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公开(公告)号：US11661600B2
公开(公告)日：2023-05-30
申请号：US16761205
申请日：2018-11-02
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Christopher Ahern , John D. Lueck
IPC: C12N15/113 , A61P43/00 , A61K9/127 , A61K31/7105
CPC classification number: C12N15/113 , A61K9/127 , A61K31/7105 , A61P43/00
Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, and anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof. In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, and anticodon-arm and an acceptor arm, (a) wherein the anticodon-arm comprises a tri-nucleotide anticodon, wherein the anticodon is 5′-UCA-3′ and recognizes TGA stop codons, and wherein the acceptor arm is operably linked to a arginine, tryptophan or glycine; (b) wherein the anticodon-arm comprises a tri-nucleotide anticodon, wherein the anticodon is 5′-UUA-3′ and recognizes TAA stop codons, and wherein the acceptor arm is operably linked to a glutamine or, glutamate; or (c) wherein the anticodon-arm comprises a tri-nucleotide anticodon, wherein the anticodon is 5′-CUA-3′ and recognizes TAG stop codons, and wherein the acceptor arm is operably linked to a tryptophan, glutamate or glutamine.
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公开(公告)号：US11634466B2
公开(公告)日：2023-04-25
申请号：US16414263
申请日：2019-05-16
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Leonid Zingman , Denice Hodgson-Zingman
Abstract: In certain embodiments, the present invention provides a musclin peptide and methods of increasing muscle growth, performance, resistance to injury and/or preventing or reducing muscle atrophy and improving overall skeletal muscle, metabolic and cardiac health in an animal in need thereof by administering a musclin peptide.
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公开(公告)号：US11591581B2
公开(公告)日：2023-02-28
申请号：US16262905
申请日：2019-01-30
Applicant: The Broad Institute, Inc. , Massachusetts Institute of Technology , University of Iowa Research Foundation
Inventor： Feng Zhang , Beverly Davidson , Chie-Yu Lin , Edgardo Rodriguez
IPC: C12N9/22 , C12N15/10 , C12N15/63 , A01K67/027 , C12N15/90 , A61K38/46 , A61K48/00 , C12N15/113 , C12N15/86 , A61K31/713 , C12N7/00 , B82Y5/00
Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a SIN CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing SIN CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
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公开(公告)号：US20230037586A1
公开(公告)日：2023-02-09
申请号：US17879385
申请日：2022-08-02
Applicant: University of Iowa Research Foundation
Inventor： Hongtao Ding , Avik Samanta , Wuji Huang
Abstract: The disclosure relates to maskless, laser-assisted methods for making a metal surface comprising at least one of hydrophobic and hydrophilic regions; and at least one of micro- and nanostructured regions.
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公开(公告)号：US11553865B2
公开(公告)日：2023-01-17
申请号：US16696715
申请日：2019-11-26
Applicant: University of Iowa Research Foundation
Inventor： Christopher Cooper , Ryan Steinberg , Lewis Thomas , Eric Pahl , Sanam Zarei , Kayla Jones
Abstract: The various embodiments disclosed here relate to systems, methods, and devices for monitoring bladder health. Certain implementations are directed to patients who require daily catheterization. The various embodiments have at least one tube coupled to a catheter, a pressure sensor, a pump, and a processor. Certain embodiments include a digital device with a software application capable of displaying the monitored readings.
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Patent Agency Ranking
公开(公告)号：US11529335B2
公开(公告)日：2022-12-20
申请号：US16945323
申请日：2020-07-31
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Michael K. Schultz , Somya Kapoor , Douglas R. Spitz
IPC: A61K31/437 , A61P35/04 , A61K31/198 , A61K31/4706 , A61K31/66 , C07K16/28
Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with a GSH synthesis inhibitor and an anti-cancer composition.
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公开(公告)号：US11525069B2
公开(公告)日：2022-12-13
申请号：US16312448
申请日：2017-06-24
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Elise Lin Cheng , C. Allan Guymon , Marian R. Hansen , Braden Leigh
IPC: C09D133/10 , A61L27/16 , A61L27/34 , A61L29/04 , A61L29/08 , A61L31/04 , A61L31/10 , C08K5/11 , C09D5/16 , C09D133/26 , C09D151/08
Abstract: Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.
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公开(公告)号：US20220364142A1
公开(公告)日：2022-11-17
申请号：US17767280
申请日：2020-10-09
Applicant: The Board of Trustees of the Leland Stanford Junior University , The United States Government as represented by the Department of Veterans Affairs , UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Vinit Mahajan , Gabriel Velez , Young Joo Sun , Kellie A Schaefer , Alexander G Bassuk
Abstract: Compositions, methods, and kits are provided for assaying calpain-5 activity and inhibition. In particular, novel peptide substrates are provided for detecting calpain-5, measuring calpain-5 activity, and screening for inhibitors of calpain-5 to identify potential therapeutic agents for treating retinal diseases and other diseases associated with calpain-5 hyperactivity. Additionally, novel inhibitors of calpain-5 are also provided.
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公开(公告)号：US11475562B2
公开(公告)日：2022-10-18
申请号：US16914972
申请日：2020-06-29
Applicant: University of Iowa Research Foundation
Inventor： Sarah E. Gerard , Joseph M. Reinhardt
Abstract: Embodiments of the present systems and methods may provide fissure detection in CT images, with improved performance, accuracy, and specificity. For example, in an embodiment, a method may comprise imaging, using a computed tomography system, at least one lung, to generate, at a computer system comprising a processor, memory accessible by the processor, and computer program instructions stored in the memory and executable by the processor, at least one computed tomography image of the at least one lung, determining, at the computer system, at least one approximate fissure region of interest in the at least one lung image, determining, at the computer system, a more precise fissure location within the at least one region of interest, and generating an image of the lung including indication of the determined fissure location.
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公开(公告)号：US20220327963A1
公开(公告)日：2022-10-13
申请号：US17848810
申请日：2022-06-24
Applicant: University of Iowa Research Foundation
Inventor： Marcus Tatum , Geb W. Thomas
Abstract: A system for simulating surgery includes an electromagnetic tracking system comprising an emitter and a plurality of electromagnetic sensors and a plurality of model bone fragments, each of the model bone fragments operatively connected to one of the plurality of electromagnetic sensors. A method for simulating surgery includes electromagnetically tracking position of a plurality of model bone fragments and a model bone shaft using an electromagnetic tracking system and displaying virtual fluoroscopic images based on sensed position of the model bone fragments and the model bone shaft.
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