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    Peptide exhibiting hydrolytic activity and use thereof
    32.
    发明授权
    Peptide exhibiting hydrolytic activity and use thereof 有权

    公开(公告)号：US10995119B2

    公开(公告)日：2021-05-04

    申请号：US16067764

    申请日：2017-01-06

    Applicant: Okinawa Institute of Science and Technology School Corporation

    Inventor： Toshifumi Akizawa ,  Tadashi Yamamoto

    IPC: C07K7/08 ,  C07K14/47 ,  C12N9/50

    Abstract: The present invention provides a novel molecule that catalyzes a hydrolysis reaction and is different from enzyme proteins. The catalytic peptide according to the present invention is a catalytic peptide that catalyzes a hydrolysis reaction, including at least one peptide selected from the group consisting of the following peptides (A1) to (A4): (A1) a peptide consisting of Box A and at least one of an upstream region and a downstream region therefrom in a Tob/BTG protein; (A2) a peptide consisting of a partial region of the peptide (A1); (A3) a peptide that consists of an amino acid sequence obtained by deletion, substitution, addition, and/or insertion of one or more amino acids in an amino acid sequence of the peptide (A1) or (A2) and has hydrolysis activity; and (A4) a peptide consisting of an amino acid sequence with a sequence identity of at least 85% to the amino acid sequence of the peptide (A1) or (A2) and having hydrolysis activity.

    Inverse reinforcement learning by density ratio estimation
    33.
    发明授权
    Inverse reinforcement learning by density ratio estimation 有权

    公开(公告)号：US10896382B2

    公开(公告)日：2021-01-19

    申请号：US15329690

    申请日：2015-08-07

    Applicant: Okinawa Institute of Science and Technology School Corporation

    Inventor： Eiji Uchibe ,  Kenji Doya

    IPC: G06N20/00 ,  G06N7/00

    Abstract: A method of inverse reinforcement learning for estimating cost and value functions of behaviors of a subject includes acquiring data representing changes in state variables that define the behaviors of the subject; applying a modified Bellman equation given by Eq. (1) to the acquired data: q(x)+gV(y)−V(x)=−ln{pi(y|x))/(p(y|x)} (1) where q(x) and V(x) denote a cost function and a value function, respectively, at state x, g represents a discount factor, and p(y|x) and pi(y|x) denote state transition probabilities before and after learning, respectively; estimating a density ratio pi(y|x)/p(y|x) in Eq. (1); estimating q(x) and V(x) in Eq. (1) using the least square method in accordance with the estimated density ratio pi(y|x)/p(y|x), and outputting the estimated q(x) and V(x).

    3D polymeric insert to apply uniform electric field in circular cultureware
    34.
    发明授权
    3D polymeric insert to apply uniform electric field in circular cultureware 有权

    公开(公告)号：US10851337B2

    公开(公告)日：2020-12-01

    申请号：US15759734

    申请日：2016-09-16

    Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

    Inventor： Hsieh-Fu Tsai ,  Amy Shen Fried ,  Ji-Yen Cheng

    IPC: C12M1/42 ,  C12M1/22 ,  C12M1/00

    Abstract: A disclosed insert for a circular-shaped petri dish can generate a substantially uniform electric field across the petri dish that is filled with a fluid establishing a salt bridge. The insert includes a circular-shaped bottom plate defining a circular-shaped space; a side channel vertically erecting from a circular periphery of said bottom plate; and a pair of current rectifying chambers each having a generally planar shape communicating with the side channel. In at least some aspects of the invention, portions of the side channel bridging the pair of current rectifying chambers each have a generally concave top profile having a lowest point at the center between the pair of current rectifying chambers such that, when the salt bridge is established, the circular-shaped space defined by the bottom plate exhibits a substantially uniform electric field in a substantially entire area of the space.

    METHOD OF NANOSCALE PATTERNING BASED ON CONTROLLED PINHOLE FORMATION
    36.
    发明申请
    METHOD OF NANOSCALE PATTERNING BASED ON CONTROLLED PINHOLE FORMATION 审中-公开

    公开(公告)号：US20190105812A1

    公开(公告)日：2019-04-11

    申请号：US16099493

    申请日：2017-06-01

    Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

    Inventor： Yabing Qi ,  Luis Katsuya Ono

    IPC: B29C41/12 ,  B29C33/38 ,  H01L51/00

    Abstract: A method of nanoscale patterning is disclosed. The method comprises: mixing predetermined amounts of a first solvent and a second solvent to generate a solvent, the first solvent and the second solvent being immiscible with each other; dissolving a solute material in the solvent to generate a coating material, the solute material having solubility that is higher in the first solvent than in the second solvent; and applying the coating material onto a substrate to form a plurality of pinholes in the coating material. The formation of the plurality of pinholes is associated with suspension drops mostly comprised of the second solvent, separated from the solute material dissolved in the first solvent, in the coating material. A method of making a stamp with a nanoscale pattern is also disclosed based on the above method.

    Doping engineered hole transport layer for perovskite-based device
    39.
    发明授权
    Doping engineered hole transport layer for perovskite-based device 有权

    公开(公告)号：US10115918B2

    公开(公告)日：2018-10-30

    申请号：US15523500

    申请日：2015-11-05

    Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

    Inventor： Yabing Qi ,  Min-Cherl Jung ,  Sonia Ruiz Raga

    IPC: H01L51/42 ,  H01L51/00

    Abstract: An optoelectronic device is provided, the device comprising an active layer comprising organometal halide perovskite and a hole transport layer (HTL) formed by vacuum evaporation and configured to transport hole carriers. The HTL includes a first sublayer comprising a hole transport material (HTM) doped with an n-dopant and disposed adjacent to the active layer, a second sublayer comprising the HTM that is undoped and disposed adjacent to the first sublayer, and a third sublayer comprising the HTM doped with a p-dopant and disposed adjacent to the second sublayer. The doping concentration of the n-dopant for the n-doped sublayer is determined to match the highest occupied molecular orbital energy level of the n-doped sublayer with the valence band maximum energy level of the perovskite active layer.

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