公开(公告)号：US11970590B2

公开(公告)日：2024-04-30

申请号：US18097986

申请日：2023-01-17

Applicant: Simon Fraser University

Inventor： Steven Holdcroft ,  Thomas J. G. Skalski ,  Michael Adamski ,  Benjamin Britton ,  Timothy J. Peckham

IPC: C08J5/22 ,  B01D69/02 ,  B01D71/82 ,  C07C211/63 ,  C07C309/44 ,  C08G61/10 ,  H01M8/10 ,  H01M8/1023

CPC classification number: C08J5/2256 ,  B01D69/02 ,  B01D71/82 ,  C07C211/63 ,  C07C309/44 ,  C08G61/10 ,  H01M8/1023 ,  B01D2325/42 ,  C08G2261/11 ,  C08G2261/1452 ,  C08G2261/148 ,  C08G2261/228 ,  C08G2261/312 ,  C08J2365/02 ,  H01M2008/1095

Abstract: Described herein are anionic phenylene oligomers and polymers, and devices including these materials. The oligomers and polymers can be prepared in a convenient and well-controlled manner, and can be used in cation exchange membranes. Also described is the controlled synthesis of anionic phenylene monomers and their use in synthesizing anionic oligomers and polymers, with precise control of the position and number of anionic groups.

公开(公告)号：US20230391796A1

公开(公告)日：2023-12-07

申请号：US18246534

申请日：2021-09-24

Applicant: UNIVERSIDAD DE SEVILLA (US) -UNIVERSITY OF SEVILLE (US) ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)- SPANISH NATIONAL RESEARCH COUNCIL (CSIC) ,  SIMON FRASER UNIVERSITY

Inventor： David VOCADLO ,  Jose Manuel GARCIA FERNANDEZ ,  Carmen ORTIZ MELLET ,  Manuel GONZALEZ CUESTA

IPC: C07D513/04

CPC classification number: C07D513/04

Abstract: The invention provides compounds of Formula (I) for inhibiting glycosidases, pro drugs of the compounds, and pharmaceutical compositions comprising the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of OGA, accumulation or deficiency of O-GlcNAc.

公开(公告)号：US20230159716A1

公开(公告)日：2023-05-25

申请号：US18097986

申请日：2023-01-17

Applicant: Simon Fraser University

Inventor： Steven Holdcroft ,  Thomas J.G. Skalski ,  Michael Adamski ,  Benjamin Britton ,  Timothy J. Peckham

IPC: C08J5/22 ,  B01D69/02 ,  B01D71/82 ,  C07C211/63 ,  C07C309/44 ,  C08G61/10 ,  H01M8/1023

CPC classification number: C08J5/2256 ,  B01D69/02 ,  B01D71/82 ,  C07C211/63 ,  C07C309/44 ,  C08G61/10 ,  H01M8/1023 ,  B01D2325/42 ,  C08G2261/11 ,  C08G2261/1452 ,  C08G2261/148 ,  C08G2261/228 ,  C08G2261/312 ,  C08J2365/02 ,  H01M2008/1095

Abstract: Described herein are anionic phenylene oligomers and polymers, and devices including these materials. The oligomers and polymers can be prepared in a convenient and well-controlled manner, and can be used in cation exchange membranes. Also described is the controlled synthesis of anionic phenylene monomers and their use in synthesizing anionic oligomers and polymers, with precise control of the position and number of anionic groups.

公开(公告)号：US11540515B2

公开(公告)日：2023-01-03

申请号：US17257844

申请日：2019-06-28

Applicant: Simon Fraser University ,  The State of Israel Ministry of Agriculture & Rural Development Agricultural Research Organization

Inventor： Erika Plettner ,  Victoria Soroker

IPC: A01N31/14

Abstract: The present disclosure provides acaricidal compounds, i.e. compounds 3c {3,6}, 3c {4,6}, 3c {3, 3}, 3c {4,3} and 3c {6,6}, that are effective in killing Varroa destructor mites while being harmless to honey bees.

公开(公告)号：US11534114B2

公开(公告)日：2022-12-27

申请号：US16327638

申请日：2017-08-23

Applicant: SIMON FRASER UNIVERSITY

Inventor： Paul Schaffer ,  Hua Yang ,  Robert Britton ,  Matthew Nodwell ,  Zheliang Yuan

IPC: A61B6/03 ,  C07K5/10 ,  A61K51/08 ,  C07K7/06 ,  C07K5/06 ,  C07K1/13 ,  C07K5/08 ,  C07K5/02 ,  C07B59/00 ,  A61K51/04 ,  C07C275/16 ,  C07C237/12 ,  C07C229/20 ,  C07C229/08 ,  C07C229/26 ,  C07C229/36

Abstract: The present invention provides 18F-labeled amino acids or derivatives thereof having formula (I) and methods of making same, which can be suitable for PET imaging:

公开(公告)号：US20220242893A1

公开(公告)日：2022-08-04

申请号：US17725689

申请日：2022-04-21

Applicant: SIMON FRASER UNIVERSITY

Inventor： Marion THÉVENIN ,  Robert N. YOUNG ,  Gang CHEN

IPC: C07F9/572 ,  C07F9/38 ,  A61K47/54 ,  A61P19/08

Abstract: The present invention relates to conjugate compounds and methods of making and using same.

公开(公告)号：US11312737B2

公开(公告)日：2022-04-26

申请号：US16518132

申请日：2019-07-22

Applicant: SIMON FRASER UNIVERSITY

Inventor： Marion Thévenin ,  Robert N. Young ,  Gang Chen

IPC: C07F9/572 ,  C07F9/38 ,  A61K47/54 ,  A61P19/08

Abstract: The present invention relates to EP4 agonist-bisphosphonate conjugates or related compounds and uses thereof. Said conjugates or related compounds may be used to provide delivery of an EP4 agonist or related compound to a desired site of action, such as a bone. Bisphosphonate moieties, linked to the EP4 agonists via amide linkers, have been implicated in the inhibition of bone resorption and bone targeting.

公开(公告)号：US20210024464A1

公开(公告)日：2021-01-28

申请号：US16774814

申请日：2020-01-28

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA ,  SIMON FRASER UNIVERSITY

Inventor： Paul RENNIE ,  Artem TCHERKASSOV ,  Robert N. YOUNG ,  Christophe M. ANDRE

IPC: C07D209/14 ,  C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07C243/22 ,  C07D209/08 ,  C07D209/10 ,  C07D209/30 ,  C07D209/34 ,  C07D209/42 ,  C07D235/18 ,  C07D235/30 ,  C07D277/82 ,  C07D401/06 ,  C07D401/10 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10

Abstract: This invention provides compound having a structure of Formulas: Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provide.

公开(公告)号：US10598248B2

公开(公告)日：2020-03-24

申请号：US15801042

申请日：2017-11-01

Applicant: SIMON FRASER UNIVERSITY

Inventor： Mohammad Mehdi Naserimojarad ,  Mehrdad Moallem ,  Siamak Arzanpour

IPC: F16F9/19 ,  F16F9/53 ,  B62K25/08 ,  B62K25/10 ,  F16F9/34 ,  B62K25/28 ,  F16F9/02 ,  F16D37/02 ,  G05G5/03

Abstract: A smart fluid damper includes a damper body defining a cavity with smart fluid. A piston head is disposed within the cavity and is slidingly displaceable. A flow control element is disposed within the cavity. The flow control element includes a main body having a central core, and an outer housing that surrounds the main body and is spaced apart therefrom to define a fluid passage between the main body and the outer housing. The fluid passage extends axially through the main body to permit fluid flow therethrough. The central core includes an energizable coil operable to apply a field. A plurality of field barriers are provided, each operable to locally block the field generated by the energizable coil such that the field cannot pass directly therethrough. The field barriers are configured to focus the field within the fluid passage.

公开(公告)号：US10512772B2

公开(公告)日：2019-12-24

申请号：US14383285

申请日：2013-03-04

Applicant: SIMON FRASER UNIVERSITY

Inventor： Joaquin Andres Hoffer ,  Marc-Andre Nolette ,  Viral Thakkar ,  Bao Dung Tran

IPC: A61N1/05 ,  A61N1/36

Abstract: The invention, in one aspect, relates to an intravascular electrode system. The system comprises one or more electrodes supported on an elongated resiliently flexible support member, and the support member may be used to introduce the electrodes into a blood vessel. As the support member is introduced into the blood vessel the support member bends to follow the path of the blood vessel.