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    Apparatus for maintaining a controlled environment
    31.
    发明授权
    Apparatus for maintaining a controlled environment 有权

    公开(公告)号：US11668525B2

    公开(公告)日：2023-06-06

    申请号：US17345779

    申请日：2021-06-11

    Applicant: Gen-Probe Incorporated

    Inventor： Byron J. Knight

    IPC: F26B5/06 ,  F26B25/06 ,  B01L7/00 ,  A01N1/02 ,  B01L9/06 ,  B01L1/02

    CPC classification number: F26B5/06 ,  A01N1/0252 ,  A01N1/0289 ,  B01L1/02 ,  B01L7/00 ,  B01L9/06 ,  F26B25/063 ,  B01L2200/0689 ,  B01L2300/042 ,  B01L2300/0829 ,  B01L2300/1894 ,  B01L2400/049

    Abstract: A lyophilization nest and method of using the same is described herein. In various embodiments, the lyophilization nest is configured to support one or more receptacles each supporting one or more substances within an interior space of the lyophilization nest. The interior space may be in fluid communication with the exterior of the lyophilization nest through one or more vent holes extending through a surface of the lyophilization nest. Each of the one or more vent holes have a corresponding sealing element configured to selectively form an air-tight seal within the vent holes, such that a controlled environment may be maintained within the interior space when the ambient conditions surrounding the lyophilization nest are not lyophilization conditions. The one or more sealing elements may be operable while the lyophilization nest is positioned within a sealed lyophilizer by depressing the sealing elements into corresponding vent holes to form the air-tight seal.

    DIAGNOSTIC SYSTEM AND METHOD
    32.
    发明申请
    DIAGNOSTIC SYSTEM AND METHOD 有权

    公开(公告)号：US20220315989A1

    公开(公告)日：2022-10-06

    申请号：US17842535

    申请日：2022-06-16

    Applicant: Gen-Probe Incorporated

    Inventor： David OPALSKY ,  Byron J. Knight

    IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

    Abstract: A nucleic acid diagnostic system includes a unit-dose reagent compartment storing at least one unit-dose pack, one or more unit-dose pack loading stations for holding a unit-dose pack at a location that permits a substance transfer device to dispense a reconstitution reagent into each well of the pack, a unit-dose pack distributor configured to transfer a unit-dose pack from the unit-dose reagent compartment to one of the unit-dose pack loading stations, and an electrostatic generator disposed within the housing of the unit-dose reagent compartment and/or adjacent the one or more unit-dose pack loading stations. The electrostatic generator imparts an electrostatic charge to each of the wells of the unit-dose pack and/or to a lyophilized reagent pellet within each well so that the electrostatic charge positions and holds each lyophilized reagent pellet at a bottom of each respective well of the unit-dose pack.

    Interlocking cap and vial
    34.
    发明授权
    Interlocking cap and vial 有权

    公开(公告)号：US11136617B2

    公开(公告)日：2021-10-05

    申请号：US17036307

    申请日：2020-09-29

    Applicant: Gen-Probe Incorporated

    Inventor： Byron J. Knight ,  David A. Buse ,  Norbert D. Hagen ,  David Opalsky ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

    IPC: C12Q1/68 ,  B01L3/00 ,  C12Q1/6806 ,  G01N35/04 ,  B01L7/00 ,  C12Q1/686

    Abstract: A cap that is securable to a vial includes a plug configured for insertion into an open end of the vial. An upper portion of the cap defines a probe recess with an open top end and configured to receive a distal end of a probe of a pipettor inserted into the open top end, to frictionally secure the cap to an end of the probe. The cap includes a radially-oriented annular surface with one or more locking members depending from a periphery of the annular surface. The locking members are spaced from the plug and each locking member includes a radial locking groove and a radial locking ridge beneath the radial locking groove. A lip of the vial snaps into the radial locking groove above the radial locking ridge to secure the cap to the vial when the plug is inserted into the open end of the vial.

    APPARATUS FOR MAINTAINING A CONTROLLED ENVIRONMENT
    36.
    发明申请
    APPARATUS FOR MAINTAINING A CONTROLLED ENVIRONMENT 审中-公开

    公开(公告)号：US20190390903A1

    公开(公告)日：2019-12-26

    申请号：US16560476

    申请日：2019-09-04

    Applicant: Gen-Probe Incorporated

    Inventor： Byron J. Knight

    IPC: F26B5/06 ,  F26B25/06 ,  B01L1/02

    Abstract: A lyophilization nest and method of using the same is described herein. In various embodiments, the lyophilization nest is configured to support one or more receptacles each supporting one or more substances within an interior space of the lyophilization nest. The interior space may be in fluid communication with the exterior of the lyophilization nest through one or more vent holes extending through a surface of the lyophilization nest. Each of the one or more vent holes have a corresponding sealing element configured to selectively form an air-tight seal within the vent holes, such that a controlled environment may be maintained within the interior space when the ambient conditions surrounding the lyophilization nest are not lyophilization conditions. The one or more sealing elements may be operable while the lyophilization nest is positioned within a sealed lyophilizer by depressing the sealing elements into corresponding vent holes to form the air-tight seal.

    METHODS AND DEVICES FOR CALIBRATING AND/OR MONITORING OPTICAL MEASUREMENT DEVICES
    40.
    发明申请
    METHODS AND DEVICES FOR CALIBRATING AND/OR MONITORING OPTICAL MEASUREMENT DEVICES 审中-公开
    用于校准和/或监测光学测量装置的方法和装置

    公开(公告)号：US20160363534A1

    公开(公告)日：2016-12-15

    申请号：US15176867

    申请日：2016-06-08

    Applicant: Gen-Probe Incorporated

    Inventor： Norbert D. HAGEN ,  David OPALSKY ,  George T. WALKER ,  Byron J. Knight

    IPC: G01N21/64

    CPC classification number: G01N21/64 ,  G01N21/276 ,  G01N21/645

    Abstract: An optical signal detection module includes an optical measurement device (OMD) configured to detect an optical emission signal from an emission signal source placed in a signal-detecting position of the OMD. The optical signal detection module also includes a cover moveable between a closed position covering the signal-detecting position and an open position not covering the signal-detecting position. The cover includes an optical reference material that emits a reference emission detectable by the OMD. The cover is configured so that, when the cover is in the closed position, the inner surface is in the signal-detecting position of the OMD so that the OMD detects the reference emission. The optical signal detection module can also include a drive assembly coupled to the cover and configured to move the cover between the open position and the closed position. In some embodiments, the OMD can include a fluorometer.

    Abstract translation: 光信号检测模块包括被配置为从放置在OMD的信号检测位置的发射信号源检测光发射信号的光学测量装置（OMD）。 光信号检测模块还包括可在覆盖信号检测位置的关闭位置和不覆盖信号检测位置的打开位置之间移动的盖。 该盖包括发射由OMD可检测的参考发射的光学参考物质。 盖被配置成使得当盖处于关闭位置时，内表面处于OMD的信号检测位置，使得OMD检测参考发射。 光信号检测模块还可以包括耦合到盖并被构造成在打开位置和关闭位置之间移动盖的驱动组件。 在一些实施方案中，OMD可以包括荧光计。

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