公开(公告)号：US20190209540A1

公开(公告)日：2019-07-11

申请号：US16299444

申请日：2019-03-12

Applicant: Insys Development Company, Inc.

Inventor： Ning Shan ,  Rajesh R. Wakaskar ,  Edwin A. Baldwin ,  Andrew B. Schlinkert ,  Min Wu ,  Ningxin Yan

IPC: A61K31/4468 ,  A61K47/26 ,  A61K31/485 ,  A61K47/10 ,  A61K9/00

CPC classification number: A61K31/4468 ,  A61K9/006 ,  A61K31/485 ,  A61K47/10 ,  A61K47/26 ,  A61K2300/00

Abstract: Sublingual formulations containing an opioid, preferably, fentanyl or a pharmaceutically acceptable salt or ester thereof, naloxone or a pharmaceutically acceptable salt or ester thereof, and a terpene; as well as methods of treating pain by administering the formulations of the invention to a patient in need thereof.

公开(公告)号：US10265309B2

公开(公告)日：2019-04-23

申请号：US15606146

申请日：2017-05-26

Applicant: Insys Development Company, Inc.

Inventor： Ning Shan ,  Rajesh R. Wakaskar ,  Edwin A. Baldwin ,  Andrew B. Schlinkert ,  Min Wu ,  Ningxin Yan

IPC: A61K9/00 ,  A61K47/10 ,  A61K47/26 ,  A61K31/485 ,  A61K31/4468 ,  A61P25/04

Abstract: Sublingual formulations containing an opioid, preferably, fentanyl or a pharmaceutically acceptable salt or ester thereof, naloxone or a pharmaceutically acceptable salt or ester thereof, and a terpene; as well as methods of treating pain by administering the formulations of the invention to a patient in need thereof.

公开(公告)号：US20190070105A1

公开(公告)日：2019-03-07

申请号：US16177361

申请日：2018-10-31

Applicant: Insys Development Company, Inc.

Inventor： Kiran Amancha ,  Chandeshwari Chilampalli ,  Thrimoorthy Potta ,  Ningxin Yan ,  Venkat R. Goskonda

IPC: A61K9/00 ,  A61K31/485

Abstract: The invention provides stable liquid formulations containing naloxone, a pharmaceutically acceptable salt or a derivative thereof. The invention further provides methods for treating opioid overdose, opioid dependence, and congenital insensitivity to pain with anhidrosis by administering the liquid formulations of the present invention intranasally to a patient in need thereof. Further, the invention provides a method of treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering intranasally the naloxone formulations of the present invention.

公开(公告)号：US20180318215A1

公开(公告)日：2018-11-08

申请号：US16023313

申请日：2018-06-29

Applicant: Insys Development Company, Inc.

Inventor： Thrimoorthy Potta ,  Craig Bastian ,  Ningxin Yan ,  Venkat Goskonda ,  Chandeshwari Chilampalli ,  Rachana Inavolu ,  Eshwaran Narayanan

IPC: A61K9/08 ,  A61K31/137 ,  A61K47/02 ,  A61K47/18 ,  A61K47/10 ,  A61K9/00 ,  A61P37/08

CPC classification number: A61K31/137 ,  A61K9/0043 ,  A61K9/006 ,  A61K9/0073 ,  A61K9/08 ,  A61K9/12 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/186 ,  A61P37/08

Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.

公开(公告)号：US10111833B2

公开(公告)日：2018-10-30

申请号：US15488660

申请日：2017-04-17

Applicant: Insys Development Company, Inc.

Inventor： Thrimoorthy Potta ,  Kiran Amancha ,  Wesley Giron ,  Ningxing Yan ,  Venkat Goskonda ,  Onkar N. Singh ,  Holly Redman ,  Rajesh R Wakaskar

IPC: A61K9/00 ,  A61K31/519 ,  A61K47/10 ,  A61K47/02

Abstract: The invention is directed to sublingual spray formulations containing sildenafil. The invention is further directed to methods of treating male sexual dysfunction or pulmonary arterial hypertension by administering sublingual spray formulations containing sildenafil to patients in need of such treatments.

公开(公告)号：US09918981B2

公开(公告)日：2018-03-20

申请号：US15336547

申请日：2016-10-27

Applicant: Insys Development Company, Inc.

Inventor： Kiran P. Amancha ,  Chandeshwari S. Chilampalli ,  Venkat R. Goskonda

IPC: A61K31/485 ,  A61K9/00 ,  A61K47/10 ,  A61K31/4748 ,  A61K47/22 ,  A61K47/18 ,  A61K47/02 ,  A61K47/40

CPC classification number: A61K31/485 ,  A61K9/006 ,  A61K9/08 ,  A61K31/4748 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/22 ,  A61K47/40 ,  A61K2300/00

Abstract: The invention provides liquid formulations containing buprenorphine, a pharmaceutically acceptable salt thereof, or a derivative thereof. The invention further provides liquid formulations containing buprenorphine and naloxone, pharmaceutically acceptable salts thereof or derivatives thereof. The invention further provides a method of treating pain or opioid dependence by administering liquid formulations containing buprenorphine or a combination of buprenorphine and naloxone, a pharmaceutically acceptable salt thereof, or a derivative thereof to a patient in need thereof.

公开(公告)号：US20170340620A1

公开(公告)日：2017-11-30

申请号：US15606146

申请日：2017-05-26

Applicant: Insys Development Company, Inc.

Inventor： Ning Shan ,  Rajesh R. Wakaskar ,  Edwin A. Baldwin ,  Andrew B. Schlinkert ,  Min Wu ,  Ningxin Yan

IPC: A61K31/4468 ,  A61K9/00 ,  A61K31/485 ,  A61K47/10

CPC classification number: A61K31/4468 ,  A61K9/006 ,  A61K31/485 ,  A61K47/10 ,  A61K47/26 ,  A61K2300/00

Abstract: Sublingual formulations containing an opioid, preferably, fentanyl or a pharmaceutically acceptable salt or ester thereof, naloxone or a pharmaceutically acceptable salt or ester thereof, and a terpene; as well as methods of treating pain by administering the formulations of the invention to a patient in need thereof.

公开(公告)号：US20170340557A1

公开(公告)日：2017-11-30

申请号：US15606125

申请日：2017-05-26

Applicant: Insys Development Company, Inc.

Inventor： Ning Shan ,  Rajesh R. Wakaskar ,  Edwin A. Baldwin ,  Andrew B. Schlinkert ,  Min Wu ,  Ningxin Yan

IPC: A61K9/00 ,  A61K31/4468 ,  A61K47/10 ,  A61K47/12

CPC classification number: A61K9/006 ,  A61K31/4468 ,  A61K47/10 ,  A61K47/12

Abstract: Sublingual formulations containing fentanyl, a pharmaceutically acceptable salt or ester thereof, ethanol, propylene glycol and menthol, as well as methods of treating pain by administering the formulations of the invention to a patient in need thereof.

公开(公告)号：US20170216199A1

公开(公告)日：2017-08-03

申请号：US15488712

申请日：2017-04-17

Applicant: Insys Development Company, Inc.

Inventor： Thrimoorthy Potta ,  Craig Bastian ,  Ningxin Yan ,  Venkat Goskonda

IPC: A61K9/00 ,  A61K47/12 ,  A61K47/10 ,  A61K47/02 ,  A61K31/137 ,  A61K47/36

CPC classification number: A61K9/0043 ,  A61K9/006 ,  A61K9/0073 ,  A61K9/0078 ,  A61K9/08 ,  A61K31/137 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  A61K47/36

Abstract: The present invention is directed to epinephrine spray formulations. The present invention is further directed to methods of treating anaphylaxis by administering epinephrine spray formulations to subjects in need of such treatments.

公开(公告)号：US20170216196A1

公开(公告)日：2017-08-03

申请号：US15488660

申请日：2017-04-17

Applicant: Insys Development Company, Inc.

Inventor： Thrimoorthy Potta ,  Kiran Amancha ,  Wesley Giron ,  Ningxing Yan ,  Venkat Goskonda ,  Onkar N. Singh

IPC: A61K9/00 ,  A61K31/519 ,  A61K47/12 ,  A61K9/08

CPC classification number: A61K9/006 ,  A61K31/519 ,  A61K47/02 ,  A61K47/10

Abstract: The invention is directed to sublingual spray formulations containing sildenafil. The invention is further directed to methods of treating male sexual dysfunction or pulmonary arterial hypertension by administering sublingual spray formulations containing sildenafil to patients in need of such treatments.