by interfering the measurement light; a second interfering polarizing plate for obtaining a second light interference signal by interfering the reference light; a first photoelectric converting section for converting the first light interference signal into a first electric signal; a second photoelectric converting section for converting the second light interference signal into a second electric signal; a first phase expanding section for expanding a phase of the first electric signal; a second phase expanding section for expanding a phase of the second electric signal; a phase difference measuring section for measuring a phase difference between a phase expanded by the first phase expanding section and a phase expanded by the second phase expanding section; and a physical amount determining section for determining the physical amount of the specific component contained in the substance to be measured depending on the phase difference measured by the phase difference measuring section.

Abstract translation: 本发明的光学测量装置用于通过使用通过待测物质的测量光和使用预定参考光来测量待测物质中所含特定成分的物理量的物理量包括：第一干涉极化 用于通过干涉测量光来获得第一光干涉信号; 第二干涉偏振板，用于通过干涉参考光来获得第二光干涉信号; 第一光电转换部分，用于将第一光干涉信号转换成第一电信号; 第二光电转换部分，用于将第二光干涉信号转换成第二电信号; 第一相位扩展部，用于扩大第一电信号的相位; 第二相位扩展部，用于扩大第二电信号的相位; 相位差测量部分，用于测量由第一相位扩展部分扩展的相位与由第二相位扩展部分扩展的相位之间的相位差; 以及物理量确定部，用于根据由相位差测量部测量的相位差确定待测物质中包含的特定成分的物理量。

公开(公告)号：US20080171925A1

公开(公告)日：2008-07-17

申请号：US12007427

申请日：2008-01-10

Applicant: Kexin Xu ,  Zhenhui Du

Inventor： Kexin Xu ,  Zhenhui Du

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B2562/0242

Abstract: This specification discloses a method and apparatus for noninvasive measurement of human body component, such as glucose, in vivo. The apparatus includes near infrared spectroscopy based laser sources driven at carrier frequency lying within the absorption line of the component. The apparatus also drive the laser diodes with a modulation frequency to generate frequency difference between the measuring light and reference beam, and the interference of the two beam results in a beat signal, which frequency is proportional to optical path difference between the measuring light and reference beam. We can detect the spectrum of the scattering light, which propagate at specifically single optical path, by select the frequency using a phase sensitive detector (PSD) circuit. The apparatus include several laser sources and its controllers which modulate the laser's radiation, and includes an optical fiber coupler and splitter to split the laser into measuring and reference beam, and includes PSD circuit to detect the signal by the frequency. The apparatus further includes a signal processor that applies a derivative spectroscopy technique, such as wavelength modulation spectroscopy, to determine the concentration of the component in the body.

Abstract translation: 本说明书公开了一种在体内无创测量人体成分如葡萄糖的方法和装置。 该装置包括在位于组件的吸收线内的载波频率驱动的基于近红外光谱的激光源。 该装置还驱动具有调制频率的激光二极管以产生测量光和参考光束之间的频率差，并且两个光束的干涉导致拍频信号，该频率与测量光和参考的光程差成比例 光束。 我们可以通过使用相位敏感检测器（PSD）电路选择频率来检测在特定的单个光路上传播的散射光的光谱。 该装置包括几个激光源及其控制器，其调制激光的辐射，并且包括光纤耦合器和分离器，以将激光器分成测量和参考光束，并且包括通过频率检测信号的PSD电路。 该装置还包括信号处理器，其应用诸如波长调制光谱的衍生光谱技术来确定体内组分的浓度。

公开(公告)号：US06404492B1

公开(公告)日：2002-06-11

申请号：US09068028

申请日：1998-07-07

Applicant: Kexin Xu ,  Keiichi Fukada

Inventor： Kexin Xu ,  Keiichi Fukada

IPC: G01J328

CPC classification number: G01J3/10 ,  G01J2003/1828

Abstract: An acousto-optic tunable filter 4 including: an acousto-optic crystal 41; an acoustic wave driver 42; and a piezoelectric transducer 43, is provided in front of a light source section 2 including a plurality of light sources 2A, 2B, . . . 2N having different wavelength characteristics. The frequency of RF generated by the acoustic wave driver 42 is varied in accordance with a desired wavelength. Thus, the light having the desired wavelength is incident on a converging lens 5 as plus and minus first-order light beams, and the light having wavelengths other than the desired wavelength is incident on a converging lens 5 as a zero-order light beam. The converging lens 5 converges the plus and minus first-order light beams and the zero-order light beams at positions different from each other. A selector 6 having openings located at the positions onto which the plus and first-order light beams are converged is provided in front of the converging lens 5. Therefore, only the light having the desired wavelength can pass through the selector 6 and is emitted from the light source apparatus 1.

Abstract translation: 声光可调滤波器4，包括：声光晶体41; 声波驱动器42; 并且在包括多个光源2A，2B的光源部2的前方设置有压电换能器43。 。 。 2N具有不同的波长特性。 由声波驱动器42产生的RF的频率根据期望的波长而变化。 因此，具有期望波长的光作为正，负一级光束入射在会聚透镜5上，并且具有期望波长的波长的光作为零级光束入射在会聚透镜5上。 会聚透镜5将正，负一级光束和零级光束会聚在彼此不同的位置。 在会聚透镜5的前面设置有具有位于正和一级光束会聚的位置的开口的选择器6。因此，只有具有所需波长的光才能通过选择器6并从 光源装置1。

公开(公告)号：US6014245A

公开(公告)日：2000-01-11

申请号：US997854

申请日：1997-12-24

Applicant: Kexin Xu ,  Hiroshi Yamamoto ,  Bin Xue

Inventor： Kexin Xu ,  Hiroshi Yamamoto ,  Bin Xue

IPC: G02F1/33 ,  G02F1/11

CPC classification number: G02F1/116

Abstract: In a non-collinear type acousto-optic tunable filter, a source light beam is made off-perpendicularly incident on a crystal body, so that the cross section of the source light beam is narrowed within the crystal body. As a result, the receiving angular aperture becomes large to increase the amount of light collected into the crystal body. Consequently, highly accurate spectrometry can be performed even if the intensity of the source light beam is low. Further, the non-diffraction part of the crystal body can be eliminated by the off-perpendicular incidence of the source light beam, so that the sufficient diffraction length of acoustic and optic waves can be obtained.

Abstract translation: 在非共线型声光可调滤波器中，源光束被垂直地入射到晶体上，使得源光束的横截面在晶体内变窄。 结果，接收角孔径变大，以增加收集到晶体中的光量。 因此，即使源光束的强度低，也可以进行高精度的光谱测定。 此外，可以通过源光束的垂直入射来消除晶体的非衍射部分，从而可以获得声光和光波的足够的衍射长度。

公开(公告)号：US5475234A

公开(公告)日：1995-12-12

申请号：US280811

申请日：1994-07-26

Applicant: Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

Inventor： Kexin Xu ,  Yutaka Yamasaki ,  Harumi Uenoyama ,  Takeshi Sakura

IPC: G01N15/06 ,  A61B5/00 ,  G01N21/27 ,  G01N21/49 ,  G01N21/85

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  G01N21/49 ,  G01N2021/1789 ,  G01N2021/1791 ,  G01N2021/4797 ,  G01N21/359

Abstract: An apparatus and method for measuring component concentrations which enables accurate measurement of concentrations of component within an object in a non-destructive, non-invasive, and bloodless procedure. The apparatus comprises a light irradiator 1 for projecting pulse laser of different wavelengths toward an object 12 by means of a variable wavelength laser generating unit 11, a photodetector 2 for performing a time resolved measurement of the quantity of transmitted light from the object which is subject to changes with lapse of time after the generation of the pulse laser, and an arithmetic unit 3 for calculating concentrations of components in the object 12 and outputting the calculation result such that the relationship between time lapse and measured quantity of light is converted into a relationship between an optical path length representing the distance of light travel within the object 12 and a change in the measured quantity of light relative to a change in unit concentration so that the optical path length and the quantity of light which is measured when the change in the quantity of light is at a peak are stored in memory for each wavelength, the quantity of light being used as a basis for the calculation.

Abstract translation: 一种用于测量组分浓度的装置和方法，其能够在非破坏性，非侵入性和无血液过程中精确测量物体内的组分的浓度。 该装置包括用于通过可变波长激光产生单元11将不同波长的脉冲激光投射到物体12的光照射器1，用于对来自被摄体的物体的透射光进行时间分辨测量的光电检测器2 在产生脉冲激光之后经过时间的变化，以及用于计算对象12中的分量的浓度的运算单元3，并输出计算结果，使得时间流逝和测量光量之间的关系被转换为关系 在表示物体12内的光行进距离的光路长度与测量的光量相对于单位浓度的变化的变化之间，使得光路长度和当光线长度变化时所测量的光量 光量处于峰值时，存储在每个波长的存储器中，光量为我们 作为计算的基础。

公开(公告)号：US20180135729A1

公开(公告)日：2018-05-17

申请号：US15578642

申请日：2015-06-10

Applicant: Zhengxian Shen ,  Kexin Xu ,  Xinghan Chen ,  Pinshu Chen

Inventor： Zhengxian Shen ,  Kexin Xu ,  Xinghan Chen ,  Pinshu Chen

IPC: F16G11/14 ,  F16B45/00

CPC classification number: F16G11/143 ,  A45F3/00 ,  A45F5/102 ,  A45F2003/001 ,  A47G25/08 ,  A47J45/02 ,  F16B45/00

Abstract: A dual side-hook structure is a hook unit with four hooks. The hook unit is latched on a horizontal, vertical or inclined rope or a long strip object without shifting to hang up an object without limitation in space. The hook unit includes positioning hooks on an upper end of the hook unit and hanging hooks on a lower end of the hook unit. A rope is enabled to pass through the positioning hooks or hanging hooks at two sides of the hook unit, and then the hook unit is secured on a fixed point on the rope without sliding freely. Edges of the positioning hooks and hanging hooks include abutting devices to prevent the rope from sliding out of the hook unit. The hook unit is positioned on a vertical rope by using the hanging hooks horizontally. The positioning hooks and the hanging hooks are used interchangeably. The entire hook unit is used very flexibly and versatilely without limitation in space, and is especially usable in a wild field, an outdoor area or a camping ground.

公开(公告)号：US08349258B2

公开(公告)日：2013-01-08

申请号：US12867964

申请日：2008-11-26

Applicant: Kexin Xu ,  Dachao Li

Inventor： Kexin Xu ,  Dachao Li

IPC: G01N33/00

CPC classification number: G01N33/66 ,  G01N29/036 ,  G01N33/5438 ,  G01N2291/0256 ,  G01N2291/0427

Abstract: Disclosed is a sensor for measuring the amount of an analyte to be detected in human interstitial fluid, comprising a micro-cantilever sensing unit which includes: a first substrate; a micro-cantilever which is substantially in parallel with the first substrate and one end of which is supported onto the first substrate; a gold film formed onto at least one side of the micro-cantilever; a protein layer formed on the gold film, the protein layer being used to adsorb, at a surface thereof, the analyte to be detected in human interstitial fluid; a driving electrode provided on the first substrate; a micro-cantilever electrode which is provided on the first substrate at a position where the micro-cantilever is supported, and which is cooperated with the driving electrode so as to drive the micro-cantilever to produce resonance in a direction perpendicular to the first substrate; and a detecting electrode which is provided on the first substrate and which is cooperated with the micro-cantilever electrode so as to detect resonance frequency of the micro-cantilever. The present invention also relates to a fluid channel unit, a sensor system, and a method for measuring the amount of an analyte to be detected in human interstitial fluid.

Abstract translation: 公开了一种用于测量人间质液中要检测的分析物的量的传感器，包括微悬臂感测单元，其包括：第一基板; 基本上与第一基板平行的微悬臂，其一端被支撑在第一基板上; 形成在微悬臂梁的至少一侧上的金膜; 形成在金膜上的蛋白质层，所述蛋白质层用于在其表面吸附要在人间质液中检测的分析物; 设置在所述第一基板上的驱动电极; 微悬臂电极，其设置在所述第一基板上的所述微悬臂支撑的位置处，并且与所述驱动电极配合，以便驱动所述微悬臂以在垂直于所述第一基板的方向上产生共振 ; 以及检测电极，其设置在所述第一基板上，并且与所述微悬臂电极配合，以检测所述微悬臂的共振频率。 本发明还涉及一种流体通道单元，传感器系统和用于测量在人类间质液中待检测的分析物的量的方法。

公开(公告)号：US5973822A

公开(公告)日：1999-10-26

申请号：US998042

申请日：1997-12-23

Applicant: Kexin Xu ,  Hiroshi Yamamoto ,  Bin Xue

Inventor： Kexin Xu ,  Hiroshi Yamamoto ,  Bin Xue

IPC: G02F1/33 ,  G02F1/11

CPC classification number: G02F1/116

Abstract: In a non-collinear type acousto-optic tunable filter, the incident angle of a source light beam L.sub.1 radiated from a light source 6 onto an acoustic medium 1 is set at an equivalence incident angle for which the wavelength .lambda..sub.i of the diffracted ordinary ray L.sub.3 and the wavelength .lambda..sub.i ' of the diffracted extraordinary ray L.sub.4 become approximately identical. Further, the diffracted ordinary ray L.sub.3 and the diffracted extraordinary ray L.sub.4 of the approximately identical wavelength are superposed, and the intensity of the superposed ray is detected. Consequently, spectrometry is performed based on the superposed diffracted ray having twice the intensity and a very sharp waveform, so that accurate spectroscopy can be made possible even if the intensity of the source light beam is low.

Abstract translation: 在非共线型声光可调滤波器中，从光源6辐射到声学介质1上的源光束L1的入射角被设定为等于入射角，对于该入射角，衍射普通光线的波长λi L3和衍射异常射线L4的波长λi'变得大致相同。 此外，将衍射的普通光线L3和大致相同波长的衍射非凡光线L4重叠，并且检测叠加的光线的强度。 因此，基于具有两倍强度和非常尖锐的波形的叠加衍射光线进行光谱测定，使得即使源光束的强度低，也可以使精确的光谱学成为可能。

公开(公告)号：US08346329B2

公开(公告)日：2013-01-01

申请号：US12007427

申请日：2008-01-10

Applicant: Kexin Xu ,  Zhenhui Du

Inventor： Kexin Xu ,  Zhenhui Du

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B2562/0242

Abstract: A method and apparatus for noninvasive measurement of a human body component, such as glucose, in vivo, include near infrared spectroscopy based laser sources driven at a carrier frequency lying within the characteristic absorption of the component. The apparatus also drives the laser diodes with a modulation frequency to generate a frequency difference between the measuring light and reference beam, and the interference of the two beams results in a beat frequency signal, which frequency is proportional to the optical path difference between the measuring light and the reference beam. The scattering lights from human tissue with different optical lengths are simultaneously detected and selected based on the beat frequency. The method is a convenient embodiment of the floating reference principle, which takes advantage of optical length selection.

Abstract translation: 用于在体内非侵入性地测量人体成分（例如葡萄糖）的方法和装置包括在位于组件的特征吸收中的载体频率下驱动的基于近红外光谱的激光源。 该装置还驱动具有调制频率的激光二极管，以产生测量光和参考光束之间的频率差，并且两个光束的干涉导致拍频信号，该频率与测量的光程差成比例 光和参考光束。 基于拍频，同时检测和选择具有不同光长度的人体组织的散射光。 该方法是利用光学长度选择的浮动参考原理的方便实施例。