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公开(公告)号：US11782192B2
公开(公告)日：2023-10-10
申请号：US17166294
申请日：2021-02-03
Applicant: University of Rochester
Inventor： David H. Lippman , Greg R. Schmidt
CPC classification number: G02B3/0087 , B29D11/00355 , G02B1/041 , G02B27/0062
Abstract: A GRIN optic having an optical axis (z-direction) and a GRIN profile varying in the x and y-directions, the profile having one or more discontinuities extending in the x-y direction. The discontinuities may form a non-closed shape or have a non-smooth rectilinear shape. The GRIN optic may have plane-parallel surfaces. A method of designing a GRIN optic which includes mapping discretized elements in the light output specification to array elements of a linear GRIN array elements, identifying for each array element, a base refractive index n0, a gradient magnitude α, and a gradient direction θG capable of directing a beamlet from the light source to a corresponding location in the light output specification, and constructing a piecewise-continuous freeform GRIN profile of the GRIN optic by integrating the discrete linear GRIN array elements into a continuous refractive index profile.
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公开(公告)号：US11776428B1
公开(公告)日：2023-10-03
申请号：US16234420
申请日：2018-12-27
Applicant: University of Rochester
Inventor： Jonathan Stone , Ahmed E. Ghazi
CPC classification number: G09B23/303 , G09B23/34
Abstract: The invention provides systems and methods for improved simulation of surgical procedures, using models of anatomical organs. The models comprise models of internal components present in the anatomical organ. The models of the internal components are registered to the position which the internal component occupies in the anatomical organ, and in some embodiments the models of the anatomical organ can lose simulated physiological fluids during simulated surgery.
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公开(公告)号：US20230293642A9
公开(公告)日：2023-09-21
申请号：US17719580
申请日：2022-04-13
Applicant: University of Miami , University of Rochester , UCL Business LTD
Inventor： Stephan L. ZUCHNER , Adriana REBELO , Andrea CORTESE , Rong Grace ZHAI , David N. HERRMANN
IPC: A61K38/44 , A61P25/28 , A61K31/198 , A61K31/352 , A61K31/4184 , A61K31/4188 , A61K31/426 , A61K31/428 , A61K31/473 , A61K31/499 , A61K31/502 , A61K31/517 , A61K31/7105 , A61K38/46 , A61K48/00 , C12N9/04 , C12N15/113 , C12N15/86 , C12Q1/6883 , G01N33/66
CPC classification number: A61K38/443 , A61P25/28 , A61K31/198 , A61K31/352 , A61K31/4184 , A61K31/4188 , A61K31/426 , A61K31/428 , A61K31/473 , A61K31/499 , A61K31/502 , A61K31/517 , A61K31/7105 , A61K38/465 , A61K48/005 , C12N9/0006 , C12N15/1137 , C12N15/86 , C12Q1/6883 , C12Y101/01014 , G01N33/66 , C12N2310/11 , C12N2750/14143 , C12Q2600/156
Abstract: The present disclosure relates to methods of detecting and treating inherited neuropathy.
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公开(公告)号：US20230293594A1
公开(公告)日：2023-09-21
申请号：US18135543
申请日：2023-04-17
Applicant: UNIVERSITY OF ROCHESTER
Inventor： Steven A. GOLDMAN , Maiken NEDERGAARD
IPC: A61K35/30 , A61P25/18 , A61K31/495 , C12N5/0735 , C12N5/074
CPC classification number: A61K35/30 , A61K31/495 , A61P25/18 , C12N5/0606 , C12N5/0696 , A61K9/0019
Abstract: The present disclosure is directed to a method of treating a neuropsychiatric disorder. This method involves selecting a subject having the neuropsychiatric disorder and administering to the selected subject a preparation of glial progenitor cells at a dosage effective to treat the neuropsychiatric disorder in the subject. Another aspect of the disclosure is directed to a method of treating a neuropsychiatric disorder that includes selecting a subject having the neuropsychiatric disorder and administering, to the selected subject, a potassium (K+) channel activator at a dosage effective to restore normal brain interstitial glial K+ levels in the selected subject and treat the neuropsychiatric disorder is also disclosed.
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35.发明公开公开(公告)号：US20230292719A1
公开(公告)日：2023-09-21
申请号：US18045148
申请日：2022-10-08
Applicant: UNIVERSITY OF ROCHESTER , UNIVERSITY OF COPENHAGEN
Inventor： Steven A. GOLDMAN , Ricardo de Costa Barbedo VIEIRA
IPC: A01K67/027
CPC classification number: A01K67/0271 , A01K2207/15 , A01K2227/105 , A01K2267/0318
Abstract: A chimeric non-human mammal disease model, wherein (1) at least 30% of all the glial cells in the corpus callosum of the chimeric non-human mammal are human glial cells, and/or (2) at least 5% of all of the glial cells in the white matter of the brain and/or brain stem of the chimeric non-human mammal are human glial cells, and wherein the human glial cells comprise a combination of a first group of human glial cells tagged with a first label and a second group of human glial cells tagged with a second label that is distinguishable from the first label.
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Patent Agency Ranking
公开(公告)号：US11690876B2
公开(公告)日：2023-07-04
申请号：US16612529
申请日：2018-05-10
Applicant: UNIVERSITY OF ROCHESTER
Inventor： Steven A. Goldman , Maiken Nedergaard
IPC: A61K35/30 , A61P25/18 , A61K31/495 , C12N5/0735 , C12N5/074 , A61K9/00
CPC classification number: A61K35/30 , A61K31/495 , A61P25/18 , C12N5/0606 , C12N5/0696 , A61K9/007 , A61K9/0019 , A61K9/0085
Abstract: The present disclosure is directed to a method of treating a neuropsychiatric disorder. This method involves selecting a subject having the neuropsychiatric disorder and administering to the selected subject a preparation of glial progenitor cells at a dosage effective to treat the neuropsychiatric disorder in the subject. Another aspect of the disclosure is directed to a method of treating a neuropsychiatric disorder that includes selecting a subject having the neuropsychiatric disorder and administering, to the selected subject, a potassium (K+) channel activator at a dosage effective to restore normal brain interstitial glial K+ levels in the selected subject and treat the neuropsychiatric disorder is also disclosed.
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公开(公告)号：US20230174987A1
公开(公告)日：2023-06-08
申请号：US17814120
申请日：2022-07-21
Applicant: Ionis Pharmaceuticals, Inc. , University of Rochester
Inventor： C. Frank Bennett , Susan M. Freier , Robert A. MacLeod , Sanjay K. Pandey , Charles A. Thornton , Thurman Wheeler , Seng H. Cheng , Andrew Leger , Bruce M. Wentworth
IPC: C12N15/113 , A61P15/00 , A61P25/18 , A61P43/00 , A61P35/00
CPC classification number: C12N15/1137 , A61P15/00 , A61P25/18 , A61P35/00 , A61P43/00 , C12N15/113 , C12Y207/11 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3181 , C12N2310/3231 , C12N2310/3341 , C12N2310/3525
Abstract: Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.
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公开(公告)号：US20230157812A1
公开(公告)日：2023-05-25
申请号：US18095748
申请日：2023-01-11
Applicant: University of Rochester
Inventor： Leonard Zheleznyak , Scott Catlin
CPC classification number: A61F2/1618 , G02B1/043 , A61F2/1451 , A61F2/1654 , A61F2/1613 , A61F2/1651 , A61F9/00806 , A61F9/00812 , A61F9/00829 , A61F9/00834 , A61F9/00838 , G02C7/049 , A61F9/00825 , A61F9/00827 , G02C7/041 , A61F2002/1696 , G02C7/048 , G02C2202/12 , G02C2202/24 , H01S3/2222
Abstract: Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical polymeric materials or optical tissues is performed to address various types of vision correction.
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公开(公告)号：US20230154001A1
公开(公告)日：2023-05-18
申请号：US18151114
申请日：2023-01-06
Applicant: UNIVERSITY OF ROCHESTER
CPC classification number: G06T7/0012 , A61B8/485 , A61B8/4444 , A61B8/469 , A61B8/4483 , G06T2207/10028 , G06T2207/30068 , G06T2207/10101 , G06T2207/10088 , G06T2207/10132 , G06T2207/30056
Abstract: Within the field of elastography, a new approach analyzes the limiting case of shear waves established as a reverberant field. In this framework, it is assumed that a distribution of shear waves exists, oriented across all directions in 3D (e.g 2D space+time). The simultaneous multi-frequency application of reverberant shear wave fields can be accomplished by applying an array of external sources that can be excited by multiple frequencies within a bandwidth, for example 50, 100, 150, . . . 500 Hz, all contributing to the shear wave field produced in the liver or other target organ. This enables the analysis of the dispersion of shear wave speed as it increases with frequency, indicating the viscoelastic and lossy nature of the tissue under study. Furthermore, dispersion images can be created and displayed alongside the shear wave speed images. Studies on breast and liver tissues using the multi-frequency reverberant shear wave technique, employing frequencies up to 700 Hz in breast tissue, and robust reverberant patterns of shear waves across the entire liver and kidney in obese patients are reported. Dispersion images are shown to have contrast between tissue types and with quantitative values that align with previous studies.
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公开(公告)号：US11634400B2
公开(公告)日：2023-04-25
申请号：US16640138
申请日：2018-08-17
Applicant: University of Rochester
Inventor： Rudi Fasan , Simone Giovani , Hanan Alwaseem
IPC: C07D307/93 , A61P35/02 , A61P35/00 , C12N9/02
Abstract: The present invention relates to derivatives of the sesquiterpene lactone micheliolide, methods and compositions for their preparation, and methods for using the micheliolide derivatives in pharmaceutical compositions as anticancer and anti-inflammatory agents. The invention also relates to methods for producing micheliolide derivatives modified at positions C2 and C14. The invention also relates to methods for producing parthenolide derivatives modified at positions C2 and C14 in conjunction with modifications at position C13, via chemoenzymatic methods. The invention further relates to methods for using parthenolide derivatives for treating cancer and inflammatory diseases.
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